| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elagolix sodium perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Elagolix sodium_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.151928 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0607315 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0466072 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0432812 |
| FN1 | fibronectin 1 | 0.0352227 |
| NDRG1 | N-myc downstream regulated 1 | 0.0339907 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0259743 |
| SUCNR1 | succinate receptor 1 | 0.0258628 |
| PODXL | podocalyxin-like | 0.0249695 |
| CDH13 | cadherin 13 | 0.0187017 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.0176573 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0175084 |
| FLT1 | fms-related tyrosine kinase 1 | 0.0169138 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0167613 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.016673 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0166671 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.016123 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0158986 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0155996 |
| CTSB | cathepsin B | 0.0154253 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0152125 |
| FLNB | filamin B, beta | 0.0149959 |
| CUL4A | cullin 4A | 0.0120962 |
| BLCAP | bladder cancer associated protein | 0.0118879 |
| DGKG | diacylglycerol kinase, gamma 90kDa | 0.0117111 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0115928 |
| CACNG8 | calcium channel, voltage-dependent, gamma subunit 8 | 0.0115639 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0115163 |
| THBS2 | thrombospondin 2 | 0.010862 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | 0.0106876 |
| EGFR | epidermal growth factor receptor | 0.0106298 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0103413 |
| OBSCN | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | 0.0101754 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.0101152 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0101106 |
| MEAK7 | MTOR associated protein, eak-7 homolog | 0.0097297 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.00970407 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0096261 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.00951806 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.00950964 |
| CARD11 | caspase recruitment domain family, member 11 | 0.00950399 |
| ANKRD30B | ankyrin repeat domain 30B | 0.0094771 |
| MTCL1 | microtubule crosslinking factor 1 | 0.0093986 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | 0.00936566 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.00932872 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.00922696 |
| NAV1 | neuron navigator 1 | 0.00919388 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.00908931 |
| MCL1 | myeloid cell leukemia 1 | 0.00892272 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | 0.00888134 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | 0.00880089 |
| SEPTIN10 | septin 10 | 0.00864807 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.00863971 |
| CDIPT | CDP-diacylglycerol--inositol 3-phosphatidyltransferase | 0.00840617 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.00836073 |
| R3HDM2 | R3H domain containing 2 | 0.00834595 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.00829421 |
| CSPG4 | chondroitin sulfate proteoglycan 4 | 0.00828626 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.00825773 |
| LAMC2 | laminin, gamma 2 | 0.00824754 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.00824131 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.00823915 |
| RAI14 | retinoic acid induced 14 | 0.0081988 |
| NHSL1 | NHS-like 1 | 0.00811908 |
| SLFN5 | schlafen family member 5 | 0.00803425 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.008029 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.00798096 |
| GOSR2 | golgi SNAP receptor complex member 2 | 0.00789824 |
| VEGFC | vascular endothelial growth factor C | 0.00787969 |
| KIAA1549L | KIAA1549-like | 0.0078768 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.00781242 |
| FLOT1 | flotillin 1 | 0.00780975 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.00774897 |
| TMEM165 | transmembrane protein 165 | 0.00766887 |
| PYGL | phosphorylase, glycogen, liver | 0.00758243 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | 0.00756329 |
| INSYN2B | inhibitory synaptic factor family member 2B | 0.00751999 |
| SIN3B | SIN3 transcription regulator family member B | 0.00746093 |
| S100A11 | S100 calcium binding protein A11 | 0.00745704 |
| SFXN3 | sideroflexin 3 | 0.0074423 |
| DGLUCY | D-glutamate cyclase | 0.00727594 |
| SHLD2 | shieldin complex subunit 2 | 0.00719708 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.00719088 |
| PLXNB3 | plexin B3 | 0.00717965 |
| DCUN1D3 | DCN1, defective in cullin neddylation 1, domain containing 3 | 0.0071568 |
| HGS | hepatocyte growth factor-regulated tyrosine kinase substrate | 0.00710531 |
| HSPA8 | heat shock 70kDa protein 8 | 0.00710438 |
| BPTF | bromodomain PHD finger transcription factor | 0.00701236 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.00700124 |
| YJEFN3 | YjeF N-terminal domain containing 3 | 0.00699806 |
| PRELID3B | PRELI domain containing 3B | 0.00693869 |
| KDSR | 3-ketodihydrosphingosine reductase | 0.0069374 |
| RBAK-RBAKDN | RBAK-RBAKDN readthrough | 0.00691133 |
| TMEM39A | transmembrane protein 39A | 0.00690159 |
| PCNX4 | pecanex 4 | 0.00682684 |
| NAA60 | N(alpha)-acetyltransferase 60, NatF catalytic subunit | 0.00680155 |
