Edoxaban (tosylate monohydrate)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Edoxaban (tosylate monohydrate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Edoxaban (tosylate monohydrate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.209771
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.145791
EZR ezrin 0.123587
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.114398
FAM13A family with sequence similarity 13, member A 0.11246
RICTOR RPTOR independent companion of MTOR, complex 2 0.109856
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.105514
ERRFI1 ERBB receptor feedback inhibitor 1 0.10254
PARD3 par-3 family cell polarity regulator 0.102446
RAB1A RAB1A, member RAS oncogene family 0.100304
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0992771
PSD3 pleckstrin and Sec7 domain containing 3 0.0991523
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0956449
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0930974
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0906654
CSNK1A1 casein kinase 1, alpha 1 0.088897
LAMB3 laminin, beta 3 0.0864713
SBF2 SET binding factor 2 0.0851943
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0823453
SLC39A11 solute carrier family 39, member 11 0.0812426
SNX9 sorting nexin 9 0.0795559
TENM3 teneurin transmembrane protein 3 0.0777032
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.076424
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0748519
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0739996
ADGRG6 adhesion G protein-coupled receptor G6 0.0715094
WDFY2 WD repeat and FYVE domain containing 2 0.0688609
USP9X ubiquitin specific peptidase 9, X-linked 0.0687092
DST dystonin 0.0683577
OGA O-GlcNAcase 0.0680702
HOOK2 hook microtubule-tethering protein 2 0.0679744
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0676142
FBXO11 F-box protein 11 0.067012
KMT2E lysine (K)-specific methyltransferase 2E 0.0659086
CHRM3 cholinergic receptor, muscarinic 3 0.0659048
MTSS1 metastasis suppressor 1 0.0645537
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0628701
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0626627
MYOF myoferlin 0.0617963
MBD5 methyl-CpG binding domain protein 5 0.0603608
AKAP12 A kinase (PRKA) anchor protein 12 0.0598175
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0577966
ZNF148 zinc finger protein 148 0.0532282
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0531198
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0530063
ERBIN erbb2 interacting protein 0.0516093
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0514929
DSCAM Down syndrome cell adhesion molecule 0.0512302
GRB10 growth factor receptor-bound protein 10 0.0494877
JARID2 jumonji, AT rich interactive domain 2 0.0491331
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0474208
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.046181
PRRC2C proline-rich coiled-coil 2C 0.0457408
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0451949
LMO7 LIM domain 7 0.0447266
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0440165
ZMYND8 zinc finger, MYND-type containing 8 0.0424545
RAB7A RAB7A, member RAS oncogene family 0.0419933
PGK1 phosphoglycerate kinase 1 0.0399574
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0386388
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0357811
ACTG1 actin gamma 1 0.0338514
BIRC6 baculoviral IAP repeat containing 6 0.0338218
DLG1 discs, large homolog 1 (Drosophila) 0.0337175
FMNL2 formin-like 2 0.0335429
USP34 ubiquitin specific peptidase 34 0.0334999
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0332783
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0308708
NCOR1 nuclear receptor corepressor 1 0.0303093
KMT2C lysine (K)-specific methyltransferase 2C 0.0290351
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.028506
NALF1 NALCN channel auxiliary factor 1 0.0273172
FLNB filamin B, beta 0.0254546
TRA2A transformer 2 alpha homolog (Drosophila) 0.0246947
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0233936
SPAG9 sperm associated antigen 9 0.0212854
RAD51B RAD51 paralog B 0.0206398
EXT1 exostosin glycosyltransferase 1 0.0205009
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0203748
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.019851
MARCHF6 membrane associated ring-CH-type finger 6 0.0187199
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0184308
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0176995
CCNL1 cyclin L1 0.0175699
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0173203
PKM pyruvate kinase, muscle 0.0171465
RBM39 RNA binding motif protein 39 0.0167021
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0148956
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0143676
ARHGAP21 Rho GTPase activating protein 21 0.0126267
RUNX1 runt-related transcription factor 1 0.012165
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0110537
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0106878
RPS8 ribosomal protein S8 0.0101903
RPS12 ribosomal protein S12 0.00986491
ZBTB20 zinc finger and BTB domain containing 20 0.00974629
