Elagolix sodium_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Elagolix sodium perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Elagolix sodium_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEP250 centrosomal protein 250kDa 0.113846
LASP1 LIM and SH3 protein 1 0.0856163
INTS6 integrator complex subunit 6 0.0847037
LOC112694756 uncharaterized LOC112694756 0.0846838
ACTG1 actin gamma 1 0.0756159
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.0701628
ERBB2 erb-b2 receptor tyrosine kinase 2 0.0661622
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0629919
SRCIN1 SRC kinase signaling inhibitor 1 0.0598269
FTH1 ferritin, heavy polypeptide 1 0.0593677
CDK12 cyclin-dependent kinase 12 0.0536022
KRT86 keratin 86, type II 0.0508465
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0508328
GRB7 growth factor receptor-bound protein 7 0.0499254
THSD4 thrombospondin, type I, domain containing 4 0.0481851
LPP LIM domain containing preferred translocation partner in lipoma 0.0473449
PLEC plectin 0.0465808
PRRC2B proline-rich coiled-coil 2B 0.0462676
KIF1A kinesin family member 1A 0.0443306
PRRC2A proline-rich coiled-coil 2A 0.0440549
EEF2 eukaryotic translation elongation factor 2 0.0426282
RNF213 ring finger protein 213 0.042178
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0418365
FASN fatty acid synthase 0.0393214
ANKRD36C ankyrin repeat domain 36C 0.0368642
EPPK1 epiplakin 1 0.0357832
PRRC2C proline-rich coiled-coil 2C 0.0356061
STXBP4 syntaxin binding protein 4 0.0352903
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0350361
ZHX2 zinc fingers and homeoboxes 2 0.0344695
FLNA filamin A, alpha 0.0333442
EIF4H eukaryotic translation initiation factor 4H 0.0327276
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.03202
RPL23 ribosomal protein L23 0.0313742
GRB10 growth factor receptor-bound protein 10 0.0310736
SMYD3 SET and MYND domain containing 3 0.0309731
UBAP2L ubiquitin associated protein 2-like 0.0302689
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0297237
HLA-B major histocompatibility complex, class I, B 0.0286178
AEBP2 AE binding protein 2 0.0284105
HLA-C major histocompatibility complex, class I, C 0.0283496
VAV2 vav 2 guanine nucleotide exchange factor 0.028274
HSPA8 heat shock 70kDa protein 8 0.0280241
LIMCH1 LIM and calponin homology domains 1 0.0280194
EGFR epidermal growth factor receptor 0.0279044
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0277637
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0276473
SP100 SP100 nuclear antigen 0.0272786
ADARB1 adenosine deaminase, RNA-specific, B1 0.0268135
NCOR2 nuclear receptor corepressor 2 0.026698
SYTL2 synaptotagmin-like 2 0.0266879
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0265809
GDF5 growth differentiation factor 5 0.0265151
KRT7 keratin 7, type II 0.0260951
STIP1 stress-induced phosphoprotein 1 0.0250821
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0248782
SQSTM1 sequestosome 1 0.0246879
LMNA lamin A/C 0.0244741
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0238305
PLSCR2 phospholipid scramblase 2 0.0233206
ACSF2 acyl-CoA synthetase family member 2 0.0231818
CEMIP cell migration inducing protein, hyaluronan binding 0.0229927
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0227169
FOXO3 forkhead box O3 0.0222436
NEBL nebulette 0.0220833
CTIF CBP80/20-dependent translation initiation factor 0.0220129
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0219845
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0219711
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0217964
TUBB tubulin, beta class I 0.0214732
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0214263
MT2A metallothionein 2A 0.0213426
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0212873
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0212661
RAD51B RAD51 paralog B 0.0211242
CDK13 cyclin-dependent kinase 13 0.0208676
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.020857
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0207416
RPLP1 ribosomal protein, large, P1 0.0206091
HELZ2 helicase with zinc finger 2, transcriptional coactivator 0.0206052
ATXN1 ataxin 1 0.0203407
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0199476
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.01992
GPATCH2L G patch domain containing 2-like 0.0198961
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.0198435
VIPR2 vasoactive intestinal peptide receptor 2 0.0198185
NIBAN2 niban apoptosis regulator 2 0.0197427
SURF4 surfeit 4 0.0197174
TNIK TRAF2 and NCK interacting kinase 0.0194923
EEIG1 estrogen-induced osteoclastogenesis regulator 1 0.0193432
MMP24OS MMP24 opposite strand 0.0193234
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0190827
ADNP activity-dependent neuroprotector homeobox 0.018754
GRHL2 grainyhead-like 2 (Drosophila) 0.0187365
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.018716
SCRIB scribbled planar cell polarity protein 0.0183185
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B 0.0182568
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 0.0180629
ANKRD17 ankyrin repeat domain 17 0.0180005
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 0.0178415

decreased expression

