| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Elimusertib hydrochloride_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CEP250 | centrosomal protein 250kDa | 0.0887868 |
| NCOA3 | nuclear receptor coactivator 3 | 0.081463 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0754292 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0702537 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0666513 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0650183 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0605201 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0568942 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0557964 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0543539 |
| FAM168A | family with sequence similarity 168, member A | 0.0538768 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0528296 |
| VEGFA | vascular endothelial growth factor A | 0.0524701 |
| KRT18 | keratin 18, type I | 0.0512223 |
| PTMA | prothymosin, alpha | 0.0499907 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.048661 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0474576 |
| INTS6 | integrator complex subunit 6 | 0.0457272 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0439478 |
| DSPP | dentin sialophosphoprotein | 0.0432071 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0425596 |
| MSI2 | musashi RNA-binding protein 2 | 0.0420241 |
| MYO10 | myosin X | 0.0379494 |
| ADAR | adenosine deaminase, RNA-specific | 0.0376093 |
| RPS6KB1 | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 0.0363083 |
| FOXO3 | forkhead box O3 | 0.035462 |
| CANX | calnexin | 0.0349487 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0347873 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.0341757 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0333616 |
| RC3H1 | ring finger and CCCH-type domains 1 | 0.0331125 |
| PRLR | prolactin receptor | 0.0328764 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0326559 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.03215 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.0317805 |
| SET | SET nuclear proto-oncogene | 0.0316804 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0314526 |
| STARD3 | StAR-related lipid transfer (START) domain containing 3 | 0.0312428 |
| LRRC59 | leucine rich repeat containing 59 | 0.0310282 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0306391 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0305573 |
| INSR | insulin receptor | 0.0305376 |
| YAP1 | Yes-associated protein 1 | 0.0302558 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | 0.0301511 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0300679 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.02991 |
| RCOR1 | REST corepressor 1 | 0.0298743 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0298028 |
| RAB10 | RAB10, member RAS oncogene family | 0.0296846 |
| FLNA | filamin A, alpha | 0.0294712 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0294712 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0294155 |
| SLFN5 | schlafen family member 5 | 0.029343 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0288961 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0281389 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0278299 |
| PLEC | plectin | 0.0276388 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0275709 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0275622 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0272556 |
| CALR | calreticulin | 0.0270309 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0267975 |
| HMGB2 | high mobility group box 2 | 0.0266399 |
| GOLGB1 | golgin B1 | 0.0265131 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0264669 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0263393 |
| YME1L1 | YME1-like 1 ATPase | 0.0262749 |
| OGA | O-GlcNAcase | 0.0257178 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0256633 |
| BCAS1 | breast carcinoma amplified sequence 1 | 0.0256345 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0255768 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0254919 |
| STIP1 | stress-induced phosphoprotein 1 | 0.0254684 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.0252268 |
| SP100 | SP100 nuclear antigen | 0.0249725 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0249108 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0248815 |
| VCP | valosin containing protein | 0.0246137 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0246122 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0243542 |
| NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | 0.0242289 |
| DNM2 | dynamin 2 | 0.0238 |
| GSDMB | gasdermin B | 0.0237737 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0237518 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0237145 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0235035 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0234451 |
| JAK1 | Janus kinase 1 | 0.0233986 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0233036 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0226894 |
| USO1 | USO1 vesicle transport factor | 0.0225914 |
| DENND5A | DENN/MADD domain containing 5A | 0.0225864 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0225557 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0225005 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0224726 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0224297 |
| PNN | pinin, desmosome associated protein | 0.021594 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0215573 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0213627 |
