Edoxaban (tosylate monohydrate)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Edoxaban (tosylate monohydrate) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Edoxaban (tosylate monohydrate)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.0858792
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0846496
CENPF centromere protein F, 350/400kDa 0.0800569
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0656958
TPX2 TPX2, microtubule-associated 0.0626411
CEP250 centrosomal protein 250kDa 0.0593371
DIAPH3 diaphanous-related formin 3 0.0516876
ZNF292 zinc finger protein 292 0.0492759
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0466945
MKI67 marker of proliferation Ki-67 0.043864
TBC1D5 TBC1 domain family, member 5 0.043295
NUP58 nucleoporin 58 0.0424925
CKAP5 cytoskeleton associated protein 5 0.042325
NCAPD2 non-SMC condensin I complex, subunit D2 0.042173
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.0412469
NUMA1 nuclear mitotic apparatus protein 1 0.0407231
FXR1 fragile X mental retardation, autosomal homolog 1 0.0399678
CPNE1 copine I 0.0394227
DNER delta/notch-like EGF repeat containing 0.037972
ANKRD28 ankyrin repeat domain 28 0.0371982
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.03663
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0362068
ECT2 epithelial cell transforming 2 0.0357893
SMC4 structural maintenance of chromosomes 4 0.035105
YAP1 Yes-associated protein 1 0.0346488
HILPDA hypoxia inducible lipid droplet-associated 0.0342958
FANCI Fanconi anemia, complementation group I 0.0333327
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0333159
XPO1 exportin 1 0.0331245
KIAA1328 KIAA1328 0.0330155
NAP1L1 nucleosome assembly protein 1-like 1 0.0327799
KIF4A kinesin family member 4A 0.0324567
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.031747
TXNRD1 thioredoxin reductase 1 0.0314236
SGO2 shugoshin 2 0.0300935
PRC1 protein regulator of cytokinesis 1 0.0299786
SET SET nuclear proto-oncogene 0.0299585
RNMT RNA (guanine-7-) methyltransferase 0.0295954
CEP70 centrosomal protein 70kDa 0.0291545
NBAS neuroblastoma amplified sequence 0.0290899
RSRC2 arginine/serine-rich coiled-coil 2 0.0289531
NCKAP1 NCK-associated protein 1 0.0280373
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0277466
ZBTB10 zinc finger and BTB domain containing 10 0.0275885
KIAA1958 KIAA1958 0.0272704
AHCTF1 AT hook containing transcription factor 1 0.0269761
BABAM2 BRISC and BRCA1 A complex member 2 0.0268722
RFC3 replication factor C (activator 1) 3, 38kDa 0.0268441
MBNL2 muscleblind-like splicing regulator 2 0.0264979
GOLGA4 golgin A4 0.0261919
ANLN anillin, actin binding protein 0.0259971
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0257821
TOP2B topoisomerase (DNA) II beta 180kDa 0.0256048
CLTC clathrin, heavy chain (Hc) 0.0252855
CKAP2 cytoskeleton associated protein 2 0.0251931
ANKRD36C ankyrin repeat domain 36C 0.0247156
AURKA aurora kinase A 0.0246672
HP1BP3 heterochromatin protein 1, binding protein 3 0.0245066
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0244029
NAV2 neuron navigator 2 0.0242364
TTK TTK protein kinase 0.0242287
PRELID2 PRELI domain containing 2 0.0241024
ZNF670 zinc finger protein 670 0.0239822
NONO non-POU domain containing, octamer-binding 0.0239038
BIRC3 baculoviral IAP repeat containing 3 0.0238878
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0237457
COG5 component of oligomeric golgi complex 5 0.0236077
RBM26 RNA binding motif protein 26 0.0235934
PDE4D phosphodiesterase 4D, cAMP-specific 0.0234874
ZFC3H1 zinc finger, C3H1-type containing 0.0234482
HJURP Holliday junction recognition protein 0.0233172
EEF2 eukaryotic translation elongation factor 2 0.0232167
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.0232156
DHDDS dehydrodolichyl diphosphate synthase 0.0231753
TMPO thymopoietin 0.0230489
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0229299
RARS1 arginyl-tRNA synthetase 1 0.02273
APOLD1 apolipoprotein L domain containing 1 0.0226218
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0225817
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0225761
HMGB2 high mobility group box 2 0.0224944
HELZ helicase with zinc finger 0.0224424
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0223268
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0222512
MSN moesin 0.0221807
ANKRD36 ankyrin repeat domain 36 0.0219752
CUL4B cullin 4B 0.0218907
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0217738
SND1 staphylococcal nuclease and tudor domain containing 1 0.0217616
PDS5B PDS5 cohesin associated factor B 0.0217437
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0216378
DEK DEK proto-oncogene 0.0215857
RPL3 ribosomal protein L3 0.0212657
KIF18B kinesin family member 18B 0.0211722
PRPF8 pre-mRNA processing factor 8 0.0210639
UBE2O ubiquitin-conjugating enzyme E2O 0.0209883
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0208206
RAD23B RAD23 homolog B (S. cerevisiae) 0.0208086
H1-4 H1.4 linker histone, cluster member 0.0207752
PRPF4B pre-mRNA processing factor 4B 0.0207744

