Elagolix sodium_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Elagolix sodium perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Elagolix sodium_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0670507
NUP58 nucleoporin 58 0.04378
BBX bobby sox homolog (Drosophila) 0.0332376
UBA6 ubiquitin-like modifier activating enzyme 6 0.0329383
WDR45B WD repeat domain 45B 0.0322383
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0299816
CHD1 chromodomain helicase DNA binding protein 1 0.0285427
DIAPH3 diaphanous-related formin 3 0.0268306
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0266194
PDE4D phosphodiesterase 4D, cAMP-specific 0.0261303
FAM117B family with sequence similarity 117, member B 0.0260421
ESYT2 extended synaptotagmin-like protein 2 0.0255792
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0244677
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0242441
NAMPT nicotinamide phosphoribosyltransferase 0.02364
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0236376
GOLGA4 golgin A4 0.0233463
SFXN1 sideroflexin 1 0.0233377
UBA2 ubiquitin-like modifier activating enzyme 2 0.023066
USP3 ubiquitin specific peptidase 3 0.0227015
RAB6A RAB6A, member RAS oncogene family 0.0226517
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0220548
ARID3A AT rich interactive domain 3A (BRIGHT-like) 0.0219985
RRM2 ribonucleotide reductase M2 0.0217155
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0216893
ANLN anillin, actin binding protein 0.021686
WSB1 WD repeat and SOCS box containing 1 0.0216663
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0213487
SEPTIN7 septin 7 0.0210487
NAP1L4 nucleosome assembly protein 1-like 4 0.0210153
ATAD2 ATPase family, AAA domain containing 2 0.0207549
LOC112694756 uncharaterized LOC112694756 0.0206981
XPO1 exportin 1 0.020666
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0206508
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0203695
CDC42SE2 CDC42 small effector 2 0.0201252
NCAPD3 non-SMC condensin II complex, subunit D3 0.0197927
CAMTA1 calmodulin binding transcription activator 1 0.0197561
KIAA1217 KIAA1217 0.0194324
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0192532
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0190297
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0189974
RUNX1 runt-related transcription factor 1 0.0187181
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0187147
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0186557
CDK19 cyclin-dependent kinase 19 0.0184258
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0182576
PRELID2 PRELI domain containing 2 0.0182447
MYO6 myosin VI 0.0182414
KMT2E lysine (K)-specific methyltransferase 2E 0.018112
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0180547
DMXL2 Dmx-like 2 0.0179165
ANKRD36 ankyrin repeat domain 36 0.017867
OGA O-GlcNAcase 0.0178112
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0177595
RAD23B RAD23 homolog B (S. cerevisiae) 0.0177008
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0175728
TTC17 tetratricopeptide repeat domain 17 0.0174858
FANCI Fanconi anemia, complementation group I 0.0172273
CEP192 centrosomal protein 192kDa 0.0171685
TAC4 tachykinin 4 (hemokinin) 0.0171612
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0171246
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0169624
CCNY cyclin Y 0.0168344
RNMT RNA (guanine-7-) methyltransferase 0.0167978
HSPA8 heat shock 70kDa protein 8 0.0165748
PHIP pleckstrin homology domain interacting protein 0.0163544
ADM adrenomedullin 0.0162282
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0159187
PDIA3 protein disulfide isomerase family A, member 3 0.0157411
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0157244
SNX9 sorting nexin 9 0.0157027
UFL1 UFM1-specific ligase 1 0.0156731
ATP11A ATPase, class VI, type 11A 0.0154198
ACBD3 acyl-CoA binding domain containing 3 0.0153708
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0152679
CABIN1 calcineurin binding protein 1 0.015265
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0151807
ZNF654 zinc finger protein 654 0.0151606
PRRC2A proline-rich coiled-coil 2A 0.0151523
USP6NL USP6 N-terminal like 0.0150843
USP37 ubiquitin specific peptidase 37 0.0150081
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.0149886
ZNF207 zinc finger protein 207 0.0149269
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0148909
SERGEF secretion regulating guanine nucleotide exchange factor 0.0148669
CHSY1 chondroitin sulfate synthase 1 0.0148328
CDC27 cell division cycle 27 0.0147519
PTBP2 polypyrimidine tract binding protein 2 0.0147411
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0146204
UHMK1 U2AF homology motif (UHM) kinase 1 0.014592
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0145404
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 0.0145259
PELI1 pellino E3 ubiquitin protein ligase 1 0.0144483
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0144091
