Edoxaban (tosylate monohydrate)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Edoxaban (tosylate monohydrate) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Edoxaban (tosylate monohydrate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.0607505
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0580603
SRRM2 serine/arginine repetitive matrix 2 0.0539586
LMO7 LIM domain 7 0.0519372
EIF4B eukaryotic translation initiation factor 4B 0.0514634
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0487161
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0462378
EEF2 eukaryotic translation elongation factor 2 0.0441514
RPL4 ribosomal protein L4 0.0431101
PRELID2 PRELI domain containing 2 0.0424596
FOXO1 forkhead box O1 0.0413954
RPL3 ribosomal protein L3 0.0393511
DSPP dentin sialophosphoprotein 0.0390469
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0389528
BTBD9 BTB (POZ) domain containing 9 0.036986
RNF145 ring finger protein 145 0.036384
BACE2 beta-site APP-cleaving enzyme 2 0.0359502
KMT2C lysine (K)-specific methyltransferase 2C 0.0332833
SMAD3 SMAD family member 3 0.0326166
AKAP13 A kinase (PRKA) anchor protein 13 0.0324463
RPL41 ribosomal protein L41 0.0320522
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0303447
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0295793
ZFC3H1 zinc finger, C3H1-type containing 0.0279367
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.027872
MPRIP myosin phosphatase Rho interacting protein 0.026953
ATXN1 ataxin 1 0.0262933
SNX13 sorting nexin 13 0.0260807
RAD51B RAD51 paralog B 0.0256018
ZFAND3 zinc finger, AN1-type domain 3 0.0251202
DSCAM Down syndrome cell adhesion molecule 0.0248068
SND1 staphylococcal nuclease and tudor domain containing 1 0.0247778
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0244004
CALR calreticulin 0.0241342
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0238457
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0237899
YEATS2 YEATS domain containing 2 0.0233821
AKAP9 A kinase (PRKA) anchor protein 9 0.023172
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0230851
AFF4 AF4/FMR2 family, member 4 0.0230378
CDK13 cyclin-dependent kinase 13 0.0223328
MACF1 microtubule-actin crosslinking factor 1 0.0223161
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0222555
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0221695
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0221039
ABHD2 abhydrolase domain containing 2 0.0220252
NUP58 nucleoporin 58 0.0219512
MYO1E myosin IE 0.0215965
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0211185
ESRP1 epithelial splicing regulatory protein 1 0.021077
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0206903
AFDN afadin, adherens junction formation factor 0.0206812
NCKAP1 NCK-associated protein 1 0.0206341
CCPG1 cell cycle progression 1 0.020309
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0202637
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0202405
METTL15 methyltransferase like 15 0.0202077
CTNND1 catenin (cadherin-associated protein), delta 1 0.0200217
SLK STE20-like kinase 0.0197411
MED13L mediator complex subunit 13-like 0.0196855
ZNF160 zinc finger protein 160 0.0196563
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0193262
NEBL nebulette 0.0191055
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0190313
GIGYF2 GRB10 interacting GYF protein 2 0.0189769
ETNK1 ethanolamine kinase 1 0.0189306
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0185682
UBN2 ubinuclein 2 0.0184531
HSPA8 heat shock 70kDa protein 8 0.0184082
PTEN phosphatase and tensin homolog 0.0182893
RREB1 ras responsive element binding protein 1 0.0182742
JMY junction mediating and regulatory protein, p53 cofactor 0.0182366
PARD3B par-3 family cell polarity regulator beta 0.0180146
TMEM39A transmembrane protein 39A 0.0179556
COG6 component of oligomeric golgi complex 6 0.0179096
TMEM45B transmembrane protein 45B 0.0178019
CEMIP cell migration inducing protein, hyaluronan binding 0.0176373
MYO6 myosin VI 0.0176186
SMAD4 SMAD family member 4 0.0176018
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0175761
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0175594
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0174876
TNIP1 TNFAIP3 interacting protein 1 0.017466
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0174585
CLTC clathrin, heavy chain (Hc) 0.0173099
CDK19 cyclin-dependent kinase 19 0.0171952
EGFR epidermal growth factor receptor 0.0170912
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0170527
TMEM41B transmembrane protein 41B 0.0168637
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.016804
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0167511
MKRN1 makorin ring finger protein 1 0.0165809
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0165622
