| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elagolix sodium perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Elagolix sodium_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.147427 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.138186 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.116062 |
| PDE10A | phosphodiesterase 10A | 0.109454 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.109125 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.10094 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0983358 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0871007 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0863371 |
| GDA | guanine deaminase | 0.0857853 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0809931 |
| EXT1 | exostosin glycosyltransferase 1 | 0.077225 |
| TMEM131 | transmembrane protein 131 | 0.0722571 |
| RBM39 | RNA binding motif protein 39 | 0.0700623 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0672396 |
| GPC6 | glypican 6 | 0.0672216 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.067198 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0670296 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0650214 |
| EFNA5 | ephrin-A5 | 0.0647049 |
| FMN1 | formin 1 | 0.0644031 |
| GOLGA4 | golgin A4 | 0.0634685 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.063162 |
| CDH13 | cadherin 13 | 0.060597 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0599937 |
| FMNL2 | formin-like 2 | 0.0559686 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0555775 |
| ASPH | aspartate beta-hydroxylase | 0.0552741 |
| USP34 | ubiquitin specific peptidase 34 | 0.0530914 |
| PRELID2 | PRELI domain containing 2 | 0.0513089 |
| SBF2 | SET binding factor 2 | 0.0502302 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.049923 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0492033 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0473168 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0472349 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0470542 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0464416 |
| MT2A | metallothionein 2A | 0.0449894 |
| TENM3 | teneurin transmembrane protein 3 | 0.0445878 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0423267 |
| B2M | beta-2-microglobulin | 0.0420505 |
| FAT1 | FAT atypical cadherin 1 | 0.0411031 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0409517 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0395112 |
| RPL37 | ribosomal protein L37 | 0.0388429 |
| EXOC6B | exocyst complex component 6B | 0.0384309 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.038352 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0382135 |
| SMYD3 | SET and MYND domain containing 3 | 0.0380712 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0353315 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0351831 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0344483 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0332915 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0324877 |
| RPS12 | ribosomal protein S12 | 0.0313661 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0304758 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0303882 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0302587 |
| NCOR1 | nuclear receptor corepressor 1 | 0.028971 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.028886 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0276922 |
| EZR | ezrin | 0.0274131 |
| CDK13 | cyclin-dependent kinase 13 | 0.0273096 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0272185 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0271054 |
| SET | SET nuclear proto-oncogene | 0.0269468 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.026605 |
| CUX1 | cut-like homeobox 1 | 0.0264374 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0262669 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0260449 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0259271 |
| JMJD1C | jumonji domain containing 1C | 0.0257029 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0239336 |
| NLGN1 | neuroligin 1 | 0.0233241 |
| NF1 | neurofibromin 1 | 0.0231474 |
| CTTN | cortactin | 0.0228683 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0223872 |
| RPS19 | ribosomal protein S19 | 0.0223495 |
| ENO1 | enolase 1, (alpha) | 0.0222803 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0220797 |
| ZNF638 | zinc finger protein 638 | 0.021775 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0214758 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0203924 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0201341 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0196995 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.0193435 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0189573 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0189037 |
| FHIT | fragile histidine triad | 0.0185964 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0185767 |
| RPL35A | ribosomal protein L35a | 0.017412 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0171383 |
| FTL | ferritin, light polypeptide | 0.0168632 |
| AHNAK | AHNAK nucleoprotein | 0.0167401 |
| VCL | vinculin | 0.0166637 |
| TBC1D22A | TBC1 domain family, member 22A | 0.016432 |
| PTGES2 | prostaglandin E synthase 2 | 0.0163344 |
| FAM107B | family with sequence similarity 107, member B | 0.0159236 |
| RPLP1 | ribosomal protein, large, P1 | 0.0147644 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0147619 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.390701 |
| UBC | ubiquitin C | -0.144519 |
| PTMA | prothymosin, alpha | -0.14188 |
| VIM | vimentin | -0.127054 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.103064 |
| RTN4 | reticulon 4 | -0.0915108 |
| PARD3 | par-3 family cell polarity regulator | -0.0794074 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0787458 |
| RLF | rearranged L-myc fusion | -0.0773345 |
| TMSB10 | thymosin beta 10 | -0.0767893 |
| CCNI | cyclin I | -0.0749105 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0733264 |
| NRG3 | neuregulin 3 | -0.0722715 |
| LDHA | lactate dehydrogenase A | -0.0722071 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0714938 |
| CD44 | CD44 molecule (Indian blood group) | -0.0683892 |
| RPL23 | ribosomal protein L23 | -0.0677549 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0653175 |
| NUP58 | nucleoporin 58 | -0.060702 |
| ACTN4 | actinin, alpha 4 | -0.0605944 |
| ANXA2 | annexin A2 | -0.0580586 |
| HMGA2 | high mobility group AT-hook 2 | -0.0550809 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0538815 |
| CANX | calnexin | -0.0525113 |
| RAD51B | RAD51 paralog B | -0.0525042 |
| MYO6 | myosin VI | -0.0522119 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.0519858 |
| SMAD3 | SMAD family member 3 | -0.0519668 |
| RPL31 | ribosomal protein L31 | -0.0505944 |
| MAP4 | microtubule-associated protein 4 | -0.0499326 |
| RPL37A | ribosomal protein L37a | -0.0497448 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0481913 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0481357 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0470548 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0453258 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0443032 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0437789 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0435345 |
| RPS6 | ribosomal protein S6 | -0.0428603 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0423489 |
| RPS27A | ribosomal protein S27a | -0.0391128 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0390732 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0384917 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0382773 |
| PGK1 | phosphoglycerate kinase 1 | -0.0374012 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0372627 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0372349 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0371448 |
| SRPK2 | SRSF protein kinase 2 | -0.0360363 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0353892 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0350013 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0349489 |
| RAB10 | RAB10, member RAS oncogene family | -0.0346539 |
| RNF213 | ring finger protein 213 | -0.0346367 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0346293 |
| OXR1 | oxidation resistance 1 | -0.0324494 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0312699 |
| GPHN | gephyrin | -0.0311382 |
| NFIA | nuclear factor I/A | -0.0310671 |
| COL6A1 | collagen, type VI, alpha 1 | -0.029199 |
| FLNB | filamin B, beta | -0.0288721 |
| SLTM | SAFB-like, transcription modulator | -0.0286563 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0283607 |
| ACTG1 | actin gamma 1 | -0.0276275 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0272701 |
| SPAG9 | sperm associated antigen 9 | -0.0272211 |
| TXNRD1 | thioredoxin reductase 1 | -0.026635 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.0262129 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0261791 |
| RUNX1 | runt-related transcription factor 1 | -0.0261258 |
| COG5 | component of oligomeric golgi complex 5 | -0.0260589 |
| OSMR | oncostatin M receptor | -0.0260256 |
| TPI1 | triosephosphate isomerase 1 | -0.0256266 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0251438 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.024643 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0245691 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0241157 |
| MYO10 | myosin X | -0.0233298 |
| TJP1 | tight junction protein 1 | -0.0233298 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0232864 |
| YAP1 | Yes-associated protein 1 | -0.0228423 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0227461 |
| MED13L | mediator complex subunit 13-like | -0.0226781 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0223008 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0222872 |
| ZNF609 | zinc finger protein 609 | -0.0222579 |
| MYOF | myoferlin | -0.0221439 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0220174 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0215561 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0214472 |
| IGF2 | insulin-like growth factor 2 | -0.0203035 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0202443 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0201744 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0200624 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0200363 |
| PKM | pyruvate kinase, muscle | -0.0198416 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0191865 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0187686 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0185538 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0179798 |
