Elagolix sodium_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Elagolix sodium perturbation in C32 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Elagolix sodium_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.398156
IGFBP3 insulin-like growth factor binding protein 3 0.265385
VIM vimentin 0.119449
ACTG1 actin gamma 1 0.0957479
AKAP12 A kinase (PRKA) anchor protein 12 0.0947118
LOC112694756 uncharaterized LOC112694756 0.0731742
CD109 CD109 molecule 0.067881
NDRG1 N-myc downstream regulated 1 0.0614166
HILPDA hypoxia inducible lipid droplet-associated 0.054028
TIMP3 TIMP metallopeptidase inhibitor 3 0.0502679
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0483431
ENO1 enolase 1, (alpha) 0.0468773
EIF4H eukaryotic translation initiation factor 4H 0.0445564
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0442548
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0440287
KTN1 kinectin 1 (kinesin receptor) 0.0416687
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.0414762
ACTN1 actinin, alpha 1 0.0411939
A2M alpha-2-macroglobulin 0.0399923
SRRM2 serine/arginine repetitive matrix 2 0.0389684
PLIN2 perilipin 2 0.0386784
EEF2 eukaryotic translation elongation factor 2 0.0381997
TAGLN2 transgelin 2 0.0354824
POTEF POTE ankyrin domain family, member F 0.034764
FRMD4A FERM domain containing 4A 0.0346723
ANXA2 annexin A2 0.0330509
STRIP2 striatin interacting protein 2 0.0314338
MCL1 myeloid cell leukemia 1 0.0307329
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0305325
VEGFA vascular endothelial growth factor A 0.0300115
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0296327
FLNA filamin A, alpha 0.0291685
CLMN calmin (calponin-like, transmembrane) 0.0290386
BHLHE40 basic helix-loop-helix family, member e40 0.0282726
IGF2 insulin-like growth factor 2 0.0278024
RNF213 ring finger protein 213 0.0275554
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0272557
ENO2 enolase 2 (gamma, neuronal) 0.0271157
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0269528
LDHA lactate dehydrogenase A 0.0267227
ITGB8 integrin, beta 8 0.0266184
EGR1 early growth response 1 0.0258185
AHR aryl hydrocarbon receptor 0.0257372
IGFBP5 insulin-like growth factor binding protein 5 0.0253196
LOC102724023 ES1 protein homolog, mitochondrial 0.0251217
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0245144
LEF1 lymphoid enhancer-binding factor 1 0.0244115
FBXO7 F-box protein 7 0.0242361
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0238973
APLP2 amyloid beta (A4) precursor-like protein 2 0.0236713
ZMIZ1 zinc finger, MIZ-type containing 1 0.0233904
ASPH aspartate beta-hydroxylase 0.0228493
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0228464
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0224987
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0223909
GDF15 growth differentiation factor 15 0.0220815
ADM adrenomedullin 0.0220351
HLA-C major histocompatibility complex, class I, C 0.021545
S100A6 S100 calcium binding protein A6 0.0213113
VDAC1 voltage-dependent anion channel 1 0.0211862
B2M beta-2-microglobulin 0.0207652
STOM stomatin 0.0207605
RACK1 receptor for activated C kinase 1 0.0206105
CENPF centromere protein F, 350/400kDa 0.0205248
FOSL1 FOS-like antigen 1 0.0197123
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0195048
MSN moesin 0.0194125
ZYX zyxin 0.0193417
CHPF chondroitin polymerizing factor 0.0191465
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0190561
BACE2 beta-site APP-cleaving enzyme 2 0.0189735
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0189435
RPL3 ribosomal protein L3 0.0188209
CEMIP cell migration inducing protein, hyaluronan binding 0.0184455
TMEM255B transmembrane protein 255B 0.0182489
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0180753
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0179086
PDIA3 protein disulfide isomerase family A, member 3 0.0178627
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0178125
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0177618
CD59 CD59 molecule, complement regulatory protein 0.0176399
ARRDC3 arrestin domain containing 3 0.0172813
FBXO17 F-box protein 17 0.0172348
GLRX glutaredoxin (thioltransferase) 0.0170816
WWTR1 WW domain containing transcription regulator 1 0.0170474
PDLIM5 PDZ and LIM domain 5 0.0170282
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0167357
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0166931
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0162084
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0162065
SDC2 syndecan 2 0.0160313
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0158009
SDC3 syndecan 3 0.0156592
DCAF8 DDB1 and CUL4 associated factor 8 0.0154764
SET SET nuclear proto-oncogene 0.015289
IFI6 interferon, alpha-inducible protein 6 0.0150295
ETV3 ets variant 3 0.0148603
PRRC2A proline-rich coiled-coil 2A 0.0145461
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0144972
ARLN allregulin 0.0144818

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.197823
