Elimusertib hydrochloride_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Elimusertib hydrochloride perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Elimusertib hydrochloride_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.139743
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.137352
VIM vimentin 0.120675
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.10166
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0955965
HMGA2 high mobility group AT-hook 2 0.0869077
ZSWIM6 zinc finger, SWIM-type containing 6 0.0703957
NEBL nebulette 0.0682037
YAP1 Yes-associated protein 1 0.0658312
DST dystonin 0.0648924
TPI1 triosephosphate isomerase 1 0.0577401
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0549762
INTS6 integrator complex subunit 6 0.052542
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.052188
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0491133
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.047501
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.047068
ANXA1 annexin A1 0.0463453
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0458723
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0445455
FLNA filamin A, alpha 0.0445371
CMIP c-Maf inducing protein 0.0442505
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0438446
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0431853
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.040475
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0398552
CALR calreticulin 0.0385004
HSPA8 heat shock 70kDa protein 8 0.0374313
PCBP2 poly(rC) binding protein 2 0.0373391
TPM3 tropomyosin 3 0.0368035
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0362442
CANX calnexin 0.0361036
DENND5A DENN/MADD domain containing 5A 0.0356093
PDE4D phosphodiesterase 4D, cAMP-specific 0.0347006
PHACTR4 phosphatase and actin regulator 4 0.0346839
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0345212
APLP2 amyloid beta (A4) precursor-like protein 2 0.0344882
JMJD1C jumonji domain containing 1C 0.0343596
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0343077
MYH9 myosin, heavy chain 9, non-muscle 0.0342881
RNF213 ring finger protein 213 0.034231
ERBIN erbb2 interacting protein 0.0340965
EZR ezrin 0.0336314
ANKRD17 ankyrin repeat domain 17 0.0334879
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0327323
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0325631
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0321586
AKAP12 A kinase (PRKA) anchor protein 12 0.0319932
BRD2 bromodomain containing 2 0.031267
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0311871
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0305802
XPOT exportin, tRNA 0.0304766
DSPP dentin sialophosphoprotein 0.0300152
EPHA6 EPH receptor A6 0.0292067
GSE1 Gse1 coiled-coil protein 0.0291535
ADIPOR2 adiponectin receptor 2 0.0289598
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0289248
AARS1 alanyl-tRNA synthetase 1 0.0288751
GOLGB1 golgin B1 0.028824
TNRC18 trinucleotide repeat containing 18 0.0288034
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0285119
WWOX WW domain containing oxidoreductase 0.0284894
CEP250 centrosomal protein 250kDa 0.0279096
RHOA ras homolog family member A 0.0278567
TAOK1 TAO kinase 1 0.0278539
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0278473
PRKCE protein kinase C, epsilon 0.0276491
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0272763
MSH6 mutS homolog 6 0.0271565
MACF1 microtubule-actin crosslinking factor 1 0.0271509
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0271407
NFE2L1 nuclear factor, erythroid 2-like 1 0.0270897
LRRC23 leucine rich repeat containing 23 0.0268167
SRRM2 serine/arginine repetitive matrix 2 0.0267766
EIF4B eukaryotic translation initiation factor 4B 0.0267622
CUX1 cut-like homeobox 1 0.026313
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.026222
EEF2 eukaryotic translation elongation factor 2 0.0259746
CEP112 centrosomal protein 112kDa 0.0259554
FADS2 fatty acid desaturase 2 0.0256131
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0253094
HDGF hepatoma-derived growth factor 0.0251224
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0248415
ETV6 ets variant 6 0.0245803
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0245361
JUN jun proto-oncogene 0.0241749
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0240082
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.023871
COL5A2 collagen, type V, alpha 2 0.0237512
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0236718
KDM2A lysine (K)-specific demethylase 2A 0.0236363
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0236311
SAMD4A sterile alpha motif domain containing 4A 0.0235111
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0234863
CLIP1 CAP-GLY domain containing linker protein 1 0.0233856
PTMS parathymosin 0.0233784
