| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Edoxaban (tosylate monohydrate) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Edoxaban (tosylate monohydrate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.161075 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.114866 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0908748 |
| EFNA5 | ephrin-A5 | 0.0779392 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0747232 |
| PTMA | prothymosin, alpha | 0.0724294 |
| ASPH | aspartate beta-hydroxylase | 0.0717974 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0704746 |
| GDA | guanine deaminase | 0.0694121 |
| SPAG9 | sperm associated antigen 9 | 0.0688981 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0686117 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0683054 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0674196 |
| ENO1 | enolase 1, (alpha) | 0.0629202 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0619034 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0565453 |
| PGK1 | phosphoglycerate kinase 1 | 0.0555427 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.05456 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0526213 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0523423 |
| NUP58 | nucleoporin 58 | 0.0505512 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0503348 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0495512 |
| RPS12 | ribosomal protein S12 | 0.0465241 |
| RPL26 | ribosomal protein L26 | 0.0437654 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0436696 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0425884 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0417044 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0404065 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0399929 |
| FAM13A | family with sequence similarity 13, member A | 0.0390898 |
| RPL37A | ribosomal protein L37a | 0.0385002 |
| MCL1 | myeloid cell leukemia 1 | 0.0384347 |
| ZNF292 | zinc finger protein 292 | 0.0376495 |
| PKM | pyruvate kinase, muscle | 0.0367498 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0365829 |
| RPS3 | ribosomal protein S3 | 0.0364802 |
| CANX | calnexin | 0.0362517 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0361594 |
| RPS6 | ribosomal protein S6 | 0.0359614 |
| RTN4 | reticulon 4 | 0.0356046 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0354461 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0353983 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0351243 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0349506 |
| ATP13A3 | ATPase type 13A3 | 0.0348822 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0343888 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0343828 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0343369 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.034223 |
| GOLGA4 | golgin A4 | 0.0342147 |
| MATR3 | matrin 3 | 0.0342068 |
| OGA | O-GlcNAcase | 0.0335269 |
| TXNRD1 | thioredoxin reductase 1 | 0.0334445 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0330019 |
| RNF145 | ring finger protein 145 | 0.0325824 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.032246 |
| CENPF | centromere protein F, 350/400kDa | 0.0315365 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0313012 |
| TPM3 | tropomyosin 3 | 0.0312624 |
| NEK7 | NIMA-related kinase 7 | 0.0311772 |
| RPL12 | ribosomal protein L12 | 0.0309255 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | 0.0308846 |
| NCKAP1 | NCK-associated protein 1 | 0.0307381 |
| RPL4 | ribosomal protein L4 | 0.0306988 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0305494 |
| HELZ | helicase with zinc finger | 0.0303329 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0303204 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0302361 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0302269 |
| TPR | translocated promoter region, nuclear basket protein | 0.0301868 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.030089 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0300087 |
| GRAMD1B | GRAM domain containing 1B | 0.0299588 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0298259 |
| RBM39 | RNA binding motif protein 39 | 0.0295189 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0294003 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0293789 |
| CALR | calreticulin | 0.0293748 |
| LDHA | lactate dehydrogenase A | 0.0293613 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0293331 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0291355 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0286429 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0284482 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0282962 |
| WDR43 | WD repeat domain 43 | 0.028077 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.0279261 |
| RPL23 | ribosomal protein L23 | 0.0279154 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0279153 |
| EZR | ezrin | 0.0278671 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0275951 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0275554 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0272182 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0270495 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0270195 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0268322 |
| WDR45B | WD repeat domain 45B | 0.0266662 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0260999 |
| RPS8 | ribosomal protein S8 | 0.0260357 |
| ANXA1 | annexin A1 | 0.0259943 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.156775 |
| FN1 | fibronectin 1 | -0.106055 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0812852 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0797173 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0676673 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0647248 |
| CDH13 | cadherin 13 | -0.0551887 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0467924 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0437333 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0419103 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0416656 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0384417 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0384218 |
| LSAMP | limbic system-associated membrane protein | -0.03639 |
| DOCK4 | dedicator of cytokinesis 4 | -0.03158 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0312944 |
| NCKAP5 | NCK-associated protein 5 | -0.0304916 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0295661 |
| VCL | vinculin | -0.0289031 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0287158 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0282028 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0273828 |
| NRCAM | neuronal cell adhesion molecule | -0.0269741 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0268186 |
| COL5A2 | collagen, type V, alpha 2 | -0.0251403 |
| PDE7B | phosphodiesterase 7B | -0.0249026 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0242185 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0238625 |
| LAMA5 | laminin, alpha 5 | -0.0226483 |
| UNC5D | unc-5 homolog D (C. elegans) | -0.0217831 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0203673 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0200218 |
| GLIS3 | GLIS family zinc finger 3 | -0.0199792 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0199081 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.019574 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0194951 |
| MAP7 | microtubule-associated protein 7 | -0.0194932 |
| SMAD2 | SMAD family member 2 | -0.0194402 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0189672 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0187775 |
| SMYD3 | SET and MYND domain containing 3 | -0.0186987 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0186383 |
| KIAA0825 | KIAA0825 | -0.018432 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0182802 |
| AUTS2 | autism susceptibility candidate 2 | -0.0181256 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.017911 |
| RAD51B | RAD51 paralog B | -0.0160071 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0159853 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0159603 |
| PALLD | palladin, cytoskeletal associated protein | -0.0158017 |
| RTN1 | reticulon 1 | -0.0157752 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0150537 |
| CADM2 | cell adhesion molecule 2 | -0.0147536 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0147305 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0146643 |
| TBXT | T-box transcription factor T | -0.0144333 |
| XYLT1 | xylosyltransferase I | -0.0144036 |
| PCDH15 | protocadherin-related 15 | -0.0143772 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.014368 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0139228 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0139083 |
| PDE1A | phosphodiesterase 1A, calmodulin-dependent | -0.0137659 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | -0.013664 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0134663 |
| TMEM178B | transmembrane protein 178B | -0.012807 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0126763 |
| PRICKLE1 | prickle homolog 1 (Drosophila) | -0.0126659 |
| PDE1C | phosphodiesterase 1C, calmodulin-dependent 70kDa | -0.0125493 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0123503 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0121368 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0120482 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0120308 |
| PAPPA2 | pappalysin 2 | -0.0119705 |
| FOXK1 | forkhead box K1 | -0.0118408 |
| RANBP17 | RAN binding protein 17 | -0.0115359 |
| NTN4 | netrin 4 | -0.0110653 |
| CTIF | CBP80/20-dependent translation initiation factor | -0.0110413 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | -0.0110411 |
| CLMP | CXADR-like membrane protein | -0.0107968 |
| PCDH9 | protocadherin 9 | -0.0107965 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0107633 |
| ESM1 | endothelial cell-specific molecule 1 | -0.0107316 |
| TENM3 | teneurin transmembrane protein 3 | -0.0107177 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0105474 |
| RAB31 | RAB31, member RAS oncogene family | -0.0101367 |
| FRMD4B | FERM domain containing 4B | -0.0101343 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0101213 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0100231 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.00999388 |
| NCAM2 | neural cell adhesion molecule 2 | -0.00998847 |
| FLNA | filamin A, alpha | -0.00988531 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0097434 |
| HDAC8 | histone deacetylase 8 | -0.00969459 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00967629 |
| NRG1 | neuregulin 1 | -0.00961149 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.00934413 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.00933694 |
| INTS6 | integrator complex subunit 6 | -0.00927165 |
| CUX1 | cut-like homeobox 1 | -0.00912253 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | -0.00910641 |
