| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elagolix sodium perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Elagolix sodium_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FAT1 | FAT atypical cadherin 1 | 0.112998 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.102313 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.091808 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0688477 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0688032 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0623704 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0599989 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0583042 |
| ACTG1 | actin gamma 1 | 0.0533782 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | 0.0377996 |
| LMO7 | LIM domain 7 | 0.0341851 |
| TNS4 | tensin 4 | 0.0321717 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0306405 |
| DSPP | dentin sialophosphoprotein | 0.0300577 |
| ITGA6 | integrin, alpha 6 | 0.0299193 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0287601 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0282708 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0269062 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0268621 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0260783 |
| CD44 | CD44 molecule (Indian blood group) | 0.0256097 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0250606 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0247532 |
| MED13 | mediator complex subunit 13 | 0.023384 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0231614 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0229376 |
| CENPF | centromere protein F, 350/400kDa | 0.022673 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0224421 |
| CYP2S1 | cytochrome P450, family 2, subfamily S, polypeptide 1 | 0.0223527 |
| POTEF | POTE ankyrin domain family, member F | 0.0205208 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0204946 |
| KRT18 | keratin 18, type I | 0.0200322 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0198894 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0197956 |
| DUSP4 | dual specificity phosphatase 4 | 0.0190271 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | 0.0189219 |
| PDE10A | phosphodiesterase 10A | 0.018896 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0188276 |
| RNF43 | ring finger protein 43 | 0.0183849 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0179948 |
| SON | SON DNA binding protein | 0.017946 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.0178351 |
| PLEC | plectin | 0.0178245 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0178164 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0175256 |
| LDHA | lactate dehydrogenase A | 0.0173375 |
| PDZD8 | PDZ domain containing 8 | 0.017143 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0167287 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.0163637 |
| FLNA | filamin A, alpha | 0.0161755 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.0161437 |
| GDA | guanine deaminase | 0.0158175 |
| PNN | pinin, desmosome associated protein | 0.0157505 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0157236 |
| TPI1 | triosephosphate isomerase 1 | 0.0156937 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0156325 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.0155577 |
| LAMA4 | laminin, alpha 4 | 0.0155474 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0154526 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0152654 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0149683 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0149464 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0149313 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.014811 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0146173 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0145063 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.0143851 |
| AREG | amphiregulin | 0.0142204 |
| SERINC5 | serine incorporator 5 | 0.0142131 |
| SLK | STE20-like kinase | 0.01417 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | 0.0141102 |
| ABCA2 | ATP-binding cassette, sub-family A (ABC1), member 2 | 0.01411 |
| ATXN2L | ataxin 2-like | 0.0141004 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0139527 |
| RNF213 | ring finger protein 213 | 0.0139335 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0139204 |
| RNF145 | ring finger protein 145 | 0.0138599 |
| PCM1 | pericentriolar material 1 | 0.0138131 |
| WDR43 | WD repeat domain 43 | 0.0136589 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0134709 |
| CLDN4 | claudin 4 | 0.0134361 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.013223 |
| RPL3 | ribosomal protein L3 | 0.0131613 |
| VEGFA | vascular endothelial growth factor A | 0.0129433 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.0127995 |
| EPHB2 | EPH receptor B2 | 0.0127024 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0126185 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.0125586 |
| HMGA1 | high mobility group AT-hook 1 | 0.0125172 |
| BRD2 | bromodomain containing 2 | 0.0123943 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0122519 |
| SET | SET nuclear proto-oncogene | 0.0122172 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0121551 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0120493 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0116915 |
| FASN | fatty acid synthase | 0.0116028 |
| LMNA | lamin A/C | 0.0115749 |
| AGRN | agrin | 0.011569 |
| PLXNB2 | plexin B2 | 0.0114407 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0113164 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.235543 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.208742 |
| PTMA | prothymosin, alpha | -0.197336 |
| NPSR1 | neuropeptide S receptor 1 | -0.168834 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.140321 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.111567 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.110536 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0887077 |
| VCL | vinculin | -0.0860787 |
| RPS6 | ribosomal protein S6 | -0.0830555 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0787871 |
| TMSB10 | thymosin beta 10 | -0.0774211 |
| AHNAK | AHNAK nucleoprotein | -0.0704495 |
| TPM4 | tropomyosin 4 | -0.06994 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0653699 |
| NDRG1 | N-myc downstream regulated 1 | -0.061939 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0615464 |
| FLNB | filamin B, beta | -0.0613218 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.056967 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0566197 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0560139 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0552291 |
| FNDC3B | fibronectin type III domain containing 3B | -0.05522 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0536726 |
| GOLGA4 | golgin A4 | -0.0532203 |
| PARD3 | par-3 family cell polarity regulator | -0.0531906 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0517854 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.05072 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0506093 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0496149 |
| FAM13A | family with sequence similarity 13, member A | -0.0492872 |
| ANXA2 | annexin A2 | -0.047408 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0471187 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0469925 |
| SMYD3 | SET and MYND domain containing 3 | -0.0461922 |
| SBF2 | SET binding factor 2 | -0.0456594 |
| CANX | calnexin | -0.0451944 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0446456 |
| EZR | ezrin | -0.0439734 |
| SAMD5 | sterile alpha motif domain containing 5 | -0.0436984 |
| CALR | calreticulin | -0.0435699 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.04299 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0427732 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0426906 |
| RPL34 | ribosomal protein L34 | -0.0425781 |
| ONECUT3 | one cut homeobox 3 | -0.0423239 |
| AGR2 | anterior gradient 2 | -0.0420762 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0412401 |
| RPS24 | ribosomal protein S24 | -0.0392111 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.0391316 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0391134 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0390971 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0385094 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0383182 |
| ZNF292 | zinc finger protein 292 | -0.0382107 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0381177 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0379924 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0375805 |
| ATXN1 | ataxin 1 | -0.0372847 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0371532 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0368055 |
| CDK13 | cyclin-dependent kinase 13 | -0.0362896 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0359722 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0357618 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0355777 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0351072 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.03496 |
| DIAPH2 | diaphanous-related formin 2 | -0.0349098 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0347655 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0347217 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0343143 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0342597 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0341013 |
| RPL26 | ribosomal protein L26 | -0.0340387 |
| MAP4 | microtubule-associated protein 4 | -0.0339347 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0337326 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0326902 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0324677 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0323602 |
| PRELID2 | PRELI domain containing 2 | -0.0319143 |
| RPS25 | ribosomal protein S25 | -0.0313239 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0313197 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0308832 |
| NFIA | nuclear factor I/A | -0.0308801 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.030735 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0306863 |
| GLG1 | golgi glycoprotein 1 | -0.0305455 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0296578 |
| RPS27A | ribosomal protein S27a | -0.0295632 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0290412 |
| FHIT | fragile histidine triad | -0.0289027 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0288405 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0287135 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0286001 |
| SEC24D | SEC24 family member D | -0.0283995 |
| PALLD | palladin, cytoskeletal associated protein | -0.0283266 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0280207 |
| RPLP2 | ribosomal protein, large, P2 | -0.0279758 |
| KRT8 | keratin 8, type II | -0.0279555 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0279202 |
