Edoxaban (tosylate monohydrate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Edoxaban (tosylate monohydrate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Edoxaban (tosylate monohydrate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.132137
VIM vimentin 0.125707
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0961077
CSF1 colony stimulating factor 1 (macrophage) 0.0878653
CALR calreticulin 0.0794925
CCL2 chemokine (C-C motif) ligand 2 0.0745954
TMSB10 thymosin beta 10 0.0687482
EEF2 eukaryotic translation elongation factor 2 0.0636754
EIF1 eukaryotic translation initiation factor 1 0.0611738
B2M beta-2-microglobulin 0.0611185
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0606783
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.059359
RPS4X ribosomal protein S4, X-linked 0.0567486
APOL1 apolipoprotein L, 1 0.0547909
PTMA prothymosin, alpha 0.0531325
MT2A metallothionein 2A 0.0525335
RPL3 ribosomal protein L3 0.0520523
RPL23 ribosomal protein L23 0.0511033
DDIT4 DNA-damage-inducible transcript 4 0.0446792
BIRC3 baculoviral IAP repeat containing 3 0.0442544
FLNA filamin A, alpha 0.043361
RPL35A ribosomal protein L35a 0.0427522
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0403515
PLEC plectin 0.038948
FTH1 ferritin, heavy polypeptide 1 0.0388517
HDGF hepatoma-derived growth factor 0.0374044
RACK1 receptor for activated C kinase 1 0.036455
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.0360155
IRS2 insulin receptor substrate 2 0.0351272
GDF15 growth differentiation factor 15 0.0349857
ZFP36L1 ZFP36 ring finger protein-like 1 0.0334041
ARRDC3 arrestin domain containing 3 0.0324928
SRRM2 serine/arginine repetitive matrix 2 0.0320941
CP ceruloplasmin (ferroxidase) 0.0320129
RPL8 ribosomal protein L8 0.0306736
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0304819
PLIN2 perilipin 2 0.0303383
PKM pyruvate kinase, muscle 0.0302384
DENND2B DENN domain containing 2B 0.0299182
ACTG1 actin gamma 1 0.0297561
RPS8 ribosomal protein S8 0.0290496
HLA-B major histocompatibility complex, class I, B 0.0290114
RPS19 ribosomal protein S19 0.0289254
G0S2 G0/G1 switch 2 0.0283908
RPL7A ribosomal protein L7a 0.0280242
PDIA6 protein disulfide isomerase family A, member 6 0.0279499
RAD23B RAD23 homolog B (S. cerevisiae) 0.0277014
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0276377
LRRC59 leucine rich repeat containing 59 0.026446
TPI1 triosephosphate isomerase 1 0.0261369
HLA-A major histocompatibility complex, class I, A 0.0259674
ADM adrenomedullin 0.0257883
TPT1 tumor protein, translationally-controlled 1 0.0257444
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0257301
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0256329
GIGYF2 GRB10 interacting GYF protein 2 0.0252808
EIF4A1 eukaryotic translation initiation factor 4A1 0.0249129
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.02481
RPL35 ribosomal protein L35 0.0247247
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0245969
RPL19 ribosomal protein L19 0.0245029
MKRN1 makorin ring finger protein 1 0.0240304
RPL4 ribosomal protein L4 0.0238846
CAVIN1 caveolae associated protein 1 0.0238831
S100A6 S100 calcium binding protein A6 0.0238584
KPNB1 karyopherin (importin) beta 1 0.0235929
FTL ferritin, light polypeptide 0.0233797
FSCN1 fascin actin-bundling protein 1 0.0228418
RPL34 ribosomal protein L34 0.0228204
TUBB tubulin, beta class I 0.0227664
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0226088
CXCL8 chemokine (C-X-C motif) ligand 8 0.0225024
LMNA lamin A/C 0.0222626
RPL37 ribosomal protein L37 0.0222529
ANKRD10 ankyrin repeat domain 10 0.0221471
SMIM44 small integral membrane protein 44 0.0221339
RPS17 ribosomal protein S17 0.0219847
RPS15A ribosomal protein S15a 0.0219316
RPS5 ribosomal protein S5 0.0219311
COL4A1 collagen, type IV, alpha 1 0.0217907
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0217346
SAA2 serum amyloid A2 0.0216067
TMED9 transmembrane emp24 protein transport domain containing 9 0.0215636
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0215621
LOC112694756 uncharaterized LOC112694756 0.021413
NFE2L1 nuclear factor, erythroid 2-like 1 0.0211936
TNIP1 TNFAIP3 interacting protein 1 0.0211699
GNAS GNAS complex locus 0.0211529
TKT transketolase 0.0209404
RPL26 ribosomal protein L26 0.0208542
ARGLU1 arginine and glutamate rich 1 0.0207424
XPOT exportin, tRNA 0.0206445
MLEC malectin 0.0206182
SET SET nuclear proto-oncogene 0.0206142
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0204853
MINDY2 MINDY lysine 48 deubiquitinase 2 0.020306
KTN1 kinectin 1 (kinesin receptor) 0.0202179
FN1 fibronectin 1 0.0201586
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.0200689
NACA nascent polypeptide-associated complex alpha subunit 0.0196604

decreased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A -0.224229
ASPH aspartate beta-hydroxylase -0.18286
EXT1 exostosin glycosyltransferase 1 -0.123514
