Elagolix sodium_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Elagolix sodium perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Elagolix sodium_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0154767
HSPA8 heat shock 70kDa protein 8 0.0140685
PRRC2A proline-rich coiled-coil 2A 0.0134549
ANK2 ankyrin 2, neuronal 0.0129924
NAMPT nicotinamide phosphoribosyltransferase 0.0122916
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0120838
TFG TRK-fused gene 0.0116153
PLPP3 phospholipid phosphatase 3 0.0111603
ARRDC3 arrestin domain containing 3 0.0110117
HLA-C major histocompatibility complex, class I, C 0.0106036
PYGB phosphorylase, glycogen; brain 0.0105188
NBAS neuroblastoma amplified sequence 0.0104498
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0101114
RUNX1 runt-related transcription factor 1 0.0100998
SERGEF secretion regulating guanine nucleotide exchange factor 0.0099722
PLXNA1 plexin A1 0.00994337
SREBF2 sterol regulatory element binding transcription factor 2 0.00987612
CASC3 cancer susceptibility candidate 3 0.00952953
TMEM39A transmembrane protein 39A 0.00952939
TNRC6A trinucleotide repeat containing 6A 0.00932254
ADAM9 ADAM metallopeptidase domain 9 0.00917611
CEP250 centrosomal protein 250kDa 0.0090119
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.00895971
TRIM25 tripartite motif containing 25 0.00882976
KMT2E lysine (K)-specific methyltransferase 2E 0.008766
NCKAP1 NCK-associated protein 1 0.00869104
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 0.00867902
NUP58 nucleoporin 58 0.00837342
ZBTB10 zinc finger and BTB domain containing 10 0.00831065
SPRED2 sprouty-related, EVH1 domain containing 2 0.00811716
KDM3A lysine (K)-specific demethylase 3A 0.00798703
SAFB2 scaffold attachment factor B2 0.00798466
ANKRD36 ankyrin repeat domain 36 0.00773875
SRP54 signal recognition particle 54kDa 0.00767761
CORO1C coronin, actin binding protein, 1C 0.00766354
PTPRH protein tyrosine phosphatase, receptor type, H 0.00754451
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00752011
ELOVL5 ELOVL fatty acid elongase 5 0.00746096
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.00740742
PER1 period circadian clock 1 0.00736214
KDM1A lysine (K)-specific demethylase 1A 0.00735408
NCOR1 nuclear receptor corepressor 1 0.00722928
EIF4H eukaryotic translation initiation factor 4H 0.00722545
KLC1 kinesin light chain 1 0.00720685
TBC1D12 TBC1 domain family, member 12 0.00717906
CCAR2 cell cycle and apoptosis regulator 2 0.00714383
PRKN parkin RBR E3 ubiquitin protein ligase 0.00711673
NKD1 naked cuticle homolog 1 (Drosophila) 0.0070895
SEC24C SEC24 family member C 0.00707444
RLF rearranged L-myc fusion 0.0070734
SESN2 sestrin 2 0.00706097
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.00705072
ELP2 elongator acetyltransferase complex subunit 2 0.00705014
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 0.00704929
MTA1 metastasis associated 1 0.00699732
LPIN1 lipin 1 0.00694908
UNC5B unc-5 homolog B (C. elegans) 0.00692205
PANK3 pantothenate kinase 3 0.00691339
UBAP2L ubiquitin associated protein 2-like 0.00690671
TMCO3 transmembrane and coiled-coil domains 3 0.00679347
HOOK2 hook microtubule-tethering protein 2 0.00677946
TOP2B topoisomerase (DNA) II beta 180kDa 0.00676503
PRPF39 pre-mRNA processing factor 39 0.0067033
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.00669463
SMAD6 SMAD family member 6 0.00667757
ZNF292 zinc finger protein 292 0.00667469
MPRIP myosin phosphatase Rho interacting protein 0.00667424
BBS9 Bardet-Biedl syndrome 9 0.00665947
KDM5C lysine (K)-specific demethylase 5C 0.00665345
LENG8 leukocyte receptor cluster (LRC) member 8 0.00665164
RSRP1 arginine/serine-rich protein 1 0.00664995
FOXJ3 forkhead box J3 0.00664909
FXR1 fragile X mental retardation, autosomal homolog 1 0.0064655
YTHDC1 YTH domain containing 1 0.0064201
WDR11 WD repeat domain 11 0.0064197
KDM7A lysine (K)-specific demethylase 7A 0.00639687
ELL elongation factor RNA polymerase II 0.00639504
NXF1 nuclear RNA export factor 1 0.00636833
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 0.00636762
SREBF1 sterol regulatory element binding transcription factor 1 0.0063656
RHBDD1 rhomboid domain containing 1 0.00636342
RUSC2 RUN and SH3 domain containing 2 0.00635667
DENND5A DENN/MADD domain containing 5A 0.00635059
C18ORF25 chromosome 18 open reading frame 25 0.0063313
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.00630005
AGK acylglycerol kinase 0.00629189
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.00628804
PTBP2 polypyrimidine tract binding protein 2 0.00627997
SH3PXD2A SH3 and PX domains 2A 0.00626531
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.00625187
RNMT RNA (guanine-7-) methyltransferase 0.00623666
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.00623569
MBD5 methyl-CpG binding domain protein 5 0.00619197
AUH AU RNA binding protein/enoyl-CoA hydratase 0.00614467
