| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elagolix sodium perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Elagolix sodium_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.109579 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0900235 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0782831 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0732699 |
| PLEC | plectin | 0.0584451 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0494393 |
| MSN | moesin | 0.0478399 |
| FLNA | filamin A, alpha | 0.0468024 |
| FNDC3B | fibronectin type III domain containing 3B | 0.040573 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0399414 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0382695 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0381038 |
| TPM3 | tropomyosin 3 | 0.0380582 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0377611 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0368785 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0360939 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0353829 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0321675 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0318077 |
| RTN4 | reticulon 4 | 0.0309261 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0305342 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0304366 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.030003 |
| RPL3 | ribosomal protein L3 | 0.0295513 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0286533 |
| VEGFA | vascular endothelial growth factor A | 0.0282187 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0281243 |
| CD109 | CD109 molecule | 0.027576 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0273654 |
| SPAG9 | sperm associated antigen 9 | 0.0270957 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0269107 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0262916 |
| WDR45B | WD repeat domain 45B | 0.0262677 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0262288 |
| HDAC9 | histone deacetylase 9 | 0.025001 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0242132 |
| MCL1 | myeloid cell leukemia 1 | 0.0241701 |
| GOLGB1 | golgin B1 | 0.0235688 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0230341 |
| SOX10 | SRY (sex determining region Y)-box 10 | 0.022983 |
| RNF145 | ring finger protein 145 | 0.0223278 |
| ARRDC3 | arrestin domain containing 3 | 0.0222544 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0222426 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.020544 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0204104 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0202904 |
| NOTCH2 | notch 2 | 0.020246 |
| CABIN1 | calcineurin binding protein 1 | 0.0200927 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0197871 |
| POTEF | POTE ankyrin domain family, member F | 0.019665 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.019658 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0196293 |
| DIAPH1 | diaphanous-related formin 1 | 0.0194551 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0194508 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0192529 |
| NDRG1 | N-myc downstream regulated 1 | 0.0190443 |
| EP300 | E1A binding protein p300 | 0.0189124 |
| AFDN | afadin, adherens junction formation factor | 0.0187577 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.018715 |
| HELZ | helicase with zinc finger | 0.0186793 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0184672 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.01836 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0183338 |
| PCBP2 | poly(rC) binding protein 2 | 0.0182689 |
| JMJD1C | jumonji domain containing 1C | 0.017983 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0177796 |
| CLINT1 | clathrin interactor 1 | 0.0177465 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.017486 |
| HPCAL1 | hippocalcin-like 1 | 0.0174568 |
| SET | SET nuclear proto-oncogene | 0.0173871 |
| ATXN2 | ataxin 2 | 0.0173563 |
| FMNL2 | formin-like 2 | 0.01734 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0173393 |
| CCNL1 | cyclin L1 | 0.0170454 |
| SMAD3 | SMAD family member 3 | 0.0169736 |
| COPA | coatomer protein complex, subunit alpha | 0.0168865 |
| MED13 | mediator complex subunit 13 | 0.0165726 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0164869 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0164844 |
| CTSB | cathepsin B | 0.0164583 |
| CLIC4 | chloride intracellular channel 4 | 0.0164257 |
| ITGB5 | integrin, beta 5 | 0.0164222 |
| CTBP2 | C-terminal binding protein 2 | 0.0163289 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0163235 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0163049 |
| CENPF | centromere protein F, 350/400kDa | 0.0161554 |
| TFG | TRK-fused gene | 0.0159994 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0159268 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0159218 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0157864 |
| FAM13A | family with sequence similarity 13, member A | 0.0157098 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0156795 |
| DSTN | destrin (actin depolymerizing factor) | 0.0156266 |
| TPM4 | tropomyosin 4 | 0.0154289 |
| DDX41 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | 0.0154194 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0154167 |