GPC6 glypican 6 -0.122677
FNDC3B fibronectin type III domain containing 3B -0.100051
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0872659
TRIO trio Rho guanine nucleotide exchange factor -0.086504
CD44 CD44 molecule (Indian blood group) -0.0850836
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.077255
IGFBP3 insulin-like growth factor binding protein 3 -0.0705769
VCL vinculin -0.0705169
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0678702
RAI14 retinoic acid induced 14 -0.065346
PDLIM5 PDZ and LIM domain 5 -0.06217
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0619119
CREB5 cAMP responsive element binding protein 5 -0.0616126
NAV2 neuron navigator 2 -0.0554985
NRIP1 nuclear receptor interacting protein 1 -0.0549062
KYNU kynureninase -0.0546208
CRY1 cryptochrome circadian clock 1 -0.0545526
FAM107B family with sequence similarity 107, member B -0.0543396
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.053556
ALCAM activated leukocyte cell adhesion molecule -0.0531366
CADM1 cell adhesion molecule 1 -0.0525801
LOXL2 lysyl oxidase-like 2 -0.051597
MAP1B microtubule-associated protein 1B -0.0511679
TUSC3 tumor suppressor candidate 3 -0.0508126
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0499073
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0497545
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0475798
NUP98 nucleoporin 98kDa -0.047522
POTEF POTE ankyrin domain family, member F -0.0452543
INTS6 integrator complex subunit 6 -0.0439489
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0439048
TLE4 transducin-like enhancer of split 4 -0.0434587
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0431989
EFNA5 ephrin-A5 -0.0429077
TXNRD1 thioredoxin reductase 1 -0.0426889
PDE4D phosphodiesterase 4D, cAMP-specific -0.0422103
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0420766
NAMPT nicotinamide phosphoribosyltransferase -0.0419955
RUNX1 runt-related transcription factor 1 -0.0409784
ZBTB20 zinc finger and BTB domain containing 20 -0.0401652
EGFR epidermal growth factor receptor -0.0400244
PALLD palladin, cytoskeletal associated protein -0.0395123
SPAG9 sperm associated antigen 9 -0.0391923
CADPS2 Ca++-dependent secretion activator 2 -0.0388504
SETX senataxin -0.0384231
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0381941
SAMD4A sterile alpha motif domain containing 4A -0.0374591
EPAS1 endothelial PAS domain protein 1 -0.0366088
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0360435
SEC24D SEC24 family member D -0.0359682
RAB7A RAB7A, member RAS oncogene family -0.035772
RIGI RNA sensor RIG-I -0.0355487
PTK2 protein tyrosine kinase 2 -0.0354859
CDCP1 CUB domain containing protein 1 -0.0345519
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0342532
ELL2 elongation factor, RNA polymerase II, 2 -0.033699
DST dystonin -0.033674
DGKI diacylglycerol kinase, iota -0.0336516
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0333951
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.033329
NABP1 nucleic acid binding protein 1 -0.0330523
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0329982
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0329477
GLIS3 GLIS family zinc finger 3 -0.0326626
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0326047
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0325505
EXOC4 exocyst complex component 4 -0.0324718
EHBP1 EH domain binding protein 1 -0.0322315
BLZF1 basic leucine zipper nuclear factor 1 -0.0316991
KIRREL3 kin of IRRE like 3 (Drosophila) -0.0316845
CLTC clathrin, heavy chain (Hc) -0.0314512
RICTOR RPTOR independent companion of MTOR, complex 2 -0.031389
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -0.0311816
OSMR oncostatin M receptor -0.0309949
CDK14 cyclin-dependent kinase 14 -0.0309644
ECPAS Ecm29 proteasome adaptor and scaffold -0.0301109
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0299471
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0299165
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0296543
SUCO SUN domain containing ossification factor -0.0295924
RND3 Rho family GTPase 3 -0.0291698
ZNF644 zinc finger protein 644 -0.0288998
TUT7 terminal uridylyl transferase 7 -0.0285866
UBQLN1 ubiquilin 1 -0.0285488
CMIP c-Maf inducing protein -0.0280088
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0278344
SMAD3 SMAD family member 3 -0.0276308
BICD1 bicaudal D homolog 1 (Drosophila) -0.0276246
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0274535
KMT2E lysine (K)-specific methyltransferase 2E -0.0273662
IFI44L interferon-induced protein 44-like -0.0267793
UBAP2 ubiquitin associated protein 2 -0.0266911
SH3RF1 SH3 domain containing ring finger 1 -0.0264081
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0263413
PRKCA protein kinase C, alpha -0.0263031
RTN4 reticulon 4 -0.0261436
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -0.0259963