Elagolix sodium_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Elagolix sodium perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Elagolix sodium_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 0.0746183
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0500282
LOC112694756 uncharaterized LOC112694756 0.0405167
KTN1 kinectin 1 (kinesin receptor) 0.0402499
FTL ferritin, light polypeptide 0.0373543
SRRM2 serine/arginine repetitive matrix 2 0.0367841
RPS8 ribosomal protein S8 0.0353397
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0338096
SQSTM1 sequestosome 1 0.0337937
OGA O-GlcNAcase 0.0323518
RPS3 ribosomal protein S3 0.0316201
HILPDA hypoxia inducible lipid droplet-associated 0.0311658
RPLP1 ribosomal protein, large, P1 0.0309913
DDIT4 DNA-damage-inducible transcript 4 0.030476
ANXA2 annexin A2 0.0303959
RACK1 receptor for activated C kinase 1 0.02906
YBX1 Y box binding protein 1 0.0279891
RPL35A ribosomal protein L35a 0.0260915
FTH1 ferritin, heavy polypeptide 1 0.0260124
FMNL2 formin-like 2 0.0256323
HSPA8 heat shock 70kDa protein 8 0.0246833
ARRDC3 arrestin domain containing 3 0.023062
UBE2O ubiquitin-conjugating enzyme E2O 0.022979
RIGI RNA sensor RIG-I 0.0229212
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0224068
PNISR PNN-interacting serine/arginine-rich protein 0.0217156
ANGPTL4 angiopoietin-like 4 0.0211024
RPS12 ribosomal protein S12 0.0207206
WDR45B WD repeat domain 45B 0.0205717
NAMPT nicotinamide phosphoribosyltransferase 0.0197662
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0195877
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0193909
PRRC2A proline-rich coiled-coil 2A 0.0190536
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0189716
ANKRD11 ankyrin repeat domain 11 0.0185483
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0180353
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.0179276
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0179215
HNRNPL heterogeneous nuclear ribonucleoprotein L 0.0179159
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0175228
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0175054
PLEC plectin 0.0173931
KDM3A lysine (K)-specific demethylase 3A 0.0173803
RAB6A RAB6A, member RAS oncogene family 0.0173619
WWTR1 WW domain containing transcription regulator 1 0.0171109
SMAD3 SMAD family member 3 0.0170973
AFAP1 actin filament associated protein 1 0.017096
PDE8A phosphodiesterase 8A 0.0170189
TFG TRK-fused gene 0.016831
YEATS2 YEATS domain containing 2 0.0167784
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0167675
GOLGA4 golgin A4 0.0167518
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0162482
HPCAL1 hippocalcin-like 1 0.0162041
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0161513
RNF145 ring finger protein 145 0.0158902
RPS20 ribosomal protein S20 0.0158544
RPL37A ribosomal protein L37a 0.0156721
EIF4H eukaryotic translation initiation factor 4H 0.0155973
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.015492
SNX14 sorting nexin 14 0.0154327
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0152678
PRELID2 PRELI domain containing 2 0.0151559
EIF1 eukaryotic translation initiation factor 1 0.0150514
XPO1 exportin 1 0.0147856
NPEPPS aminopeptidase puromycin sensitive 0.0147305
AHDC1 AT hook, DNA binding motif, containing 1 0.0146327
RB1CC1 RB1-inducible coiled-coil 1 0.0142737
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0141471
MATR3 matrin 3 0.0139857
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0139853
OLA1 Obg-like ATPase 1 0.0139653
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0137857
RPL37 ribosomal protein L37 0.0137501
SNX3 sorting nexin 3 0.0137483
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0137065
MARCHF6 membrane associated ring-CH-type finger 6 0.0136562
RPS27A ribosomal protein S27a 0.0135843
FOXO3 forkhead box O3 0.0135457
S100A6 S100 calcium binding protein A6 0.0134213
WSB1 WD repeat and SOCS box containing 1 0.0132541
USP3 ubiquitin specific peptidase 3 0.0132312
CAMTA1 calmodulin binding transcription activator 1 0.013202
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0130335
FXR1 fragile X mental retardation, autosomal homolog 1 0.0129886
SET SET nuclear proto-oncogene 0.0127526
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0126737
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0123971
ACTG1 actin gamma 1 0.0122668
FOXK2 forkhead box K2 0.0122354
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0121245
BACE2 beta-site APP-cleaving enzyme 2 0.0121207
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0121062
RPL31 ribosomal protein L31 0.0119434
NAV2 neuron navigator 2 0.0119294
EIF4B eukaryotic translation initiation factor 4B 0.0117975
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 0.011767
RPS25 ribosomal protein S25 0.0117172
UBE2B ubiquitin-conjugating enzyme E2B 0.0116531
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0115629

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.190313
