| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elagolix sodium perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Elagolix sodium_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTG1 | actin gamma 1 | 0.273608 |
| FN1 | fibronectin 1 | 0.207717 |
| NDRG1 | N-myc downstream regulated 1 | 0.127105 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.122883 |
| POTEF | POTE ankyrin domain family, member F | 0.11527 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.080957 |
| FTL | ferritin, light polypeptide | 0.0780891 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0740517 |
| ARRDC3 | arrestin domain containing 3 | 0.0679723 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0654642 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0643136 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0630235 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0565208 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0479274 |
| HSPA8 | heat shock 70kDa protein 8 | 0.047065 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0429354 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0417948 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0410102 |
| BRD2 | bromodomain containing 2 | 0.0371219 |
| VEGFA | vascular endothelial growth factor A | 0.0364157 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0357468 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0320324 |
| RPS3 | ribosomal protein S3 | 0.0319357 |
| ANXA2 | annexin A2 | 0.0316436 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.031221 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0311342 |
| HLA-C | major histocompatibility complex, class I, C | 0.0309111 |
| LAMB3 | laminin, beta 3 | 0.0306511 |
| RACK1 | receptor for activated C kinase 1 | 0.0302091 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0301978 |
| HMGA1 | high mobility group AT-hook 1 | 0.0284749 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0276643 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0276518 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0276268 |
| MXD1 | MAX dimerization protein 1 | 0.0271315 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0264797 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0261937 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0260444 |
| RPS8 | ribosomal protein S8 | 0.0257321 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0248634 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0244229 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0241725 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0235567 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0233586 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0233175 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0229632 |
| CENPF | centromere protein F, 350/400kDa | 0.0224431 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0219443 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0213659 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0213647 |
| DSTN | destrin (actin depolymerizing factor) | 0.0212969 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0209693 |
| LDHB | lactate dehydrogenase B | 0.0190821 |
| LMNA | lamin A/C | 0.0190612 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0184423 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.01757 |
| RBM25 | RNA binding motif protein 25 | 0.0174904 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0172848 |
| S100A6 | S100 calcium binding protein A6 | 0.0172348 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0170185 |
| DUSP5 | dual specificity phosphatase 5 | 0.0169717 |
| CLDN4 | claudin 4 | 0.0168863 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0167666 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0165902 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0163984 |
| LOXL2 | lysyl oxidase-like 2 | 0.0163294 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.016026 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0158835 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.0157252 |
| TPM4 | tropomyosin 4 | 0.0156735 |
| CALR | calreticulin | 0.0156531 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0155892 |
| INTS6 | integrator complex subunit 6 | 0.0155688 |
| ADM | adrenomedullin | 0.0155148 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0153857 |
| TPM3 | tropomyosin 3 | 0.0153638 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0153622 |
| AREG | amphiregulin | 0.0150673 |
| VDAC1 | voltage-dependent anion channel 1 | 0.0149705 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0148197 |
| AHDC1 | AT hook, DNA binding motif, containing 1 | 0.0147741 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0147255 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0146718 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0146621 |
| DIAPH1 | diaphanous-related formin 1 | 0.0142488 |
| PLEC | plectin | 0.0141711 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0141202 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0140628 |
| NTN4 | netrin 4 | 0.0140169 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0139822 |
| HLA-A | major histocompatibility complex, class I, A | 0.0138981 |
| MLEC | malectin | 0.0138861 |
| SGMS2 | sphingomyelin synthase 2 | 0.013585 |
| HDGF | hepatoma-derived growth factor | 0.0135204 |
| TAPBP | TAP binding protein (tapasin) | 0.0133409 |
| RPL7 | ribosomal protein L7 | 0.0132935 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0132371 |
| SET | SET nuclear proto-oncogene | 0.0132219 |
| TPR | translocated promoter region, nuclear basket protein | 0.0132164 |
| CLINT1 | clathrin interactor 1 | 0.0131644 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.132757 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0909735 |
| AHNAK | AHNAK nucleoprotein | -0.0859993 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0651609 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0536682 |
| FBXO32 | F-box protein 32 | -0.0504319 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0482783 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0454568 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0439831 |
| TMSB10 | thymosin beta 10 | -0.0428679 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0394797 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0394352 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0372286 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.036594 |
| TMSB4X | thymosin beta 4, X-linked | -0.0358836 |
| RAI14 | retinoic acid induced 14 | -0.0348817 |
| OGA | O-GlcNAcase | -0.0328278 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0325968 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0321865 |
| LAMC2 | laminin, gamma 2 | -0.0316964 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0316763 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0313611 |
| KRT8 | keratin 8, type II | -0.0308627 |
| FAM3C | family with sequence similarity 3, member C | -0.0307883 |
| ASPH | aspartate beta-hydroxylase | -0.0303068 |
| H1-0 | H1.0 linker histone | -0.0302466 |
| RIGI | RNA sensor RIG-I | -0.0298269 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.029819 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0294753 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.027838 |
| NAV2 | neuron navigator 2 | -0.026988 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0269559 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0268393 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0267925 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0264312 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0263352 |
| CYRIB | CYFIP related Rac1 interactor B | -0.026317 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0259747 |
| MAP1B | microtubule-associated protein 1B | -0.0259342 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0258898 |
| ZNF217 | zinc finger protein 217 | -0.0257823 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0254409 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0252295 |
| ZNF292 | zinc finger protein 292 | -0.0250886 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.025053 |
| RBM39 | RNA binding motif protein 39 | -0.024449 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0237849 |
| CD2AP | CD2-associated protein | -0.0235843 |
| SEC24D | SEC24 family member D | -0.0234276 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0233432 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0232794 |
| FLNB | filamin B, beta | -0.0229856 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0228881 |
| RRBP1 | ribosome binding protein 1 | -0.0225594 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.022444 |
| FBXO34 | F-box protein 34 | -0.0220946 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0220034 |
| CAB39 | calcium binding protein 39 | -0.0219014 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0218367 |
| RAD51B | RAD51 paralog B | -0.0214358 |
| EXOC4 | exocyst complex component 4 | -0.0213058 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0210161 |
| FHIT | fragile histidine triad | -0.0208975 |
| ETV6 | ets variant 6 | -0.0206884 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0206613 |
| SYT1 | synaptotagmin I | -0.0206191 |
| FRMD5 | FERM domain containing 5 | -0.0206041 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0205754 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0200616 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0197518 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0197121 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.0193303 |
| MAP4 | microtubule-associated protein 4 | -0.019287 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0191978 |
| CUX1 | cut-like homeobox 1 | -0.019168 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0190688 |
| MSI2 | musashi RNA-binding protein 2 | -0.0190504 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.01886 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.0187089 |
| SP100 | SP100 nuclear antigen | -0.0185877 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.0185808 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0184852 |
| PGBD5 | piggyBac transposable element derived 5 | -0.0184413 |
| SLMAP | sarcolemma associated protein | -0.0183125 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0182912 |
| MCU | mitochondrial calcium uniporter | -0.0181824 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0180727 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0180271 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0180079 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0178925 |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 | -0.017445 |
| SBF2 | SET binding factor 2 | -0.0174042 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0172975 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0172237 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0170528 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0170015 |
| PRELID2 | PRELI domain containing 2 | -0.0168753 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0168211 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.016728 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0167112 |
