Econazole_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Econazole perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Econazole_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.0475947
ERRFI1 ERBB receptor feedback inhibitor 1 0.0446846
ZNF292 zinc finger protein 292 0.0377376
TMEM59 transmembrane protein 59 0.0357703
PRRC2C proline-rich coiled-coil 2C 0.0351418
AMPD3 adenosine monophosphate deaminase 3 0.0337652
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0336565
RAB8B RAB8B, member RAS oncogene family 0.0328299
DSCAM Down syndrome cell adhesion molecule 0.0320285
NUP58 nucleoporin 58 0.0319309
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0311676
KIF14 kinesin family member 14 0.0310979
ZMIZ1 zinc finger, MIZ-type containing 1 0.0305953
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0298589
UGCG UDP-glucose ceramide glucosyltransferase 0.0287918
ABI1 abl-interactor 1 0.0287107
ANLN anillin, actin binding protein 0.0280709
FAM13A family with sequence similarity 13, member A 0.0280643
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0269796
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0268294
IRF1 interferon regulatory factor 1 0.0267799
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.026677
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0266688
WNT5A wingless-type MMTV integration site family, member 5A 0.0266541
CUL4B cullin 4B 0.0263233
ACBD3 acyl-CoA binding domain containing 3 0.0263004
YBX1 Y box binding protein 1 0.0262195
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0256432
CARD16 caspase recruitment domain family, member 16 0.025335
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0252768
EPCAM epithelial cell adhesion molecule 0.0251493
WTAP Wilms tumor 1 associated protein 0.0249487
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0244328
IER2 immediate early response 2 0.0242806
SGCE sarcoglycan, epsilon 0.0241104
USP53 ubiquitin specific peptidase 53 0.0240692
PAPOLA poly(A) polymerase alpha 0.0239886
AKAP10 A kinase (PRKA) anchor protein 10 0.0238612
WDR45B WD repeat domain 45B 0.0237431
GCLC glutamate-cysteine ligase, catalytic subunit 0.0237192
RICTOR RPTOR independent companion of MTOR, complex 2 0.0237049
EEF1AKMT2 EEF1A lysine methyltransferase 2 0.0236072
RNF144B ring finger protein 144B 0.0235671
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.023427
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0227533
ANKRD33B ankyrin repeat domain 33B 0.022688
PLAUR plasminogen activator, urokinase receptor 0.0224587
USP12 ubiquitin specific peptidase 12 0.0223032
TWSG1 twisted gastrulation BMP signaling modulator 1 0.0222743
FNBP1 formin binding protein 1 0.0221937
NPTN neuroplastin 0.02219
SSBP1 single-stranded DNA binding protein 1, mitochondrial 0.022031
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0220141
ZBTB11 zinc finger and BTB domain containing 11 0.0217215
ANKRD37 ankyrin repeat domain 37 0.0216314
C1ORF21 chromosome 1 open reading frame 21 0.0214423
C1S complement component 1, s subcomponent 0.0213272
RNASE3 ribonuclease, RNase A family, 3 0.0212734
GPBP1 GC-rich promoter binding protein 1 0.0212488
CALR calreticulin 0.0212295
BIRC3 baculoviral IAP repeat containing 3 0.02115
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.021106
UPP1 uridine phosphorylase 1 0.0211024
ATXN3 ataxin 3 0.0210204
RABGAP1 RAB GTPase activating protein 1 0.0210161
MORC3 MORC family CW-type zinc finger 3 0.0209914
IL1B interleukin 1, beta 0.0209821
CHURC1-FNTB CHURC1-FNTB readthrough 0.0209544
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0209429
RASA3 RAS p21 protein activator 3 0.020849
MMUT methylmalonyl-CoA mutase 0.020839
HMGA1 high mobility group AT-hook 1 0.0208319
ATP9A ATPase, class II, type 9A 0.0207868
ORC4 origin recognition complex, subunit 4 0.0205966
RASA2 RAS p21 protein activator 2 0.0203306
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 0.0202387
IL1R1 interleukin 1 receptor, type I 0.0201807
BIRC6 baculoviral IAP repeat containing 6 0.020174
CADM1 cell adhesion molecule 1 0.0200476
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0200415
RNMT RNA (guanine-7-) methyltransferase 0.0200167
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0198905
MMP1 matrix metallopeptidase 1 0.0198693
KDM6A lysine (K)-specific demethylase 6A 0.0198214
MED15 mediator complex subunit 15 0.0197951
SYT1 synaptotagmin I 0.0197428
GTF2A2 general transcription factor IIA, 2, 12kDa 0.0197124
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0196461
LACTB lactamase, beta 0.0195497
CNTROB centrobin, centrosomal BRCA2 interacting protein 0.0194562
NPEPPS aminopeptidase puromycin sensitive 0.0194216
ELP3 elongator acetyltransferase complex subunit 3 0.0194007
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing 0.0193988
BTBD7 BTB (POZ) domain containing 7 0.0193763
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0192627
WASL Wiskott-Aldrich syndrome-like 0.0192539
