Elagolix sodium_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Elagolix sodium perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Elagolix sodium_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GLIS3 GLIS family zinc finger 3 0.0647111
IGFBP3 insulin-like growth factor binding protein 3 0.0638694
HLA-C major histocompatibility complex, class I, C 0.0545579
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.052123
HMGA2 high mobility group AT-hook 2 0.0505612
INTS6 integrator complex subunit 6 0.0498085
HDAC9 histone deacetylase 9 0.0437809
FTH1 ferritin, heavy polypeptide 1 0.0402672
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0393127
ZMIZ1 zinc finger, MIZ-type containing 1 0.0393012
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0358141
COL6A3 collagen, type VI, alpha 3 0.0305104
EPAS1 endothelial PAS domain protein 1 0.030172
LOC112694756 uncharaterized LOC112694756 0.0300935
FLNA filamin A, alpha 0.0256201
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.024281
TMEM132D transmembrane protein 132D 0.0241287
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0240644
CDH13 cadherin 13 0.0237952
RNF213 ring finger protein 213 0.0223466
EEF2 eukaryotic translation elongation factor 2 0.0213487
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0209246
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0209141
EIF4H eukaryotic translation initiation factor 4H 0.0208758
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0200706
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0200013
ARHGAP22 Rho GTPase activating protein 22 0.0191455
SQSTM1 sequestosome 1 0.0189792
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0186537
UBASH3B ubiquitin associated and SH3 domain containing B 0.0178656
CEP250 centrosomal protein 250kDa 0.0176566
ATXN1 ataxin 1 0.0171707
MACF1 microtubule-actin crosslinking factor 1 0.0171435
THBS2 thrombospondin 2 0.0165338
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.016529
COL5A1 collagen, type V, alpha 1 0.0162534
PTH2R parathyroid hormone 2 receptor 0.0162296
ZDHHC14 zinc finger, DHHC-type containing 14 0.0157587
COL27A1 collagen, type XXVII, alpha 1 0.0157174
GTPBP2 GTP binding protein 2 0.0156822
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0156083
SAMD3 sterile alpha motif domain containing 3 0.0155201
PDLIM5 PDZ and LIM domain 5 0.0154822
COL4A2 collagen, type IV, alpha 2 0.0150499
MLPH melanophilin 0.0150253
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0149871
NCOR2 nuclear receptor corepressor 2 0.0148114
TLE4 transducin-like enhancer of split 4 0.0148074
EGFR epidermal growth factor receptor 0.014507
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0140384
IGF1R insulin-like growth factor 1 receptor 0.0139129
SRRM2 serine/arginine repetitive matrix 2 0.0138057
DUSP10 dual specificity phosphatase 10 0.0137855
FBXL7 F-box and leucine-rich repeat protein 7 0.0134736
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0134584
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0134459
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.0133372
VAC14 Vac14 homolog (S. cerevisiae) 0.0133128
PLEC plectin 0.0130775
VEGFA vascular endothelial growth factor A 0.0128448
ZHX2 zinc fingers and homeoboxes 2 0.0125048
TUT7 terminal uridylyl transferase 7 0.012502
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0124874
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 0.0124768
TBX3 T-box 3 0.0123939
NTN4 netrin 4 0.01221
FAT1 FAT atypical cadherin 1 0.0121165
NGF nerve growth factor (beta polypeptide) 0.012049
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0118005
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0117664
ZSWIM6 zinc finger, SWIM-type containing 6 0.0116164
CLSTN2 calsyntenin 2 0.0116004
FLRT2 fibronectin leucine rich transmembrane protein 2 0.011521
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.011464
ZNF841 zinc finger protein 841 0.0114636
KLHL29 kelch-like family member 29 0.0113746
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0113651
HOMER1 homer scaffolding protein 1 0.011365
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0113112
BICC1 BicC family RNA binding protein 1 0.0112863
ABTB3 ankyrin repeat and BTB domain containing 3 0.0111983
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0111835
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0111634
ZBTB38 zinc finger and BTB domain containing 38 0.0111469
WDR27 WD repeat domain 27 0.0111367
GMDS GDP-mannose 4,6-dehydratase 0.0111363
FAM20C family with sequence similarity 20, member C 0.0111169
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0110953
THSD4 thrombospondin, type I, domain containing 4 0.0110234
PRELID2 PRELI domain containing 2 0.0109614
SH2B3 SH2B adaptor protein 3 0.0109068
EFNA5 ephrin-A5 0.0108948
UBAP2L ubiquitin associated protein 2-like 0.0108855
CMIP c-Maf inducing protein 0.0107983