| RNASE12 | ribonuclease, RNase A family, 12 (non-active) | 0.0213427 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.14343 |
| VMP1 | vacuole membrane protein 1 | -0.116882 |
| ASPH | aspartate beta-hydroxylase | -0.103791 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0745748 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0715482 |
| TENM2 | teneurin transmembrane protein 2 | -0.0708713 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0701098 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0630695 |
| ACTG1 | actin gamma 1 | -0.061044 |
| RPL23 | ribosomal protein L23 | -0.0607356 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0601998 |
| CCND1 | cyclin D1 | -0.0594743 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0586598 |
| OSMR | oncostatin M receptor | -0.0576185 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0567945 |
| POTEF | POTE ankyrin domain family, member F | -0.0490327 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0465656 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0458189 |
| ANXA2 | annexin A2 | -0.0457003 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0453461 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.044721 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0444799 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0444545 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0436153 |
| RPL35A | ribosomal protein L35a | -0.043555 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0423331 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0420707 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0410017 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0401812 |
| NTN4 | netrin 4 | -0.0379889 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0353376 |
| TMEM165 | transmembrane protein 165 | -0.0350852 |
| TMSB10 | thymosin beta 10 | -0.0344264 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0338727 |
| RAB22A | RAB22A, member RAS oncogene family | -0.0331366 |
| TMEM45B | transmembrane protein 45B | -0.0326112 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0324189 |
| TMEM123 | transmembrane protein 123 | -0.0315464 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0310083 |
| RPL37A | ribosomal protein L37a | -0.0303621 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0303602 |
| ITGB6 | integrin, beta 6 | -0.0302543 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.0302295 |
| EGR1 | early growth response 1 | -0.0301784 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | -0.0298499 |
| DENND1B | DENN/MADD domain containing 1B | -0.0297211 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0295859 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0288253 |
| TMC5 | transmembrane channel-like 5 | -0.0283362 |
| S100A9 | S100 calcium binding protein A9 | -0.0282857 |
| MIPOL1 | mirror-image polydactyly 1 | -0.0281822 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0278456 |
| MYOF | myoferlin | -0.027788 |
| RPS24 | ribosomal protein S24 | -0.0276495 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.027218 |
| CLTC | clathrin, heavy chain (Hc) | -0.0271808 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0271037 |
| LDLR | low density lipoprotein receptor | -0.0265768 |
| GRB7 | growth factor receptor-bound protein 7 | -0.0265042 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.026157 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0261449 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.0259922 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0254836 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0248248 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0247434 |
| IER3 | immediate early response 3 | -0.0247382 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0240952 |
| MSMO1 | methylsterol monooxygenase 1 | -0.0238612 |
| FTL | ferritin, light polypeptide | -0.0237651 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0236119 |
| RPS12 | ribosomal protein S12 | -0.0235222 |
| RPL30 | ribosomal protein L30 | -0.0234227 |
| TNIK | TRAF2 and NCK interacting kinase | -0.0233395 |
| RPS19 | ribosomal protein S19 | -0.0232763 |
| GDPD1 | glycerophosphodiester phosphodiesterase domain containing 1 | -0.0230891 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0230786 |
| NCOA6 | nuclear receptor coactivator 6 | -0.0230472 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0230219 |
| TXNRD1 | thioredoxin reductase 1 | -0.0228877 |
| NF1 | neurofibromin 1 | -0.0226758 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0221583 |
| GLCCI1 | glucocorticoid induced 1 | -0.0221334 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0220339 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0216614 |
| KRT7 | keratin 7, type II | -0.0215498 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0214357 |
| SPTSSB | serine palmitoyltransferase, small subunit B | -0.021238 |
| RPL34 | ribosomal protein L34 | -0.0210496 |
| RPL5 | ribosomal protein L5 | -0.0209694 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0208996 |
| RPL9 | ribosomal protein L9 | -0.0203839 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0203528 |
| RPS3 | ribosomal protein S3 | -0.0202542 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | -0.0201736 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.020019 |
| S100A14 | S100 calcium binding protein A14 | -0.0200051 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0196714 |
| CLDN4 | claudin 4 | -0.0196303 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0194741 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0193825 |
