Elagolix sodium_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Elagolix sodium perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Elagolix sodium_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0547984
GRAMD1B GRAM domain containing 1B 0.0366908
ACTG1 actin gamma 1 0.0355577
MT2A metallothionein 2A 0.0317961
HSPA8 heat shock 70kDa protein 8 0.0295662
MAML3 mastermind-like 3 (Drosophila) 0.0282177
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0274708
PRELID2 PRELI domain containing 2 0.0270267
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0220182
EEF2 eukaryotic translation elongation factor 2 0.0212258
DISP1 dispatched homolog 1 (Drosophila) 0.0200053
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0194477
LOC112694756 uncharaterized LOC112694756 0.0186393
TM4SF1 transmembrane 4 L six family member 1 0.0181651
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0171092
HLA-C major histocompatibility complex, class I, C 0.0166883
ADGRD1 adhesion G protein-coupled receptor D1 0.0164113
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.015791
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0153983
ANXA2 annexin A2 0.0153281
RPL7A ribosomal protein L7a 0.0150642
RAB3B RAB3B, member RAS oncogene family 0.014041
AUTS2 autism susceptibility candidate 2 0.0140046
SRRM2 serine/arginine repetitive matrix 2 0.0138694
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0137656
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.0137186
CDH13 cadherin 13 0.0136862
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0123609
DPYSL2 dihydropyrimidinase-like 2 0.0123605
ADARB1 adenosine deaminase, RNA-specific, B1 0.0120298
HDAC4 histone deacetylase 4 0.0119333
N4BP2L2 NEDD4 binding protein 2-like 2 0.0116866
CADM2 cell adhesion molecule 2 0.0113618
AEBP2 AE binding protein 2 0.0113349
PTPRG protein tyrosine phosphatase, receptor type, G 0.011303
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0112952
PRDX1 peroxiredoxin 1 0.0111528
FBXL7 F-box and leucine-rich repeat protein 7 0.0110381
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0109035
NFE2L2 nuclear factor, erythroid 2-like 2 0.0108994
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0105686
PCDH9 protocadherin 9 0.010557
FRY furry homolog (Drosophila) 0.0104007
CFLAR CASP8 and FADD-like apoptosis regulator 0.0103751
RPS23 ribosomal protein S23 0.0101549
NIBAN2 niban apoptosis regulator 2 0.0101304
RPS29 ribosomal protein S29 0.0100739
PTPRM protein tyrosine phosphatase, receptor type, M 0.0100449
RPL13A ribosomal protein L13a 0.00997442
LINGO2 leucine rich repeat and Ig domain containing 2 0.00996486
SLFN5 schlafen family member 5 0.00986014
SMOX spermine oxidase 0.00970828
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.00969829
LRMDA leucine rich melanocyte differentiation associated 0.0096882
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.00968079
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.00956034
HEATR5A HEAT repeat containing 5A 0.00955197
EIF4H eukaryotic translation initiation factor 4H 0.00935174
ZNF516 zinc finger protein 516 0.00933944
PLCB4 phospholipase C, beta 4 0.00928277
MAPK8 mitogen-activated protein kinase 8 0.00928089
RPS20 ribosomal protein S20 0.00927522
RNF213 ring finger protein 213 0.00912258
NCOA1 nuclear receptor coactivator 1 0.00873852
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.00871979
WWOX WW domain containing oxidoreductase 0.00867181
PYGL phosphorylase, glycogen, liver 0.00861166
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.00855305
NRIP1 nuclear receptor interacting protein 1 0.00854284
STX8 syntaxin 8 0.0085288
CCNY cyclin Y 0.00847276
AHNAK2 AHNAK nucleoprotein 2 0.00843297
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 0.00841396
TSC22D1 TSC22 domain family, member 1 0.00834197
MT1X metallothionein 1X 0.00812426
CFAP44 cilia and flagella associated protein 44 0.00803289
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.00801277
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.0078808
CMIP c-Maf inducing protein 0.0078368
SMOC1 SPARC related modular calcium binding 1 0.00782662
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 0.00778616
CTIF CBP80/20-dependent translation initiation factor 0.00773189
NUMB numb homolog (Drosophila) 0.00766415
FBXL17 F-box and leucine-rich repeat protein 17 0.00766084
R3HDM2 R3H domain containing 2 0.00762434
CREM cAMP responsive element modulator 0.00762362
WWTR1 WW domain containing transcription regulator 1 0.00758471
ARL15 ADP-ribosylation factor-like 15 0.00751658
MTAP methylthioadenosine phosphorylase 0.00748718
RCC1 regulator of chromosome condensation 1 0.00735593
GPC5 glypican 5 0.00719211
TBL1X transducin (beta)-like 1X-linked 0.00717535
SUMF1 sulfatase modifying factor 1 0.00711858
GADD45A growth arrest and DNA-damage-inducible, alpha 0.00710642
ARHGAP21 Rho GTPase activating protein 21 0.0070802
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.00707298
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.00703582
KMT2A lysine (K)-specific methyltransferase 2A 0.00700941
EXOC6B exocyst complex component 6B 0.00698196
KIAA1328 KIAA1328 0.0069309

decreased expression