CEMIP cell migration inducing protein, hyaluronan binding 0.0107718
CEMIP2 cell migration inducing hyaluronidase 2 0.0107264
GPC6 glypican 6 0.010723
NPAS2 neuronal PAS domain protein 2 0.0104502
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0104379
AHNAK2 AHNAK nucleoprotein 2 0.0104044

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.228589
NAMPT nicotinamide phosphoribosyltransferase -0.183545
VIM vimentin -0.181532
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.163018
HLA-B major histocompatibility complex, class I, B -0.13819
RPS6 ribosomal protein S6 -0.106792
ELL2 elongation factor, RNA polymerase II, 2 -0.10522
TMSB10 thymosin beta 10 -0.0957883
PTMA prothymosin, alpha -0.0903416
UGCG UDP-glucose ceramide glucosyltransferase -0.0858586
FTL ferritin, light polypeptide -0.0834156
SOD2 superoxide dismutase 2, mitochondrial -0.0782636
B2M beta-2-microglobulin -0.0779834
CD44 CD44 molecule (Indian blood group) -0.0768517
FNDC3B fibronectin type III domain containing 3B -0.0743469
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0723315
PGK1 phosphoglycerate kinase 1 -0.0686028
TPT1 tumor protein, translationally-controlled 1 -0.0669192
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0644328
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0643388
MT2A metallothionein 2A -0.0629349
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0610692
RPLP2 ribosomal protein, large, P2 -0.0603021
RPS24 ribosomal protein S24 -0.058221
RPS12 ribosomal protein S12 -0.0570877
SPAG9 sperm associated antigen 9 -0.0570409
RPL23 ribosomal protein L23 -0.0561024
ZNF292 zinc finger protein 292 -0.0554259
RPS8 ribosomal protein S8 -0.0525332
GOLGA4 golgin A4 -0.0517209
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0489154
RPS23 ribosomal protein S23 -0.0485178
ADM adrenomedullin -0.0479623
UBC ubiquitin C -0.0470758
MYH9 myosin, heavy chain 9, non-muscle -0.0465901
RTN4 reticulon 4 -0.0460629
RPL36A ribosomal protein L36a -0.0459141
RPS2 ribosomal protein S2 -0.0451353
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0442389
IER3 immediate early response 3 -0.0435847
FRMD4A FERM domain containing 4A -0.0433531
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0429792
RBM39 RNA binding motif protein 39 -0.042784
EIF1 eukaryotic translation initiation factor 1 -0.0423119
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0416181
RB1CC1 RB1-inducible coiled-coil 1 -0.0414352
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0413997
OGA O-GlcNAcase -0.0411517
RPL19 ribosomal protein L19 -0.0409718
RPL37A ribosomal protein L37a -0.0409155
MSN moesin -0.0399403
ICAM1 intercellular adhesion molecule 1 -0.0399037
RPL26 ribosomal protein L26 -0.0397147
SFTPA2 surfactant protein A2 -0.039604
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0394709
RPL5 ribosomal protein L5 -0.0391405
LAMP2 lysosomal-associated membrane protein 2 -0.0388075
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.038699
CDCP1 CUB domain containing protein 1 -0.0385684
CADM1 cell adhesion molecule 1 -0.0381927
SBF2 SET binding factor 2 -0.0375793
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0374199
PKM pyruvate kinase, muscle -0.0373952
ANLN anillin, actin binding protein -0.0371127
BASP1 brain abundant, membrane attached signal protein 1 -0.0369945
JMJD1C jumonji domain containing 1C -0.0368002
RPL11 ribosomal protein L11 -0.0367367
RPL32 ribosomal protein L32 -0.0367056
RPS19 ribosomal protein S19 -0.0366105
TPM4 tropomyosin 4 -0.0362331
NAP1L1 nucleosome assembly protein 1-like 1 -0.0360268
RPS21 ribosomal protein S21 -0.0359375
RPS13 ribosomal protein S13 -0.0359129
RPLP1 ribosomal protein, large, P1 -0.0349664
RPL9 ribosomal protein L9 -0.0346306
MKI67 marker of proliferation Ki-67 -0.0339936
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0334496
TENT5A terminal nucleotidyltransferase 5A -0.0331451
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0330591
CCNL1 cyclin L1 -0.0327396
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0327235
RPS3 ribosomal protein S3 -0.0326938
WSB1 WD repeat and SOCS box containing 1 -0.032316
SETD5 SET domain containing 5 -0.0322521
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0322502
SYAP1 synapse associated protein 1 -0.0320896
ENO1 enolase 1, (alpha) -0.0319117
GNAS GNAS complex locus -0.0318965
TGFBI transforming growth factor, beta-induced, 68kDa -0.0316098
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0315769
MAP4 microtubule-associated protein 4 -0.0315701
ATP13A3 ATPase type 13A3 -0.0314516
RPS27A ribosomal protein S27a -0.0313229
ZMYND8 zinc finger, MYND-type containing 8 -0.0313178
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0311507
LDHA lactate dehydrogenase A -0.03115
S100A9 S100 calcium binding protein A9 -0.0311101
PCBP2 poly(rC) binding protein 2 -0.0309664
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0309338
RPL12 ribosomal protein L12 -0.0308413