Edoxaban (tosylate monohydrate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Edoxaban (tosylate monohydrate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Edoxaban (tosylate monohydrate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.1728
SRRM2 serine/arginine repetitive matrix 2 0.106253
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.103345
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0949689
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0768605
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0758105
DLC1 DLC1 Rho GTPase activating protein 0.0724859
NUP58 nucleoporin 58 0.0722643
TRIO trio Rho guanine nucleotide exchange factor 0.0694673
FRMD6 FERM domain containing 6 0.069406
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.068639
MYH9 myosin, heavy chain 9, non-muscle 0.0649077
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.064768
RPL3 ribosomal protein L3 0.0640559
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0632121
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0618435
ATP13A3 ATPase type 13A3 0.0613296
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0595954
SET SET nuclear proto-oncogene 0.0592189
ZEB1 zinc finger E-box binding homeobox 1 0.0591462
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0590294
ENO1 enolase 1, (alpha) 0.0587852
KMT2C lysine (K)-specific methyltransferase 2C 0.0572829
PKM pyruvate kinase, muscle 0.0572357
NAV2 neuron navigator 2 0.0572154
FMNL2 formin-like 2 0.05696
ZFAND3 zinc finger, AN1-type domain 3 0.0568227
ELL2 elongation factor, RNA polymerase II, 2 0.0560337
PTK2 protein tyrosine kinase 2 0.0555397
FRMD4A FERM domain containing 4A 0.0553009
SAMD4A sterile alpha motif domain containing 4A 0.0549957
KMT2E lysine (K)-specific methyltransferase 2E 0.0549742
MACF1 microtubule-actin crosslinking factor 1 0.0546708
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0542171
CALR calreticulin 0.053419
DSCAM Down syndrome cell adhesion molecule 0.0533981
NCKAP1 NCK-associated protein 1 0.0527311
NAP1L1 nucleosome assembly protein 1-like 1 0.0525635
EXT1 exostosin glycosyltransferase 1 0.0518513
UPP1 uridine phosphorylase 1 0.0514392
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0512182
USP9X ubiquitin specific peptidase 9, X-linked 0.0511626
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0502939
LPP LIM domain containing preferred translocation partner in lipoma 0.0501899
CAPRIN2 caprin family member 2 0.0501478
MCL1 myeloid cell leukemia 1 0.0499697
CORO1C coronin, actin binding protein, 1C 0.0484698
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0475155
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0446638
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0443441
EIF4B eukaryotic translation initiation factor 4B 0.0441812
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0440725
KDM6A lysine (K)-specific demethylase 6A 0.0437905
EEF2 eukaryotic translation elongation factor 2 0.0436399
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0424885
PBX3 pre-B-cell leukemia homeobox 3 0.0424304
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.041767
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0413604
GIGYF2 GRB10 interacting GYF protein 2 0.0411913
PHC2 polyhomeotic homolog 2 (Drosophila) 0.041048
BIRC6 baculoviral IAP repeat containing 6 0.0410127
CHD7 chromodomain helicase DNA binding protein 7 0.0405459
RAD23B RAD23 homolog B (S. cerevisiae) 0.0402285
SRRM1 serine/arginine repetitive matrix 1 0.0401755
ADAM9 ADAM metallopeptidase domain 9 0.0397656
ARGLU1 arginine and glutamate rich 1 0.0393403
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.038914
UBA6 ubiquitin-like modifier activating enzyme 6 0.0388419
PICALM phosphatidylinositol binding clathrin assembly protein 0.038629
ASPH aspartate beta-hydroxylase 0.0384421
YTHDC1 YTH domain containing 1 0.0382063
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0380279
LAMB3 laminin, beta 3 0.0380264
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0379273
SFPQ splicing factor proline/glutamine-rich 0.037919
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0374164
EXOC4 exocyst complex component 4 0.0372623
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0367544
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0367381
ANO6 anoctamin 6 0.0366535
ARHGAP22 Rho GTPase activating protein 22 0.0365576
ZNF292 zinc finger protein 292 0.0359633
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0358337
RPS12 ribosomal protein S12 0.0356828
CLTC clathrin, heavy chain (Hc) 0.0355579
PNISR PNN-interacting serine/arginine-rich protein 0.0355562
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0355134
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0354324
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0353051
PRKCE protein kinase C, epsilon 0.03505
RB1CC1 RB1-inducible coiled-coil 1 0.0344039
PCM1 pericentriolar material 1 0.0343711
MAST4 microtubule associated serine/threonine kinase family member 4 0.0342827
