| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elagolix sodium perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Elagolix sodium_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.132291 |
| IGF2 | insulin-like growth factor 2 | 0.117778 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.10787 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.090274 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0726613 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0650717 |
| MT2A | metallothionein 2A | 0.0611174 |
| VEGFA | vascular endothelial growth factor A | 0.0579316 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0506441 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0489092 |
| TNS1 | tensin 1 | 0.0472619 |
| PLEC | plectin | 0.0453413 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0430426 |
| SVIL | supervillin | 0.0420876 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0417325 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0394885 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.0394387 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0390705 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0380571 |
| RUNX1 | runt-related transcription factor 1 | 0.0375745 |
| DSPP | dentin sialophosphoprotein | 0.0368717 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0357342 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0354599 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0353867 |
| SMAD3 | SMAD family member 3 | 0.0352532 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.0337661 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0331859 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.032389 |
| CEP250 | centrosomal protein 250kDa | 0.030583 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0305583 |
| RPL3 | ribosomal protein L3 | 0.0287501 |
| FLNA | filamin A, alpha | 0.0279109 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0276678 |
| NDRG1 | N-myc downstream regulated 1 | 0.0274341 |
| ACTG1 | actin gamma 1 | 0.0272046 |
| JMJD1C | jumonji domain containing 1C | 0.0270255 |
| IQSEC1 | IQ motif and Sec7 domain 1 | 0.0265884 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0259002 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0257421 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0253564 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0247415 |
| ACTN1 | actinin, alpha 1 | 0.0244348 |
| PCBP2 | poly(rC) binding protein 2 | 0.0242748 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0240385 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0236042 |
| NPTN | neuroplastin | 0.0224431 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0222279 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0222039 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0219736 |
| MCL1 | myeloid cell leukemia 1 | 0.0217828 |
| ANXA5 | annexin A5 | 0.0217729 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0214253 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0212604 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0211668 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0206578 |
| SEC24C | SEC24 family member C | 0.0197701 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0195382 |
| ITGB5 | integrin, beta 5 | 0.0195268 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0191692 |
| EPHA2 | EPH receptor A2 | 0.0191561 |
| YBX1 | Y box binding protein 1 | 0.0191443 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.0188191 |
| ARRDC3 | arrestin domain containing 3 | 0.0187823 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0186296 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0184417 |
| YAP1 | Yes-associated protein 1 | 0.0181817 |
| CLTB | clathrin, light chain B | 0.018081 |
| BRD2 | bromodomain containing 2 | 0.0177644 |
| GSE1 | Gse1 coiled-coil protein | 0.0176869 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0176299 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0175591 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.017532 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0175177 |
| ZNF638 | zinc finger protein 638 | 0.0174719 |
| CMIP | c-Maf inducing protein | 0.0172262 |
| EZR | ezrin | 0.0170922 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0169624 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | 0.0168965 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.0167403 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0167216 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0165611 |
| RTN4 | reticulon 4 | 0.0163666 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0160835 |
| FAM219A | family with sequence similarity 219, member A | 0.016079 |
| CAND1 | cullin-associated and neddylation-dissociated 1 | 0.0160186 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0160001 |
| CCNY | cyclin Y | 0.0159451 |
| PDZD8 | PDZ domain containing 8 | 0.015904 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0158583 |
| SMAD4 | SMAD family member 4 | 0.0158135 |
| RELL1 | RELT-like 1 | 0.0157741 |
| HDLBP | high density lipoprotein binding protein | 0.0157506 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.015689 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0154445 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0154401 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0153847 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0153187 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0152025 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 0.0151415 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.015045 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GPC3 | glypican 3 | -0.153402 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.150341 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.118412 |
| SLC38A2 | solute carrier family 38, member 2 | -0.116556 |
| TMSB10 | thymosin beta 10 | -0.105901 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0973943 |
| CP | ceruloplasmin (ferroxidase) | -0.0969665 |
| RPS24 | ribosomal protein S24 | -0.0932695 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0930417 |
| ENO1 | enolase 1, (alpha) | -0.0913612 |
| EHBP1 | EH domain binding protein 1 | -0.0875546 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0839544 |
| APOB | apolipoprotein B | -0.0782408 |
| AHSG | alpha-2-HS-glycoprotein | -0.0769483 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0766302 |
| APOA2 | apolipoprotein A-II | -0.0729323 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0726551 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0722246 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0701742 |
| GPC6 | glypican 6 | -0.0662312 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0606008 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0577923 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.055317 |
| TRIM26 | tripartite motif containing 26 | -0.0539407 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0532091 |
| RPS8 | ribosomal protein S8 | -0.0523903 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.052251 |
| TMEM123 | transmembrane protein 123 | -0.0521124 |
| RPL26 | ribosomal protein L26 | -0.0511324 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0491162 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0490282 |
| RPLP0 | ribosomal protein, large, P0 | -0.048807 |
| PEG3 | paternally expressed 3 | -0.0486696 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0484949 |
| RPL37A | ribosomal protein L37a | -0.0481356 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0466268 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0466172 |
| RPS27A | ribosomal protein S27a | -0.0449697 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0449296 |
| LYZ | lysozyme | -0.0435621 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0434655 |
| SDC4 | syndecan 4 | -0.0433218 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0428852 |
| RPL35A | ribosomal protein L35a | -0.0427713 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0424073 |
| GNAS | GNAS complex locus | -0.0415174 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0414845 |
| KLF6 | Kruppel-like factor 6 | -0.0413233 |
| FRMD5 | FERM domain containing 5 | -0.0411384 |
| RPL9 | ribosomal protein L9 | -0.04084 |
| STK17A | serine/threonine kinase 17a | -0.0404689 |
| GK | glycerol kinase | -0.0402258 |
| ASPH | aspartate beta-hydroxylase | -0.0401949 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.039525 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0392966 |
| PTMA | prothymosin, alpha | -0.0387105 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0385419 |
| RPL12 | ribosomal protein L12 | -0.0367651 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0364736 |
| NPR2 | natriuretic peptide receptor 2 | -0.0362743 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0362006 |
| HMGA1 | high mobility group AT-hook 1 | -0.0361222 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0360651 |
| RPL23 | ribosomal protein L23 | -0.0352174 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0350014 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0347342 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0342852 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.034253 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0341396 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0339209 |
| PERP | PERP, TP53 apoptosis effector | -0.0331816 |
| H1-0 | H1.0 linker histone | -0.0330627 |
| RPL31 | ribosomal protein L31 | -0.0328202 |
| PLIN2 | perilipin 2 | -0.0325583 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0323614 |
| RPS21 | ribosomal protein S21 | -0.0319984 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0316855 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0314937 |
| PTCHD4 | patched domain containing 4 | -0.0314184 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0312405 |
| RPS5 | ribosomal protein S5 | -0.0307178 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0305367 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0301618 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0289045 |
| PARD3 | par-3 family cell polarity regulator | -0.028557 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0283714 |
| CNKSR3 | CNKSR family member 3 | -0.0283365 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0280698 |
| LDHA | lactate dehydrogenase A | -0.028054 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.027853 |
| PALLD | palladin, cytoskeletal associated protein | -0.0277358 |
| RPS19 | ribosomal protein S19 | -0.0276648 |
| RBM39 | RNA binding motif protein 39 | -0.0276591 |
| FTL | ferritin, light polypeptide | -0.0275695 |
| RPL5 | ribosomal protein L5 | -0.0275591 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0274317 |
| RPL19 | ribosomal protein L19 | -0.02698 |
| EGR1 | early growth response 1 | -0.0268787 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.026591 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0265091 |