VCL vinculin -0.176053
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.128374
DST dystonin -0.097951
SLC35F3 solute carrier family 35, member F3 -0.0959043
CD44 CD44 molecule (Indian blood group) -0.0874646
AHNAK AHNAK nucleoprotein -0.0870472
EGFR epidermal growth factor receptor -0.0820604
TMSB10 thymosin beta 10 -0.0818836
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0678963
AKAP12 A kinase (PRKA) anchor protein 12 -0.0678499
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0678469
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0675986
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0635767
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0613464
RASAL2 RAS protein activator like 2 -0.0601153
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0600822
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0586086
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0578961
ACTN4 actinin, alpha 4 -0.0575635
UBASH3B ubiquitin associated and SH3 domain containing B -0.0545333
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0524749
EGR1 early growth response 1 -0.0524556
MAP1B microtubule-associated protein 1B -0.0510166
ASPH aspartate beta-hydroxylase -0.0494845
SLC38A2 solute carrier family 38, member 2 -0.0483233
ZNF780B zinc finger protein 780B -0.0480608
SDK1 sidekick cell adhesion molecule 1 -0.0455714
VMP1 vacuole membrane protein 1 -0.0453675
EHBP1 EH domain binding protein 1 -0.0443526
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0436429
SBF2 SET binding factor 2 -0.0434769
HMGA2 high mobility group AT-hook 2 -0.0430894
CARD18 caspase recruitment domain family, member 18 -0.041878
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.040233
THSD4 thrombospondin, type I, domain containing 4 -0.0399236
ARHGAP29 Rho GTPase activating protein 29 -0.0396277
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0393021
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0384769
FBL fibrillarin -0.0380734
NCEH1 neutral cholesterol ester hydrolase 1 -0.0379132
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0365438
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.036521
RABGAP1L RAB GTPase activating protein 1-like -0.0353396
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0353264
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0350458
TPM1 tropomyosin 1 (alpha) -0.0347946
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0339653
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.033715
ATG7 autophagy related 7 -0.0334192
PTK2 protein tyrosine kinase 2 -0.0326182
EXT1 exostosin glycosyltransferase 1 -0.0323802
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0321172
EFNA5 ephrin-A5 -0.0316363
PTMA prothymosin, alpha -0.031484
TMEM123 transmembrane protein 123 -0.0312781
MCL1 myeloid cell leukemia 1 -0.0312688
SMYD3 SET and MYND domain containing 3 -0.031119
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0310633
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0307702
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0304784
MSRB3 methionine sulfoxide reductase B3 -0.0302026
EXOC4 exocyst complex component 4 -0.0299483
MYH9 myosin, heavy chain 9, non-muscle -0.0295614
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0294512
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 -0.0294293
LPP LIM domain containing preferred translocation partner in lipoma -0.0293787
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0292356
MAML3 mastermind-like 3 (Drosophila) -0.0287969
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0286515
MCTP1 multiple C2 domains, transmembrane 1 -0.0283344
ANLN anillin, actin binding protein -0.0283257
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0281524
MACF1 microtubule-actin crosslinking factor 1 -0.0277776
MAP4 microtubule-associated protein 4 -0.0276146
SIK3 SIK family kinase 3 -0.0274492
CD59 CD59 molecule, complement regulatory protein -0.0267849
MYOF myoferlin -0.0262358
DIAPH2 diaphanous-related formin 2 -0.0260178
THOC2 THO complex 2 -0.0260144
ADGRG6 adhesion G protein-coupled receptor G6 -0.0259836
UBC ubiquitin C -0.0258553
AKAP13 A kinase (PRKA) anchor protein 13 -0.0258336
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0256328
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0255348
ANO6 anoctamin 6 -0.0254876
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0254436
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0248254
TM4SF1 transmembrane 4 L six family member 1 -0.024685
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0246109
ANKRD12 ankyrin repeat domain 12 -0.0245479
FRMD5 FERM domain containing 5 -0.0244613
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0242621
UBAP2 ubiquitin associated protein 2 -0.0241354
GARS1 glycyl-tRNA synthetase 1 -0.0237474
UTRN utrophin -0.023661
ATM ATM serine/threonine kinase -0.0235119
TRIO trio Rho guanine nucleotide exchange factor -0.023484
ELL2 elongation factor, RNA polymerase II, 2 -0.0233497
LDHA lactate dehydrogenase A -0.023177