| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Elimusertib hydrochloride_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.288681 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.141098 |
| FLNA | filamin A, alpha | 0.119672 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.113958 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.108565 |
| CALR | calreticulin | 0.108552 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0950744 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0871712 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0869829 |
| CANX | calnexin | 0.083683 |
| FLNB | filamin B, beta | 0.0798147 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0786524 |
| PTMA | prothymosin, alpha | 0.0747224 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0703767 |
| HDAC9 | histone deacetylase 9 | 0.0688744 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0642571 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0640965 |
| L1CAM | L1 cell adhesion molecule | 0.0607522 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0600856 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0593961 |
| LMNA | lamin A/C | 0.0557187 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0554653 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0508188 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0506771 |
| TPM3 | tropomyosin 3 | 0.0481204 |
| SEPTIN9 | septin 9 | 0.0461442 |
| KRT18 | keratin 18, type I | 0.0460488 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0458921 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0455326 |
| MSN | moesin | 0.0454713 |
| SQSTM1 | sequestosome 1 | 0.0450057 |
| PLEC | plectin | 0.0449331 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0446468 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0440878 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0426427 |
| LDHA | lactate dehydrogenase A | 0.0422807 |
| DSPP | dentin sialophosphoprotein | 0.0422151 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.041972 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0408583 |
| RHOA | ras homolog family member A | 0.0400291 |
| TPM4 | tropomyosin 4 | 0.0391616 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0386553 |
| PKM | pyruvate kinase, muscle | 0.0382025 |
| OPTN | optineurin | 0.0379806 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0370861 |
| ACTN4 | actinin, alpha 4 | 0.0370725 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 0.0367636 |
| VEGFA | vascular endothelial growth factor A | 0.0362648 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0355874 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0353613 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0353452 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0336797 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0327288 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0326212 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0324395 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0324389 |
| RND3 | Rho family GTPase 3 | 0.0323255 |
| EZR | ezrin | 0.0320118 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0316496 |
| TMSB4X | thymosin beta 4, X-linked | 0.0296868 |
| RNF213 | ring finger protein 213 | 0.029626 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0288959 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0287509 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0285794 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0281738 |
| MT2A | metallothionein 2A | 0.0278396 |
| GOLGA4 | golgin A4 | 0.0277305 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0277053 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | 0.0272151 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0271933 |
| BCL2L1 | BCL2-like 1 | 0.026791 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0263613 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0263022 |
| RIOK3 | RIO kinase 3 | 0.025933 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0257253 |
| CEP250 | centrosomal protein 250kDa | 0.0256351 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0255515 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0252415 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0251247 |
| RNF187 | ring finger protein 187 | 0.0251061 |
| RAB11FIP3 | RAB11 family interacting protein 3 (class II) | 0.0250235 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.0244864 |
| DST | dystonin | 0.0244734 |
| SET | SET nuclear proto-oncogene | 0.0243988 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0243541 |
| S100A6 | S100 calcium binding protein A6 | 0.0240317 |
| NAV2 | neuron navigator 2 | 0.0236993 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0236437 |
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | 0.0236099 |
| JUN | jun proto-oncogene | 0.023523 |
| AXL | AXL receptor tyrosine kinase | 0.0234977 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0230672 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0229365 |
| PCBP2 | poly(rC) binding protein 2 | 0.0226904 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0226839 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | 0.0224538 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0223205 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0222813 |
| PDXK | pyridoxal (pyridoxine, vitamin B6) kinase | 0.0222174 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0220901 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.230523 |
| LOX | lysyl oxidase | -0.211382 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.154682 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.128261 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.121992 |
| NAV1 | neuron navigator 1 | -0.0793459 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0788297 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0787126 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0777305 |
| THBS2 | thrombospondin 2 | -0.0705645 |
| CDH13 | cadherin 13 | -0.0649709 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0648379 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0647765 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0643769 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0565146 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0551242 |
| TMSB10 | thymosin beta 10 | -0.0544665 |
| FRMD4A | FERM domain containing 4A | -0.0536568 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.052875 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0504828 |
| COL1A2 | collagen, type I, alpha 2 | -0.048962 |
| GLIS3 | GLIS family zinc finger 3 | -0.0489009 |
| PLAT | plasminogen activator, tissue | -0.0482319 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0468953 |
| RIGI | RNA sensor RIG-I | -0.0405113 |
| HLA-B | major histocompatibility complex, class I, B | -0.0399936 |
| AUTS2 | autism susceptibility candidate 2 | -0.0387278 |
| SUCNR1 | succinate receptor 1 | -0.0387061 |
| ANXA2 | annexin A2 | -0.0387021 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0372978 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0370296 |
| GPC6 | glypican 6 | -0.0357246 |
| FBN1 | fibrillin 1 | -0.0351081 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0349507 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0344798 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.033683 |
| AHNAK | AHNAK nucleoprotein | -0.0334568 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0334374 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0331411 |
| FN1 | fibronectin 1 | -0.0331012 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.03302 |
| EFNA5 | ephrin-A5 | -0.0326806 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0323128 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0322867 |
| EHBP1 | EH domain binding protein 1 | -0.0321787 |
| ZNF217 | zinc finger protein 217 | -0.0319545 |
| MEIS2 | Meis homeobox 2 | -0.0318178 |
| STC1 | stanniocalcin 1 | -0.0314093 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0312739 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.030936 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0297674 |
| JAZF1 | JAZF zinc finger 1 | -0.0295152 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | -0.0295077 |
| COL5A2 | collagen, type V, alpha 2 | -0.0277983 |
| MAP1B | microtubule-associated protein 1B | -0.0276623 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0265891 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0261188 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0259803 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0254276 |
| MX2 | MX dynamin-like GTPase 2 | -0.0249575 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0247739 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0247451 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0246539 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0245516 |
| CCND1 | cyclin D1 | -0.0242548 |
| NF1 | neurofibromin 1 | -0.023775 |
| PRSS23 | protease, serine, 23 | -0.0237384 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0236415 |
| CEP170 | centrosomal protein 170kDa | -0.0234557 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0234202 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0234174 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0233203 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0228754 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0227812 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0223198 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0221556 |
| ARF1 | ADP-ribosylation factor 1 | -0.0218714 |
| CDK14 | cyclin-dependent kinase 14 | -0.021047 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0210433 |
| HLA-C | major histocompatibility complex, class I, C | -0.0209747 |
| SP3 | Sp3 transcription factor | -0.0204238 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0203688 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0203543 |
| IPO9 | importin 9 | -0.0203031 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0201513 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0201473 |
| MPZL1 | myelin protein zero-like 1 | -0.0194202 |
| RPS24 | ribosomal protein S24 | -0.0193151 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.019189 |
| MED13L | mediator complex subunit 13-like | -0.0190514 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0190215 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0189462 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0187082 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.018688 |
| TNS3 | tensin 3 | -0.0184688 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0183125 |
| IL7R | interleukin 7 receptor | -0.0182903 |
| FRMD5 | FERM domain containing 5 | -0.0182697 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0181381 |
| LOC105378220 | macrophage receptor MARCO-like | -0.0180886 |