FYN FYN proto-oncogene, Src family tyrosine kinase 0.00611419
PSAT1 phosphoserine aminotransferase 1 0.00609106
CLK4 CDC-like kinase 4 0.00605077
ZFC3H1 zinc finger, C3H1-type containing 0.00601341
AUTS2 autism susceptibility candidate 2 0.00597872
MTMR3 myotubularin related protein 3 0.00597439

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.355295
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.353577
PDE4B phosphodiesterase 4B, cAMP-specific -0.155843
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.140756
RPS6 ribosomal protein S6 -0.125416
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.114863
RPS8 ribosomal protein S8 -0.108581
TPT1 tumor protein, translationally-controlled 1 -0.107862
CPED1 cadherin-like and PC-esterase domain containing 1 -0.100158
PKM pyruvate kinase, muscle -0.0970721
VCL vinculin -0.0941855
FOXP1 forkhead box P1 -0.0900341
AHNAK AHNAK nucleoprotein -0.0753959
DLG1 discs, large homolog 1 (Drosophila) -0.0750266
BMP10 bone morphogenetic protein 10 -0.0745159
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0744978
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0711573
ARL4C ADP-ribosylation factor-like 4C -0.070747
ENO1 enolase 1, (alpha) -0.0666819
PDE4D phosphodiesterase 4D, cAMP-specific -0.0641868
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.063984
RPL35A ribosomal protein L35a -0.0626453
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0623013
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0602031
SOX6 SRY (sex determining region Y)-box 6 -0.0599212
HSPB1 heat shock 27kDa protein 1 -0.059503
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0580611
TJP1 tight junction protein 1 -0.0560346
RPLP1 ribosomal protein, large, P1 -0.0552825
TMSB4X thymosin beta 4, X-linked -0.0552121
RPL19 ribosomal protein L19 -0.0533726
MKI67 marker of proliferation Ki-67 -0.0523207
NBEA neurobeachin -0.0522322
RPL34 ribosomal protein L34 -0.0520194
RPL12 ribosomal protein L12 -0.0510011
RPS19 ribosomal protein S19 -0.0496871
RPS23 ribosomal protein S23 -0.0482434
RPLP2 ribosomal protein, large, P2 -0.0482205
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0476518
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0474612
RPL31 ribosomal protein L31 -0.0473812
CCND1 cyclin D1 -0.0469568
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0467857
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0462735
RPL23 ribosomal protein L23 -0.0454265
RPL7A ribosomal protein L7a -0.0454146
RPS13 ribosomal protein S13 -0.0449361
S100A4 S100 calcium binding protein A4 -0.0448409
RPL26 ribosomal protein L26 -0.0444929
NPAS2 neuronal PAS domain protein 2 -0.0443268
RPS25 ribosomal protein S25 -0.0439644
ACTG1 actin gamma 1 -0.0433113
SLC38A2 solute carrier family 38, member 2 -0.0424099
HDAC9 histone deacetylase 9 -0.0422554
RPL37A ribosomal protein L37a -0.0422193
PFN1 profilin 1 -0.0416847
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0411635
DIAPH3 diaphanous-related formin 3 -0.0404485
SSBP2 single-stranded DNA binding protein 2 -0.0403278
RPLP0 ribosomal protein, large, P0 -0.0401779
POTEF POTE ankyrin domain family, member F -0.0399476
NAP1L1 nucleosome assembly protein 1-like 1 -0.0388337
RPL32 ribosomal protein L32 -0.0382855
EBNA1BP2 EBNA1 binding protein 2 -0.0381919
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0379525
TPI1 triosephosphate isomerase 1 -0.0372987
DPYD dihydropyrimidine dehydrogenase -0.037178
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.03678
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0364152
ANXA1 annexin A1 -0.0356531
CAMKMT calmodulin-lysine N-methyltransferase -0.035264
MYL12B myosin, light chain 12B, regulatory -0.0351968
S100A10 S100 calcium binding protein A10 -0.0346375
RPS27A ribosomal protein S27a -0.0343847
RPS24 ribosomal protein S24 -0.0339994
RPL9 ribosomal protein L9 -0.0337519
S100A6 S100 calcium binding protein A6 -0.0335181
RPS3 ribosomal protein S3 -0.0334903
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0333219
KPNB1 karyopherin (importin) beta 1 -0.033309
RPL5 ribosomal protein L5 -0.0330188
RPS11 ribosomal protein S11 -0.0326472
RPS14 ribosomal protein S14 -0.0323115
RPL11 ribosomal protein L11 -0.0322835
RPS16 ribosomal protein S16 -0.0316931
LDHA lactate dehydrogenase A -0.0315798
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0314161
TPM4 tropomyosin 4 -0.0311482
SMC4 structural maintenance of chromosomes 4 -0.0310433
S100A9 S100 calcium binding protein A9 -0.031018
RHOA ras homolog family member A -0.030164
LOC102724023 ES1 protein homolog, mitochondrial -0.0300743
RPL8 ribosomal protein L8 -0.0300677
RPS21 ribosomal protein S21 -0.0297628
TUBA1B tubulin, alpha 1b -0.0296084
GPHN gephyrin -0.0293855
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0293047
RPS17 ribosomal protein S17 -0.0289383
ZMYND8 zinc finger, MYND-type containing 8 -0.028565
CUX1 cut-like homeobox 1 -0.0285314