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.0144051
UBA5 ubiquitin-like modifier activating enzyme 5 0.0141958
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.0141899
ACADVL acyl-CoA dehydrogenase, very long chain 0.0141621
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0141183

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.140726
PTMA prothymosin, alpha -0.138507
TMSB10 thymosin beta 10 -0.121863
AHNAK AHNAK nucleoprotein -0.106235
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.105699
ERRFI1 ERBB receptor feedback inhibitor 1 -0.10047
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0998237
TPT1 tumor protein, translationally-controlled 1 -0.0994743
RPS6 ribosomal protein S6 -0.0871184
CANX calnexin -0.0745585
RPS8 ribosomal protein S8 -0.0719826
EGR1 early growth response 1 -0.0681788
EZR ezrin -0.067372
PATJ PATJ crumbs cell polarity complex component -0.0664967
LDHA lactate dehydrogenase A -0.0645281
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0570251
DSCAM Down syndrome cell adhesion molecule -0.056634
SERINC5 serine incorporator 5 -0.0537705
KRT8 keratin 8, type II -0.0536114
PKM pyruvate kinase, muscle -0.0515096
TPM4 tropomyosin 4 -0.0508335
RPL35A ribosomal protein L35a -0.0482298
TXNRD1 thioredoxin reductase 1 -0.0449659
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0443182
SLC38A2 solute carrier family 38, member 2 -0.0441139
JUN jun proto-oncogene -0.0441028
ENO1 enolase 1, (alpha) -0.0438959
CUX1 cut-like homeobox 1 -0.0423
HDLBP high density lipoprotein binding protein -0.0417198
RPL23 ribosomal protein L23 -0.0415756
RPLP2 ribosomal protein, large, P2 -0.0412567
FAT1 FAT atypical cadherin 1 -0.0403245
AKAP9 A kinase (PRKA) anchor protein 9 -0.0397587
ARF4 ADP-ribosylation factor 4 -0.0387991
SDC4 syndecan 4 -0.038096
RPL37 ribosomal protein L37 -0.0379943
KRT18 keratin 18, type I -0.037991
UGDH UDP-glucose 6-dehydrogenase -0.0377202
KDM4C lysine (K)-specific demethylase 4C -0.0375298
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0365014
S100A10 S100 calcium binding protein A10 -0.0360687
LOC102724023 ES1 protein homolog, mitochondrial -0.0360177
KRT19 keratin 19, type I -0.0355638
BPTF bromodomain PHD finger transcription factor -0.0351585
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0351278
GOLGB1 golgin B1 -0.0346961
TBC1D22A TBC1 domain family, member 22A -0.0339072
UBC ubiquitin C -0.0337545
SMYD3 SET and MYND domain containing 3 -0.0337239
SQSTM1 sequestosome 1 -0.0336276
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0332699
RPL34 ribosomal protein L34 -0.033049
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0330019
ACTG1 actin gamma 1 -0.0329778
KLF6 Kruppel-like factor 6 -0.0328454
RAB7A RAB7A, member RAS oncogene family -0.0327576
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0325832
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0324791
RPLP1 ribosomal protein, large, P1 -0.0322575
POTEF POTE ankyrin domain family, member F -0.0321011
FOS FBJ murine osteosarcoma viral oncogene homolog -0.031745
RPL26 ribosomal protein L26 -0.0316257
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0314605
SPDYA speedy/RINGO cell cycle regulator family member A -0.0313793
RPLP0 ribosomal protein, large, P0 -0.0313525
RBBP6 retinoblastoma binding protein 6 -0.0312668
MT2A metallothionein 2A -0.0311107
VCL vinculin -0.0307858
CDK13 cyclin-dependent kinase 13 -0.0306136
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0304946
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0302058
ASPH aspartate beta-hydroxylase -0.0301982
RPS17 ribosomal protein S17 -0.0298234
RSF1 remodeling and spacing factor 1 -0.0295941
MTDH metadherin -0.029463
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0293756
SERBP1 SERPINE1 mRNA binding protein 1 -0.0292384
ZFHX3 zinc finger homeobox 3 -0.0292101
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0290078
MORF4L2 mortality factor 4 like 2 -0.0288984
LRRC23 leucine rich repeat containing 23 -0.0285756
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0283399
RPL32 ribosomal protein L32 -0.0279214
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0279106
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0277973
HM13 histocompatibility (minor) 13 -0.0277734
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.02766
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0275694
RPL19 ribosomal protein L19 -0.0272219
SLC38A1 solute carrier family 38, member 1 -0.0272125
TENM3 teneurin transmembrane protein 3 -0.0269573
S100A9 S100 calcium binding protein A9 -0.0269447
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0267495
ADIPOR2 adiponectin receptor 2 -0.0263991
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0263379
HLA-B major histocompatibility complex, class I, B -0.0263124
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0261882
HMGB1 high mobility group box 1 -0.0261404
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0259169
LSR lipolysis stimulated lipoprotein receptor -0.0256805