| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elagolix sodium perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Elagolix sodium_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.175381 |
| NDRG1 | N-myc downstream regulated 1 | 0.104557 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0993987 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.07123 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0579855 |
| MCL1 | myeloid cell leukemia 1 | 0.0574893 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0529391 |
| CAV2 | caveolin 2 | 0.050659 |
| PLEC | plectin | 0.047658 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0460889 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0437958 |
| MSN | moesin | 0.0431326 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0423499 |
| FNDC3B | fibronectin type III domain containing 3B | 0.041279 |
| SCEL | sciellin | 0.037924 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0367326 |
| STC1 | stanniocalcin 1 | 0.0367104 |
| ACTG1 | actin gamma 1 | 0.0356826 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0348915 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0342853 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0340754 |
| FAM13A | family with sequence similarity 13, member A | 0.0324015 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0316407 |
| FLNB | filamin B, beta | 0.0316355 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0304547 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0298158 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0292216 |
| HSPA8 | heat shock 70kDa protein 8 | 0.029067 |
| KRT7 | keratin 7, type II | 0.0290228 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0275542 |
| TPM4 | tropomyosin 4 | 0.0272284 |
| POTEF | POTE ankyrin domain family, member F | 0.0269638 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0260723 |
| SMAD3 | SMAD family member 3 | 0.026009 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.02554 |
| ACTN1 | actinin, alpha 1 | 0.0248073 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0246815 |
| ARRDC3 | arrestin domain containing 3 | 0.024127 |
| VEGFA | vascular endothelial growth factor A | 0.0238402 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0234073 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0227616 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0221204 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.021692 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0215727 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0214226 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0206379 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0204077 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0203808 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0200085 |
| SMTN | smoothelin | 0.0198318 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0197168 |
| TPM3 | tropomyosin 3 | 0.0194817 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.019062 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0190315 |
| FLNA | filamin A, alpha | 0.0189304 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.018843 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0188218 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.018778 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0186334 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0181303 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0180193 |
| RPS3 | ribosomal protein S3 | 0.0179443 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0176274 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.017283 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0171687 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.01701 |
| RAI14 | retinoic acid induced 14 | 0.0167635 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.0167489 |
| DSPP | dentin sialophosphoprotein | 0.0166632 |
| ITGA6 | integrin, alpha 6 | 0.0164169 |
| HLA-C | major histocompatibility complex, class I, C | 0.0163592 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.0158648 |
| PARD3 | par-3 family cell polarity regulator | 0.0158569 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.01567 |
| ANXA1 | annexin A1 | 0.0156456 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0156402 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0155808 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.015542 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0154622 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0153919 |
| LAMB3 | laminin, beta 3 | 0.0153098 |
| PCBP2 | poly(rC) binding protein 2 | 0.0152228 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0148571 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0148006 |
| RPL3 | ribosomal protein L3 | 0.0146382 |
| DIAPH1 | diaphanous-related formin 1 | 0.0145276 |
| STC2 | stanniocalcin 2 | 0.0145178 |
| DYNC2I1 | dynein 2 intermediate chain 1 | 0.0143857 |
| FMNL2 | formin-like 2 | 0.0143187 |
| ANGPTL4 | angiopoietin-like 4 | 0.0142752 |
| RNF149 | ring finger protein 149 | 0.0142468 |
| CMIP | c-Maf inducing protein | 0.0142084 |
| PDGFC | platelet derived growth factor C | 0.0141423 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0141055 |
| GSAP | gamma-secretase activating protein | 0.0139878 |
| FN1 | fibronectin 1 | 0.0138183 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0138022 |
| ZNF185 | zinc finger protein 185 (LIM domain) | 0.0137121 |
| EPHA2 | EPH receptor A2 | 0.0136041 |
| SLK | STE20-like kinase | 0.013578 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.405875 |
| TXNRD1 | thioredoxin reductase 1 | -0.205391 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0818814 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0766627 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0717078 |
| OSMR | oncostatin M receptor | -0.06795 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0675015 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0662432 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0633997 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0624097 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0623681 |
| SPAG9 | sperm associated antigen 9 | -0.0615178 |
| CANX | calnexin | -0.0553825 |
| H1-0 | H1.0 linker histone | -0.0551052 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0545123 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0542278 |
| NABP1 | nucleic acid binding protein 1 | -0.0538388 |
| USP34 | ubiquitin specific peptidase 34 | -0.0538035 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0531565 |
| TOP1 | topoisomerase (DNA) I | -0.0528014 |
| PGK1 | phosphoglycerate kinase 1 | -0.0516022 |
| ABLIM1 | actin binding LIM protein 1 | -0.0515215 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0509762 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0482201 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0480085 |
| JMJD1C | jumonji domain containing 1C | -0.0433147 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0431973 |
| LMO7 | LIM domain 7 | -0.0422297 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0420817 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0411864 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0401923 |
| RPS24 | ribosomal protein S24 | -0.0394098 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0394087 |
| AGO2 | argonaute RISC catalytic component 2 | -0.039055 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0375956 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0375864 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0374337 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0367976 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0367786 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0367539 |
| HLA-B | major histocompatibility complex, class I, B | -0.0360988 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0359756 |
| AHNAK | AHNAK nucleoprotein | -0.0359727 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0356714 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0356166 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0355701 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0352224 |
| PAPOLA | poly(A) polymerase alpha | -0.0350176 |
| CES1 | carboxylesterase 1 | -0.0348191 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0345864 |
| SP100 | SP100 nuclear antigen | -0.034248 |
| RBM39 | RNA binding motif protein 39 | -0.0341696 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0339936 |
| GM2A | GM2 ganglioside activator | -0.0336525 |
| OGA | O-GlcNAcase | -0.0331742 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0331483 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0327396 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0325284 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0325052 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0323294 |
| MKI67 | marker of proliferation Ki-67 | -0.0321698 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0320005 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0318805 |
| RPS6 | ribosomal protein S6 | -0.0318279 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | -0.0316267 |
| RPS25 | ribosomal protein S25 | -0.0315617 |
| TES | testin LIM domain protein | -0.0311895 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0310486 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0301543 |
| RAB10 | RAB10, member RAS oncogene family | -0.0299159 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0294183 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0292963 |
| RPLP1 | ribosomal protein, large, P1 | -0.0292594 |
| RUNX1 | runt-related transcription factor 1 | -0.0292563 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.02921 |
| FTL | ferritin, light polypeptide | -0.0291992 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0291711 |
| RPL4 | ribosomal protein L4 | -0.0290924 |
| UBC | ubiquitin C | -0.0289108 |
| TMSB10 | thymosin beta 10 | -0.028828 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0288033 |
| RPLP0 | ribosomal protein, large, P0 | -0.0286294 |
| RPS23 | ribosomal protein S23 | -0.0283555 |
| VCL | vinculin | -0.0283052 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0278694 |
| NGLY1 | N-glycanase 1 | -0.027831 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0278013 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0276968 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0273248 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0272173 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.0267774 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0264546 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0259954 |
| PTMA | prothymosin, alpha | -0.0258902 |
| TJP1 | tight junction protein 1 | -0.0255083 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0254099 |
| TAOK1 | TAO kinase 1 | -0.0253267 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0251473 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0249971 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0248916 |
