Elagolix sodium_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Elagolix sodium perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Elagolix sodium_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.282749
NDRG1 N-myc downstream regulated 1 0.142556
FN1 fibronectin 1 0.107785
VEGFA vascular endothelial growth factor A 0.0748969
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0354105
ARRDC3 arrestin domain containing 3 0.0338451
FTH1 ferritin, heavy polypeptide 1 0.0335045
EEF2 eukaryotic translation elongation factor 2 0.0324085
PLEC plectin 0.0300296
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0297743
HLA-C major histocompatibility complex, class I, C 0.0290884
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0264328
LOC112694756 uncharaterized LOC112694756 0.0256915
NAV2 neuron navigator 2 0.0252399
SRRM2 serine/arginine repetitive matrix 2 0.0234368
HSPA8 heat shock 70kDa protein 8 0.0230005
TNIP1 TNFAIP3 interacting protein 1 0.0210227
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0191549
TAPBP TAP binding protein (tapasin) 0.0174673
BHLHE40 basic helix-loop-helix family, member e40 0.0173923
FOSL1 FOS-like antigen 1 0.0173326
RPL3 ribosomal protein L3 0.0171779
GRB10 growth factor receptor-bound protein 10 0.0170972
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0169403
HILPDA hypoxia inducible lipid droplet-associated 0.0163274
EIF4H eukaryotic translation initiation factor 4H 0.0159138
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0158285
DPYSL2 dihydropyrimidinase-like 2 0.0155532
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.015478
CAMTA1 calmodulin binding transcription activator 1 0.0154192
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0154105
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0149439
WWTR1 WW domain containing transcription regulator 1 0.0148082
RPL7 ribosomal protein L7 0.0140182
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0137654
MIER1 mesoderm induction early response 1, transcriptional regulator 0.013407
RIGI RNA sensor RIG-I 0.01337
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0132332
CSF1 colony stimulating factor 1 (macrophage) 0.0129788
TPM3 tropomyosin 3 0.0128551
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0125033
SHB Src homology 2 domain containing adaptor protein B 0.0124515
MT2A metallothionein 2A 0.0122099
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0117462
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0116972
CENPF centromere protein F, 350/400kDa 0.0116872
AXL AXL receptor tyrosine kinase 0.0116735
PGM3 phosphoglucomutase 3 0.0113958
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0113127
HYOU1 hypoxia up-regulated 1 0.0109948
RACK1 receptor for activated C kinase 1 0.0109668
PPARD peroxisome proliferator-activated receptor delta 0.010881
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0107168
FLNA filamin A, alpha 0.0106184
KLF7 Kruppel-like factor 7 (ubiquitous) 0.010484
MRTFA myocardin related transcription factor A 0.010438
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0103726
ACTG1 actin gamma 1 0.0103712
MSN moesin 0.010292
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.0102785
HMOX1 heme oxygenase 1 0.0102577
ADAM17 ADAM metallopeptidase domain 17 0.0101787
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0100194
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.00997823
MYO1B myosin IB 0.00986506
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.00959119
CABIN1 calcineurin binding protein 1 0.0093721
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0093438
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.00932045
PRRC2A proline-rich coiled-coil 2A 0.00925633
PDIA6 protein disulfide isomerase family A, member 6 0.00925459
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.00921705
BBX bobby sox homolog (Drosophila) 0.00919144
PHC3 polyhomeotic homolog 3 (Drosophila) 0.00910897
TNS1 tensin 1 0.0090611
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.00881814
PDIA3 protein disulfide isomerase family A, member 3 0.00874841
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.00866423
TOP2A topoisomerase (DNA) II alpha 170kDa 0.00865013
SCARA3 scavenger receptor class A, member 3 0.00862013
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.00860228
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.00850033
CTNNBL1 catenin, beta like 1 0.00849461
SMAD3 SMAD family member 3 0.00838896
RPL37A ribosomal protein L37a 0.00838865
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) 0.00835182
RSAD2 radical S-adenosyl methionine domain containing 2 0.00831571
SMTN smoothelin 0.00830221
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.00826203
MIDEAS mitotic deacetylase associated SANT domain protein 0.00823745
FBXO7 F-box protein 7 0.00818102
AHDC1 AT hook, DNA binding motif, containing 1 0.00810098
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.00791344
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.00790211
SP3 Sp3 transcription factor 0.00784302
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.00780129
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.00777048
