| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elagolix sodium perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Elagolix sodium_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLEC | plectin | 0.0303964 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0249686 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0243253 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0200256 |
| RPS12 | ribosomal protein S12 | 0.0197346 |
| FLNA | filamin A, alpha | 0.0188822 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0177129 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0161868 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0152126 |
| RPL3 | ribosomal protein L3 | 0.0139108 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0131023 |
| INTS6 | integrator complex subunit 6 | 0.0126148 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.012261 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0115747 |
| BRD2 | bromodomain containing 2 | 0.0114051 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0111426 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0111406 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0110104 |
| TNS4 | tensin 4 | 0.0109952 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.010916 |
| AMOTL2 | angiomotin like 2 | 0.010813 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.0106832 |
| ARRDC3 | arrestin domain containing 3 | 0.0105848 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | 0.0104024 |
| EGFR | epidermal growth factor receptor | 0.0102432 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0101689 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0101279 |
| DCUN1D3 | DCN1, defective in cullin neddylation 1, domain containing 3 | 0.00979776 |
| CEP250 | centrosomal protein 250kDa | 0.00973596 |
| RUNX1 | runt-related transcription factor 1 | 0.00938658 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.00935614 |
| TPM3 | tropomyosin 3 | 0.00931691 |
| PABPC1L | poly(A) binding protein, cytoplasmic 1-like | 0.00921163 |
| HLA-C | major histocompatibility complex, class I, C | 0.00920849 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.00896002 |
| PCM1 | pericentriolar material 1 | 0.0088894 |
| HYOU1 | hypoxia up-regulated 1 | 0.00878944 |
| NOS1AP | nitric oxide synthase 1 (neuronal) adaptor protein | 0.00877525 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.00864781 |
| RPS26 | ribosomal protein S26 | 0.00858169 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.00854169 |
| FOSL1 | FOS-like antigen 1 | 0.00852106 |
| DOCK5 | dedicator of cytokinesis 5 | 0.00848435 |
| CABIN1 | calcineurin binding protein 1 | 0.00836472 |
| PRSS22 | protease, serine, 22 | 0.00833859 |
| SMTN | smoothelin | 0.00831709 |
| SSBP3 | single stranded DNA binding protein 3 | 0.00823813 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.00818922 |
| VEGFA | vascular endothelial growth factor A | 0.00810038 |
| CYP2S1 | cytochrome P450, family 2, subfamily S, polypeptide 1 | 0.00808441 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.00797695 |
| CTNNBL1 | catenin, beta like 1 | 0.00793065 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.00783718 |
| PHRF1 | PHD and ring finger domains 1 | 0.00783588 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.00782113 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.00778279 |
| DOCK4 | dedicator of cytokinesis 4 | 0.00771807 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.00749683 |
| SMAD3 | SMAD family member 3 | 0.00748886 |
| PNN | pinin, desmosome associated protein | 0.00745235 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.00732668 |
| SFPQ | splicing factor proline/glutamine-rich | 0.00719786 |
| IRS2 | insulin receptor substrate 2 | 0.00710457 |
| PTK2B | protein tyrosine kinase 2 beta | 0.00707799 |
| HOXA3 | homeobox A3 | 0.00698444 |
| FOSL2 | FOS-like antigen 2 | 0.00695281 |
| SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | 0.00691889 |
| NXF1 | nuclear RNA export factor 1 | 0.00688854 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.00685212 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.00678657 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.00675321 |
| CDK5RAP3 | CDK5 regulatory subunit associated protein 3 | 0.00672059 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.00667924 |
| BSN | bassoon presynaptic cytomatrix protein | 0.00661122 |
| PGM3 | phosphoglucomutase 3 | 0.00659261 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.00658962 |
| FAM91A1 | family with sequence similarity 91, member A1 | 0.0065437 |
| PLXNA3 | plexin A3 | 0.00654261 |
| CNNM4 | cyclin and CBS domain divalent metal cation transport mediator 4 | 0.006531 |
| TAF4 | TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa | 0.00650032 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.00649562 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.00645254 |
| MYO18A | myosin XVIIIA | 0.00638465 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.00635079 |
| DNMBP | dynamin binding protein | 0.00631504 |
| SESN3 | sestrin 3 | 0.0063025 |
| PCDH1 | protocadherin 1 | 0.0062554 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | 0.00624091 |
| HEBP2 | heme binding protein 2 | 0.00622541 |
| CNOT3 | CCR4-NOT transcription complex, subunit 3 | 0.00622248 |
| BTBD10 | BTB (POZ) domain containing 10 | 0.00617424 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.00615058 |
| EPHA2 | EPH receptor A2 | 0.00613642 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.00613519 |
| MPZL3 | myelin protein zero-like 3 | 0.00612018 |
