| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elagolix sodium perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Elagolix sodium_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.158179 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.116282 |
| EFNA5 | ephrin-A5 | 0.107577 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.10355 |
| IGF2 | insulin-like growth factor 2 | 0.0988128 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0966512 |
| FLNB | filamin B, beta | 0.0786213 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0769719 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.07626 |
| EGFR | epidermal growth factor receptor | 0.074469 |
| AHNAK | AHNAK nucleoprotein | 0.0688719 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0684059 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0659296 |
| DOCK4 | dedicator of cytokinesis 4 | 0.063962 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.063813 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0617703 |
| DSG2 | desmoglein 2 | 0.060965 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0604836 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0602225 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0579205 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0576905 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0574527 |
| LAMA4 | laminin, alpha 4 | 0.0554399 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0545861 |
| SERINC5 | serine incorporator 5 | 0.0543026 |
| SLTM | SAFB-like, transcription modulator | 0.0537071 |
| CENPF | centromere protein F, 350/400kDa | 0.0501682 |
| MEF2A | myocyte enhancer factor 2A | 0.0500247 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0497238 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0489836 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0488695 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0482434 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0479061 |
| RPS12 | ribosomal protein S12 | 0.0471879 |
| BICC1 | BicC family RNA binding protein 1 | 0.0471242 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.047053 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0451498 |
| LAMB3 | laminin, beta 3 | 0.0450415 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.04481 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0446245 |
| SMG6 | SMG6 nonsense mediated mRNA decay factor | 0.0442462 |
| SP100 | SP100 nuclear antigen | 0.0435869 |
| VCL | vinculin | 0.043583 |
| FMNL2 | formin-like 2 | 0.0429494 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0426925 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0424246 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0419474 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.0416308 |
| ACTN4 | actinin, alpha 4 | 0.0413406 |
| ACTG1 | actin gamma 1 | 0.0408667 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0405924 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0404687 |
| ZNF638 | zinc finger protein 638 | 0.0403666 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0402799 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0402617 |
| YAP1 | Yes-associated protein 1 | 0.0402432 |
| RPS19 | ribosomal protein S19 | 0.0402186 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0401316 |
| PCNX1 | pecanex 1 | 0.039692 |
| SON | SON DNA binding protein | 0.0391525 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0390716 |
| YTHDC1 | YTH domain containing 1 | 0.0390345 |
| CFDP1 | craniofacial development protein 1 | 0.0388538 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0383416 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0377992 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0377404 |
| NPTN | neuroplastin | 0.0376645 |
| CD47 | CD47 molecule | 0.037116 |
| DIAPH2 | diaphanous-related formin 2 | 0.0367033 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0364087 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0362414 |
| STK24 | serine/threonine kinase 24 | 0.0360677 |
| WDR45B | WD repeat domain 45B | 0.0358504 |
| RNF213 | ring finger protein 213 | 0.0358342 |
| ABHD17C | abhydrolase domain containing 17C | 0.0357933 |
| C3 | complement component 3 | 0.0357917 |
| MRTFA | myocardin related transcription factor A | 0.0354234 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0353753 |
| SLK | STE20-like kinase | 0.0353557 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0352749 |
| VEGFA | vascular endothelial growth factor A | 0.0347095 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0346729 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0346219 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0346177 |
| SIK3 | SIK family kinase 3 | 0.0343733 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0338598 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0336989 |
| FOXO1 | forkhead box O1 | 0.0336718 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0336237 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0335875 |
| PPP4R3B | protein phosphatase 4 regulatory subunit 3B | 0.0335846 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0335431 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0333185 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0329254 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0327166 |
| RPL37A | ribosomal protein L37a | 0.0324583 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0323249 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0321275 |
| GLIS3 | GLIS family zinc finger 3 | 0.0318669 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0318338 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.0985686 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0871408 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0786907 |
| PTMA | prothymosin, alpha | -0.0782316 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0771507 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0763031 |
| VMP1 | vacuole membrane protein 1 | -0.0757759 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0723366 |
| SPAG9 | sperm associated antigen 9 | -0.0712807 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0661309 |
| FTL | ferritin, light polypeptide | -0.0643699 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0640988 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0618975 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0608443 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0608397 |
| ASPH | aspartate beta-hydroxylase | -0.0591783 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0573889 |
| KRT17 | keratin 17, type I | -0.0572728 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0562071 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0550595 |
| B2M | beta-2-microglobulin | -0.0549641 |
| GPC6 | glypican 6 | -0.0531231 |
| RPL35A | ribosomal protein L35a | -0.053058 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0521321 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.051143 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0510869 |
| STC1 | stanniocalcin 1 | -0.0509311 |
| MORF4L2 | mortality factor 4 like 2 | -0.0506983 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0499511 |
| SETD5 | SET domain containing 5 | -0.0498846 |
| AK1 | adenylate kinase 1 | -0.0493757 |
| LSAMP | limbic system-associated membrane protein | -0.048976 |
| ARF1 | ADP-ribosylation factor 1 | -0.0489564 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0487329 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0483036 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.047688 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0475023 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0469744 |
| NBAS | neuroblastoma amplified sequence | -0.0458139 |
| ANXA1 | annexin A1 | -0.0451039 |
| RORA | RAR-related orphan receptor A | -0.0448151 |
| COPA | coatomer protein complex, subunit alpha | -0.0442924 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0442519 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0440973 |
| PTK2 | protein tyrosine kinase 2 | -0.0437205 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0433605 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0425423 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0423599 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0418369 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0416439 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.040402 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0403242 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0402923 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0402594 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0394933 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0394232 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0393788 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0393489 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0385191 |
| GPR107 | G protein-coupled receptor 107 | -0.0382677 |
| RNF145 | ring finger protein 145 | -0.0376612 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0376136 |
| MATR3 | matrin 3 | -0.0369008 |
| ANXA2 | annexin A2 | -0.0365902 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0365737 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0364255 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.036425 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0364169 |
| RPS6 | ribosomal protein S6 | -0.036198 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0360678 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0358875 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0356704 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0355252 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0354194 |
| MSN | moesin | -0.035345 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0352732 |
| MCL1 | myeloid cell leukemia 1 | -0.0351784 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0350415 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.0347154 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0344115 |
| ZNF609 | zinc finger protein 609 | -0.0342973 |
| SDC4 | syndecan 4 | -0.0341288 |
| EGR1 | early growth response 1 | -0.0338655 |
| XPO1 | exportin 1 | -0.0335063 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0333308 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0327704 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0326776 |
| S100A6 | S100 calcium binding protein A6 | -0.0323143 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0318271 |
| EZR | ezrin | -0.0316437 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.031556 |
| ZFR | zinc finger RNA binding protein | -0.0314946 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0312201 |
| TAOK3 | TAO kinase 3 | -0.031215 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | -0.0310263 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0305664 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.0304066 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | -0.0303984 |
| NRG1 | neuregulin 1 | -0.029916 |
| POTEF | POTE ankyrin domain family, member F | -0.0298479 |
