Edoxaban (tosylate monohydrate)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Edoxaban (tosylate monohydrate) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Edoxaban (tosylate monohydrate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.269499
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0843373
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0811914
MYH9 myosin, heavy chain 9, non-muscle 0.073421
TNIP1 TNFAIP3 interacting protein 1 0.0566055
TMSB10 thymosin beta 10 0.0548044
PLEC plectin 0.0516223
ANGPTL4 angiopoietin-like 4 0.0497574
EIF1 eukaryotic translation initiation factor 1 0.0493145
EEF2 eukaryotic translation elongation factor 2 0.0485839
PGK1 phosphoglycerate kinase 1 0.0485105
PTMA prothymosin, alpha 0.0482095
RPS19 ribosomal protein S19 0.0449124
TOP2A topoisomerase (DNA) II alpha 170kDa 0.037824
MT2A metallothionein 2A 0.0378061
RPL3 ribosomal protein L3 0.0354483
RPL4 ribosomal protein L4 0.0344254
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0336967
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0333598
RPL23 ribosomal protein L23 0.0321274
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0319861
PFKP phosphofructokinase, platelet 0.0298884
SRRM2 serine/arginine repetitive matrix 2 0.029562
IGFBP4 insulin-like growth factor binding protein 4 0.0295558
KRT7 keratin 7, type II 0.0288571
TMSB4X thymosin beta 4, X-linked 0.0285215
VIM vimentin 0.0280687
ACTG1 actin gamma 1 0.0274913
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0268234
FTH1 ferritin, heavy polypeptide 1 0.0255773
NUP58 nucleoporin 58 0.0248475
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0248379
PTPRJ protein tyrosine phosphatase, receptor type, J 0.024767
PTPRF protein tyrosine phosphatase, receptor type, F 0.0241953
LMNA lamin A/C 0.0228862
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.022827
C3 complement component 3 0.0221263
AKR1C2 aldo-keto reductase family 1, member C2 0.0220541
KRT81 keratin 81, type II 0.0218777
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0218099
ADM adrenomedullin 0.0216435
PKM pyruvate kinase, muscle 0.0216148
TPI1 triosephosphate isomerase 1 0.0215784
AHNAK AHNAK nucleoprotein 0.0213241
RPS4X ribosomal protein S4, X-linked 0.0210679
RPL35A ribosomal protein L35a 0.0210324
BHLHE40 basic helix-loop-helix family, member e40 0.0210133
EEF1G eukaryotic translation elongation factor 1 gamma 0.0205597
MT1X metallothionein 1X 0.0201307
RPL7A ribosomal protein L7a 0.0200246
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0199558
RPS3 ribosomal protein S3 0.0196507
MINK1 misshapen-like kinase 1 0.0195479
ESYT2 extended synaptotagmin-like protein 2 0.0193516
DGKD diacylglycerol kinase, delta 130kDa 0.0193447
ANKRD11 ankyrin repeat domain 11 0.0192537
TUBB tubulin, beta class I 0.0189768
EIF4A1 eukaryotic translation initiation factor 4A1 0.0189505
HILPDA hypoxia inducible lipid droplet-associated 0.0185984
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.0185381
KRT18 keratin 18, type I 0.0179881
SRGN serglycin 0.0179414
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0178735
CEMIP cell migration inducing protein, hyaluronan binding 0.017752
WDR45B WD repeat domain 45B 0.0177391
CALR calreticulin 0.0175104
KRT8 keratin 8, type II 0.0171415
RPL8 ribosomal protein L8 0.0171179
FLNA filamin A, alpha 0.0169761
NACA nascent polypeptide-associated complex alpha subunit 0.0168873
UBE2O ubiquitin-conjugating enzyme E2O 0.0168408
RPS17 ribosomal protein S17 0.0168018
KLF10 Kruppel-like factor 10 0.0167917
FBL fibrillarin 0.0166803
RNF145 ring finger protein 145 0.0162919
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0161548
RACK1 receptor for activated C kinase 1 0.0159201
NCOR2 nuclear receptor corepressor 2 0.0158707
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0158202
LOC112694756 uncharaterized LOC112694756 0.01563
PABPN1 poly(A) binding protein, nuclear 1 0.0155519
MTUS1 microtubule associated tumor suppressor 1 0.0152555
SSRP1 structure specific recognition protein 1 0.0151576
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.015069
LDHB lactate dehydrogenase B 0.0149696
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0148426
HDGF hepatoma-derived growth factor 0.0147952
LPIN2 lipin 2 0.014657
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0145509
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0144556
RPS15A ribosomal protein S15a 0.014434
MCL1 myeloid cell leukemia 1 0.0143724
RPL37A ribosomal protein L37a 0.0142451
AGFG1 ArfGAP with FG repeats 1 0.0141887
RPL26 ribosomal protein L26 0.014047
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0140024
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0139887
CASC3 cancer susceptibility candidate 3 0.0136732
CHD3 chromodomain helicase DNA binding protein 3 0.0136346
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0135425

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.188093
EFNA5 ephrin-A5 -0.157947
