Elagolix sodium_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Elagolix sodium perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Elagolix sodium_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.148842
NDRG1 N-myc downstream regulated 1 0.114192
FTH1 ferritin, heavy polypeptide 1 0.107341
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.074792
COL6A3 collagen, type VI, alpha 3 0.0610073
LOC112694756 uncharaterized LOC112694756 0.058369
BHLHE40 basic helix-loop-helix family, member e40 0.0562265
B2M beta-2-microglobulin 0.0467699
INTS6 integrator complex subunit 6 0.0460631
POTEF POTE ankyrin domain family, member F 0.0456709
SYNPO synaptopodin 0.0447141
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0437824
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0434353
VEGFA vascular endothelial growth factor A 0.0424893
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.042268
GPBP1 GC-rich promoter binding protein 1 0.041449
ENO1 enolase 1, (alpha) 0.0408739
ARRDC3 arrestin domain containing 3 0.0405711
MYLK myosin light chain kinase 0.0402212
ADM adrenomedullin 0.0385199
HILPDA hypoxia inducible lipid droplet-associated 0.0373918
ACTG1 actin gamma 1 0.0372376
ANKRD37 ankyrin repeat domain 37 0.0370968
ZSWIM6 zinc finger, SWIM-type containing 6 0.0369633
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0366489
KYNU kynureninase 0.0366024
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0351443
ECE1 endothelin converting enzyme 1 0.0347068
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0345091
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0344965
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0339262
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0337419
HLA-A major histocompatibility complex, class I, A 0.033638
USP37 ubiquitin specific peptidase 37 0.03354
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0324841
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0320512
TPI1 triosephosphate isomerase 1 0.0308451
ZNF292 zinc finger protein 292 0.03079
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0303743
FNDC3A fibronectin type III domain containing 3A 0.0302098
CCNL1 cyclin L1 0.0302089
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0300565
SMTN smoothelin 0.0298887
KMT2E lysine (K)-specific methyltransferase 2E 0.0297854
PFN1 profilin 1 0.0295825
TAPBP TAP binding protein (tapasin) 0.0294829
PCBP2 poly(rC) binding protein 2 0.0293529
HSPA8 heat shock 70kDa protein 8 0.0293411
FSTL1 follistatin-like 1 0.0288038
EEF2 eukaryotic translation elongation factor 2 0.0286269
UGCG UDP-glucose ceramide glucosyltransferase 0.0285575
CD109 CD109 molecule 0.0285484
MCTP1 multiple C2 domains, transmembrane 1 0.0282035
LOC102724023 ES1 protein homolog, mitochondrial 0.0278027
LOX lysyl oxidase 0.027694
MACF1 microtubule-actin crosslinking factor 1 0.0276936
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 0.0276784
PDIA3 protein disulfide isomerase family A, member 3 0.0275364
CMIP c-Maf inducing protein 0.0274907
FN1 fibronectin 1 0.0272183
SEC61G Sec61 gamma subunit 0.0271989
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0271851
TMEM51 transmembrane protein 51 0.027125
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0269708
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0267307
STC1 stanniocalcin 1 0.026563
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0265043
COPA coatomer protein complex, subunit alpha 0.0263785
ZNF395 zinc finger protein 395 0.0259513
SEC31A SEC31 homolog A (S. cerevisiae) 0.0258504
ZNF638 zinc finger protein 638 0.0256618
SBF2 SET binding factor 2 0.0253345
MYDGF myeloid-derived growth factor 0.0250581
INSIG2 insulin induced gene 2 0.0250255
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0248738
PTGES2 prostaglandin E synthase 2 0.0246064
LMO7 LIM domain 7 0.0244669
ZNF451 zinc finger protein 451 0.0244155
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0241774
ZMIZ1 zinc finger, MIZ-type containing 1 0.0241713
GRID1 glutamate receptor, ionotropic, delta 1 0.0241521
POFUT2 protein O-fucosyltransferase 2 0.0241441
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0240913
SUN1 Sad1 and UNC84 domain containing 1 0.0236687
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.0236606
YBX1 Y box binding protein 1 0.023618
MPZL1 myelin protein zero-like 1 0.0235659
IRAK2 interleukin-1 receptor-associated kinase 2 0.0234708
UBN2 ubinuclein 2 0.0234185
TLN1 talin 1 0.0234062
EXOC4 exocyst complex component 4 0.0233477
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0232035
COL6A1 collagen, type VI, alpha 1 0.0231383
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0228611
TIMP2 TIMP metallopeptidase inhibitor 2 0.0228439
SSBP3 single stranded DNA binding protein 3 0.0228
H2AC6 H2A clustered histone 6 0.0225984
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0225708
TNRC6A trinucleotide repeat containing 6A 0.0225464
FOCAD focadhesin 0.0225189

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.214301