RBM33 RNA binding motif protein 33 0.016511
COPA coatomer protein complex, subunit alpha 0.0164087
RABGGTB Rab geranylgeranyltransferase, beta subunit 0.0163754
NPTN neuroplastin 0.0163562
MYO5B myosin VB 0.0163365
XPOT exportin, tRNA 0.0163111
USP53 ubiquitin specific peptidase 53 0.0161434

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.294977
RPLP1 ribosomal protein, large, P1 -0.20563
TPT1 tumor protein, translationally-controlled 1 -0.196328
RPS6 ribosomal protein S6 -0.194974
PTMA prothymosin, alpha -0.160088
TMSB10 thymosin beta 10 -0.145784
RPLP0 ribosomal protein, large, P0 -0.140689
RPS19 ribosomal protein S19 -0.119996
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.113374
RPS8 ribosomal protein S8 -0.113086
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.102021
ACTG1 actin gamma 1 -0.0943097
RPL12 ribosomal protein L12 -0.0898838
RPL35A ribosomal protein L35a -0.0884733
RPS23 ribosomal protein S23 -0.0879998
RPL23 ribosomal protein L23 -0.0847586
RPL34 ribosomal protein L34 -0.0844198
RPS25 ribosomal protein S25 -0.0745647
RPLP2 ribosomal protein, large, P2 -0.0720313
RPS13 ribosomal protein S13 -0.0714302
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.071429
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0683589
RPS24 ribosomal protein S24 -0.0682806
RPL19 ribosomal protein L19 -0.0679836
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0663992
RPL31 ribosomal protein L31 -0.0663697
RPS14 ribosomal protein S14 -0.0642551
RPL8 ribosomal protein L8 -0.0639966
RPS27A ribosomal protein S27a -0.0639356
EIF1 eukaryotic translation initiation factor 1 -0.0612416
S100A10 S100 calcium binding protein A10 -0.0604863
RPL11 ribosomal protein L11 -0.0578255
RPS16 ribosomal protein S16 -0.054878
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0542913
RPL27A ribosomal protein L27a -0.0529483
RPS5 ribosomal protein S5 -0.0523407
RPS29 ribosomal protein S29 -0.0520054
PDIA3 protein disulfide isomerase family A, member 3 -0.0517773
RACK1 receptor for activated C kinase 1 -0.0515144
RPL13A ribosomal protein L13a -0.0505731
NAP1L1 nucleosome assembly protein 1-like 1 -0.0505514
RPL32 ribosomal protein L32 -0.0505196
RPL28 ribosomal protein L28 -0.050365
HLA-B major histocompatibility complex, class I, B -0.0490723
RPL36 ribosomal protein L36 -0.0480407
RPS21 ribosomal protein S21 -0.0464685
KRT18 keratin 18, type I -0.0461962
RPS27 ribosomal protein S27 -0.0460217
LOC112694756 uncharaterized LOC112694756 -0.0455867
RPS11 ribosomal protein S11 -0.0443498
PGK1 phosphoglycerate kinase 1 -0.0438875
RPL9 ribosomal protein L9 -0.0428012
RPL37A ribosomal protein L37a -0.0427691
S100A9 S100 calcium binding protein A9 -0.041955
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0414172
RPS15 ribosomal protein S15 -0.0411423
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0406198
GDF15 growth differentiation factor 15 -0.0405486
RRBP1 ribosome binding protein 1 -0.0402438
ANXA2 annexin A2 -0.0395507
POTEF POTE ankyrin domain family, member F -0.038825
EZR ezrin -0.0388229
HMGA1 high mobility group AT-hook 1 -0.0387652
IER3 immediate early response 3 -0.0387145
VDAC1 voltage-dependent anion channel 1 -0.0385593
RPL5 ribosomal protein L5 -0.0384749
EGR1 early growth response 1 -0.038422
MT2A metallothionein 2A -0.0379124
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0358911
TPI1 triosephosphate isomerase 1 -0.0349217
CCNI cyclin I -0.0340221
RPL18 ribosomal protein L18 -0.0337106
RPL10A ribosomal protein L10a -0.033668
RPL7A ribosomal protein L7a -0.0331638
PKM pyruvate kinase, muscle -0.0328094
RPL35 ribosomal protein L35 -0.0327996
DEK DEK proto-oncogene -0.0326033
SEC61G Sec61 gamma subunit -0.0324483
RPS20 ribosomal protein S20 -0.0324439
FTL ferritin, light polypeptide -0.0320788
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0319937
IFITM3 interferon induced transmembrane protein 3 -0.0318613
LDHA lactate dehydrogenase A -0.0309834
S100A6 S100 calcium binding protein A6 -0.0307405
AHNAK AHNAK nucleoprotein -0.0306392
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0303516
RPL26 ribosomal protein L26 -0.0302846
RPL36A ribosomal protein L36a -0.0299815
RPL15 ribosomal protein L15 -0.0297302
SP100 SP100 nuclear antigen -0.0295403
PTPRG protein tyrosine phosphatase, receptor type, G -0.0295239
ATP5F1B ATP synthase F1 subunit beta -0.0288719
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.02885
OXSR1 oxidative stress responsive 1 -0.0284148
LOC102724023 ES1 protein homolog, mitochondrial -0.028363
IFI6 interferon, alpha-inducible protein 6 -0.0282043
RPS17 ribosomal protein S17 -0.0281841
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0280314
GSTP1 glutathione S-transferase pi 1 -0.0279445
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0278345