Symbol Name Standardized Value
COL5A2 collagen, type V, alpha 2 -0.0939165
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0925448
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0873149
GDA guanine deaminase -0.0862106
FNDC3B fibronectin type III domain containing 3B -0.0752686
LIMCH1 LIM and calponin homology domains 1 -0.0736995
NAMPT nicotinamide phosphoribosyltransferase -0.0731075
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0714554
ZEB2 zinc finger E-box binding homeobox 2 -0.0645179
TRIO trio Rho guanine nucleotide exchange factor -0.0636939
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0618772
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0565751
PDLIM5 PDZ and LIM domain 5 -0.0555673
SMYD3 SET and MYND domain containing 3 -0.0537372
PDE4D phosphodiesterase 4D, cAMP-specific -0.0506405
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.049626
ELL2 elongation factor, RNA polymerase II, 2 -0.0492725
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0480717
MYOF myoferlin -0.0473452
EFNA5 ephrin-A5 -0.0467745
P3H2 prolyl 3-hydroxylase 2 -0.0463575
IGFBP3 insulin-like growth factor binding protein 3 -0.0463316
COPA coatomer protein complex, subunit alpha -0.0459042
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0456596
PTMA prothymosin, alpha -0.0456159
SPAG9 sperm associated antigen 9 -0.045595
FNDC3A fibronectin type III domain containing 3A -0.0441987
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0440273
ASPH aspartate beta-hydroxylase -0.0426415
VIM vimentin -0.0414596
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0414287
SAMD4A sterile alpha motif domain containing 4A -0.0400755
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0395817
TMSB10 thymosin beta 10 -0.0386839
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0382797
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0365488
KMT2C lysine (K)-specific methyltransferase 2C -0.0364889
SLC38A2 solute carrier family 38, member 2 -0.0363094
CD109 CD109 molecule -0.0347417
CANX calnexin -0.0344981
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0335199
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.033479
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0331031
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.032529
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0314471
PGK1 phosphoglycerate kinase 1 -0.0309412
NEK7 NIMA-related kinase 7 -0.0305131
TGFBR1 transforming growth factor, beta receptor 1 -0.0299533
NPAS2 neuronal PAS domain protein 2 -0.0299498
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0299202
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.029398
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0293024
ATAD1 ATPase family, AAA domain containing 1 -0.02895
KYNU kynureninase -0.0288889
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0285438
HLA-B major histocompatibility complex, class I, B -0.0283856
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0281755
PTEN phosphatase and tensin homolog -0.0281176
TENT5A terminal nucleotidyltransferase 5A -0.0277473
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0277169
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0272376
GOLGA4 golgin A4 -0.0271582
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0266583
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.026601
RBM39 RNA binding motif protein 39 -0.0264835
PDIA3 protein disulfide isomerase family A, member 3 -0.0264157
AGTPBP1 ATP/GTP binding protein 1 -0.026185
DNER delta/notch-like EGF repeat containing -0.0261756
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.026166
MCL1 myeloid cell leukemia 1 -0.0261336
NRCAM neuronal cell adhesion molecule -0.0261158
IL6 interleukin 6 -0.0260334
DGKD diacylglycerol kinase, delta 130kDa -0.025947
USP34 ubiquitin specific peptidase 34 -0.0257004
SOD2 superoxide dismutase 2, mitochondrial -0.0253245
ESYT2 extended synaptotagmin-like protein 2 -0.0247415
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0243177
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0239964
PDIA6 protein disulfide isomerase family A, member 6 -0.0237897
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0234673
IFIH1 interferon induced with helicase C domain 1 -0.0232515
SBF2 SET binding factor 2 -0.023159
PSD3 pleckstrin and Sec7 domain containing 3 -0.0227178
NBEAL1 neurobeachin-like 1 -0.0225051
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.022055
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0219972
WARS1 tryptophanyl-tRNA synthetase 1 -0.0218586
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0218247
UBE2H ubiquitin-conjugating enzyme E2H -0.0215666
BIRC6 baculoviral IAP repeat containing 6 -0.0214457
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0211279
ATP13A3 ATPase type 13A3 -0.0211204
LAMB1 laminin, beta 1 -0.0210924
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0210882
TXNRD1 thioredoxin reductase 1 -0.0210275
S100A6 S100 calcium binding protein A6 -0.0209141
CTBP2 C-terminal binding protein 2 -0.0208695
RAB1A RAB1A, member RAS oncogene family -0.0208113
PALLD palladin, cytoskeletal associated protein -0.0206363
ABLIM1 actin binding LIM protein 1 -0.0200269