HLA-B major histocompatibility complex, class I, B -0.0997377
TMSB10 thymosin beta 10 -0.0775554
COL1A2 collagen, type I, alpha 2 -0.074667
MT2A metallothionein 2A -0.0737457
TRIO trio Rho guanine nucleotide exchange factor -0.0734037
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0726567
CALD1 caldesmon 1 -0.0715977
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0701287
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0691901
TENT5A terminal nucleotidyltransferase 5A -0.0686
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0654705
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0649182
WSB1 WD repeat and SOCS box containing 1 -0.0646955
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0640506
PRELID2 PRELI domain containing 2 -0.0623613
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0588211
NAMPT nicotinamide phosphoribosyltransferase -0.0563938
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0560862
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0516454
TPT1 tumor protein, translationally-controlled 1 -0.0512255
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0497992
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0491426
ELL2 elongation factor, RNA polymerase II, 2 -0.0476209
ZMYND8 zinc finger, MYND-type containing 8 -0.0469615
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0468451
MT1X metallothionein 1X -0.0466133
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0461754
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0448722
ZBTB20 zinc finger and BTB domain containing 20 -0.0441618
AKAP9 A kinase (PRKA) anchor protein 9 -0.044052
CALU calumenin -0.0435562
ZFAND3 zinc finger, AN1-type domain 3 -0.0429987
VCL vinculin -0.042482
ATP13A3 ATPase type 13A3 -0.0421905
EIF1 eukaryotic translation initiation factor 1 -0.0414873
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0414641
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0412801
PDIA5 protein disulfide isomerase family A, member 5 -0.0407248
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0406086
DYM dymeclin -0.0399104
SOD2 superoxide dismutase 2, mitochondrial -0.039026
INHBA inhibin, beta A -0.0390203
TGFBI transforming growth factor, beta-induced, 68kDa -0.0387551
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0382498
SEPTIN2 septin 2 -0.0380714
GCC2 GRIP and coiled-coil domain containing 2 -0.037792
IARS1 isoleucyl-tRNA synthetase 1 -0.0360318
ARF4 ADP-ribosylation factor 4 -0.0356502
KMT2C lysine (K)-specific methyltransferase 2C -0.0354999
AVL9 AVL9 homolog (S. cerevisiase) -0.034739
ABLIM3 actin binding LIM protein family, member 3 -0.0343427
EGR1 early growth response 1 -0.0341468
MYOF myoferlin -0.0332039
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0331645
OGA O-GlcNAcase -0.032861
SDC4 syndecan 4 -0.0327327
UBC ubiquitin C -0.0325751
CDH13 cadherin 13 -0.0324039
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0322084
AUTS2 autism susceptibility candidate 2 -0.0319904
TPST1 tyrosylprotein sulfotransferase 1 -0.0319821
TPM4 tropomyosin 4 -0.0317413
RAI1 retinoic acid induced 1 -0.0315438
PHKB phosphorylase kinase, beta -0.0313947
NKTR natural killer cell triggering receptor -0.0313216
RPS6 ribosomal protein S6 -0.0311854
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0311385
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0310314
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0306684
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -0.0305272
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0303579
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0303309
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0302029
UBE2H ubiquitin-conjugating enzyme E2H -0.0299755
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0297696
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0293528
ZEB1 zinc finger E-box binding homeobox 1 -0.0293067
USP34 ubiquitin specific peptidase 34 -0.0292493
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0291684
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0291282
MAP4 microtubule-associated protein 4 -0.0290517
GOLGA4 golgin A4 -0.0289746
WTAP Wilms tumor 1 associated protein -0.0288677
CD2AP CD2-associated protein -0.0287728
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0282769
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0281882
FNIP1 folliculin interacting protein 1 -0.0281329
MARCHF6 membrane associated ring-CH-type finger 6 -0.0280982
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0280868
THRAP3 thyroid hormone receptor associated protein 3 -0.0280789
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0280675
KDM3A lysine (K)-specific demethylase 3A -0.0280036
TSPAN5 tetraspanin 5 -0.0279982
FAM20C family with sequence similarity 20, member C -0.0279006
HMBOX1 homeobox containing 1 -0.0278781
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.027717
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0275946
PSD3 pleckstrin and Sec7 domain containing 3 -0.0274299
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.0272632