Elagolix sodium_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Elagolix sodium perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Elagolix sodium_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.0475834
VEGFA vascular endothelial growth factor A 0.046701
STC2 stanniocalcin 2 0.046317
MRPS6 mitochondrial ribosomal protein S6 0.0422279
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0337365
RAI14 retinoic acid induced 14 0.0296377
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0279157
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0273248
HILPDA hypoxia inducible lipid droplet-associated 0.0271237
ZFP36L1 ZFP36 ring finger protein-like 1 0.0267165
IGFBP3 insulin-like growth factor binding protein 3 0.0222552
NDRG1 N-myc downstream regulated 1 0.0222282
CD109 CD109 molecule 0.0214743
ZCCHC7 zinc finger, CCHC domain containing 7 0.0202561
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0200073
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0196973
DDIT4 DNA-damage-inducible transcript 4 0.019558
PLIN2 perilipin 2 0.0194334
TTC3 tetratricopeptide repeat domain 3 0.017927
TMEM165 transmembrane protein 165 0.0173367
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0172273
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.016962
HLA-C major histocompatibility complex, class I, C 0.0167092
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0160234
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0153984
PIM3 Pim-3 proto-oncogene, serine/threonine kinase 0.0152951
FBN1 fibrillin 1 0.0151618
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0147952
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0146252
SRRM2 serine/arginine repetitive matrix 2 0.0143787
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 0.01427
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0140898
PLEC plectin 0.014063
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0139583
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0139408
MCL1 myeloid cell leukemia 1 0.0136181
IL6 interleukin 6 0.0136085
HDGF hepatoma-derived growth factor 0.0135033
LIMCH1 LIM and calponin homology domains 1 0.0132958
AKAP12 A kinase (PRKA) anchor protein 12 0.0130572
SRP54 signal recognition particle 54kDa 0.0126575
ESYT2 extended synaptotagmin-like protein 2 0.0124438
FAM193B family with sequence similarity 193, member B 0.0123502
VAC14 Vac14 homolog (S. cerevisiae) 0.0122161
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0121947
INTS6 integrator complex subunit 6 0.0121547
AKAP9 A kinase (PRKA) anchor protein 9 0.0114203
UBN2 ubinuclein 2 0.0114138
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0113467
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0112899
CALR calreticulin 0.0111212
ZMIZ1 zinc finger, MIZ-type containing 1 0.010821
RAB6A RAB6A, member RAS oncogene family 0.010695
BRD2 bromodomain containing 2 0.0106618
COG6 component of oligomeric golgi complex 6 0.0102847
GPR176 G protein-coupled receptor 176 0.0101852
TMF1 TATA element modulatory factor 1 0.0101543
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 0.0101392
CEMIP cell migration inducing protein, hyaluronan binding 0.00987079
RNMT RNA (guanine-7-) methyltransferase 0.00984884
MINDY2 MINDY lysine 48 deubiquitinase 2 0.00970475
SIRT1 sirtuin 1 0.00962112
MAX MYC associated factor X 0.00951841
TNRC6C trinucleotide repeat containing 6C 0.00946649
RNF145 ring finger protein 145 0.00941805
PKP2 plakophilin 2 0.00939758
NOTCH2 notch 2 0.00924635
USP8 ubiquitin specific peptidase 8 0.00919805
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.00916308
TTC19 tetratricopeptide repeat domain 19 0.00910338
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.0089997
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.00898224
HLA-E major histocompatibility complex, class I, E 0.00881074
COPS8 COP9 signalosome subunit 8 0.00879173
KAZN kazrin, periplakin interacting protein 0.00871946
EPAS1 endothelial PAS domain protein 1 0.00870112
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0086901
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0086491
GMCL1 germ cell-less, spermatogenesis associated 1 0.00864393
SCFD2 sec1 family domain containing 2 0.00861659
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.00860577
POM121C POM121 transmembrane nucleoporin C 0.00859852
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.00857355
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.00855472
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.00848001
CXCL2 chemokine (C-X-C motif) ligand 2 0.00841694
ACADVL acyl-CoA dehydrogenase, very long chain 0.00839679
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.00837758
AOPEP aminopeptidase O (putative) 0.00835137
MKRN1 makorin ring finger protein 1 0.00830657
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.00827605
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.00823469
CRTAC1 cartilage acidic protein 1 0.00816953
PALLD palladin, cytoskeletal associated protein 0.00816
CTBP2 C-terminal binding protein 2 0.00814968
