Edoxaban (tosylate monohydrate)_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Edoxaban (tosylate monohydrate) perturbation in NCI-H661 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Edoxaban (tosylate monohydrate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.0680978
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0586664
RPL35A ribosomal protein L35a 0.0426586
TPT1 tumor protein, translationally-controlled 1 0.0398353
SPAG9 sperm associated antigen 9 0.038041
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.0357793
RPL23 ribosomal protein L23 0.034204
IFIH1 interferon induced with helicase C domain 1 0.0330657
COL1A2 collagen, type I, alpha 2 0.0318819
RIGI RNA sensor RIG-I 0.0316399
SRRM2 serine/arginine repetitive matrix 2 0.0311987
B2M beta-2-microglobulin 0.0299274
TTC28 tetratricopeptide repeat domain 28 0.0292749
ISG15 ISG15 ubiquitin-like modifier 0.0253288
FNDC3A fibronectin type III domain containing 3A 0.0244073
CNRIP1 cannabinoid receptor interacting protein 1 0.0226662
OASL 2'-5'-oligoadenylate synthetase-like 0.0223444
FGF13 fibroblast growth factor 13 0.0219733
RPL9 ribosomal protein L9 0.0216303
RPS13 ribosomal protein S13 0.0209137
BPTF bromodomain PHD finger transcription factor 0.0208531
PCLO piccolo presynaptic cytomatrix protein 0.0205735
FTL ferritin, light polypeptide 0.0199568
LRRC4C leucine rich repeat containing 4C 0.0198734
GSE1 Gse1 coiled-coil protein 0.0195669
IGF2 insulin-like growth factor 2 0.019245
RPS11 ribosomal protein S11 0.01906
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0176297
MB21D2 Mab-21 domain containing 2 0.0176263
DENND4A DENN/MADD domain containing 4A 0.0173811
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0173568
CNIH4 cornichon family AMPA receptor auxiliary protein 4 0.0169362
PA2G4 proliferation-associated 2G4, 38kDa 0.0167086
RPS4X ribosomal protein S4, X-linked 0.0166904
S100A10 S100 calcium binding protein A10 0.0162651
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0161616
ARHGAP12 Rho GTPase activating protein 12 0.0161571
MT2A metallothionein 2A 0.0161111
ZNF568 zinc finger protein 568 0.0159561
SAMD11 sterile alpha motif domain containing 11 0.0159202
PHF20 PHD finger protein 20 0.0159061
PTPRF protein tyrosine phosphatase, receptor type, F 0.0158124
RPLP1 ribosomal protein, large, P1 0.0158015
APOE apolipoprotein E 0.0157828
MED12L mediator complex subunit 12-like 0.0157602
CSMD3 CUB and Sushi multiple domains 3 0.0157581
SOX5 SRY (sex determining region Y)-box 5 0.0155369
MDK midkine (neurite growth-promoting factor 2) 0.015519
NKD1 naked cuticle homolog 1 (Drosophila) 0.0154774
RCOR1 REST corepressor 1 0.015458
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0152809
COX6C cytochrome c oxidase subunit VIc 0.0152519
EIF1 eukaryotic translation initiation factor 1 0.0150968
FBXO11 F-box protein 11 0.0150216
FOXN3 forkhead box N3 0.0149873
NFE2L2 nuclear factor, erythroid 2-like 2 0.0149828
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0149623
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0148224
DLL3 delta-like 3 (Drosophila) 0.0147981
HLA-B major histocompatibility complex, class I, B 0.0147827
SEPTIN9 septin 9 0.014757
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0147181
TUBA1A tubulin, alpha 1a 0.0145517
NUCB2 nucleobindin 2 0.0145334
BIRC3 baculoviral IAP repeat containing 3 0.0144007
RPS23 ribosomal protein S23 0.0143523
DOK6 docking protein 6 0.0143001
YARS1 tyrosyl-tRNA synthetase 1 0.0142224
MED29 mediator complex subunit 29 0.0140089
PTMA prothymosin, alpha 0.0140036
HSPB1 heat shock 27kDa protein 1 0.0139988
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0139827
NACA nascent polypeptide-associated complex alpha subunit 0.013977
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0137145
KCTD16 potassium channel tetramerization domain containing 16 0.0136757
ROMO1 reactive oxygen species modulator 1 0.013653
RAD23B RAD23 homolog B (S. cerevisiae) 0.0136456
TTC17 tetratricopeptide repeat domain 17 0.0135959
ZNF207 zinc finger protein 207 0.0134792
COLGALT2 collagen beta(1-O)galactosyltransferase 2 0.0134384
ALKBH5 AlkB family member 5, RNA demethylase 0.0133974
NBEAL1 neurobeachin-like 1 0.0132972
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0131679
RPL13A ribosomal protein L13a 0.0131391
ELAVL3 ELAV like neuron-specific RNA binding protein 3 0.013049
CFDP1 craniofacial development protein 1 0.0130216
VASP vasodilator-stimulated phosphoprotein 0.0129464
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0128886
TMED9 transmembrane emp24 protein transport domain containing 9 0.0128422
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.0128225
RPS14 ribosomal protein S14 0.0127553
CHEK2 checkpoint kinase 2 0.012713
CHD9 chromodomain helicase DNA binding protein 9 0.0126581
PURB purine-rich element binding protein B 0.0126532
CUX1 cut-like homeobox 1 0.0125799
SYT1 synaptotagmin I 0.0125738
NKAP NFKB activating protein 0.0124272
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0123933
PRSS23 protease, serine, 23 0.0123615
PLIN3 perilipin 3 0.0123591