| OPTN | optineurin | 0.0153774 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0153079 |
| CDC73 | cell division cycle 73 | 0.0152173 |
| CEP250 | centrosomal protein 250kDa | 0.0152011 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.198199 |
| NLGN1 | neuroligin 1 | -0.174974 |
| MT2A | metallothionein 2A | -0.151473 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.149799 |
| FMN1 | formin 1 | -0.138909 |
| LSAMP | limbic system-associated membrane protein | -0.130397 |
| NRG3 | neuregulin 3 | -0.110575 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.10935 |
| TMSB10 | thymosin beta 10 | -0.0974066 |
| VIM | vimentin | -0.0961801 |
| PTMA | prothymosin, alpha | -0.0681946 |
| RPLP1 | ribosomal protein, large, P1 | -0.0547669 |
| FRMD4A | FERM domain containing 4A | -0.0534202 |
| RPL23 | ribosomal protein L23 | -0.0520348 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0502871 |
| PGK1 | phosphoglycerate kinase 1 | -0.0485403 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.048059 |
| RPL35A | ribosomal protein L35a | -0.0447441 |
| RPLP2 | ribosomal protein, large, P2 | -0.0436389 |
| RPL12 | ribosomal protein L12 | -0.0420762 |
| RPS24 | ribosomal protein S24 | -0.0420593 |
| RPS21 | ribosomal protein S21 | -0.0420551 |
| RPL32 | ribosomal protein L32 | -0.0405242 |
| FHIT | fragile histidine triad | -0.0401287 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0395957 |
| SMYD3 | SET and MYND domain containing 3 | -0.0393334 |
| FTL | ferritin, light polypeptide | -0.0384236 |
| RPS6 | ribosomal protein S6 | -0.0371967 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0369991 |
| RPL34 | ribosomal protein L34 | -0.0360791 |
| MT1X | metallothionein 1X | -0.0359467 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.035307 |
| RPL38 | ribosomal protein L38 | -0.0349097 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0348469 |
| RPS23 | ribosomal protein S23 | -0.034121 |
| TNNC1 | troponin C type 1 (slow) | -0.0332774 |
| PRELID2 | PRELI domain containing 2 | -0.0325608 |
| RPS13 | ribosomal protein S13 | -0.031895 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0316356 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0316018 |
| RPS16 | ribosomal protein S16 | -0.0309064 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0303614 |
| RPL37A | ribosomal protein L37a | -0.0295068 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0288926 |
| FUS | FUS RNA binding protein | -0.0287881 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0284628 |
| RPL31 | ribosomal protein L31 | -0.0283496 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0280751 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0277698 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0273721 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0273561 |
| RAD51B | RAD51 paralog B | -0.027246 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0272175 |
| RPS29 | ribosomal protein S29 | -0.0271313 |
| GPHN | gephyrin | -0.0269344 |
| RPL36A | ribosomal protein L36a | -0.0269116 |
| RPS19 | ribosomal protein S19 | -0.0268709 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | -0.0264545 |
| EXOC4 | exocyst complex component 4 | -0.0258173 |
| SQSTM1 | sequestosome 1 | -0.0250099 |
| RPS12 | ribosomal protein S12 | -0.0249006 |
| RPL9 | ribosomal protein L9 | -0.0247325 |
| S100A9 | S100 calcium binding protein A9 | -0.0243507 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0241588 |
| CHD6 | chromodomain helicase DNA binding protein 6 | -0.0241194 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0240966 |
| PDE10A | phosphodiesterase 10A | -0.0240175 |
| CDH13 | cadherin 13 | -0.0239457 |
| RPS27A | ribosomal protein S27a | -0.0231908 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0225513 |
| HLA-B | major histocompatibility complex, class I, B | -0.0223876 |
| RPS14 | ribosomal protein S14 | -0.0222618 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0221864 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.022185 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0221688 |
| RPLP0 | ribosomal protein, large, P0 | -0.0219488 |
| RPL11 | ribosomal protein L11 | -0.0217946 |
| SBF2 | SET binding factor 2 | -0.0217327 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0215128 |
| RPL26 | ribosomal protein L26 | -0.0213172 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0209032 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0208273 |
| RPL19 | ribosomal protein L19 | -0.020819 |
| RPS8 | ribosomal protein S8 | -0.0205251 |
| CCND1 | cyclin D1 | -0.0205057 |
| RPL27A | ribosomal protein L27a | -0.0200743 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0200486 |
| GSTO1 | glutathione S-transferase omega 1 | -0.0200068 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0198491 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0197642 |
| RPL5 | ribosomal protein L5 | -0.0196561 |
| CA8 | carbonic anhydrase VIII | -0.0195016 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0194908 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0192706 |
| RPL28 | ribosomal protein L28 | -0.0191316 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0190314 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0189759 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.018969 |
| NHSL1 | NHS-like 1 | -0.018913 |
| RPL36 | ribosomal protein L36 | -0.018885 |