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.190499
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.159712
VGF VGF nerve growth factor inducible -0.114589
FMN1 formin 1 -0.111388
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.107237
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0779096
MACROD2 MACRO domain containing 2 -0.0749385
HMCN1 hemicentin 1 -0.0703381
CDK14 cyclin-dependent kinase 14 -0.0653866
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0638936
SRPK2 SRSF protein kinase 2 -0.062994
IFRD1 interferon-related developmental regulator 1 -0.0622626
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0607206
PDIA4 protein disulfide isomerase family A, member 4 -0.0585665
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0565153
NAV3 neuron navigator 3 -0.0555057
KMT2C lysine (K)-specific methyltransferase 2C -0.0551449
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0506818
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0500136
AHNAK AHNAK nucleoprotein -0.0481281
NLGN1 neuroligin 1 -0.0478484
NAMPT nicotinamide phosphoribosyltransferase -0.0460634
EHBP1 EH domain binding protein 1 -0.0456324
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0442467
PTK2 protein tyrosine kinase 2 -0.0428358
TBC1D22A TBC1 domain family, member 22A -0.0422876
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0399719
MAML3 mastermind-like 3 (Drosophila) -0.0399539
COG5 component of oligomeric golgi complex 5 -0.0392565
EXT1 exostosin glycosyltransferase 1 -0.0389289
FUS FUS RNA binding protein -0.0385178
PDE10A phosphodiesterase 10A -0.0377868
UBE2H ubiquitin-conjugating enzyme E2H -0.0369883
PTCHD4 patched domain containing 4 -0.0368795
FBXL7 F-box and leucine-rich repeat protein 7 -0.0364194
DST dystonin -0.0363093
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.035997
CALU calumenin -0.0353523
TAS2R14 taste receptor, type 2, member 14 -0.0352568
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0351205
LAMB1 laminin, beta 1 -0.0350648
IGF1R insulin-like growth factor 1 receptor -0.0348351
SOX5 SRY (sex determining region Y)-box 5 -0.0347674
LSAMP limbic system-associated membrane protein -0.034403
LRMDA leucine rich melanocyte differentiation associated -0.0339602
COPA coatomer protein complex, subunit alpha -0.0338835
FRMD5 FERM domain containing 5 -0.0337257
CDC73 cell division cycle 73 -0.0336764
NPAS2 neuronal PAS domain protein 2 -0.0331709
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0329133
GOLGA4 golgin A4 -0.0324105
CUX1 cut-like homeobox 1 -0.0324019
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0323822
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0320493
GSN gelsolin -0.0319218
NHSL1 NHS-like 1 -0.0318472
NRCAM neuronal cell adhesion molecule -0.0316603
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -0.0306698
ZFAND3 zinc finger, AN1-type domain 3 -0.0304518
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0303271
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0302585
SCFD2 sec1 family domain containing 2 -0.0299104
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0292188
RFX7 regulatory factor X, 7 -0.0290717
RHEB Ras homolog enriched in brain -0.0289755
FHIT fragile histidine triad -0.0288079
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0287774
PGK1 phosphoglycerate kinase 1 -0.0287349
FOXJ3 forkhead box J3 -0.0286095
PRELID2 PRELI domain containing 2 -0.0285103
COL19A1 collagen, type XIX, alpha 1 -0.0283738
PTPRM protein tyrosine phosphatase, receptor type, M -0.0283312
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0283047
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0275295
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0272198
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.027209
DPYD dihydropyrimidine dehydrogenase -0.0270274
SEC24D SEC24 family member D -0.0269343
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0266849
MT2A metallothionein 2A -0.0263191
RBM33 RNA binding motif protein 33 -0.0259264
SEM1 SEM1 26S proteasome subunit -0.0258432
ZNF704 zinc finger protein 704 -0.0258424
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0257913
FNDC3B fibronectin type III domain containing 3B -0.0254701
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0254114
PDE4D phosphodiesterase 4D, cAMP-specific -0.0251351
GMDS GDP-mannose 4,6-dehydratase -0.0249225
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0244893
NBAS neuroblastoma amplified sequence -0.0244393
RBM39 RNA binding motif protein 39 -0.0243763
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0241965
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0240891
OXR1 oxidation resistance 1 -0.0240679
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0239776
PUM2 pumilio RNA-binding family member 2 -0.0238148
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0237448
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0236273
WDPCP WD repeat containing planar cell polarity effector -0.0236211