Edoxaban (tosylate monohydrate)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Edoxaban (tosylate monohydrate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Edoxaban (tosylate monohydrate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
APOB apolipoprotein B 0.229385
C3 complement component 3 0.154626
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.146003
FNDC3B fibronectin type III domain containing 3B 0.0938281
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0852646
SLC38A2 solute carrier family 38, member 2 0.0791276
IGFBP1 insulin-like growth factor binding protein 1 0.078178
ERRFI1 ERBB receptor feedback inhibitor 1 0.0736678
DSPP dentin sialophosphoprotein 0.0712586
LRMDA leucine rich melanocyte differentiation associated 0.0698326
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0641516
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0623187
ENO1 enolase 1, (alpha) 0.0605863
DST dystonin 0.0553423
VCL vinculin 0.0544612
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0539064
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0528914
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0520472
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0505284
AFDN afadin, adherens junction formation factor 0.0494135
FMNL2 formin-like 2 0.0487019
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.04816
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0470891
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0451624
ARHGAP9 Rho GTPase activating protein 9 0.0447039
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0431299
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0424522
PTBP3 polypyrimidine tract binding protein 3 0.0417222
SESTD1 SEC14 and spectrin domains 1 0.0413516
MYH9 myosin, heavy chain 9, non-muscle 0.0412249
DOCK4 dedicator of cytokinesis 4 0.0412143
MAN1A1 mannosidase, alpha, class 1A, member 1 0.040833
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0406385
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0395352
SVIL supervillin 0.038829
ATXN1 ataxin 1 0.0387419
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0376575
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0363245
AHR aryl hydrocarbon receptor 0.0362392
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0362241
SOX5 SRY (sex determining region Y)-box 5 0.0360363
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0357289
LCOR ligand dependent nuclear receptor corepressor 0.0354596
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.0353141
GMDS GDP-mannose 4,6-dehydratase 0.0352831
SDC4 syndecan 4 0.0351661
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0351395
ZNF292 zinc finger protein 292 0.035096
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0340418
MED13L mediator complex subunit 13-like 0.0332012
PRRC2C proline-rich coiled-coil 2C 0.0329784
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0329022
ITGAV integrin, alpha V 0.0322454
EPS8 epidermal growth factor receptor pathway substrate 8 0.032062
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0320181
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0308047
NRIP1 nuclear receptor interacting protein 1 0.030617
MYO1B myosin IB 0.030227
CRLS1 cardiolipin synthase 1 0.0300539
MSI2 musashi RNA-binding protein 2 0.0298065
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0297854
INSIG2 insulin induced gene 2 0.0289493
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0288917
RB1CC1 RB1-inducible coiled-coil 1 0.0283814
TOP1 topoisomerase (DNA) I 0.0283153
MRTFA myocardin related transcription factor A 0.0279896
SAMD4A sterile alpha motif domain containing 4A 0.0277481
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0271649
YAP1 Yes-associated protein 1 0.0270917
TF transferrin 0.0269663
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0267825
ADAM9 ADAM metallopeptidase domain 9 0.0267476
TMSB10 thymosin beta 10 0.025933
KDM6A lysine (K)-specific demethylase 6A 0.0257755
KDM7A lysine (K)-specific demethylase 7A 0.0256886
PRELID2 PRELI domain containing 2 0.0256502
ANKRD12 ankyrin repeat domain 12 0.0255405
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.025307
CEMIP2 cell migration inducing hyaluronidase 2 0.0250303
PTPRK protein tyrosine phosphatase, receptor type, K 0.0249446
FNIP1 folliculin interacting protein 1 0.0249364
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0248416
ZFAND3 zinc finger, AN1-type domain 3 0.0247904
LPP LIM domain containing preferred translocation partner in lipoma 0.0244389
CCL20 chemokine (C-C motif) ligand 20 0.024275
PTPRM protein tyrosine phosphatase, receptor type, M 0.0241918
JMJD1C jumonji domain containing 1C 0.0241197
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0239142
NCKAP1 NCK-associated protein 1 0.0237957
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0236156
USP47 ubiquitin specific peptidase 47 0.0234415
ABTB3 ankyrin repeat and BTB domain containing 3 0.0229422
HLF hepatic leukemia factor 0.0228611
PUM2 pumilio RNA-binding family member 2 0.022846
RPS12 ribosomal protein S12 0.0223574
NKD1 naked cuticle homolog 1 (Drosophila) 0.0223102