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.00806512
SOD2 superoxide dismutase 2, mitochondrial 0.00806427
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.00806342
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.00800755
RNF217 ring finger protein 217 0.00797501

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.268732
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.268122
NAMPT nicotinamide phosphoribosyltransferase -0.128652
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.127395
ASPH aspartate beta-hydroxylase -0.120334
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.113834
FNDC3B fibronectin type III domain containing 3B -0.0980665
ITGA1 integrin, alpha 1 -0.0892074
OSMR oncostatin M receptor -0.0792215
TMEM156 transmembrane protein 156 -0.0767044
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0742037
MT2A metallothionein 2A -0.070214
EXT1 exostosin glycosyltransferase 1 -0.0693764
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0684283
SQSTM1 sequestosome 1 -0.0626032
CANX calnexin -0.0619708
HLA-B major histocompatibility complex, class I, B -0.0595552
GLIS3 GLIS family zinc finger 3 -0.0585548
SYT1 synaptotagmin I -0.0583629
FN1 fibronectin 1 -0.05825
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0573449
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0559109
HMGA2 high mobility group AT-hook 2 -0.0558724
VIM vimentin -0.0558704
STAT1 signal transducer and activator of transcription 1, 91kDa -0.055579
RPL26 ribosomal protein L26 -0.0541439
CD44 CD44 molecule (Indian blood group) -0.0535892
SMYD3 SET and MYND domain containing 3 -0.0528875
VCL vinculin -0.0519691
CENPF centromere protein F, 350/400kDa -0.0519152
ETV1 ets variant 1 -0.0478092
MAP1B microtubule-associated protein 1B -0.0466978
FNBP1 formin binding protein 1 -0.0463613
PELO pelota homolog (Drosophila) -0.0463181
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0459331
TOP1 topoisomerase (DNA) I -0.0451566
PTK2 protein tyrosine kinase 2 -0.043509
TPT1 tumor protein, translationally-controlled 1 -0.0434136
RPL23 ribosomal protein L23 -0.0432002
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0429223
IFI16 interferon, gamma-inducible protein 16 -0.0427656
MCTP2 multiple C2 domains, transmembrane 2 -0.0426913
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0426859
TMSB10 thymosin beta 10 -0.0426599
IFI27 interferon, alpha-inducible protein 27 -0.0426509
NRP1 neuropilin 1 -0.042348
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0422125
RPL9 ribosomal protein L9 -0.0416532
EREG epiregulin -0.041443
ENO1 enolase 1, (alpha) -0.0411863
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.040779
RPS24 ribosomal protein S24 -0.0405058
FOXP1 forkhead box P1 -0.0401375
NAP1L1 nucleosome assembly protein 1-like 1 -0.0396161
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0392704
PRRC2C proline-rich coiled-coil 2C -0.0389164
OGA O-GlcNAcase -0.0378671
MBD5 methyl-CpG binding domain protein 5 -0.0374825
ATXN1 ataxin 1 -0.0374369
ZNF292 zinc finger protein 292 -0.0369961
MKI67 marker of proliferation Ki-67 -0.036698
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0366921
TPI1 triosephosphate isomerase 1 -0.0365639
KLHL5 kelch-like family member 5 -0.0363943
SPRED2 sprouty-related, EVH1 domain containing 2 -0.036385
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0363708
S100A6 S100 calcium binding protein A6 -0.0363229
RBM39 RNA binding motif protein 39 -0.0362859
DST dystonin -0.0355355
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0355246
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0353408
ETV6 ets variant 6 -0.0352608
PKM pyruvate kinase, muscle -0.0347362
CAB39 calcium binding protein 39 -0.0346152
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0341204
TRIO trio Rho guanine nucleotide exchange factor -0.0331282
ELL2 elongation factor, RNA polymerase II, 2 -0.0329854
SMAD3 SMAD family member 3 -0.0329788
NRG1 neuregulin 1 -0.0329482
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0327921
ACTN4 actinin, alpha 4 -0.0326182
TAS2R14 taste receptor, type 2, member 14 -0.0325939
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0325768
SVIL supervillin -0.0325125
RPS21 ribosomal protein S21 -0.0322581
RPL12 ribosomal protein L12 -0.031933
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0313775
PDE4D phosphodiesterase 4D, cAMP-specific -0.0312848
PGK1 phosphoglycerate kinase 1 -0.0311871
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.031121
ZBTB20 zinc finger and BTB domain containing 20 -0.0310416
LRMDA leucine rich melanocyte differentiation associated -0.0308907
RPL35A ribosomal protein L35a -0.0308
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0306904
RRBP1 ribosome binding protein 1 -0.0302428
IL6ST interleukin 6 signal transducer -0.0294398
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0293911
TGFA transforming growth factor, alpha -0.0291043
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0289469
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0288166