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.00957965
ANKRD17 ankyrin repeat domain 17 0.0082912
RB1CC1 RB1-inducible coiled-coil 1 0.00734546
KIF5B kinesin family member 5B 0.00721297

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.237966
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.222796
MT2A metallothionein 2A -0.18721
FTL ferritin, light polypeptide -0.167753
TMSB10 thymosin beta 10 -0.129765
RPS19 ribosomal protein S19 -0.114507
AK1 adenylate kinase 1 -0.109085
ZNF638 zinc finger protein 638 -0.108478
RPS6 ribosomal protein S6 -0.0950631
FN1 fibronectin 1 -0.0939163
PTMA prothymosin, alpha -0.093099
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0929176
RPLP1 ribosomal protein, large, P1 -0.0916528
IGF2 insulin-like growth factor 2 -0.0889741
NAP1L1 nucleosome assembly protein 1-like 1 -0.0874639
B2M beta-2-microglobulin -0.0858785
RTN4 reticulon 4 -0.0821885
GNAS GNAS complex locus -0.0806787
MBNL1 muscleblind-like splicing regulator 1 -0.0738868
TM4SF1 transmembrane 4 L six family member 1 -0.0738108
PDE10A phosphodiesterase 10A -0.072241
NAMPT nicotinamide phosphoribosyltransferase -0.0684952
RPL19 ribosomal protein L19 -0.0672399
AGO3 argonaute RISC catalytic component 3 -0.067032
SRPK2 SRSF protein kinase 2 -0.0669555
GOLGB1 golgin B1 -0.0663476
FNDC3B fibronectin type III domain containing 3B -0.0635099
JMJD1C jumonji domain containing 1C -0.0610624
SCFD1 sec1 family domain containing 1 -0.0589928
CD44 CD44 molecule (Indian blood group) -0.057106
STAU1 staufen double-stranded RNA binding protein 1 -0.0555349
ENO1 enolase 1, (alpha) -0.0552888
EEF2 eukaryotic translation elongation factor 2 -0.0542005
WSB1 WD repeat and SOCS box containing 1 -0.0519901
ANKRD11 ankyrin repeat domain 11 -0.0515488
APP amyloid beta (A4) precursor protein -0.0507138
RPL35A ribosomal protein L35a -0.0494033
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0475811
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0474313
DDIT4 DNA-damage-inducible transcript 4 -0.0465041
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0454258
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0436825
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0434704
RPL11 ribosomal protein L11 -0.042228
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0405675
NDRG1 N-myc downstream regulated 1 -0.0396796
CALR calreticulin -0.0392587
RPS16 ribosomal protein S16 -0.0390147
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0387576
HLA-B major histocompatibility complex, class I, B -0.0387239
PRKCA protein kinase C, alpha -0.0370974
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0355588
OSBPL8 oxysterol binding protein-like 8 -0.0347885
MCTP1 multiple C2 domains, transmembrane 1 -0.0347649
RIGI RNA sensor RIG-I -0.0346021
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0345272
ZEB1 zinc finger E-box binding homeobox 1 -0.033302
SEC31A SEC31 homolog A (S. cerevisiae) -0.0331233
IGFBP3 insulin-like growth factor binding protein 3 -0.0328047
CDK19 cyclin-dependent kinase 19 -0.0327478
USP33 ubiquitin specific peptidase 33 -0.0327005
MACF1 microtubule-actin crosslinking factor 1 -0.0317066
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0316719
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0309492
WAPL WAPL cohesin release factor -0.0299664
PDIA3 protein disulfide isomerase family A, member 3 -0.0293799
NKD1 naked cuticle homolog 1 (Drosophila) -0.0286681
RPL8 ribosomal protein L8 -0.0284935
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0282735
AKAP9 A kinase (PRKA) anchor protein 9 -0.0278863
INSIG1 insulin induced gene 1 -0.0278126
RPS3 ribosomal protein S3 -0.0272148
MAP4 microtubule-associated protein 4 -0.0259527
CYRIB CYFIP related Rac1 interactor B -0.0240118
FBF1 Fas (TNFRSF6) binding factor 1 -0.0222835
CARD16 caspase recruitment domain family, member 16 -0.021845
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0212842
LMAN1 lectin, mannose-binding, 1 -0.0212766
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0202773
POTEF POTE ankyrin domain family, member F -0.020193
EIF1 eukaryotic translation initiation factor 1 -0.0201642
ASPH aspartate beta-hydroxylase -0.0200689
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0198458
TMEM165 transmembrane protein 165 -0.01982
SMYD3 SET and MYND domain containing 3 -0.0192268
PEAK1 pseudopodium-enriched atypical kinase 1 -0.0188636
TPT1 tumor protein, translationally-controlled 1 -0.0185261
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0161878
GLS2 glutaminase 2 (liver, mitochondrial) -0.0156266
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0155861
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0155649
ZFAND3 zinc finger, AN1-type domain 3 -0.0145093
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0130764
SEPTIN2 septin 2 -0.0128373
HELZ helicase with zinc finger -0.0128083
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0126018
LDHA lactate dehydrogenase A -0.0122702
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0115485
TRIO trio Rho guanine nucleotide exchange factor -0.0114976
SEPTIN7 septin 7 -0.0109816