CYB5R3 cytochrome b5 reductase 3 0.00776619
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 0.00770171
ALKBH5 AlkB family member 5, RNA demethylase 0.00765993

decreased expression

Symbol Name Standardized Value
COL1A1 collagen, type I, alpha 1 -0.24202
TIMP3 TIMP metallopeptidase inhibitor 3 -0.148472
COL1A2 collagen, type I, alpha 2 -0.126295
VIM vimentin -0.122092
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.118589
EXT1 exostosin glycosyltransferase 1 -0.106422
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.102132
PSD3 pleckstrin and Sec7 domain containing 3 -0.102123
CDH13 cadherin 13 -0.0874101
TMSB10 thymosin beta 10 -0.0752795
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0749137
ZBTB20 zinc finger and BTB domain containing 20 -0.0724989
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0700972
IER3 immediate early response 3 -0.0633418
DPYD dihydropyrimidine dehydrogenase -0.062521
ASPH aspartate beta-hydroxylase -0.0619046
FBN1 fibrillin 1 -0.0586298
TPM4 tropomyosin 4 -0.0573263
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0569884
FNDC3B fibronectin type III domain containing 3B -0.0560207
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0543151
COL6A3 collagen, type VI, alpha 3 -0.0541675
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0540491
COL5A1 collagen, type V, alpha 1 -0.0510128
AHNAK AHNAK nucleoprotein -0.0468938
RRBP1 ribosome binding protein 1 -0.0462345
VCAN versican -0.0454944
CALD1 caldesmon 1 -0.0453706
LOX lysyl oxidase -0.0439223
TRPS1 trichorhinophalangeal syndrome I -0.0437631
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0433295
INHBA inhibin, beta A -0.0429162
PTK2 protein tyrosine kinase 2 -0.0397318
TGFBI transforming growth factor, beta-induced, 68kDa -0.0387622
LTBP1 latent transforming growth factor beta binding protein 1 -0.0378025
CAVIN1 caveolae associated protein 1 -0.037126
MAP1B microtubule-associated protein 1B -0.0360258
CANX calnexin -0.035689
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0356156
NALF1 NALCN channel auxiliary factor 1 -0.0355662
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0347236
HLA-B major histocompatibility complex, class I, B -0.0346851
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0339311
VCL vinculin -0.0329917
CADM1 cell adhesion molecule 1 -0.0328022
CALU calumenin -0.0324116
SBF2 SET binding factor 2 -0.0318277
GLIS3 GLIS family zinc finger 3 -0.0317855
SMYD3 SET and MYND domain containing 3 -0.0316649
TRIO trio Rho guanine nucleotide exchange factor -0.0312611
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0311818
MAML2 mastermind-like 2 (Drosophila) -0.0305456
DST dystonin -0.0304273
PDE4D phosphodiesterase 4D, cAMP-specific -0.0304245
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0304068
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0300769
TPT1 tumor protein, translationally-controlled 1 -0.0300711
COL3A1 collagen, type III, alpha 1 -0.0299981
POSTN periostin, osteoblast specific factor -0.0299598
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.02962
CNTN5 contactin 5 -0.0288594
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.028064
MAP4 microtubule-associated protein 4 -0.0280408
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0277103
JARID2 jumonji, AT rich interactive domain 2 -0.0273897
ABI3BP ABI family, member 3 (NESH) binding protein -0.0271762
OSMR oncostatin M receptor -0.0270286
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0268918
TTC3 tetratricopeptide repeat domain 3 -0.0267901
CLIC4 chloride intracellular channel 4 -0.0264243
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0264143
GNAS GNAS complex locus -0.0260114
F3 coagulation factor III (thromboplastin, tissue factor) -0.0259476
LMAN1 lectin, mannose-binding, 1 -0.025914
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0253565
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0252075
PRELID2 PRELI domain containing 2 -0.0250572
LPP LIM domain containing preferred translocation partner in lipoma -0.0246981
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0246524
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0237607
ARHGAP35 Rho GTPase activating protein 35 -0.0233097
ZEB1 zinc finger E-box binding homeobox 1 -0.0230639
ZMYND8 zinc finger, MYND-type containing 8 -0.0230527
BNC2 basonuclin 2 -0.0229893
MBNL1 muscleblind-like splicing regulator 1 -0.0225721
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.022448
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0223323
KPNB1 karyopherin (importin) beta 1 -0.0222865
NRP1 neuropilin 1 -0.0222779
SDC2 syndecan 2 -0.0221541
SLC38A2 solute carrier family 38, member 2 -0.0220361
CD44 CD44 molecule (Indian blood group) -0.0217608
NAV1 neuron navigator 1 -0.0217491
COL6A2 collagen, type VI, alpha 2 -0.0216785
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0216543
DOCK5 dedicator of cytokinesis 5 -0.0215923
TMEM263 transmembrane protein 263 -0.0214554
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0214022
CDK13 cyclin-dependent kinase 13 -0.0213769
ZFPM2 zinc finger protein, FOG family member 2 -0.021318