Edoxaban (tosylate monohydrate)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Edoxaban (tosylate monohydrate) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Edoxaban (tosylate monohydrate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0603898
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0550037
PDE4B phosphodiesterase 4B, cAMP-specific 0.0505965
FLOT1 flotillin 1 0.0487469
BIRC3 baculoviral IAP repeat containing 3 0.0456311
ITPRID2 ITPR interacting domain containing 2 0.0422902
NUP58 nucleoporin 58 0.0387322
RUNX2 runt-related transcription factor 2 0.0385288
SRRM2 serine/arginine repetitive matrix 2 0.0369427
EGFR epidermal growth factor receptor 0.0334867
EIF4B eukaryotic translation initiation factor 4B 0.0322229
KDM6A lysine (K)-specific demethylase 6A 0.031529
KMT2C lysine (K)-specific methyltransferase 2C 0.0295195
RNF43 ring finger protein 43 0.0293475
FAR1 fatty acyl CoA reductase 1 0.0290001
DSPP dentin sialophosphoprotein 0.0284046
NBAS neuroblastoma amplified sequence 0.0282766
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.02735
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0269502
CPOX coproporphyrinogen oxidase 0.0266992
FAT1 FAT atypical cadherin 1 0.0264063
TGFB2 transforming growth factor, beta 2 0.0241984
CCNL1 cyclin L1 0.0240811
EREG epiregulin 0.0239821
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0239045
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0235651
DSCAM Down syndrome cell adhesion molecule 0.0232518
GCLC glutamate-cysteine ligase, catalytic subunit 0.0227302
RPL3 ribosomal protein L3 0.0227075
PRELID2 PRELI domain containing 2 0.0226298
EPHA2 EPH receptor A2 0.0225636
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0218916
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0218698
DST dystonin 0.0216553
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0211014
ITGA6 integrin, alpha 6 0.0210636
AXIN2 axin 2 0.0210279
EWSR1 EWS RNA-binding protein 1 0.0204697
FNDC3B fibronectin type III domain containing 3B 0.020439
EDAR ectodysplasin A receptor 0.0204286
BBX bobby sox homolog (Drosophila) 0.0204241
MSI2 musashi RNA-binding protein 2 0.020244
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0200717
SEPTIN9 septin 9 0.0200584
SND1 staphylococcal nuclease and tudor domain containing 1 0.0196609
ATXN1 ataxin 1 0.0196438
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0196403
MED13L mediator complex subunit 13-like 0.0193482
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0188742
WAC WW domain containing adaptor with coiled-coil 0.018385
NCKAP1 NCK-associated protein 1 0.0182098
MACF1 microtubule-actin crosslinking factor 1 0.0180607
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0179682
USP9X ubiquitin specific peptidase 9, X-linked 0.0178223
ANK2 ankyrin 2, neuronal 0.017815
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.017706
ESRP1 epithelial splicing regulatory protein 1 0.0175846
NAMPT nicotinamide phosphoribosyltransferase 0.0173734
ANKRD11 ankyrin repeat domain 11 0.0173272
MYH9 myosin, heavy chain 9, non-muscle 0.0173183
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.0169119
SFPQ splicing factor proline/glutamine-rich 0.0169053
INSIG2 insulin induced gene 2 0.0167228
RREB1 ras responsive element binding protein 1 0.01672
SPAG9 sperm associated antigen 9 0.0166839
SEC23A Sec23 homolog A (S. cerevisiae) 0.016557
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0162193
ADAM17 ADAM metallopeptidase domain 17 0.0159955
ZNRF3 zinc and ring finger 3 0.0159138
ANKRD10 ankyrin repeat domain 10 0.015817
MBNL2 muscleblind-like splicing regulator 2 0.0155296
KLC1 kinesin light chain 1 0.0153483
NIBAN2 niban apoptosis regulator 2 0.0153167
COG5 component of oligomeric golgi complex 5 0.0153055
VEGFA vascular endothelial growth factor A 0.0152146
RPL41 ribosomal protein L41 0.0148966
RFX7 regulatory factor X, 7 0.0148038
ATP11B ATPase, class VI, type 11B 0.0147118
UBA5 ubiquitin-like modifier activating enzyme 5 0.0143629
ANKRD36 ankyrin repeat domain 36 0.014308
CCSER1 coiled-coil serine-rich protein 1 0.0142533
CAMTA1 calmodulin binding transcription activator 1 0.0142308
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0141936
ARHGAP32 Rho GTPase activating protein 32 0.0141903
HOOK2 hook microtubule-tethering protein 2 0.0141473
NAV2 neuron navigator 2 0.0141369
UTRN utrophin 0.0139071
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0138809
WDFY3 WD repeat and FYVE domain containing 3 0.0138628
SACK1B scaffolding CK1 anchoring protein B 0.0136559
CD46 CD46 molecule, complement regulatory protein 0.0135947
PFKP phosphofructokinase, platelet 0.0135211
HSPA8 heat shock 70kDa protein 8 0.0135124
