Edoxaban (tosylate monohydrate)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Edoxaban (tosylate monohydrate) perturbation in HOP62 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Edoxaban (tosylate monohydrate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.0903672
FAM13A family with sequence similarity 13, member A 0.0806336
FNDC3B fibronectin type III domain containing 3B 0.0613406
ERRFI1 ERBB receptor feedback inhibitor 1 0.0587321
ELL2 elongation factor, RNA polymerase II, 2 0.0537851
PLEC plectin 0.0436618
CD109 CD109 molecule 0.0392472
PRELID2 PRELI domain containing 2 0.0356843
NGLY1 N-glycanase 1 0.0356837
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0330662
PDE10A phosphodiesterase 10A 0.0322197
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.03179
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0316482
OGA O-GlcNAcase 0.0316479
FLNB filamin B, beta 0.031236
SEPTIN9 septin 9 0.0305151
RNMT RNA (guanine-7-) methyltransferase 0.0290317
TRIO trio Rho guanine nucleotide exchange factor 0.0287898
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0286067
SPAG9 sperm associated antigen 9 0.0259315
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0257294
KDM3A lysine (K)-specific demethylase 3A 0.0249322
RPL3 ribosomal protein L3 0.0247014
SHB Src homology 2 domain containing adaptor protein B 0.0237203
TNS1 tensin 1 0.0233883
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0227761
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.02247
RUNX1 runt-related transcription factor 1 0.0220434
UBA6 ubiquitin-like modifier activating enzyme 6 0.0217771
DOT1L DOT1-like histone H3K79 methyltransferase 0.0217204
ATP13A3 ATPase type 13A3 0.0215126
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0212316
INSIG2 insulin induced gene 2 0.0206526
HELZ helicase with zinc finger 0.0205298
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0201108
RASA3 RAS p21 protein activator 3 0.0198094
IRS2 insulin receptor substrate 2 0.0195269
YEATS2 YEATS domain containing 2 0.0189203
ZNF292 zinc finger protein 292 0.0186619
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0183941
MIMS1 mitochondrial inner membrane scaffold 1 0.0183392
NAV2 neuron navigator 2 0.0178814
SBF2 SET binding factor 2 0.0178794
ARRDC3 arrestin domain containing 3 0.0175261
HOOK2 hook microtubule-tethering protein 2 0.0173083
NAMPT nicotinamide phosphoribosyltransferase 0.0172004
JARID2 jumonji, AT rich interactive domain 2 0.0170799
USP3 ubiquitin specific peptidase 3 0.0168808
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0167627
TNIP1 TNFAIP3 interacting protein 1 0.0163341
CAMTA1 calmodulin binding transcription activator 1 0.0161341
ADM adrenomedullin 0.0161032
IQGAP3 IQ motif containing GTPase activating protein 3 0.0159995
SPTBN1 spectrin, beta, non-erythrocytic 1 0.015779
WDR45B WD repeat domain 45B 0.0157346
CEP250 centrosomal protein 250kDa 0.0156547
AMPD3 adenosine monophosphate deaminase 3 0.0156385
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0154537
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0154053
ESYT2 extended synaptotagmin-like protein 2 0.015275
MSN moesin 0.0151777
CUL4B cullin 4B 0.0150289
UBE2O ubiquitin-conjugating enzyme E2O 0.0150069
SETD5 SET domain containing 5 0.0147054
NUP58 nucleoporin 58 0.0146381
H1-4 H1.4 linker histone, cluster member 0.0144697
NFE2L1 nuclear factor, erythroid 2-like 1 0.0143811
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0143391
PCBP3 poly(rC) binding protein 3 0.0142374
CAPRIN2 caprin family member 2 0.0140555
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0140402
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0140125
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0138856
FLNA filamin A, alpha 0.0138091
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0135974
GRB10 growth factor receptor-bound protein 10 0.0134049
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0132246
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0131085
USP37 ubiquitin specific peptidase 37 0.0129939
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0129852
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0129586
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0129513
SMAD3 SMAD family member 3 0.0127552
RNF149 ring finger protein 149 0.012657
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0123999
AKAP10 A kinase (PRKA) anchor protein 10 0.0123027
COL6A2 collagen, type VI, alpha 2 0.0122607
LCORL ligand dependent nuclear receptor corepressor-like 0.012086
RNF24 ring finger protein 24 0.0119913
MARCHF6 membrane associated ring-CH-type finger 6 0.0119318
CASC3 cancer susceptibility candidate 3 0.011912
RLIM ring finger protein, LIM domain interacting 0.0119014
TMF1 TATA element modulatory factor 1 0.0118897