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0221149
CDK19 cyclin-dependent kinase 19 0.0221052
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0220923
SRRM1 serine/arginine repetitive matrix 1 0.0220607

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.521413
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.130019
AKAP12 A kinase (PRKA) anchor protein 12 -0.0966279
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0923811
NDRG1 N-myc downstream regulated 1 -0.0568319
LOC112694756 uncharaterized LOC112694756 -0.0516506
CP ceruloplasmin (ferroxidase) -0.0497706
FTL ferritin, light polypeptide -0.0431467
RPLP1 ribosomal protein, large, P1 -0.0412207
TPT1 tumor protein, translationally-controlled 1 -0.0402012
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0400131
RPS8 ribosomal protein S8 -0.0397725
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0393377
GK glycerol kinase -0.0391016
GNAS GNAS complex locus -0.0357891
RPLP0 ribosomal protein, large, P0 -0.0324477
RACK1 receptor for activated C kinase 1 -0.0291936
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0282792
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.028093
RPS6 ribosomal protein S6 -0.0262732
UGDH UDP-glucose 6-dehydrogenase -0.0259299
RPL28 ribosomal protein L28 -0.024856
EPAS1 endothelial PAS domain protein 1 -0.0244957
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0242784
KDM3A lysine (K)-specific demethylase 3A -0.023822
WDR45B WD repeat domain 45B -0.0237946
RPL34 ribosomal protein L34 -0.0237338
DLC1 DLC1 Rho GTPase activating protein -0.0232126
RPL13A ribosomal protein L13a -0.0229427
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0227773
GDF15 growth differentiation factor 15 -0.0225452
ATP10A ATPase, class V, type 10A -0.0221342
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0215703
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0213451
RPL38 ribosomal protein L38 -0.0207019
IER3 immediate early response 3 -0.0203461
RPS5 ribosomal protein S5 -0.0199492
TMEM181 transmembrane protein 181 -0.019632
RRBP1 ribosome binding protein 1 -0.0195717
APOA2 apolipoprotein A-II -0.0191251
RPL35A ribosomal protein L35a -0.0190705
FLNB filamin B, beta -0.0186729
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0173396
FTH1 ferritin, heavy polypeptide 1 -0.0172358
RPS29 ribosomal protein S29 -0.0171779
TIMP1 TIMP metallopeptidase inhibitor 1 -0.017112
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0170236
RPS14 ribosomal protein S14 -0.0167922
HLA-E major histocompatibility complex, class I, E -0.0166843
PPARG peroxisome proliferator-activated receptor gamma -0.0165639
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0165236
APOA1 apolipoprotein A-I -0.016179
GCC2 GRIP and coiled-coil domain containing 2 -0.015978
KDM5B lysine (K)-specific demethylase 5B -0.0156774
AHNAK AHNAK nucleoprotein -0.0154528
LMAN1 lectin, mannose-binding, 1 -0.0154184
RPS19 ribosomal protein S19 -0.0152967
UBC ubiquitin C -0.0152921
PDGFB platelet-derived growth factor beta polypeptide -0.0152816
GPC3 glypican 3 -0.0152346
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0150159
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0149889
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0149191
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 -0.0145727
SOS1 son of sevenless homolog 1 (Drosophila) -0.0144165
LAMA4 laminin, alpha 4 -0.0143772
NPEPPS aminopeptidase puromycin sensitive -0.0143337
INSR insulin receptor -0.0142989
ADIPOR2 adiponectin receptor 2 -0.0142307
STK17A serine/threonine kinase 17a -0.0141933
VDAC1 voltage-dependent anion channel 1 -0.0140984
CDK13 cyclin-dependent kinase 13 -0.0140207
APOE apolipoprotein E -0.0140165
AMBP alpha-1-microglobulin/bikunin precursor -0.0138029
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0137747
FCHSD2 FCH and double SH3 domains 2 -0.0137463
DUSP6 dual specificity phosphatase 6 -0.013732
RAI14 retinoic acid induced 14 -0.0136531
ATF3 activating transcription factor 3 -0.013607
RPS20 ribosomal protein S20 -0.0136033
EEF1G eukaryotic translation elongation factor 1 gamma -0.0135617
PIBF1 progesterone immunomodulatory binding factor 1 -0.0135244
TTC3 tetratricopeptide repeat domain 3 -0.0135013
EHBP1 EH domain binding protein 1 -0.0133879
ZNF207 zinc finger protein 207 -0.0133637
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0133198
RPS10 ribosomal protein S10 -0.0133151
TM4SF1 transmembrane 4 L six family member 1 -0.0132901
RPL31 ribosomal protein L31 -0.0132201
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0131927
CLIP2 CAP-GLY domain containing linker protein 2 -0.0131816
B2M beta-2-microglobulin -0.0131008
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0130703
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0130594
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0130543
SREBF2 sterol regulatory element binding transcription factor 2 -0.0127605
IGFBP3 insulin-like growth factor binding protein 3 -0.0126212
RPL39 ribosomal protein L39 -0.0125347
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0125186
ENSA endosulfine alpha -0.0125081