Econazole_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Econazole perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Econazole_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0587744
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0508996
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0502451
AHR aryl hydrocarbon receptor 0.047679
TRIO trio Rho guanine nucleotide exchange factor 0.047677
IGFBP3 insulin-like growth factor binding protein 3 0.0382468
AFDN afadin, adherens junction formation factor 0.0313317
SFTPA2 surfactant protein A2 0.0295793
MRPS6 mitochondrial ribosomal protein S6 0.0289463
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0280183
ARRDC3 arrestin domain containing 3 0.0271551
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0268623
UBAP2L ubiquitin associated protein 2-like 0.0258921
MXI1 MAX interactor 1, dimerization protein 0.0246499
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0220848
APP amyloid beta (A4) precursor protein 0.0215351
ERRFI1 ERBB receptor feedback inhibitor 1 0.020806
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0186174
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0185778
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0185434
GRB10 growth factor receptor-bound protein 10 0.0182441
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0179114
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.0177302
PLAUR plasminogen activator, urokinase receptor 0.016216
RAB8B RAB8B, member RAS oncogene family 0.0158802
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0156592
ZNF217 zinc finger protein 217 0.0154948
PDE8A phosphodiesterase 8A 0.0151512
NGLY1 N-glycanase 1 0.0150141
SERINC1 serine incorporator 1 0.0149851
CTBP2 C-terminal binding protein 2 0.0149815
DGKD diacylglycerol kinase, delta 130kDa 0.0149558
ATP13A3 ATPase type 13A3 0.0148331
ITPRID2 ITPR interacting domain containing 2 0.0147876
PTPRF protein tyrosine phosphatase, receptor type, F 0.014752
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0143732
CEP95 centrosomal protein 95kDa 0.0142569
BIRC6 baculoviral IAP repeat containing 6 0.0140193
CDC27 cell division cycle 27 0.0139173
ANLN anillin, actin binding protein 0.0138752
KDM7A lysine (K)-specific demethylase 7A 0.0136816
HSPA8 heat shock 70kDa protein 8 0.0136746
MED15 mediator complex subunit 15 0.0136267
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0136256
NPC1 Niemann-Pick disease, type C1 0.0135999
ABHD17C abhydrolase domain containing 17C 0.0132744
CAPN2 calpain 2, (m/II) large subunit 0.0132663
RO60 Ro60, Y RNA binding protein 0.0132576
SMOX spermine oxidase 0.0132023
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0131994
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0126936
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0125544
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0124808
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.012434
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0124246
IL6 interleukin 6 0.0124207
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.012362
ARGLU1 arginine and glutamate rich 1 0.0121009
STK10 serine/threonine kinase 10 0.0118055
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.01153
BTBD9 BTB (POZ) domain containing 9 0.0114873
RAB18 RAB18, member RAS oncogene family 0.011421
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0114123
SUB1 SUB1 homolog (S. cerevisiae) 0.0112232
RAB6A RAB6A, member RAS oncogene family 0.0111527
TM4SF1 transmembrane 4 L six family member 1 0.0111331
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0110349
CSNK1E casein kinase 1, epsilon 0.0109468
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.010936
NT5E 5'-nucleotidase, ecto (CD73) 0.0108553
SLC16A6 solute carrier family 16, member 6 0.0108384
NUP153 nucleoporin 153kDa 0.0108376
ZDHHC17 zinc finger, DHHC-type containing 17 0.0107469
MKRN1 makorin ring finger protein 1 0.0106872
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.010636
ARHGAP29 Rho GTPase activating protein 29 0.0105813
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 0.0105597
ZNF841 zinc finger protein 841 0.0104787
TNRC6C trinucleotide repeat containing 6C 0.0104349
RUFY2 RUN and FYVE domain containing 2 0.0104188
EIF4H eukaryotic translation initiation factor 4H 0.0102149
TENT5A terminal nucleotidyltransferase 5A 0.0100795
CLK4 CDC-like kinase 4 0.010032
PRPF8 pre-mRNA processing factor 8 0.0100155
TMED2 transmembrane emp24 domain trafficking protein 2 0.00996863
KLF6 Kruppel-like factor 6 0.00995591
CKAP5 cytoskeleton associated protein 5 0.0099301
COPG1 coatomer protein complex, subunit gamma 1 0.00990292
DDIT4 DNA-damage-inducible transcript 4 0.00989885
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.00988593
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.00985245
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.00978953
ZMIZ1 zinc finger, MIZ-type containing 1 0.00978483
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.00969785
SDF4 stromal cell derived factor 4 0.00959001