SYNE2 spectrin repeat containing, nuclear envelope 2 0.023139
AHRR aryl-hydrocarbon receptor repressor 0.023132
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0231227
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0231121

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.160433
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.119284
FTL ferritin, light polypeptide -0.116521
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0951406
BIRC3 baculoviral IAP repeat containing 3 -0.0801106
AREG amphiregulin -0.0764668
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0681193
CNRIP1 cannabinoid receptor interacting protein 1 -0.063809
RPL35A ribosomal protein L35a -0.0619751
ACTG1 actin gamma 1 -0.0596686
LMO7 LIM domain 7 -0.0587278
ATP5F1B ATP synthase F1 subunit beta -0.0586782
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0577482
ECT2 epithelial cell transforming 2 -0.0569086
RPS8 ribosomal protein S8 -0.0519203
ANKRD12 ankyrin repeat domain 12 -0.0515045
SMC4 structural maintenance of chromosomes 4 -0.0506183
RPLP2 ribosomal protein, large, P2 -0.0505039
RPL37A ribosomal protein L37a -0.0494265
RPS19 ribosomal protein S19 -0.0488378
NLGN1 neuroligin 1 -0.0482165
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0474029
RPS24 ribosomal protein S24 -0.0472554
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0450551
TMEM123 transmembrane protein 123 -0.0433159
EGR1 early growth response 1 -0.0426688
ADGRG6 adhesion G protein-coupled receptor G6 -0.0408286
ZNF804A zinc finger protein 804A -0.0405016
TPT1 tumor protein, translationally-controlled 1 -0.0400775
CENPF centromere protein F, 350/400kDa -0.0391072
RPS21 ribosomal protein S21 -0.0389326
RPS12 ribosomal protein S12 -0.0385558
RPL26 ribosomal protein L26 -0.0379198
RPLP1 ribosomal protein, large, P1 -0.0376565
RPL34 ribosomal protein L34 -0.0375363
RPS3 ribosomal protein S3 -0.0373674
SQSTM1 sequestosome 1 -0.0373496
PUM2 pumilio RNA-binding family member 2 -0.0370956
SLC38A2 solute carrier family 38, member 2 -0.0364452
RPL31 ribosomal protein L31 -0.0350549
CELF2 CUGBP, Elav-like family member 2 -0.0349615
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0346714
MARCHF6 membrane associated ring-CH-type finger 6 -0.0346184
CDK17 cyclin-dependent kinase 17 -0.0339784
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0336815
VDAC1 voltage-dependent anion channel 1 -0.0335011
RPS29 ribosomal protein S29 -0.0334379
RPS16 ribosomal protein S16 -0.0332338
RPLP0 ribosomal protein, large, P0 -0.0331492
TMEM41B transmembrane protein 41B -0.0325444
CENPE centromere protein E, 312kDa -0.0324507
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0324476
RPL36 ribosomal protein L36 -0.0322437
TMEM131 transmembrane protein 131 -0.0318938
ZNF217 zinc finger protein 217 -0.0316199
RPL12 ribosomal protein L12 -0.031609
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0315851
YBX1 Y box binding protein 1 -0.0313436
RPL38 ribosomal protein L38 -0.0308559
RACK1 receptor for activated C kinase 1 -0.0305764
RPL37 ribosomal protein L37 -0.0303055
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0301195
ANKRD28 ankyrin repeat domain 28 -0.029991
RPL5 ribosomal protein L5 -0.0299653
RPL32 ribosomal protein L32 -0.0296727
WDR43 WD repeat domain 43 -0.0294459
MIS18BP1 MIS18 binding protein 1 -0.028989
HMGA1 high mobility group AT-hook 1 -0.0285695
RPL11 ribosomal protein L11 -0.0284483
NEK7 NIMA-related kinase 7 -0.0281041
RPL19 ribosomal protein L19 -0.0278068
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0277385
TXNRD1 thioredoxin reductase 1 -0.0275498
CXADR coxsackie virus and adenovirus receptor -0.0272994
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0269791
RPS27A ribosomal protein S27a -0.0269294
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.026805
RPS6 ribosomal protein S6 -0.0264236
CLTC clathrin, heavy chain (Hc) -0.0263211
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0261977
THOC2 THO complex 2 -0.0261699
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0258254
FUS FUS RNA binding protein -0.0258098
NHSL1 NHS-like 1 -0.0253378
RPS14 ribosomal protein S14 -0.0253044
ZNF292 zinc finger protein 292 -0.025274
RPL13A ribosomal protein L13a -0.0252701
BCHE butyrylcholinesterase -0.0251959
TNPO1 transportin 1 -0.0251708
ZFAND6 zinc finger, AN1-type domain 6 -0.0250426
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0250353
ZFR zinc finger RNA binding protein -0.0250207
RPS5 ribosomal protein S5 -0.0250198
PFN1 profilin 1 -0.0250146
RPL9 ribosomal protein L9 -0.0249878
TIGAR TP53 induced glycolysis regulatory phosphatase -0.0248932
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.024885
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0248686
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0247948
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0247615