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.342316
TPT1 tumor protein, translationally-controlled 1 -0.142953
VIM vimentin -0.135587
FNDC3B fibronectin type III domain containing 3B -0.134776
TMSB10 thymosin beta 10 -0.124957
LDHA lactate dehydrogenase A -0.0950295
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0914636
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0893393
HMGA2 high mobility group AT-hook 2 -0.0854323
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0830991
ANXA2 annexin A2 -0.0765641
ZBTB20 zinc finger and BTB domain containing 20 -0.0749536
MACF1 microtubule-actin crosslinking factor 1 -0.0744236
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0673168
TM4SF1 transmembrane 4 L six family member 1 -0.0662881
DST dystonin -0.0646429
RPL35A ribosomal protein L35a -0.0636605
SH3KBP1 SH3-domain kinase binding protein 1 -0.0613835
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0610986
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0589567
SVIL supervillin -0.0586468
CD44 CD44 molecule (Indian blood group) -0.056421
ANGPTL4 angiopoietin-like 4 -0.0544875
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0544451
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0543588
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0535967
RPLP1 ribosomal protein, large, P1 -0.0534122
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0530311
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0529054
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0520081
MT2A metallothionein 2A -0.0516847
NALCN sodium leak channel, non selective -0.0503168
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0501456
SLC38A2 solute carrier family 38, member 2 -0.0500811
HLA-C major histocompatibility complex, class I, C -0.0486938
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0485745
RAI14 retinoic acid induced 14 -0.048508
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0475928
FTH1 ferritin, heavy polypeptide 1 -0.0462125
PCED1B PC-esterase domain containing 1B -0.0454025
PRSS23 protease, serine, 23 -0.0448273
NPAS2 neuronal PAS domain protein 2 -0.0440082
HLA-B major histocompatibility complex, class I, B -0.0436286
POTEF POTE ankyrin domain family, member F -0.0434792
BTG1 B-cell translocation gene 1, anti-proliferative -0.0429575
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0418309
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0410687
RIGI RNA sensor RIG-I -0.0406905
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0404186
CAPRIN2 caprin family member 2 -0.0402415
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0395837
CAVIN1 caveolae associated protein 1 -0.0394963
NT5E 5'-nucleotidase, ecto (CD73) -0.0394925
DOCK4 dedicator of cytokinesis 4 -0.0383697
PRR16 proline rich 16 -0.0379724
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0379237
OSMR oncostatin M receptor -0.0377766
RIN2 Ras and Rab interactor 2 -0.0375998
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0374577
EGR1 early growth response 1 -0.0374461
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0371754
PODXL podocalyxin-like -0.0370521
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0370409
FTL ferritin, light polypeptide -0.0370214
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0366433
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0365051
SDC4 syndecan 4 -0.0364862
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0363637
ENO2 enolase 2 (gamma, neuronal) -0.0362452
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0361384
UBB ubiquitin B -0.0358573
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0354429
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0347712
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0346002
DPYD dihydropyrimidine dehydrogenase -0.0343751
NDRG1 N-myc downstream regulated 1 -0.0340458
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0335751
FLNB filamin B, beta -0.0332961
AHNAK AHNAK nucleoprotein -0.0331406
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0329158
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0321558
SAMD4A sterile alpha motif domain containing 4A -0.0321372
ATG7 autophagy related 7 -0.0317945
RAB7A RAB7A, member RAS oncogene family -0.0313702
IGFBP3 insulin-like growth factor binding protein 3 -0.0312892
IER3 immediate early response 3 -0.0310399
CEMIP2 cell migration inducing hyaluronidase 2 -0.0309476
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0309167
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0307867
LOC112694756 uncharaterized LOC112694756 -0.030228
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.029995
GPC5 glypican 5 -0.0299325
ANKRD11 ankyrin repeat domain 11 -0.0297925
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0295399
GPC6 glypican 6 -0.0294241
COL5A1 collagen, type V, alpha 1 -0.0291514
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0290888
IL1RAP interleukin 1 receptor accessory protein -0.0290709
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0290293
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0287919