Elagolix sodium_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Elagolix sodium perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Elagolix sodium_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0277116
APP amyloid beta (A4) precursor protein 0.0242806
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0236296
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.020566
PRRC2A proline-rich coiled-coil 2A 0.0196915
MATR3 matrin 3 0.0183627
TSC22D2 TSC22 domain family, member 2 0.0182182
NCKAP1 NCK-associated protein 1 0.0166957
MYH9 myosin, heavy chain 9, non-muscle 0.0165338
CDC73 cell division cycle 73 0.0159397
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0149133
IWS1 IWS1 homolog (S. cerevisiae) 0.0148016
FXR1 fragile X mental retardation, autosomal homolog 1 0.0147424
KDM3A lysine (K)-specific demethylase 3A 0.0145444
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0142236
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0136882
EIF4H eukaryotic translation initiation factor 4H 0.0136155
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0135887
UTRN utrophin 0.013517
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0134006
GASK1B golgi associated kinase 1B 0.0133757
FMNL2 formin-like 2 0.0132538
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.013199
PTK2 protein tyrosine kinase 2 0.0131411
FLNA filamin A, alpha 0.012938
USP3 ubiquitin specific peptidase 3 0.0128458
NPTN neuroplastin 0.0128331
STIP1 stress-induced phosphoprotein 1 0.0127244
ATP13A3 ATPase type 13A3 0.0125869
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0123824
OLA1 Obg-like ATPase 1 0.0123255
TRA2A transformer 2 alpha homolog (Drosophila) 0.0123027
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0120768
UBQLN1 ubiquilin 1 0.011898
ZNF608 zinc finger protein 608 0.0118867
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 0.0117709
UBA2 ubiquitin-like modifier activating enzyme 2 0.0117381
CUL4B cullin 4B 0.0116806
RAB21 RAB21, member RAS oncogene family 0.0116425
WDR43 WD repeat domain 43 0.0115152
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0114761
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0114517
RPL3 ribosomal protein L3 0.0114105
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0112762
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 0.0112401
RHOH ras homolog family member H 0.0111738
BHLHE40 basic helix-loop-helix family, member e40 0.0111254
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0109844
NOP58 NOP58 ribonucleoprotein 0.0109332
ZNF292 zinc finger protein 292 0.0108856
ZC3H15 zinc finger CCCH-type containing 15 0.0108843
BZW1 basic leucine zipper and W2 domains 1 0.0108399
CSNK1G3 casein kinase 1, gamma 3 0.0108259
SARNP SAP domain containing ribonucleoprotein 0.0107074
YLPM1 YLP motif containing 1 0.0105432
PCDH18 protocadherin 18 0.0105328
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0105235
TRIO trio Rho guanine nucleotide exchange factor 0.0104553
AHNAK AHNAK nucleoprotein 0.0103955
SESN2 sestrin 2 0.0103796
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0103313
COG6 component of oligomeric golgi complex 6 0.0103273
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 0.0103037
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0102943
RBM10 RNA binding motif protein 10 0.010272
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.0101355
MPRIP myosin phosphatase Rho interacting protein 0.0100937
GOLIM4 golgi integral membrane protein 4 0.0100458
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.00996102
CNOT6 CCR4-NOT transcription complex, subunit 6 0.00990756
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0098346
ITSN2 intersectin 2 0.0097978
TGFB2 transforming growth factor, beta 2 0.00975475
FGFR1OP2 FGFR1 oncogene partner 2 0.00972306
LARS1 leucyl-tRNA synthetase 1 0.00971126
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.00970959
EIF3H eukaryotic translation initiation factor 3, subunit H 0.00965729
RBM28 RNA binding motif protein 28 0.00958219
ATL2 atlastin GTPase 2 0.00949855
PNPLA8 patatin-like phospholipase domain containing 8 0.00948518
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.00947371
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 0.00946196
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.00944823
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.00942368
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 0.00932643
AHNAK2 AHNAK nucleoprotein 2 0.00932304
SUCO SUN domain containing ossification factor 0.00929844
ELF2 E74-like factor 2 (ets domain transcription factor) 0.00925938
CEP250 centrosomal protein 250kDa 0.0092576
NONO non-POU domain containing, octamer-binding 0.00922369
HSPA8 heat shock 70kDa protein 8 0.00919228
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.00915647
RPS3A ribosomal protein S3A 0.00911615
UBAP2 ubiquitin associated protein 2 0.00911173
MARCHF8 membrane associated ring-CH-type finger 8 0.00907416
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.0090564