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0134925
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0134459
YEATS2 YEATS domain containing 2 0.0132761
TOP1 topoisomerase (DNA) I 0.0132595
GRB10 growth factor receptor-bound protein 10 0.0132549
RB1CC1 RB1-inducible coiled-coil 1 0.0132422
SNX13 sorting nexin 13 0.0130658

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.313666
PTMA prothymosin, alpha -0.287464
TMSB10 thymosin beta 10 -0.230194
RPS6 ribosomal protein S6 -0.176939
TPT1 tumor protein, translationally-controlled 1 -0.156022
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.146209
IER3 immediate early response 3 -0.139995
ACTG1 actin gamma 1 -0.128723
RPLP1 ribosomal protein, large, P1 -0.126503
RPL35A ribosomal protein L35a -0.120425
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.116837
RPS19 ribosomal protein S19 -0.106095
RPS24 ribosomal protein S24 -0.105825
RPS8 ribosomal protein S8 -0.0925905
RPL23 ribosomal protein L23 -0.0892938
RPL34 ribosomal protein L34 -0.0839397
RPS27A ribosomal protein S27a -0.0801088
EGR1 early growth response 1 -0.0799243
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0794911
RPS25 ribosomal protein S25 -0.0771068
RPL12 ribosomal protein L12 -0.076512
RPLP0 ribosomal protein, large, P0 -0.0764563
RPL11 ribosomal protein L11 -0.073067
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0721026
RPS29 ribosomal protein S29 -0.0715216
RPS4X ribosomal protein S4, X-linked -0.0690082
RPL26 ribosomal protein L26 -0.0682713
ANXA2 annexin A2 -0.0681633
RPL32 ribosomal protein L32 -0.0678357
RPL36 ribosomal protein L36 -0.0667058
EIF1 eukaryotic translation initiation factor 1 -0.066518
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0641542
RPL19 ribosomal protein L19 -0.0634579
HMGA1 high mobility group AT-hook 1 -0.0622498
RPLP2 ribosomal protein, large, P2 -0.0615881
UBC ubiquitin C -0.0602655
EMP1 epithelial membrane protein 1 -0.0599807
RPS3 ribosomal protein S3 -0.0599672
S100A10 S100 calcium binding protein A10 -0.0595605
RPS14 ribosomal protein S14 -0.0593038
RPL8 ribosomal protein L8 -0.0583975
RPL5 ribosomal protein L5 -0.0582304
RPL31 ribosomal protein L31 -0.0573192
S100A6 S100 calcium binding protein A6 -0.0572231
EEF2 eukaryotic translation elongation factor 2 -0.0559473
RPS13 ribosomal protein S13 -0.0531032
LAMB3 laminin, beta 3 -0.0529253
MT2A metallothionein 2A -0.0528277
RPS15 ribosomal protein S15 -0.0523996
RACK1 receptor for activated C kinase 1 -0.0523209
LOC112694756 uncharaterized LOC112694756 -0.0509114
LDHA lactate dehydrogenase A -0.0506369
RPL35 ribosomal protein L35 -0.0490865
RPS5 ribosomal protein S5 -0.0486579
ANXA1 annexin A1 -0.0474107
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0473121
FTL ferritin, light polypeptide -0.0473085
RPL13A ribosomal protein L13a -0.0461926
AHNAK AHNAK nucleoprotein -0.0460033
RPS28 ribosomal protein S28 -0.0455146
RPS16 ribosomal protein S16 -0.0447608
RPS21 ribosomal protein S21 -0.0443153
S100A9 S100 calcium binding protein A9 -0.0439356
RPL7A ribosomal protein L7a -0.0435787
RPL7 ribosomal protein L7 -0.0434215
RPL15 ribosomal protein L15 -0.0433429
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0432225
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.04316
RPS23 ribosomal protein S23 -0.0426547
RPL28 ribosomal protein L28 -0.0410632
RPL9 ribosomal protein L9 -0.0407943
RPS12 ribosomal protein S12 -0.0405084
RSL1D1 ribosomal L1 domain containing 1 -0.0404929
MT1X metallothionein 1X -0.0401299
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.039832
RPS27 ribosomal protein S27 -0.0390326
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0388246
LOC102724023 ES1 protein homolog, mitochondrial -0.0385557
SQSTM1 sequestosome 1 -0.0376321
RPL18 ribosomal protein L18 -0.0371654
RPS17 ribosomal protein S17 -0.0369568
HLA-B major histocompatibility complex, class I, B -0.0367961
RPL37A ribosomal protein L37a -0.0357402
RPL10A ribosomal protein L10a -0.0356674
PERP PERP, TP53 apoptosis effector -0.0353909
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0346766
AREG amphiregulin -0.0341378
S100A11 S100 calcium binding protein A11 -0.0341125
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0336324
ATP5F1B ATP synthase F1 subunit beta -0.0333481
ENO1 enolase 1, (alpha) -0.0330229
RPS11 ribosomal protein S11 -0.0327368
HMGA2 high mobility group AT-hook 2 -0.0315707
KLF6 Kruppel-like factor 6 -0.0314308
RPL38 ribosomal protein L38 -0.0310609
RPL30 ribosomal protein L30 -0.0300736
RPL27A ribosomal protein L27a -0.0300736
EEF1G eukaryotic translation elongation factor 1 gamma -0.0294203
ARF1 ADP-ribosylation factor 1 -0.0292492
ZFP36L1 ZFP36 ring finger protein-like 1 -0.029165