Edoxaban (tosylate monohydrate)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Edoxaban (tosylate monohydrate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Edoxaban (tosylate monohydrate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.230481
PDE4D phosphodiesterase 4D, cAMP-specific 0.15744
NAMPT nicotinamide phosphoribosyltransferase 0.111449
FAM13A family with sequence similarity 13, member A 0.0901843
FNDC3B fibronectin type III domain containing 3B 0.0827688
MYH9 myosin, heavy chain 9, non-muscle 0.0814158
PRELID2 PRELI domain containing 2 0.070527
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0687443
ATP13A3 ATPase type 13A3 0.0674308
HMGA2 high mobility group AT-hook 2 0.0655511
FN1 fibronectin 1 0.0644495
TRIO trio Rho guanine nucleotide exchange factor 0.0624964
SMAD3 SMAD family member 3 0.0581519
USP34 ubiquitin specific peptidase 34 0.0575407
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0575396
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0571644
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0569091
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0558216
DOCK5 dedicator of cytokinesis 5 0.0546586
GRB10 growth factor receptor-bound protein 10 0.0540255
SOD2 superoxide dismutase 2, mitochondrial 0.0539591
GPC6 glypican 6 0.0520108
DST dystonin 0.0509453
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.050899
PCBP2 poly(rC) binding protein 2 0.0496127
ESYT2 extended synaptotagmin-like protein 2 0.0487636
PIAS2 protein inhibitor of activated STAT, 2 0.048381
HIPK2 homeodomain interacting protein kinase 2 0.0469794
KDM3A lysine (K)-specific demethylase 3A 0.0448371
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0435079
FAM20C family with sequence similarity 20, member C 0.0432565
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0423067
MYO1B myosin IB 0.0410532
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0407321
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0406578
EFNA5 ephrin-A5 0.0402664
NRG1 neuregulin 1 0.0396647
NGLY1 N-glycanase 1 0.0395917
ANKRD11 ankyrin repeat domain 11 0.0388896
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0387484
RICTOR RPTOR independent companion of MTOR, complex 2 0.0387201
RAD51B RAD51 paralog B 0.0385416
RUNX2 runt-related transcription factor 2 0.0382919
KDM2A lysine (K)-specific demethylase 2A 0.0376607
YEATS2 YEATS domain containing 2 0.0373854
GOLGA4 golgin A4 0.036242
DSCAM Down syndrome cell adhesion molecule 0.0358968
APP amyloid beta (A4) precursor protein 0.0357862
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0347208
PSD3 pleckstrin and Sec7 domain containing 3 0.0342876
CDH13 cadherin 13 0.033395
ANKRD36 ankyrin repeat domain 36 0.0332636
ASPH aspartate beta-hydroxylase 0.0331482
CEP250 centrosomal protein 250kDa 0.0328627
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0325169
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0324557
PFKP phosphofructokinase, platelet 0.0324321
KYNU kynureninase 0.0322944
NFE2L1 nuclear factor, erythroid 2-like 1 0.031966
SDK1 sidekick cell adhesion molecule 1 0.031962
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0317735
DPYD dihydropyrimidine dehydrogenase 0.0316652
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0314612
PICALM phosphatidylinositol binding clathrin assembly protein 0.0311757
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0311515
SETD5 SET domain containing 5 0.0311482
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0309952
UBA6 ubiquitin-like modifier activating enzyme 6 0.030794
MACF1 microtubule-actin crosslinking factor 1 0.0305088
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0300412
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0299323
KMT2C lysine (K)-specific methyltransferase 2C 0.0296273
KTN1 kinectin 1 (kinesin receptor) 0.02957
RAI14 retinoic acid induced 14 0.0292985
ITCH itchy E3 ubiquitin protein ligase 0.0286186
COPA coatomer protein complex, subunit alpha 0.0285793
PID1 phosphotyrosine interaction domain containing 1 0.0283977
MEF2A myocyte enhancer factor 2A 0.0283203
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0280619
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0280046
TNIP1 TNFAIP3 interacting protein 1 0.0279382
TAS2R14 taste receptor, type 2, member 14 0.0278772
FMNL2 formin-like 2 0.0278205
ANGPTL4 angiopoietin-like 4 0.0273439
PKM pyruvate kinase, muscle 0.0271349
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.027058
NPAS2 neuronal PAS domain protein 2 0.0269523
MYOF myoferlin 0.0269309
HELZ helicase with zinc finger 0.0267239
RERE arginine-glutamic acid dipeptide (RE) repeats 0.026536
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0264613
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0264269
SRRM2 serine/arginine repetitive matrix 2 0.0264096
WAC WW domain containing adaptor with coiled-coil 0.0263732