| ARCN1 | archain 1 | 0.00677475 |
| SYTL3 | synaptotagmin-like 3 | 0.00665996 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.00661827 |
| NMT2 | N-myristoyltransferase 2 | 0.00656916 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.266589 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.187299 |
| TMSB10 | thymosin beta 10 | -0.103242 |
| AHNAK | AHNAK nucleoprotein | -0.0814283 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0756359 |
| LOX | lysyl oxidase | -0.0728873 |
| POTEF | POTE ankyrin domain family, member F | -0.0721319 |
| MAP1B | microtubule-associated protein 1B | -0.0712939 |
| FBN1 | fibrillin 1 | -0.0695829 |
| PKM | pyruvate kinase, muscle | -0.0632549 |
| CD44 | CD44 molecule (Indian blood group) | -0.0626635 |
| LDHA | lactate dehydrogenase A | -0.0625062 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.061501 |
| DST | dystonin | -0.0610632 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0603956 |
| S100A10 | S100 calcium binding protein A10 | -0.0582228 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0553877 |
| SQSTM1 | sequestosome 1 | -0.0547727 |
| COL5A2 | collagen, type V, alpha 2 | -0.0546708 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0542828 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0528673 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0519921 |
| UBC | ubiquitin C | -0.05145 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0499779 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0491946 |
| PTMA | prothymosin, alpha | -0.0487676 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.048486 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.048103 |
| LMNA | lamin A/C | -0.0476878 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0468978 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0450602 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0443938 |
| COL1A2 | collagen, type I, alpha 2 | -0.0433828 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0432047 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0430481 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0418128 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0407177 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0385709 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0383561 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0374978 |
| ENO1 | enolase 1, (alpha) | -0.0374722 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0371108 |
| TAGLN2 | transgelin 2 | -0.0370318 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0353673 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0352883 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0347005 |
| CANX | calnexin | -0.0342468 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0334755 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0333567 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0329151 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0328243 |
| TPM4 | tropomyosin 4 | -0.0328103 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0326876 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0317944 |
| MYOF | myoferlin | -0.0316685 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0313174 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0308828 |
| ATP13A3 | ATPase type 13A3 | -0.0304644 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0303379 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0303031 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0297355 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0297346 |
| APP | amyloid beta (A4) precursor protein | -0.029659 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0295923 |
| TLE4 | transducin-like enhancer of split 4 | -0.0294689 |
| SPAG9 | sperm associated antigen 9 | -0.0294463 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0293545 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0293258 |
| COL3A1 | collagen, type III, alpha 1 | -0.0289325 |
| SFTPA2 | surfactant protein A2 | -0.0288837 |
| KLF6 | Kruppel-like factor 6 | -0.0288044 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0287681 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.028695 |
| OGA | O-GlcNAcase | -0.0286878 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0284831 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0282006 |
| B2M | beta-2-microglobulin | -0.0279138 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0276814 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0275582 |
| RRBP1 | ribosome binding protein 1 | -0.0272758 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0272696 |
| SBF2 | SET binding factor 2 | -0.0271635 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0270764 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.02676 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0265186 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0263137 |
| NAV2 | neuron navigator 2 | -0.0261453 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0246408 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0245884 |
| VIM | vimentin | -0.0242794 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0242214 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0232997 |
| ACTN4 | actinin, alpha 4 | -0.0232437 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0232399 |
| CENPF | centromere protein F, 350/400kDa | -0.0231646 |
| SEPTIN7 | septin 7 | -0.0230359 |
| PLAT | plasminogen activator, tissue | -0.0229818 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0228021 |
| JUN | jun proto-oncogene | -0.0226822 |
| PGK1 | phosphoglycerate kinase 1 | -0.0224236 |