Symbol Name Standardized Value
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.166926
VMP1 vacuole membrane protein 1 -0.130115
ZMYND8 zinc finger, MYND-type containing 8 -0.111372
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.109611
RPL19 ribosomal protein L19 -0.101303
PTMA prothymosin, alpha -0.100197
CLTC clathrin, heavy chain (Hc) -0.0842077
NAMPT nicotinamide phosphoribosyltransferase -0.0832588
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0819667
ITCH itchy E3 ubiquitin protein ligase -0.0806638
TOM1L1 target of myb1 (chicken)-like 1 -0.0694642
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0665226
IGFBP5 insulin-like growth factor binding protein 5 -0.0607694
PRR11 proline rich 11 -0.056812
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0559399
TSC22D2 TSC22 domain family, member 2 -0.0554114
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0535783
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0509515
TMEM165 transmembrane protein 165 -0.0496371
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0482027
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0481869
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0474733
CCNL1 cyclin L1 -0.0465039
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0464676
SETD5 SET domain containing 5 -0.0460201
DSTN destrin (actin depolymerizing factor) -0.0457394
SBF2 SET binding factor 2 -0.0445724
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0422606
GOLGA4 golgin A4 -0.0413939
RAB6A RAB6A, member RAS oncogene family -0.0405689
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0404881
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0403154
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0402446
ACACA acetyl-CoA carboxylase alpha -0.0393004
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0391162
B2M beta-2-microglobulin -0.0390604
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0389412
MYO1B myosin IB -0.0388284
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0379092
RAB22A RAB22A, member RAS oncogene family -0.0374251
RBM39 RNA binding motif protein 39 -0.0371531
OSMR oncostatin M receptor -0.0368643
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0365165
KMT2C lysine (K)-specific methyltransferase 2C -0.0362397
GSK3B glycogen synthase kinase 3 beta -0.0361992
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0360767
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0356218
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0355005
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0353965
ELL2 elongation factor, RNA polymerase II, 2 -0.0353446
UGCG UDP-glucose ceramide glucosyltransferase -0.0348595
JMJD1C jumonji domain containing 1C -0.0344282
TENM2 teneurin transmembrane protein 2 -0.0343891
POTEF POTE ankyrin domain family, member F -0.0343688
SLC38A1 solute carrier family 38, member 1 -0.034291
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0338615
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0337707
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0336403
ZC3H11A zinc finger CCCH-type containing 11A -0.0327795
SRPK1 SRSF protein kinase 1 -0.0326262
BCAS1 breast carcinoma amplified sequence 1 -0.0325202
UBE2H ubiquitin-conjugating enzyme E2H -0.0323936
LDLR low density lipoprotein receptor -0.0319702
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0317988
RPS2 ribosomal protein S2 -0.0309552
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.030946
PKM pyruvate kinase, muscle -0.0307043
TMEM123 transmembrane protein 123 -0.0306429
MYO10 myosin X -0.0306379
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.030603
UBXN4 UBX domain protein 4 -0.0305988
ESYT2 extended synaptotagmin-like protein 2 -0.0301847
TOP6BL TOP6B like initiator of meiotic double strand breaks -0.0299995
PCBP2 poly(rC) binding protein 2 -0.0296775
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.029263
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0291523
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0289206
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0288944
USP53 ubiquitin specific peptidase 53 -0.0288252
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0288125
PATJ PATJ crumbs cell polarity complex component -0.0286796
IFNGR1 interferon gamma receptor 1 -0.0285034
USP47 ubiquitin specific peptidase 47 -0.0280733
SHROOM3 shroom family member 3 -0.0279695
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0274489
FDPS farnesyl diphosphate synthase -0.0274266
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0271299
ANLN anillin, actin binding protein -0.0265317
UBA6 ubiquitin-like modifier activating enzyme 6 -0.026439
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0262945
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0259539
CSNK1A1 casein kinase 1, alpha 1 -0.0259496
EXT1 exostosin glycosyltransferase 1 -0.0256664
ALCAM activated leukocyte cell adhesion molecule -0.0256116
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0255336
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0252303
CFB complement factor B -0.0252128
TUBA1B tubulin, alpha 1b -0.0249803
PERP PERP, TP53 apoptosis effector -0.024819
AURKA aurora kinase A -0.0246108