MAP2K1 mitogen-activated protein kinase kinase 1 0.0263161
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0262456
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0260711
ZNF638 zinc finger protein 638 0.0260118
CPNE1 copine I 0.0260014
RPL3 ribosomal protein L3 0.0258112

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.347068
VIM vimentin -0.147733
FTL ferritin, light polypeptide -0.127782
TMSB10 thymosin beta 10 -0.120949
MT2A metallothionein 2A -0.0774019
RPLP1 ribosomal protein, large, P1 -0.0773025
IER3 immediate early response 3 -0.057961
EGR1 early growth response 1 -0.053491
RPL35A ribosomal protein L35a -0.0508066
NDRG1 N-myc downstream regulated 1 -0.0489534
HMGA1 high mobility group AT-hook 1 -0.0486033
CD44 CD44 molecule (Indian blood group) -0.0480628
RPS19 ribosomal protein S19 -0.0475143
STC1 stanniocalcin 1 -0.0424332
RPS24 ribosomal protein S24 -0.0407658
TM4SF1 transmembrane 4 L six family member 1 -0.036959
RPL28 ribosomal protein L28 -0.0362633
C15ORF48 chromosome 15 open reading frame 48 -0.0359319
RPS6 ribosomal protein S6 -0.0355863
S100A10 S100 calcium binding protein A10 -0.0350792
RPS21 ribosomal protein S21 -0.0348723
GLCCI1 glucocorticoid induced 1 -0.0344909
RPLP2 ribosomal protein, large, P2 -0.0338382
RPL32 ribosomal protein L32 -0.0337195
RPL36 ribosomal protein L36 -0.033238
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0331647
TPT1 tumor protein, translationally-controlled 1 -0.0330565
RPS29 ribosomal protein S29 -0.032241
NCOA7 nuclear receptor coactivator 7 -0.0321618
RPL12 ribosomal protein L12 -0.0320329
RAP1B RAP1B, member of RAS oncogene family -0.0312288
RPLP0 ribosomal protein, large, P0 -0.0311063
FTH1 ferritin, heavy polypeptide 1 -0.0302298
RPL23 ribosomal protein L23 -0.0296973
RPL11 ribosomal protein L11 -0.0294164
P4HB prolyl 4-hydroxylase, beta polypeptide -0.02911
TFPI2 tissue factor pathway inhibitor 2 -0.0290928
HLA-B major histocompatibility complex, class I, B -0.0286426
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0283845
RPL34 ribosomal protein L34 -0.0279283
PTMA prothymosin, alpha -0.0278246
RPS23 ribosomal protein S23 -0.0272981
BTG1 B-cell translocation gene 1, anti-proliferative -0.0267895
S100A6 S100 calcium binding protein A6 -0.0265962
RPS25 ribosomal protein S25 -0.0259851
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0259715
RPS13 ribosomal protein S13 -0.0259035
BLZF1 basic leucine zipper nuclear factor 1 -0.0255428
TMEM263 transmembrane protein 263 -0.0255352
RPS16 ribosomal protein S16 -0.0249626
RPL31 ribosomal protein L31 -0.0248623
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0246678
ANXA2 annexin A2 -0.0245594
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0244873
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0242899
VDAC1 voltage-dependent anion channel 1 -0.0242429
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0241076
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.023478
S100A9 S100 calcium binding protein A9 -0.0230517
RPL19 ribosomal protein L19 -0.0228673
LMAN1 lectin, mannose-binding, 1 -0.0226281
RPS11 ribosomal protein S11 -0.0225677
DDIT3 DNA-damage-inducible transcript 3 -0.0225515
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0221246
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0220565
IFITM3 interferon induced transmembrane protein 3 -0.0216825
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0216733
EMP1 epithelial membrane protein 1 -0.0216089
RPS8 ribosomal protein S8 -0.0215079
GSTP1 glutathione S-transferase pi 1 -0.0212999
H1-0 H1.0 linker histone -0.021147
RPS15 ribosomal protein S15 -0.0209517
RPL37 ribosomal protein L37 -0.0207772
RPL38 ribosomal protein L38 -0.0204168
RPL9 ribosomal protein L9 -0.0204153
SLC38A1 solute carrier family 38, member 1 -0.0200734
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0193951
LOC102724023 ES1 protein homolog, mitochondrial -0.0193143
B2M beta-2-microglobulin -0.0192634
KLF6 Kruppel-like factor 6 -0.0192445
RAB7A RAB7A, member RAS oncogene family -0.0192228
ACTG1 actin gamma 1 -0.0191851
LOC112694756 uncharaterized LOC112694756 -0.0190501
NABP1 nucleic acid binding protein 1 -0.0182441
EIF1 eukaryotic translation initiation factor 1 -0.0182353
ARF4 ADP-ribosylation factor 4 -0.018214
OSMR oncostatin M receptor -0.0181644
RPL13A ribosomal protein L13a -0.0181128
YBX3 Y box binding protein 3 -0.0180146
RPS5 ribosomal protein S5 -0.0177919
TNNC1 troponin C type 1 (slow) -0.0177235
CCNI cyclin I -0.0174736
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0172722
RPS14 ribosomal protein S14 -0.0168441
ATP5F1E ATP synthase F1 subunit epsilon -0.0164489
PFN1 profilin 1 -0.0161556
GNAS GNAS complex locus -0.0160288
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0159449
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.015936
RACK1 receptor for activated C kinase 1 -0.0157924