GAK cyclin G associated kinase 0.00905299
ACSL3 acyl-CoA synthetase long-chain family member 3 0.00905235
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.00904197
PDZD8 PDZ domain containing 8 0.00902708

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.206229
COL11A1 collagen, type XI, alpha 1 -0.175635
TMSB10 thymosin beta 10 -0.142345
CADM2 cell adhesion molecule 2 -0.137492
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.111107
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0990636
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0957614
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0826255
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0820641
RPS16 ribosomal protein S16 -0.0808416
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.076225
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0709399
RPS6 ribosomal protein S6 -0.0698907
MDK midkine (neurite growth-promoting factor 2) -0.0674195
ITGAV integrin, alpha V -0.0668734
RPS8 ribosomal protein S8 -0.0649951
COL1A2 collagen, type I, alpha 2 -0.0623735
PCDH9 protocadherin 9 -0.0610443
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.05854
GPC3 glypican 3 -0.0574266
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0564353
ADGRL2 adhesion G protein-coupled receptor L2 -0.0547881
PHIP pleckstrin homology domain interacting protein -0.053462
PCLO piccolo presynaptic cytomatrix protein -0.0522312
PTMA prothymosin, alpha -0.0519472
RPS19 ribosomal protein S19 -0.0508015
RPL35A ribosomal protein L35a -0.0500899
RPL11 ribosomal protein L11 -0.0495361
B2M beta-2-microglobulin -0.0494645
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0482985
ADGRV1 adhesion G protein-coupled receptor V1 -0.0453041
PLPP1 phospholipid phosphatase 1 -0.0445342
RPLP1 ribosomal protein, large, P1 -0.044096
PGK1 phosphoglycerate kinase 1 -0.0433449
WSB1 WD repeat and SOCS box containing 1 -0.0413607
PRTG protogenin -0.0407662
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0404472
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.040387
TPT1 tumor protein, translationally-controlled 1 -0.03989
RPL31 ribosomal protein L31 -0.0395354
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0394355
HSPB1 heat shock 27kDa protein 1 -0.0391981
RPL5 ribosomal protein L5 -0.0389991
PARD3B par-3 family cell polarity regulator beta -0.0387212
COL5A2 collagen, type V, alpha 2 -0.0385386
PGAP1 post-GPI attachment to proteins 1 -0.0376855
ISG15 ISG15 ubiquitin-like modifier -0.0376074
RPL23 ribosomal protein L23 -0.0375544
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0369857
SLIT2 slit homolog 2 (Drosophila) -0.0366857
LRRC4C leucine rich repeat containing 4C -0.0364611
RPL36A ribosomal protein L36a -0.0357548
JMJD1C jumonji domain containing 1C -0.0353917
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0351669
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0348616
ANKRD12 ankyrin repeat domain 12 -0.0348541
RPS25 ribosomal protein S25 -0.0346866
RPL19 ribosomal protein L19 -0.0345514
WASF2 WAS protein family, member 2 -0.0345378
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0344829
RPL12 ribosomal protein L12 -0.0344269
RPS27A ribosomal protein S27a -0.0336429
ADGRL3 adhesion G protein-coupled receptor L3 -0.0335519
RPLP0 ribosomal protein, large, P0 -0.0335203
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0333921
LDHA lactate dehydrogenase A -0.0327287
SNX6 sorting nexin 6 -0.0326152
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0318165
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0318119
RPLP2 ribosomal protein, large, P2 -0.0317211
FTL ferritin, light polypeptide -0.0316953
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0315749
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0315027
ENO1 enolase 1, (alpha) -0.0302867
TENM3 teneurin transmembrane protein 3 -0.0301549
S100A9 S100 calcium binding protein A9 -0.0298905
NCAM2 neural cell adhesion molecule 2 -0.0296103
COL3A1 collagen, type III, alpha 1 -0.0293212
RBM20 RNA binding motif protein 20 -0.0293011
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0291769
MAP4 microtubule-associated protein 4 -0.0287926
SBF2 SET binding factor 2 -0.0286499
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0285355
RAI1 retinoic acid induced 1 -0.0283871
RPS21 ribosomal protein S21 -0.0282588
GNAS GNAS complex locus -0.0282548
CNRIP1 cannabinoid receptor interacting protein 1 -0.0279942
NEBL nebulette -0.027897
RPS12 ribosomal protein S12 -0.0278405
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0271026
MRPS6 mitochondrial ribosomal protein S6 -0.0263221
LPIN2 lipin 2 -0.0259274
MYL12B myosin, light chain 12B, regulatory -0.0259115
CBX3 chromobox homolog 3 -0.0258129
CSMD3 CUB and Sushi multiple domains 3 -0.0257972
ANK2 ankyrin 2, neuronal -0.0256585
RPS24 ribosomal protein S24 -0.0255905
SLC38A2 solute carrier family 38, member 2 -0.0254485
TENM2 teneurin transmembrane protein 2 -0.0251652
SERF2 small EDRK-rich factor 2 -0.0251299