NBAS neuroblastoma amplified sequence 0.0118429
ZNF148 zinc finger protein 148 0.011819
CDK19 cyclin-dependent kinase 19 0.0117371
MYO1B myosin IB 0.011731
COPA coatomer protein complex, subunit alpha 0.0117237
FAM219A family with sequence similarity 219, member A 0.0116409
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0116308

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.469038
VIM vimentin -0.436044
MT2A metallothionein 2A -0.167256
TMSB10 thymosin beta 10 -0.160773
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.160641
CD44 CD44 molecule (Indian blood group) -0.121625
EXT1 exostosin glycosyltransferase 1 -0.0847907
RPS6 ribosomal protein S6 -0.0780781
HMGA2 high mobility group AT-hook 2 -0.07798
TPT1 tumor protein, translationally-controlled 1 -0.0763295
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0742374
ENO1 enolase 1, (alpha) -0.0698205
CDH13 cadherin 13 -0.0683497
IGF2 insulin-like growth factor 2 -0.0677264
RPLP1 ribosomal protein, large, P1 -0.0653914
FTL ferritin, light polypeptide -0.0638628
EGR1 early growth response 1 -0.0619977
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0616258
ACTG1 actin gamma 1 -0.0594491
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0568967
NAV1 neuron navigator 1 -0.0534401
RPL35A ribosomal protein L35a -0.0506842
COL6A1 collagen, type VI, alpha 1 -0.0486533
RPS8 ribosomal protein S8 -0.0483466
ANXA2 annexin A2 -0.0482547
CLMP CXADR-like membrane protein -0.0474191
NALF1 NALCN channel auxiliary factor 1 -0.0464602
RPS19 ribosomal protein S19 -0.0427068
MYO10 myosin X -0.0406994
RAI14 retinoic acid induced 14 -0.0404042
RPL12 ribosomal protein L12 -0.0400399
CCND1 cyclin D1 -0.0397574
ASPH aspartate beta-hydroxylase -0.0390965
RPLP2 ribosomal protein, large, P2 -0.0360889
NDRG1 N-myc downstream regulated 1 -0.0358045
LAMB3 laminin, beta 3 -0.0354928
COL5A1 collagen, type V, alpha 1 -0.0349613
HMGA1 high mobility group AT-hook 1 -0.0336602
MAP1B microtubule-associated protein 1B -0.0332476
RPL9 ribosomal protein L9 -0.03319
RPL31 ribosomal protein L31 -0.033106
RPS16 ribosomal protein S16 -0.0330666
LDHA lactate dehydrogenase A -0.0326363
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0321294
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0316151
RPS24 ribosomal protein S24 -0.0315314
RPL23 ribosomal protein L23 -0.0310236
RPS13 ribosomal protein S13 -0.0309375
PTMA prothymosin, alpha -0.0304465
RPL34 ribosomal protein L34 -0.030383
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0300934
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0300874
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0291765
TPM4 tropomyosin 4 -0.0289037
RPL19 ribosomal protein L19 -0.0287251
RPL37A ribosomal protein L37a -0.0286286
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0281428
GLIS3 GLIS family zinc finger 3 -0.0279868
COL1A1 collagen, type I, alpha 1 -0.0273778
S100A10 S100 calcium binding protein A10 -0.0272132
RPS23 ribosomal protein S23 -0.0271292
VDAC1 voltage-dependent anion channel 1 -0.0269691
RPLP0 ribosomal protein, large, P0 -0.0265832
RPL37 ribosomal protein L37 -0.0259371
ZBTB20 zinc finger and BTB domain containing 20 -0.025882
RPL32 ribosomal protein L32 -0.0257886
RPL11 ribosomal protein L11 -0.0256923
RPL28 ribosomal protein L28 -0.025513
RPL30 ribosomal protein L30 -0.0251746
RPS20 ribosomal protein S20 -0.02504
ENO2 enolase 2 (gamma, neuronal) -0.024998
IER3 immediate early response 3 -0.0247412
RPS3 ribosomal protein S3 -0.0246392
KPNB1 karyopherin (importin) beta 1 -0.0245612
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0245093
EGFR epidermal growth factor receptor -0.0244363
IL1B interleukin 1, beta -0.0243439
TUBB6 tubulin, beta 6 class V -0.0240899
MAML3 mastermind-like 3 (Drosophila) -0.023847
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0236905
RPL8 ribosomal protein L8 -0.0236522
RPS14 ribosomal protein S14 -0.0235235
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0228033
PLAUR plasminogen activator, urokinase receptor -0.0228021
BICD1 bicaudal D homolog 1 (Drosophila) -0.0227922
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0226427
RPS27A ribosomal protein S27a -0.0225005
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0224609
BTG1 B-cell translocation gene 1, anti-proliferative -0.0223823
RAB7A RAB7A, member RAS oncogene family -0.0223164
RPL27A ribosomal protein L27a -0.0222304
GNAS GNAS complex locus -0.02168
RPS21 ribosomal protein S21 -0.0215177
IL11 interleukin 11 -0.0215099
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0214496
CAPN2 calpain 2, (m/II) large subunit -0.0213876
LOC102724023 ES1 protein homolog, mitochondrial -0.0213811
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0213643
RACK1 receptor for activated C kinase 1 -0.0213331
B2M beta-2-microglobulin -0.021313