Elagolix sodium_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Elagolix sodium perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Elagolix sodium_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0582495
GSE1 Gse1 coiled-coil protein 0.0565187
ZMIZ1 zinc finger, MIZ-type containing 1 0.0529229
TSHZ2 teashirt zinc finger homeobox 2 0.0453343
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0428865
THSD4 thrombospondin, type I, domain containing 4 0.0376209
FNIP1 folliculin interacting protein 1 0.0352962
VEGFA vascular endothelial growth factor A 0.0343707
TRIO trio Rho guanine nucleotide exchange factor 0.0326291
HMGA2 high mobility group AT-hook 2 0.0305678
NCOR2 nuclear receptor corepressor 2 0.0290833
LINGO2 leucine rich repeat and Ig domain containing 2 0.0282867
HSPA8 heat shock 70kDa protein 8 0.0277533
MYOF myoferlin 0.0268384
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 0.0257458
SIK3 SIK family kinase 3 0.0251978
IPO7 importin 7 0.0242427
FLNA filamin A, alpha 0.0241743
PRRC2A proline-rich coiled-coil 2A 0.023661
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0223033
SFPQ splicing factor proline/glutamine-rich 0.0211237
ANO6 anoctamin 6 0.0200178
EGFR epidermal growth factor receptor 0.0198454
KDM5C lysine (K)-specific demethylase 5C 0.0195821
AOPEP aminopeptidase O (putative) 0.019125
UBE3A ubiquitin protein ligase E3A 0.0189067
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.0188377
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0186789
ATP11A ATPase, class VI, type 11A 0.0186342
PANK3 pantothenate kinase 3 0.0186131
MSRB3 methionine sulfoxide reductase B3 0.0185194
SERBP1 SERPINE1 mRNA binding protein 1 0.0182854
PICALM phosphatidylinositol binding clathrin assembly protein 0.0182502
SRRM2 serine/arginine repetitive matrix 2 0.0180172
NBEA neurobeachin 0.0179419
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0179002
PLCG1 phospholipase C, gamma 1 0.017837
ARID1A AT rich interactive domain 1A (SWI-like) 0.0171617
ACVR1 activin A receptor, type I 0.0170908
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.0169004
ZEB1 zinc finger E-box binding homeobox 1 0.0167862
ZBTB44 zinc finger and BTB domain containing 44 0.0167096
FAM13B family with sequence similarity 13, member B 0.016649
DOCK3 dedicator of cytokinesis 3 0.0164814
SH3PXD2A SH3 and PX domains 2A 0.0164627
CTBP2 C-terminal binding protein 2 0.0162779
ZZZ3 zinc finger, ZZ-type containing 3 0.0162773
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) 0.0159227
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0156917
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0154669
NHSL1 NHS-like 1 0.0154458
PDE10A phosphodiesterase 10A 0.0154214
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0153418
KDM6A lysine (K)-specific demethylase 6A 0.0153247
ATP11B ATPase, class VI, type 11B 0.0152974
JMJD1C jumonji domain containing 1C 0.0150973
DENND1A DENN/MADD domain containing 1A 0.0148905
USP9X ubiquitin specific peptidase 9, X-linked 0.0148454
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0148005
IGF2R insulin-like growth factor 2 receptor 0.0147037
CLIP2 CAP-GLY domain containing linker protein 2 0.0145609
EIF4H eukaryotic translation initiation factor 4H 0.014459
LARP4B La ribonucleoprotein domain family, member 4B 0.0144278
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.014271
SSBP3 single stranded DNA binding protein 3 0.0139858
HIRA histone cell cycle regulator 0.0139569
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0138827
TSC22D1 TSC22 domain family, member 1 0.0137141
ACADVL acyl-CoA dehydrogenase, very long chain 0.0136609
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.0135577
TMEM117 transmembrane protein 117 0.013556
FRMD6 FERM domain containing 6 0.0135432
GATAD2B GATA zinc finger domain containing 2B 0.0134388
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0133786
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0133143
AFF4 AF4/FMR2 family, member 4 0.0132699
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.013052
PRPF18 pre-mRNA processing factor 18 0.0128944
CNN3 calponin 3, acidic 0.0128654
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0127918
SOS2 son of sevenless homolog 2 (Drosophila) 0.012745
METTL15 methyltransferase like 15 0.0127353
PDZD8 PDZ domain containing 8 0.0126605
RPL3 ribosomal protein L3 0.0126212
KDM4B lysine (K)-specific demethylase 4B 0.012598
MAPK8 mitogen-activated protein kinase 8 0.0125904
MACF1 microtubule-actin crosslinking factor 1 0.0125442
MTMR3 myotubularin related protein 3 0.0124711
ZNF516 zinc finger protein 516 0.012469
KAT6B K(lysine) acetyltransferase 6B 0.0124511
FGFR1 fibroblast growth factor receptor 1 0.012444
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.012442
MTREX Mtr4 exosome RNA helicase 0.0124221
KANK1 KN motif and ankyrin repeat domains 1 0.0124205
