Edoxaban (tosylate monohydrate)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Edoxaban (tosylate monohydrate) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Edoxaban (tosylate monohydrate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.223339
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.167691
TMSB4X thymosin beta 4, X-linked 0.14226
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.132976
APP amyloid beta (A4) precursor protein 0.118542
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.105773
ASPH aspartate beta-hydroxylase 0.0865681
ENO1 enolase 1, (alpha) 0.0743055
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0740071
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0707956
AHNAK AHNAK nucleoprotein 0.0687783
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0687615
PRELID2 PRELI domain containing 2 0.0677004
ZNF292 zinc finger protein 292 0.0666956
MACF1 microtubule-actin crosslinking factor 1 0.0660601
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0635919
ANLN anillin, actin binding protein 0.0631944
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0631179
SMAD3 SMAD family member 3 0.0608957
SRRM2 serine/arginine repetitive matrix 2 0.0597951
ITGB8 integrin, beta 8 0.059707
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0594755
SET SET nuclear proto-oncogene 0.0593344
KDM3A lysine (K)-specific demethylase 3A 0.0558099
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0530945
USP9X ubiquitin specific peptidase 9, X-linked 0.0527537
TRIO trio Rho guanine nucleotide exchange factor 0.0523277
MATR3 matrin 3 0.0507699
PGK1 phosphoglycerate kinase 1 0.0507409
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0497059
ANKRD36 ankyrin repeat domain 36 0.0488111
CALR calreticulin 0.0483249
NCKAP1 NCK-associated protein 1 0.0479501
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0475781
B2M beta-2-microglobulin 0.0467083
FNBP1L formin binding protein 1-like 0.0463492
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0460251
LPP LIM domain containing preferred translocation partner in lipoma 0.0459228
EZR ezrin 0.045616
ERRFI1 ERBB receptor feedback inhibitor 1 0.0452943
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0448085
ANXA1 annexin A1 0.0443357
PLEC plectin 0.0433476
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0431176
UTRN utrophin 0.0430981
RNF145 ring finger protein 145 0.0428988
RAD23B RAD23 homolog B (S. cerevisiae) 0.0428717
BHLHE40 basic helix-loop-helix family, member e40 0.0423507
DSPP dentin sialophosphoprotein 0.0418601
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0417537
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0416047
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0408999
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0405373
HSPA8 heat shock 70kDa protein 8 0.0403101
SCRN1 secernin 1 0.040095
CANX calnexin 0.0399766
DDIT4 DNA-damage-inducible transcript 4 0.0399331
VCAN versican 0.0398735
TBC1D5 TBC1 domain family, member 5 0.0389661
HMGB2 high mobility group box 2 0.0387344
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0385743
TPM3 tropomyosin 3 0.038472
DSG2 desmoglein 2 0.0383936
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0380904
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0379368
TOP2B topoisomerase (DNA) II beta 180kDa 0.0378349
TXNRD1 thioredoxin reductase 1 0.0377686
INSIG2 insulin induced gene 2 0.0376613
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0374544
HELZ helicase with zinc finger 0.0374427
ADAM9 ADAM metallopeptidase domain 9 0.0371199
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0369825
AFDN afadin, adherens junction formation factor 0.0365954
SNX9 sorting nexin 9 0.0365766
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0363915
LAMC2 laminin, gamma 2 0.0363144
MKI67 marker of proliferation Ki-67 0.0361375
HLTF helicase-like transcription factor 0.0360355
PKM pyruvate kinase, muscle 0.0357057
YEATS2 YEATS domain containing 2 0.0356801
OGA O-GlcNAcase 0.0355364
RSRC2 arginine/serine-rich coiled-coil 2 0.0351009
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0350441
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0349557
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0347759
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0345742
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0345327
SLTM SAFB-like, transcription modulator 0.0341615
H1-0 H1.0 linker histone 0.0333714
RPL3 ribosomal protein L3 0.033341
APOL1 apolipoprotein L, 1 0.0329828
OSBPL10 oxysterol binding protein-like 10 0.032795
IQGAP1 IQ motif containing GTPase activating protein 1 0.0327252
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0327119
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0326993
CSDE1 cold shock domain containing E1, RNA-binding 0.0326698
