Edoxaban (tosylate monohydrate)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Edoxaban (tosylate monohydrate) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Edoxaban (tosylate monohydrate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEP250 centrosomal protein 250kDa 0.108501
MYH9 myosin, heavy chain 9, non-muscle 0.0979766
ZMYND8 zinc finger, MYND-type containing 8 0.082405
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0817669
THSD4 thrombospondin, type I, domain containing 4 0.0736534
VMP1 vacuole membrane protein 1 0.0660816
MACF1 microtubule-actin crosslinking factor 1 0.0589374
ANKRD36C ankyrin repeat domain 36C 0.0584177
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0523663
NAMPT nicotinamide phosphoribosyltransferase 0.0501693
CTNND1 catenin (cadherin-associated protein), delta 1 0.0460002
IGFBP5 insulin-like growth factor binding protein 5 0.0412835
DSPP dentin sialophosphoprotein 0.0411042
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0410879
NCOA3 nuclear receptor coactivator 3 0.0405027
SRCIN1 SRC kinase signaling inhibitor 1 0.0403719
CEMIP cell migration inducing protein, hyaluronan binding 0.0399785
KIAA1217 KIAA1217 0.0395485
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.038577
PDLIM5 PDZ and LIM domain 5 0.0383538
PLEC plectin 0.0381903
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0376573
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0348633
PBX1 pre-B-cell leukemia homeobox 1 0.0326085
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0325406
ACSL3 acyl-CoA synthetase long-chain family member 3 0.031344
MCL1 myeloid cell leukemia 1 0.0309904
SFPQ splicing factor proline/glutamine-rich 0.0308887
RAD51B RAD51 paralog B 0.030815
MLPH melanophilin 0.0305344
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0303685
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0303126
MYO1B myosin IB 0.0301124
HSPA8 heat shock 70kDa protein 8 0.0300576
APP amyloid beta (A4) precursor protein 0.0300333
LRRC59 leucine rich repeat containing 59 0.0297818
TPM3 tropomyosin 3 0.0294735
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0292324
SET SET nuclear proto-oncogene 0.0291293
LGALS12 lectin, galactoside-binding, soluble, 12 0.0285086
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0284518
TC2N tandem C2 domains, nuclear 0.0283995
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0283948
TENM2 teneurin transmembrane protein 2 0.0283656
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0273757
MSI2 musashi RNA-binding protein 2 0.0272591
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0267779
KAZN kazrin, periplakin interacting protein 0.0264612
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0260485
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0256859
CEMIP2 cell migration inducing hyaluronidase 2 0.0255783
DOCK5 dedicator of cytokinesis 5 0.0254842
TRPS1 trichorhinophalangeal syndrome I 0.0254521
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0251527
ELOVL5 ELOVL fatty acid elongase 5 0.0245159
TRIO trio Rho guanine nucleotide exchange factor 0.024128
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0235296
LPP LIM domain containing preferred translocation partner in lipoma 0.0223703
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0223639
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0223073
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0222841
KDM6A lysine (K)-specific demethylase 6A 0.0220338
TMSB4X thymosin beta 4, X-linked 0.0220254
KLC1 kinesin light chain 1 0.0219695
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0219333
PRLR prolactin receptor 0.0215399
MACROD2 MACRO domain containing 2 0.021207
USP53 ubiquitin specific peptidase 53 0.0210534
FNDC3B fibronectin type III domain containing 3B 0.0210388
TOM1L1 target of myb1 (chicken)-like 1 0.0207934
NIBAN2 niban apoptosis regulator 2 0.0207254
LRP1B low density lipoprotein receptor-related protein 1B 0.0206845
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.0206203
TOP6BL TOP6B like initiator of meiotic double strand breaks 0.0206182
KDM7A lysine (K)-specific demethylase 7A 0.0205733
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.020334
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.020253
GSE1 Gse1 coiled-coil protein 0.0202177
SLC22A23 solute carrier family 22, member 23 0.0202016
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0201453
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0200793
MYO5B myosin VB 0.0199447
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.019939
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0198423
SRSF1 serine/arginine-rich splicing factor 1 0.0197155
SAMD12 sterile alpha motif domain containing 12 0.0193754
AHR aryl hydrocarbon receptor 0.0193025
WWOX WW domain containing oxidoreductase 0.01879
AUTS2 autism susceptibility candidate 2 0.0187555
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.0186143
ARHGAP26 Rho GTPase activating protein 26 0.0186005
USP9X ubiquitin specific peptidase 9, X-linked 0.0183996
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0182152