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 0.00957502
VEGFC vascular endothelial growth factor C 0.00953135
NCOR1 nuclear receptor corepressor 1 0.00952063
TMEM41B transmembrane protein 41B 0.00948715
LIMCH1 LIM and calponin homology domains 1 0.00947409

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.465963
MT2A metallothionein 2A -0.222698
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.146865
FTH1 ferritin, heavy polypeptide 1 -0.120937
FN1 fibronectin 1 -0.114289
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.110993
NRG1 neuregulin 1 -0.098933
TMSB10 thymosin beta 10 -0.0950247
PTMA prothymosin, alpha -0.0788564
EXT1 exostosin glycosyltransferase 1 -0.0774426
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0771191
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0756981
NAMPT nicotinamide phosphoribosyltransferase -0.0721409
AKAP12 A kinase (PRKA) anchor protein 12 -0.0712055
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0639268
FTL ferritin, light polypeptide -0.0638606
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0628025
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0619718
S100A6 S100 calcium binding protein A6 -0.061292
HMGA2 high mobility group AT-hook 2 -0.0599383
LMNA lamin A/C -0.059537
RPS6 ribosomal protein S6 -0.0585268
RPS19 ribosomal protein S19 -0.0535311
RPLP1 ribosomal protein, large, P1 -0.0524991
LOC112694756 uncharaterized LOC112694756 -0.0524649
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0522758
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0519955
LOC102724023 ES1 protein homolog, mitochondrial -0.0517462
IFI27 interferon, alpha-inducible protein 27 -0.0514553
RPL28 ribosomal protein L28 -0.0513637
TXNIP thioredoxin interacting protein -0.0508893
FKBP5 FK506 binding protein 5 -0.0504142
IRAK3 interleukin-1 receptor-associated kinase 3 -0.0503975
RPS20 ribosomal protein S20 -0.0502438
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0487289
B2M beta-2-microglobulin -0.0479341
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0478478
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0478041
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0471387
RNF145 ring finger protein 145 -0.046861
MT1X metallothionein 1X -0.0466965
RPL11 ribosomal protein L11 -0.0453247
RPL35A ribosomal protein L35a -0.0445835
HIPK2 homeodomain interacting protein kinase 2 -0.04397
CANX calnexin -0.0437719
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0435891
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0435857
PDIA3 protein disulfide isomerase family A, member 3 -0.0430552
S100A10 S100 calcium binding protein A10 -0.0418766
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0411603
ASPH aspartate beta-hydroxylase -0.0410463
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0410311
MBNL1 muscleblind-like splicing regulator 1 -0.0406166
TPI1 triosephosphate isomerase 1 -0.0405999
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0396409
VIM vimentin -0.0396135
TNS3 tensin 3 -0.0394957
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.039269
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0385216
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0385014
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0382861
HLA-B major histocompatibility complex, class I, B -0.0376522
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0375341
HILPDA hypoxia inducible lipid droplet-associated -0.0375278
VCL vinculin -0.0360363
BIRC3 baculoviral IAP repeat containing 3 -0.0359377
RPS24 ribosomal protein S24 -0.0357815
IRS2 insulin receptor substrate 2 -0.0355519
GLUL glutamate-ammonia ligase -0.0346151
ANKRD28 ankyrin repeat domain 28 -0.0343445
PFN1 profilin 1 -0.0343019
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0342474
RPL31 ribosomal protein L31 -0.0338126
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0337905
COPA coatomer protein complex, subunit alpha -0.0336775
FNDC3B fibronectin type III domain containing 3B -0.0329667
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0328038
GOLGB1 golgin B1 -0.0327776
RPS21 ribosomal protein S21 -0.0324266
EGR1 early growth response 1 -0.0321717
UBXN4 UBX domain protein 4 -0.031832
SOD2 superoxide dismutase 2, mitochondrial -0.0314041
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0313682
RAD21 RAD21 homolog (S. pombe) -0.0308974
ENO2 enolase 2 (gamma, neuronal) -0.0307878
TMEM156 transmembrane protein 156 -0.0307634
LOX lysyl oxidase -0.0303078
ACTG1 actin gamma 1 -0.0303008
TOP1 topoisomerase (DNA) I -0.0302518
BSG basigin (Ok blood group) -0.030225
NRP1 neuropilin 1 -0.0301104
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0301078
LDHB lactate dehydrogenase B -0.0300711
RPS5 ribosomal protein S5 -0.0299188
RPL19 ribosomal protein L19 -0.0298415
SRRM2 serine/arginine repetitive matrix 2 -0.0297569
ADAM9 ADAM metallopeptidase domain 9 -0.0295588
RBM39 RNA binding motif protein 39 -0.0295162
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.029387
DNM1L dynamin 1-like -0.0292469