SMC1A structural maintenance of chromosomes 1A 0.0326482
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0325018
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0321545
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0318725

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.228963
TMSB10 thymosin beta 10 -0.117238
RPL35A ribosomal protein L35a -0.0858742
FTL ferritin, light polypeptide -0.0717843
HMGA1 high mobility group AT-hook 1 -0.0699011
NDRG1 N-myc downstream regulated 1 -0.0589336
MT2A metallothionein 2A -0.0537525
RPS6 ribosomal protein S6 -0.0501606
RPL31 ribosomal protein L31 -0.0497709
RAB7A RAB7A, member RAS oncogene family -0.0475192
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0424483
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0423636
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0415267
RPL28 ribosomal protein L28 -0.0415256
POTEF POTE ankyrin domain family, member F -0.0414229
RPS23 ribosomal protein S23 -0.0380934
IGFBP3 insulin-like growth factor binding protein 3 -0.0377279
CCDC138 coiled-coil domain containing 138 -0.0371979
INTS6 integrator complex subunit 6 -0.0368566
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0367445
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0364046
RPL23 ribosomal protein L23 -0.0359499
WWC1 WW and C2 domain containing 1 -0.0356747
RPS29 ribosomal protein S29 -0.0348881
ACTG1 actin gamma 1 -0.0346979
ENO2 enolase 2 (gamma, neuronal) -0.0344068
RPL9 ribosomal protein L9 -0.0328492
IARS1 isoleucyl-tRNA synthetase 1 -0.0327851
RPS25 ribosomal protein S25 -0.032191
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0304227
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0302681
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0296621
EGR1 early growth response 1 -0.0294949
PCNX4 pecanex 4 -0.0292491
HMGA2 high mobility group AT-hook 2 -0.0288069
RPS24 ribosomal protein S24 -0.028286
MON2 MON2 homolog (S. cerevisiae) -0.0281506
RPL37A ribosomal protein L37a -0.0275031
RPLP1 ribosomal protein, large, P1 -0.0272633
RPS19 ribosomal protein S19 -0.0272489
RPS13 ribosomal protein S13 -0.0271083
RPS8 ribosomal protein S8 -0.0265781
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0258572
SHISA5 shisa family member 5 -0.0257995
SCFD1 sec1 family domain containing 1 -0.0257593
RPS14 ribosomal protein S14 -0.0257511
TAPBP TAP binding protein (tapasin) -0.0250703
KRT86 keratin 86, type II -0.0247828
ATP5F1B ATP synthase F1 subunit beta -0.0247812
ERBIN erbb2 interacting protein -0.0244528
RPS10 ribosomal protein S10 -0.0238521
UBAP2 ubiquitin associated protein 2 -0.0237591
AKAP9 A kinase (PRKA) anchor protein 9 -0.0234059
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0233843
DLC1 DLC1 Rho GTPase activating protein -0.0233808
GOLGB1 golgin B1 -0.0230397
AEBP2 AE binding protein 2 -0.0229933
RPS15 ribosomal protein S15 -0.0229432
HM13 histocompatibility (minor) 13 -0.0220712
PTEN phosphatase and tensin homolog -0.0218266
EXT1 exostosin glycosyltransferase 1 -0.0216728
AGO3 argonaute RISC catalytic component 3 -0.0216581
RPL5 ribosomal protein L5 -0.0216174
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0215053
RPS11 ribosomal protein S11 -0.0214069
RPS16 ribosomal protein S16 -0.021369
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0212832
TNRC6C trinucleotide repeat containing 6C -0.0212096
AGRN agrin -0.0211224
VDAC1 voltage-dependent anion channel 1 -0.0210049
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0207582
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.020604
CDK13 cyclin-dependent kinase 13 -0.0203918
ZNF609 zinc finger protein 609 -0.0196824
NLK nemo-like kinase -0.019662
RPLP2 ribosomal protein, large, P2 -0.0195806
FTH1 ferritin, heavy polypeptide 1 -0.0193444
ATN1 atrophin 1 -0.0193075
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0191292
LOC112694756 uncharaterized LOC112694756 -0.0191076
FNIP1 folliculin interacting protein 1 -0.0190372
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0189934
TP53 tumor protein p53 -0.0187849
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0186993
CREB5 cAMP responsive element binding protein 5 -0.0186236
CAPN7 calpain 7 -0.0180096
ADAM32 ADAM metallopeptidase domain 32 -0.0179145
RTN3 reticulon 3 -0.0178587
RPL38 ribosomal protein L38 -0.0175817
SCAPER S-phase cyclin A-associated protein in the ER -0.0175322
STXBP4 syntaxin binding protein 4 -0.0173771
CCND1 cyclin D1 -0.0171548
KLHL29 kelch-like family member 29 -0.0169911
TMEM165 transmembrane protein 165 -0.0168712
GPATCH8 G patch domain containing 8 -0.016792
MBD5 methyl-CpG binding domain protein 5 -0.0167683
BBS9 Bardet-Biedl syndrome 9 -0.0164276
RPL15 ribosomal protein L15 -0.0163924
TINAGL1 tubulointerstitial nephritis antigen-like 1 -0.0163014
JUP junction plakoglobin -0.0161808