PDE10A phosphodiesterase 10A -0.114612
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.108889
EXT1 exostosin glycosyltransferase 1 -0.104311
EGFR epidermal growth factor receptor -0.100215
TM4SF1 transmembrane 4 L six family member 1 -0.0997027
KYNU kynureninase -0.0996528
ANXA2 annexin A2 -0.0981759
GRB10 growth factor receptor-bound protein 10 -0.0974443
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0925586
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0899842
STC1 stanniocalcin 1 -0.0898948
VCL vinculin -0.0897812
ALCAM activated leukocyte cell adhesion molecule -0.0891405
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0863986
NDRG1 N-myc downstream regulated 1 -0.0848046
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.080301
FNDC3B fibronectin type III domain containing 3B -0.0770662
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0758986
AUTS2 autism susceptibility candidate 2 -0.0732504
ASPH aspartate beta-hydroxylase -0.0732401
CD44 CD44 molecule (Indian blood group) -0.071661
SLC35F3 solute carrier family 35, member F3 -0.0682158
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0680782
PDLIM5 PDZ and LIM domain 5 -0.0679441
DOCK5 dedicator of cytokinesis 5 -0.0624606
FAM107B family with sequence similarity 107, member B -0.0613444
FBXO11 F-box protein 11 -0.0583663
ELL2 elongation factor, RNA polymerase II, 2 -0.0578909
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0560889
PARD3 par-3 family cell polarity regulator -0.0555012
GOLGB1 golgin B1 -0.05514
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0550989
ZBTB20 zinc finger and BTB domain containing 20 -0.0542478
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0524564
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.049558
LIMCH1 LIM and calponin homology domains 1 -0.0474018
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0472981
OSMR oncostatin M receptor -0.0466927
MYO10 myosin X -0.0466724
NRIP1 nuclear receptor interacting protein 1 -0.046569
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0460251
KIRREL3 kin of IRRE like 3 (Drosophila) -0.0457558
TXNRD1 thioredoxin reductase 1 -0.0444437
PRKCA protein kinase C, alpha -0.0444139
FRMD6 FERM domain containing 6 -0.0444063
SAMD4A sterile alpha motif domain containing 4A -0.0442667
SPAG9 sperm associated antigen 9 -0.0439512
TPM1 tropomyosin 1 (alpha) -0.0439229
MAML3 mastermind-like 3 (Drosophila) -0.043772
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.042753
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.042363
MYO1E myosin IE -0.0419698
LAMC2 laminin, gamma 2 -0.0412218
DUSP16 dual specificity phosphatase 16 -0.0401924
VMP1 vacuole membrane protein 1 -0.0401489
RAI14 retinoic acid induced 14 -0.0400071
HMGA2 high mobility group AT-hook 2 -0.0396602
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0396396
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0395212
PALLD palladin, cytoskeletal associated protein -0.0395019
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.039495
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.03925
ARHGAP26 Rho GTPase activating protein 26 -0.0391932
GLS2 glutaminase 2 (liver, mitochondrial) -0.0389892
MAP1B microtubule-associated protein 1B -0.0389302
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0387947
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0387845
BMAL2 basic helix-loop-helix ARNT like 2 -0.0382633
EHBP1 EH domain binding protein 1 -0.0374648
TNS3 tensin 3 -0.037195
ARHGAP5 Rho GTPase activating protein 5 -0.0370582
FNIP1 folliculin interacting protein 1 -0.0360755
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0356833
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0354958
JMJD1C jumonji domain containing 1C -0.0354506
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0353594
LMO7 LIM domain 7 -0.0353337
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.035196
PTK2 protein tyrosine kinase 2 -0.0349436
PTPRM protein tyrosine phosphatase, receptor type, M -0.0348815
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0346046
INTS6 integrator complex subunit 6 -0.0345881
PTBP3 polypyrimidine tract binding protein 3 -0.0345123
KANK1 KN motif and ankyrin repeat domains 1 -0.0343657
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0342707
TRIP12 thyroid hormone receptor interactor 12 -0.0342452
IGFBP3 insulin-like growth factor binding protein 3 -0.0341506
AKAP13 A kinase (PRKA) anchor protein 13 -0.0339922
CMIP c-Maf inducing protein -0.0333396
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0328679
NRG1 neuregulin 1 -0.0322811
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0320225
DSCAM Down syndrome cell adhesion molecule -0.0318417
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0313761
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0312506
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.031217
DOCK4 dedicator of cytokinesis 4 -0.0309415
RAD51B RAD51 paralog B -0.0308573