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.034263
PGK1 phosphoglycerate kinase 1 0.0341499
YEATS2 YEATS domain containing 2 0.0340675
WDR43 WD repeat domain 43 0.0340652
SON SON DNA binding protein 0.0339249
RPL4 ribosomal protein L4 0.0337764
FNDC3B fibronectin type III domain containing 3B 0.0337528

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.178399
HMGA1 high mobility group AT-hook 1 -0.100818
MT2A metallothionein 2A -0.0950747
EGR1 early growth response 1 -0.0575914
ACTG1 actin gamma 1 -0.0528227
FTL ferritin, light polypeptide -0.0513416
RPLP1 ribosomal protein, large, P1 -0.0506333
RPLP0 ribosomal protein, large, P0 -0.0492097
POTEF POTE ankyrin domain family, member F -0.0427136
RPS6 ribosomal protein S6 -0.0413614
IFI16 interferon, gamma-inducible protein 16 -0.0408222
RPS24 ribosomal protein S24 -0.0384133
TPT1 tumor protein, translationally-controlled 1 -0.0371447
RPS21 ribosomal protein S21 -0.0366197
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0361694
RPL35A ribosomal protein L35a -0.0356589
TUBB4B tubulin, beta 4B class IVb -0.0348552
TMSB10 thymosin beta 10 -0.0346466
RPS15 ribosomal protein S15 -0.034301
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.033866
BLZF1 basic leucine zipper nuclear factor 1 -0.0333592
RPS8 ribosomal protein S8 -0.0327535
ATP5F1B ATP synthase F1 subunit beta -0.0321197
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0307412
LOC112694756 uncharaterized LOC112694756 -0.0306627
RPL19 ribosomal protein L19 -0.0306538
GNAS GNAS complex locus -0.0305801
RPS19 ribosomal protein S19 -0.0305339
RAB7A RAB7A, member RAS oncogene family -0.0300769
PFN1 profilin 1 -0.0276357
SP100 SP100 nuclear antigen -0.0275251
RPL23 ribosomal protein L23 -0.0261025
RPL8 ribosomal protein L8 -0.0254672
HLA-C major histocompatibility complex, class I, C -0.024991
TM4SF1 transmembrane 4 L six family member 1 -0.0244117
RPS5 ribosomal protein S5 -0.0243254
RPL28 ribosomal protein L28 -0.024301
RPL36 ribosomal protein L36 -0.0238618
CD68 CD68 molecule -0.0238492
HMGB1 high mobility group box 1 -0.0235689
RPS13 ribosomal protein S13 -0.0225989
RPL31 ribosomal protein L31 -0.0221782
RPS25 ribosomal protein S25 -0.0221574
RPS16 ribosomal protein S16 -0.0217898
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0215961
S100A9 S100 calcium binding protein A9 -0.0215273
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0209221
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0208566
RPS23 ribosomal protein S23 -0.0208146
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0207836
TUBA1B tubulin, alpha 1b -0.020542
ATN1 atrophin 1 -0.0204982
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0204947
TCF12 transcription factor 12 -0.0204405
IL6ST interleukin 6 signal transducer -0.0203556
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0202668
IARS1 isoleucyl-tRNA synthetase 1 -0.0202252
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0200297
RPL34 ribosomal protein L34 -0.0199732
C2CD2 C2 calcium-dependent domain containing 2 -0.0197341
RPL27A ribosomal protein L27a -0.0191931
RPLP2 ribosomal protein, large, P2 -0.0191454
RPS14 ribosomal protein S14 -0.0189915
CPNE3 copine III -0.0186944
RPS29 ribosomal protein S29 -0.018618
S100A10 S100 calcium binding protein A10 -0.0184067
SPRY4 sprouty homolog 4 (Drosophila) -0.0182279
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0181656
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0178351
RPL13A ribosomal protein L13a -0.0175207
S100A11 S100 calcium binding protein A11 -0.0171517
MTDH metadherin -0.0171216
IFITM2 interferon induced transmembrane protein 2 -0.0169065
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0168244
NDRG1 N-myc downstream regulated 1 -0.0167908
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.016508
LOC102724023 ES1 protein homolog, mitochondrial -0.0163833
VDAC1 voltage-dependent anion channel 1 -0.0163782
ENO2 enolase 2 (gamma, neuronal) -0.0163632
HSPB1 heat shock 27kDa protein 1 -0.0162741
GTF2B general transcription factor IIB -0.0161755
RPS11 ribosomal protein S11 -0.0160201
H3-3B H3.3 histone B -0.0160015
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0155725
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0151618
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0151526
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0149725
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.014955
RPL12 ribosomal protein L12 -0.0149063
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0147674
B2M beta-2-microglobulin -0.0147441
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0146953
NANS N-acetylneuraminic acid synthase -0.0146588
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.014475
TXNRD1 thioredoxin reductase 1 -0.0144202
TMEM87A transmembrane protein 87A -0.0143911
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0143285
GSTP1 glutathione S-transferase pi 1 -0.014289
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0142633
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0142182