EXOC4 exocyst complex component 4 0.0180408
MYOF myoferlin 0.0180016
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0179194
SRSF5 serine/arginine-rich splicing factor 5 0.017877
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0178077
ARGLU1 arginine and glutamate rich 1 0.017734
NRIP1 nuclear receptor interacting protein 1 0.0175165

decreased expression

Symbol Name Standardized Value
RPL19 ribosomal protein L19 -0.283889
RPL23 ribosomal protein L23 -0.238886
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.218966
FTH1 ferritin, heavy polypeptide 1 -0.142294
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.108188
ACTG1 actin gamma 1 -0.0855715
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0855255
TMSB10 thymosin beta 10 -0.0807915
NDRG1 N-myc downstream regulated 1 -0.0747516
FBXL20 F-box and leucine-rich repeat protein 20 -0.061891
RAB7A RAB7A, member RAS oncogene family -0.0598736
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.055757
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0549865
RPL35A ribosomal protein L35a -0.0543014
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0539333
MT2A metallothionein 2A -0.0530463
SLC38A1 solute carrier family 38, member 1 -0.0526359
POTEF POTE ankyrin domain family, member F -0.0518899
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0494168
TMEM123 transmembrane protein 123 -0.0458227
CCNI cyclin I -0.045321
RPL12 ribosomal protein L12 -0.0447574
LOC112694756 uncharaterized LOC112694756 -0.044712
GRB7 growth factor receptor-bound protein 7 -0.0435825
FTL ferritin, light polypeptide -0.0428152
LDHA lactate dehydrogenase A -0.0423375
CCND1 cyclin D1 -0.0416216
RPS6 ribosomal protein S6 -0.0415625
RPS19 ribosomal protein S19 -0.0403986
RPLP1 ribosomal protein, large, P1 -0.0392242
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0391631
LOC102724023 ES1 protein homolog, mitochondrial -0.0387819
PTMA prothymosin, alpha -0.0381347
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0376865
PFDN4 prefoldin subunit 4 -0.0376587
KRT19 keratin 19, type I -0.0374794
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.037392
RPL31 ribosomal protein L31 -0.0369113
TPT1 tumor protein, translationally-controlled 1 -0.0361437
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0355931
RPL8 ribosomal protein L8 -0.0350113
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.034182
TUBA1B tubulin, alpha 1b -0.0339605
RPS8 ribosomal protein S8 -0.0334188
RAB22A RAB22A, member RAS oncogene family -0.033334
PFN1 profilin 1 -0.0331062
S100A14 S100 calcium binding protein A14 -0.0330906
FASN fatty acid synthase -0.0328724
S100A9 S100 calcium binding protein A9 -0.0327874
B2M beta-2-microglobulin -0.0317278
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0316938
UBC ubiquitin C -0.0313559
LMAN1 lectin, mannose-binding, 1 -0.0307395
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -0.0302492
RPS29 ribosomal protein S29 -0.0300493
RPS3 ribosomal protein S3 -0.0300367
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0299967
DSTN destrin (actin depolymerizing factor) -0.0298727
RPLP0 ribosomal protein, large, P0 -0.0294156
RPL28 ribosomal protein L28 -0.0293147
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0291032
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0290354
RPL27A ribosomal protein L27a -0.0288081
RPS13 ribosomal protein S13 -0.0284666
S100A8 S100 calcium binding protein A8 -0.0280744
HLA-C major histocompatibility complex, class I, C -0.0279992
TUBB4B tubulin, beta 4B class IVb -0.0278511
KDM2A lysine (K)-specific demethylase 2A -0.0273666
HLA-B major histocompatibility complex, class I, B -0.0271715
ENO1 enolase 1, (alpha) -0.0271585
EEF2 eukaryotic translation elongation factor 2 -0.0269388
RPL37 ribosomal protein L37 -0.0265459
MYL12B myosin, light chain 12B, regulatory -0.026456
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0264222
GNAS GNAS complex locus -0.0263967
EGR1 early growth response 1 -0.0258028
MUC6 mucin 6, oligomeric mucus/gel-forming -0.025707
ATP5F1B ATP synthase F1 subunit beta -0.0253566
RPL30 ribosomal protein L30 -0.0253023
TAPBP TAP binding protein (tapasin) -0.0251455
S100A6 S100 calcium binding protein A6 -0.0243027
ANKRD12 ankyrin repeat domain 12 -0.0242395
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0238463
RPL34 ribosomal protein L34 -0.0238453
RAB2A RAB2A, member RAS oncogene family -0.0237848
RACK1 receptor for activated C kinase 1 -0.0237765
CLDN4 claudin 4 -0.0235912
EIF5B eukaryotic translation initiation factor 5B -0.0235568
RPS16 ribosomal protein S16 -0.0235292
NCOA6 nuclear receptor coactivator 6 -0.023518
CDK12 cyclin-dependent kinase 12 -0.0232545
EIF1 eukaryotic translation initiation factor 1 -0.0231943
RPL5 ribosomal protein L5 -0.0231871
TAOK3 TAO kinase 3 -0.0231374
RPS14 ribosomal protein S14 -0.0231162
RPL37A ribosomal protein L37a -0.0229516
MDK midkine (neurite growth-promoting factor 2) -0.0226478
MYADM myeloid-associated differentiation marker -0.0224625
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0223862
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0223015