| EFNA5 | ephrin-A5 | 0.00611648 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.00609053 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.00604204 |
| STRN4 | striatin, calmodulin binding protein 4 | 0.00603836 |
| PRPF8 | pre-mRNA processing factor 8 | 0.00598614 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.308389 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.198412 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.130252 |
| FTL | ferritin, light polypeptide | -0.121227 |
| KRT8 | keratin 8, type II | -0.11179 |
| TMSB10 | thymosin beta 10 | -0.106131 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0970832 |
| KRT18 | keratin 18, type I | -0.0818461 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0789773 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0747792 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0732745 |
| RPS6 | ribosomal protein S6 | -0.070393 |
| EPCAM | epithelial cell adhesion molecule | -0.0664724 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0633487 |
| TMEM123 | transmembrane protein 123 | -0.0621737 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0560411 |
| RPS24 | ribosomal protein S24 | -0.0540333 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0537264 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0525144 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0524529 |
| RPS21 | ribosomal protein S21 | -0.052182 |
| AHNAK | AHNAK nucleoprotein | -0.0521722 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0520131 |
| IER3 | immediate early response 3 | -0.0519109 |
| RPLP1 | ribosomal protein, large, P1 | -0.051134 |
| RPL35A | ribosomal protein L35a | -0.0507 |
| CCND1 | cyclin D1 | -0.0502713 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.049682 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0490917 |
| GNAS | GNAS complex locus | -0.0488459 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0487367 |
| PGK1 | phosphoglycerate kinase 1 | -0.0484876 |
| S100A10 | S100 calcium binding protein A10 | -0.0475561 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.047143 |
| RPLP2 | ribosomal protein, large, P2 | -0.0470522 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0469539 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0468041 |
| SLC38A1 | solute carrier family 38, member 1 | -0.046418 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0454347 |
| S100A6 | S100 calcium binding protein A6 | -0.0452355 |
| RPS25 | ribosomal protein S25 | -0.0447992 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0442214 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0439921 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0439341 |
| CD2AP | CD2-associated protein | -0.0435504 |
| EHBP1 | EH domain binding protein 1 | -0.0435035 |
| BCL2L1 | BCL2-like 1 | -0.0433351 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0432648 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0431678 |
| H1-0 | H1.0 linker histone | -0.0431053 |
| GOLGA4 | golgin A4 | -0.042695 |
| PERP | PERP, TP53 apoptosis effector | -0.04229 |
| UBC | ubiquitin C | -0.0421611 |
| RPL12 | ribosomal protein L12 | -0.0421479 |
| RPS11 | ribosomal protein S11 | -0.041815 |
| RPL28 | ribosomal protein L28 | -0.0415507 |
| RPL32 | ribosomal protein L32 | -0.0404951 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0404868 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0400364 |
| LDHA | lactate dehydrogenase A | -0.0398741 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.039791 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0397133 |
| RBM39 | RNA binding motif protein 39 | -0.0394647 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0394176 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0390449 |
| TMSB4X | thymosin beta 4, X-linked | -0.0389186 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0388741 |
| RPL36A | ribosomal protein L36a | -0.0387684 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0380327 |
| RPLP0 | ribosomal protein, large, P0 | -0.0376718 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0375854 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.037385 |
| TPM4 | tropomyosin 4 | -0.0373474 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0372285 |
| RPL8 | ribosomal protein L8 | -0.0370524 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0366028 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0363157 |
| KRT19 | keratin 19, type I | -0.0363083 |
| CANX | calnexin | -0.0358538 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0356541 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0353446 |
| MKI67 | marker of proliferation Ki-67 | -0.0352011 |
| CUX1 | cut-like homeobox 1 | -0.0350643 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0346867 |
| RPL19 | ribosomal protein L19 | -0.0342212 |
| EZR | ezrin | -0.0325722 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0324203 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0322859 |
| RPL7A | ribosomal protein L7a | -0.0321837 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0320945 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0318957 |
| SETD5 | SET domain containing 5 | -0.0318531 |
| ACTN4 | actinin, alpha 4 | -0.0318495 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0318165 |
| NFIA | nuclear factor I/A | -0.0318037 |
| RPS13 | ribosomal protein S13 | -0.03169 |
| TOP1 | topoisomerase (DNA) I | -0.031554 |
| EGR1 | early growth response 1 | -0.031535 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0314153 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0313245 |