decreased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.111275
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0944587
TSC22D2 TSC22 domain family, member 2 -0.0891992
HDAC9 histone deacetylase 9 -0.0890426
DST dystonin -0.0861872
COL5A2 collagen, type V, alpha 2 -0.0844098
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0821857
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0782357
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0732827
FNDC3B fibronectin type III domain containing 3B -0.0708626
GPC3 glypican 3 -0.0681907
POTEF POTE ankyrin domain family, member F -0.065969
ITGAV integrin, alpha V -0.0632849
SNX6 sorting nexin 6 -0.0599713
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0586538
SRP54 signal recognition particle 54kDa -0.0583723
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0578334
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0577203
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0575328
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0575282
PEG10 paternally expressed 10 -0.0572803
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0566238
RPS2 ribosomal protein S2 -0.0561517
CKAP5 cytoskeleton associated protein 5 -0.0555433
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0554578
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0543773
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0542296
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0534707
ADGRL2 adhesion G protein-coupled receptor L2 -0.0534253
ZFAND3 zinc finger, AN1-type domain 3 -0.0523431
ZNF292 zinc finger protein 292 -0.051559
ATP5F1B ATP synthase F1 subunit beta -0.0497709
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0490678
CLTC clathrin, heavy chain (Hc) -0.0481552
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0476604
RBM39 RNA binding motif protein 39 -0.0476122
MAP4 microtubule-associated protein 4 -0.0473818
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0472345
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0453247
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0450945
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0447942
TPX2 TPX2, microtubule-associated -0.043785
CFL2 cofilin 2 (muscle) -0.043066
H1-4 H1.4 linker histone, cluster member -0.0427512
OGA O-GlcNAcase -0.0427233
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0420973
NOP58 NOP58 ribonucleoprotein -0.041132
CENPF centromere protein F, 350/400kDa -0.0407507
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0405485
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0404767
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0403215
ZFR zinc finger RNA binding protein -0.0399803
TRPS1 trichorhinophalangeal syndrome I -0.0395001
ZC3H15 zinc finger CCCH-type containing 15 -0.0393615
TXNRD1 thioredoxin reductase 1 -0.0390445
TMSB4X thymosin beta 4, X-linked -0.038973
MEIS2 Meis homeobox 2 -0.0386753
ARHGAP15 Rho GTPase activating protein 15 -0.0384355
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0384196
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0382434
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0374056
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0372953
PDIA3 protein disulfide isomerase family A, member 3 -0.0372534
STAG2 stromal antigen 2 -0.0368395
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0367459
COL11A1 collagen, type XI, alpha 1 -0.0365526
SFRP4 secreted frizzled-related protein 4 -0.036175
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0361365
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0361041
TARS1 threonyl-tRNA synthetase 1 -0.0360314
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0353916
ATAD2 ATPase family, AAA domain containing 2 -0.0351659
THBS1 thrombospondin 1 -0.0349749
ANXA2 annexin A2 -0.034857
RAB31 RAB31, member RAS oncogene family -0.0347524
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0346148
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.034262
MATR3 matrin 3 -0.0342462
TPM3 tropomyosin 3 -0.0342028
EMP1 epithelial membrane protein 1 -0.0340712
ADGRL3 adhesion G protein-coupled receptor L3 -0.0339533
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0339054
RBM25 RNA binding motif protein 25 -0.033654
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0334772
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0334763
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0334279
MARCHF6 membrane associated ring-CH-type finger 6 -0.0332611
CANX calnexin -0.0330464
APP amyloid beta (A4) precursor protein -0.0329707
XPO1 exportin 1 -0.0327888
RLF rearranged L-myc fusion -0.0326678
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -0.0324176
HMGB2 high mobility group box 2 -0.0324077
TEX11 testis expressed 11 -0.032341
TFRC transferrin receptor -0.0315877
NAP1L1 nucleosome assembly protein 1-like 1 -0.0314394
SET SET nuclear proto-oncogene -0.0309623
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0307863
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0307032
PRKD1 protein kinase D1 -0.0306853