| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Elimusertib hydrochloride_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GPC6 | glypican 6 | 0.142356 |
| KYNU | kynureninase | 0.121165 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.108572 |
| TXNRD1 | thioredoxin reductase 1 | 0.103544 |
| RNF213 | ring finger protein 213 | 0.100965 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0918376 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0833394 |
| CA12 | carbonic anhydrase XII | 0.0802123 |
| GLIS3 | GLIS family zinc finger 3 | 0.0768189 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0762907 |
| CP | ceruloplasmin (ferroxidase) | 0.0734449 |
| ASPH | aspartate beta-hydroxylase | 0.072788 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0675933 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0672933 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0604617 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0579548 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0576475 |
| TNS3 | tensin 3 | 0.0534247 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.053069 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0524913 |
| ETV6 | ets variant 6 | 0.0492128 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0475704 |
| APOL1 | apolipoprotein L, 1 | 0.047082 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0468734 |
| FAT1 | FAT atypical cadherin 1 | 0.0455181 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0450241 |
| MX1 | MX dynamin-like GTPase 1 | 0.0447061 |
| PALLD | palladin, cytoskeletal associated protein | 0.0431609 |
| SMAD3 | SMAD family member 3 | 0.0407501 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0398012 |
| FN1 | fibronectin 1 | 0.0395927 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0392221 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0387556 |
| NFIB | nuclear factor I/B | 0.0359779 |
| APP | amyloid beta (A4) precursor protein | 0.0359611 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.0356419 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0350451 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 0.033551 |
| IFI44L | interferon-induced protein 44-like | 0.0333569 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0329956 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0322753 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0322561 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 0.0310651 |
| MYOF | myoferlin | 0.0309611 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.030319 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0301507 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0295064 |
| BICC1 | BicC family RNA binding protein 1 | 0.0292865 |
| ANXA4 | annexin A4 | 0.0285155 |
| RBPMS | RNA binding protein with multiple splicing | 0.0279046 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.027872 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0274055 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0271473 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0269996 |
| EXOC4 | exocyst complex component 4 | 0.0259259 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0258901 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0252698 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.0252228 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0251524 |
| FLNA | filamin A, alpha | 0.0249378 |
| RIGI | RNA sensor RIG-I | 0.0246535 |
| ACLY | ATP citrate lyase | 0.0245338 |
| RPS4X | ribosomal protein S4, X-linked | 0.0244069 |
| TLE4 | transducin-like enhancer of split 4 | 0.024208 |
| HDAC9 | histone deacetylase 9 | 0.0240848 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0239501 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0239193 |
| ADAR | adenosine deaminase, RNA-specific | 0.0231493 |
| MRTFA | myocardin related transcription factor A | 0.0223824 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0220742 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0219521 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 0.0218063 |
| ATF3 | activating transcription factor 3 | 0.021699 |
| TGFB2 | transforming growth factor, beta 2 | 0.0213385 |
| PREX2 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 | 0.021221 |
| PLIN2 | perilipin 2 | 0.0212176 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0211906 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0210436 |
| PTGR1 | prostaglandin reductase 1 | 0.0207058 |
| HKDC1 | hexokinase domain containing 1 | 0.0206146 |
| ABLIM1 | actin binding LIM protein 1 | 0.0205855 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0204233 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.0203299 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.0202194 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0201291 |
| ENAH | enabled homolog (Drosophila) | 0.0201253 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.020061 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0198435 |
| EPAS1 | endothelial PAS domain protein 1 | 0.019712 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.019705 |
| WWOX | WW domain containing oxidoreductase | 0.0195701 |
| PLK2 | polo-like kinase 2 | 0.0195393 |
| RAD51B | RAD51 paralog B | 0.0194985 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0194777 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0193224 |
| SLFN5 | schlafen family member 5 | 0.0192884 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0192535 |
| SFTPA2 | surfactant protein A2 | 0.0191533 |