SMAD3 SMAD family member 3 0.012416
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0123074
CHKA choline kinase alpha 0.0122996
KIAA1549 KIAA1549 0.0121321
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0121212
UIMC1 ubiquitin interaction motif containing 1 0.0120403

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.211872
MEST mesoderm specific transcript -0.211452
VIM vimentin -0.149512
PTMA prothymosin, alpha -0.136913
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0995108
SOX4 SRY (sex determining region Y)-box 4 -0.0916119
PEG10 paternally expressed 10 -0.0884935
CANX calnexin -0.0741238
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.073268
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0731159
MGP matrix Gla protein -0.0671751
RPS6 ribosomal protein S6 -0.0652543
TMSB10 thymosin beta 10 -0.0623775
MEOX2 mesenchyme homeobox 2 -0.0583638
RPL12 ribosomal protein L12 -0.0521951
NFIB nuclear factor I/B -0.0520062
RPS8 ribosomal protein S8 -0.050561
PKM pyruvate kinase, muscle -0.0476481
RPLP2 ribosomal protein, large, P2 -0.0472146
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0471986
IER3 immediate early response 3 -0.0464794
TPK1 thiamin pyrophosphokinase 1 -0.0461461
FTL ferritin, light polypeptide -0.0449792
COL1A2 collagen, type I, alpha 2 -0.0446791
RPS24 ribosomal protein S24 -0.0441675
PDIA3 protein disulfide isomerase family A, member 3 -0.0441643
ENO1 enolase 1, (alpha) -0.0437384
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0429974
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0418594
MT2A metallothionein 2A -0.0417095
LDHA lactate dehydrogenase A -0.0413045
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.041096
RPLP1 ribosomal protein, large, P1 -0.0400333
RPL19 ribosomal protein L19 -0.0387388
CALR calreticulin -0.0385104
TPT1 tumor protein, translationally-controlled 1 -0.0384472
PGK1 phosphoglycerate kinase 1 -0.0373371
CENPF centromere protein F, 350/400kDa -0.036897
NFIA nuclear factor I/A -0.0368202
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.03648
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0364681
NAMPT nicotinamide phosphoribosyltransferase -0.0353526
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0347922
RPL28 ribosomal protein L28 -0.0341855
RPL23 ribosomal protein L23 -0.0339546
RPS3 ribosomal protein S3 -0.0339171
SEPTIN11 septin 11 -0.0311583
CSDE1 cold shock domain containing E1, RNA-binding -0.0309575
MAP1B microtubule-associated protein 1B -0.0308876
RPL35A ribosomal protein L35a -0.0306732
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0300503
RPS25 ribosomal protein S25 -0.0297421
APP amyloid beta (A4) precursor protein -0.0296588
QKI QKI, KH domain containing, RNA binding -0.0293081
ASPH aspartate beta-hydroxylase -0.0292447
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0290609
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0290192
EIF5B eukaryotic translation initiation factor 5B -0.0289575
TET1 tet methylcytosine dioxygenase 1 -0.0289217
RPS11 ribosomal protein S11 -0.0287487
S100A9 S100 calcium binding protein A9 -0.0286805
NAP1L1 nucleosome assembly protein 1-like 1 -0.0281377
CCNI cyclin I -0.0280599
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0279604
CBX3 chromobox homolog 3 -0.0275797
KPNB1 karyopherin (importin) beta 1 -0.0275328
RBM39 RNA binding motif protein 39 -0.0274238
RPS19 ribosomal protein S19 -0.0270441
TPI1 triosephosphate isomerase 1 -0.0268981
PCBP2 poly(rC) binding protein 2 -0.0268478
DIAPH3 diaphanous-related formin 3 -0.0266858
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0266751
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0266633
PDE4D phosphodiesterase 4D, cAMP-specific -0.0265686
KIF5B kinesin family member 5B -0.0255632
RPL34 ribosomal protein L34 -0.0253539
SEC31A SEC31 homolog A (S. cerevisiae) -0.0252634
MKI67 marker of proliferation Ki-67 -0.0252109
ARID4B AT rich interactive domain 4B (RBP1-like) -0.02511
RPL5 ribosomal protein L5 -0.024942
ZBTB20 zinc finger and BTB domain containing 20 -0.024917
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0246824
FN1 fibronectin 1 -0.024665
UBC ubiquitin C -0.0245652
FOXC1 forkhead box C1 -0.0245238
RPL26 ribosomal protein L26 -0.0243082
NIPBL Nipped-B homolog (Drosophila) -0.0240859
RAD21 RAD21 homolog (S. pombe) -0.0240629
RPS21 ribosomal protein S21 -0.0239544
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0237539
RPL8 ribosomal protein L8 -0.0235213
GNAS GNAS complex locus -0.0235151
WTAP Wilms tumor 1 associated protein -0.0234718
RPLP0 ribosomal protein, large, P0 -0.0234484
CADM2 cell adhesion molecule 2 -0.0232993
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0232607
RPL7 ribosomal protein L7 -0.0231929
MEIS2 Meis homeobox 2 -0.0231142
TPX2 TPX2, microtubule-associated -0.0230279
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0227818