IRAK2 interleukin-1 receptor-associated kinase 2 0.0191902
GADD45B growth arrest and DNA-damage-inducible, beta 0.0191814
OXSR1 oxidative stress responsive 1 0.0191705
ZNF143 zinc finger protein 143 0.0191045

decreased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 -0.23537
FN1 fibronectin 1 -0.182919
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.169391
VIM vimentin -0.141321
MT2A metallothionein 2A -0.13892
TIMP3 TIMP metallopeptidase inhibitor 3 -0.138029
IGFBP3 insulin-like growth factor binding protein 3 -0.13009
F3 coagulation factor III (thromboplastin, tissue factor) -0.12582
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.114341
TMSB10 thymosin beta 10 -0.107544
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.102195
PSD3 pleckstrin and Sec7 domain containing 3 -0.100206
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0998868
HLA-B major histocompatibility complex, class I, B -0.0986122
TGFBI transforming growth factor, beta-induced, 68kDa -0.0984296
CALU calumenin -0.0968936
LOXL2 lysyl oxidase-like 2 -0.0900037
POTEF POTE ankyrin domain family, member F -0.0816794
CDH13 cadherin 13 -0.0782314
HMGA2 high mobility group AT-hook 2 -0.0765466
GLIS3 GLIS family zinc finger 3 -0.0762592
LOC112694756 uncharaterized LOC112694756 -0.0718128
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0710777
CD44 CD44 molecule (Indian blood group) -0.0698731
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0675087
STC1 stanniocalcin 1 -0.0674357
COL1A2 collagen, type I, alpha 2 -0.0671788
FTH1 ferritin, heavy polypeptide 1 -0.0649034
PDIA3 protein disulfide isomerase family A, member 3 -0.0646527
COL6A1 collagen, type VI, alpha 1 -0.0637817
MAP1B microtubule-associated protein 1B -0.0623221
TPM4 tropomyosin 4 -0.0616469
RTN4 reticulon 4 -0.061627
NAMPT nicotinamide phosphoribosyltransferase -0.0608272
FNDC3B fibronectin type III domain containing 3B -0.0586657
COL6A2 collagen, type VI, alpha 2 -0.0576372
PRSS23 protease, serine, 23 -0.0570991
CALD1 caldesmon 1 -0.0564843
MACF1 microtubule-actin crosslinking factor 1 -0.0562317
AHNAK AHNAK nucleoprotein -0.0559718
SEPTIN7 septin 7 -0.0557941
MYOF myoferlin -0.0553375
GARS1 glycyl-tRNA synthetase 1 -0.0552425
COL5A1 collagen, type V, alpha 1 -0.0532185
ACTG1 actin gamma 1 -0.0518624
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0508798
LOX lysyl oxidase -0.05023
PTMA prothymosin, alpha -0.0497001
HLA-C major histocompatibility complex, class I, C -0.0494652
RRBP1 ribosome binding protein 1 -0.0485367
TPT1 tumor protein, translationally-controlled 1 -0.0484186
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0480862
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0480256
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0468779
NAV1 neuron navigator 1 -0.0467466
CDK6 cyclin-dependent kinase 6 -0.0463236
RAI14 retinoic acid induced 14 -0.0460901
VCL vinculin -0.0445555
PDLIM5 PDZ and LIM domain 5 -0.043185
AKAP12 A kinase (PRKA) anchor protein 12 -0.0427543
MYH9 myosin, heavy chain 9, non-muscle -0.0414078
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0408006
NRXN3 neurexin 3 -0.0404433
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0403911
CLIC4 chloride intracellular channel 4 -0.0397763
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0397469
HIPK2 homeodomain interacting protein kinase 2 -0.0395206
HLA-A major histocompatibility complex, class I, A -0.0392712
LDHA lactate dehydrogenase A -0.0385621
CAVIN1 caveolae associated protein 1 -0.0384957
DPYD dihydropyrimidine dehydrogenase -0.0384886
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0382683
TPM1 tropomyosin 1 (alpha) -0.0380719
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0379893
HM13 histocompatibility (minor) 13 -0.0379658
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.0378975
FTL ferritin, light polypeptide -0.0372562
TAS2R14 taste receptor, type 2, member 14 -0.0371119
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0369885
ABLIM3 actin binding LIM protein family, member 3 -0.0368407
ENO1 enolase 1, (alpha) -0.0367974
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0367204
COL5A2 collagen, type V, alpha 2 -0.0365604
TENT5A terminal nucleotidyltransferase 5A -0.0364863
MEF2A myocyte enhancer factor 2A -0.0362071
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.035432
SBF2 SET binding factor 2 -0.035082
EXT1 exostosin glycosyltransferase 1 -0.0350643
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0350509
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0343396
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0342394
ARB2A ARB2 cotranscriptional regulator A -0.0342343
ZMYND8 zinc finger, MYND-type containing 8 -0.0331618
ELL2 elongation factor, RNA polymerase II, 2 -0.0330623
DST dystonin -0.033022
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0329249
CDK13 cyclin-dependent kinase 13 -0.0327506
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0327329
TOP1 topoisomerase (DNA) I -0.0325839
TNS3 tensin 3 -0.0324789