| AOPEP | aminopeptidase O (putative) | 0.0191242 |
| TRIM22 | tripartite motif containing 22 | 0.0190396 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.176734 |
| CD44 | CD44 molecule (Indian blood group) | -0.140488 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.133363 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.123462 |
| TMSB10 | thymosin beta 10 | -0.112801 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0965029 |
| NDRG1 | N-myc downstream regulated 1 | -0.0946508 |
| RPS6 | ribosomal protein S6 | -0.0928613 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0809993 |
| FTL | ferritin, light polypeptide | -0.0743414 |
| PFN1 | profilin 1 | -0.0687139 |
| RTN4 | reticulon 4 | -0.0677816 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.066239 |
| CADM1 | cell adhesion molecule 1 | -0.0631549 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0610564 |
| MT2A | metallothionein 2A | -0.0576368 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0567846 |
| MAP1B | microtubule-associated protein 1B | -0.0561054 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0554515 |
| NAV2 | neuron navigator 2 | -0.0548108 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0543887 |
| RPL35A | ribosomal protein L35a | -0.0512972 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0487102 |
| GOLGA4 | golgin A4 | -0.048454 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0467658 |
| RPS8 | ribosomal protein S8 | -0.0451666 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0446594 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0442976 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0441633 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0433568 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0431034 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0430812 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0423099 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0416435 |
| PTMA | prothymosin, alpha | -0.0407451 |
| HMGA1 | high mobility group AT-hook 1 | -0.0379754 |
| HLA-B | major histocompatibility complex, class I, B | -0.0372716 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0368774 |
| MYADM | myeloid-associated differentiation marker | -0.0366855 |
| RPLP2 | ribosomal protein, large, P2 | -0.0366598 |
| MTDH | metadherin | -0.0366025 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0365491 |
| ATP13A3 | ATPase type 13A3 | -0.0362383 |
| SEPTIN7 | septin 7 | -0.0361743 |
| RAI14 | retinoic acid induced 14 | -0.0360892 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0356434 |
| RPLP1 | ribosomal protein, large, P1 | -0.0354735 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0341897 |
| SPAG9 | sperm associated antigen 9 | -0.0339688 |
| RPL34 | ribosomal protein L34 | -0.0338441 |
| RPL37A | ribosomal protein L37a | -0.0337063 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0336584 |
| NOP58 | NOP58 ribonucleoprotein | -0.0330787 |
| RPL28 | ribosomal protein L28 | -0.033064 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0329989 |
| RPL31 | ribosomal protein L31 | -0.032854 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0325675 |
| RPS19 | ribosomal protein S19 | -0.0325149 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0321525 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0321302 |
| GDF15 | growth differentiation factor 15 | -0.0319109 |
| GNAS | GNAS complex locus | -0.0311818 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0310671 |
| RPL26 | ribosomal protein L26 | -0.0308359 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0305955 |
| RPS24 | ribosomal protein S24 | -0.0304513 |
| SDCBP | syndecan binding protein (syntenin) | -0.0303393 |
| POTEF | POTE ankyrin domain family, member F | -0.0302358 |
| S100A10 | S100 calcium binding protein A10 | -0.030188 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0300518 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.029932 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0298891 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0292841 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0290755 |
| CD82 | CD82 molecule | -0.0288969 |
| RPS13 | ribosomal protein S13 | -0.0288655 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0288612 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0288503 |
| TUBA1B | tubulin, alpha 1b | -0.0287977 |
| HIP1 | huntingtin interacting protein 1 | -0.0287897 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0285638 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0284714 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0283588 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0282667 |
| S100A6 | S100 calcium binding protein A6 | -0.0281933 |
| ANXA5 | annexin A5 | -0.0281286 |
| CTSD | cathepsin D | -0.02808 |
| ADM | adrenomedullin | -0.0280298 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0280281 |
| INSIG1 | insulin induced gene 1 | -0.0280246 |
| RPL23 | ribosomal protein L23 | -0.0279806 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0277649 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0276384 |
| PKM | pyruvate kinase, muscle | -0.027608 |
| RPL9 | ribosomal protein L9 | -0.0273757 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0271613 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0271239 |
| CBX3 | chromobox homolog 3 | -0.0270391 |
| RPS21 | ribosomal protein S21 | -0.0264916 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0264392 |
