Elimusertib hydrochloride_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Elimusertib hydrochloride perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Elimusertib hydrochloride_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIM2 tripartite motif containing 2 0.0852204
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0846625
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0811525
FMNL2 formin-like 2 0.0712838
FMN1 formin 1 0.0667526
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0667315
UTRN utrophin 0.0628185
PDIA4 protein disulfide isomerase family A, member 4 0.0625956
NAV3 neuron navigator 3 0.054691
ASPH aspartate beta-hydroxylase 0.0509691
MT2A metallothionein 2A 0.0492072
PRKD1 protein kinase D1 0.0478546
APLP2 amyloid beta (A4) precursor-like protein 2 0.0476337
SEPTIN9 septin 9 0.0456397
TIMP3 TIMP metallopeptidase inhibitor 3 0.0452755
LGALS3 lectin, galactoside-binding, soluble, 3 0.0444723
AKAP9 A kinase (PRKA) anchor protein 9 0.0444148
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.0438358
ANXA2 annexin A2 0.0436101
CLIC4 chloride intracellular channel 4 0.0432161
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0415203
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0404735
S100A6 S100 calcium binding protein A6 0.0402173
NAV1 neuron navigator 1 0.0393729
APP amyloid beta (A4) precursor protein 0.0371113
A2M alpha-2-macroglobulin 0.0366429
MACF1 microtubule-actin crosslinking factor 1 0.0360848
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0355436
NAV2 neuron navigator 2 0.034695
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0343791
BHLHE40 basic helix-loop-helix family, member e40 0.0343451
LMNA lamin A/C 0.0343383
MYOF myoferlin 0.0340236
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0337775
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0333249
ZMIZ1 zinc finger, MIZ-type containing 1 0.0331987
FLNB filamin B, beta 0.0331497
MYH9 myosin, heavy chain 9, non-muscle 0.0327736
FLNA filamin A, alpha 0.03251
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0322897
TLE4 transducin-like enhancer of split 4 0.0317571
ACTN4 actinin, alpha 4 0.0317031
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0317018
MED13L mediator complex subunit 13-like 0.029323
BABAM2 BRISC and BRCA1 A complex member 2 0.0292008
LDHA lactate dehydrogenase A 0.0291848
LRMDA leucine rich melanocyte differentiation associated 0.0287598
LYST lysosomal trafficking regulator 0.0286211
VCL vinculin 0.0285959
SSH2 slingshot protein phosphatase 2 0.0285206
KIF13A kinesin family member 13A 0.0284687
RNF150 ring finger protein 150 0.0283415
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0277656
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0277031
CABIN1 calcineurin binding protein 1 0.0273348
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0271301
HSPB1 heat shock 27kDa protein 1 0.0265817
VEGFA vascular endothelial growth factor A 0.0263666
ANK2 ankyrin 2, neuronal 0.0261138
TRIM9 tripartite motif containing 9 0.0260679
IGFBP5 insulin-like growth factor binding protein 5 0.0260199
ANKRD17 ankyrin repeat domain 17 0.0259486
TIMP2 TIMP metallopeptidase inhibitor 2 0.0255046
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0251472
DSCAM Down syndrome cell adhesion molecule 0.0248814
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0246689
RHOBTB3 Rho-related BTB domain containing 3 0.0246361
CD109 CD109 molecule 0.024579
ZNF827 zinc finger protein 827 0.0242888
RAD21 RAD21 homolog (S. pombe) 0.0242392
FER fer (fps/fes related) tyrosine kinase 0.0241502
PDE4D phosphodiesterase 4D, cAMP-specific 0.023886
DMD dystrophin 0.0238844
SORBS1 sorbin and SH3 domain containing 1 0.0238645
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0238404
ARHGAP24 Rho GTPase activating protein 24 0.0237339
IVNS1ABP influenza virus NS1A binding protein 0.0236265
SLC4A2 solute carrier family 4 (anion exchanger), member 2 0.0233999
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 0.0232977
KDM4B lysine (K)-specific demethylase 4B 0.0232707
AUTS2 autism susceptibility candidate 2 0.0230369
S100A10 S100 calcium binding protein A10 0.0230127
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0226794
DST dystonin 0.0222753
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0222677
TXNIP thioredoxin interacting protein 0.0222636
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.0222454
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0219703
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.021799
S100A9 S100 calcium binding protein A9 0.0216293
ANKRD12 ankyrin repeat domain 12 0.0214389
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0213349
PHACTR1 phosphatase and actin regulator 1 0.0213061
HELZ helicase with zinc finger 0.0212879
XPO1 exportin 1 0.0212867
BBX bobby sox homolog (Drosophila) 0.0211753
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0209005
MIDEAS mitotic deacetylase associated SANT domain protein 0.0206614
TMEM178B transmembrane protein 178B 0.0206547
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0206516

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.136066
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.106081
NPC1 Niemann-Pick disease, type C1 -0.105992
FN1 fibronectin 1 -0.104594
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.103744
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.101826
NDRG1 N-myc downstream regulated 1 -0.0936747
IGFBP3 insulin-like growth factor binding protein 3 -0.0827902
COL19A1 collagen, type XIX, alpha 1 -0.0825666
FRMD4A FERM domain containing 4A -0.0797995
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0781542
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0763095
CERT1 ceramide transporter 1 -0.0762661
NLGN1 neuroligin 1 -0.0730016
NPAS2 neuronal PAS domain protein 2 -0.0712368
RPL37A ribosomal protein L37a -0.068238
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0639288
EXT1 exostosin glycosyltransferase 1 -0.0632277
CALD1 caldesmon 1 -0.0630904
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0602425
CHSY1 chondroitin sulfate synthase 1 -0.0591074
RPS12 ribosomal protein S12 -0.0589523
CDK14 cyclin-dependent kinase 14 -0.0572795
C10ORF90 chromosome 10 open reading frame 90 -0.056814
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0564919
MAML3 mastermind-like 3 (Drosophila) -0.0557609
MFSD12 major facilitator superfamily domain containing 12 -0.0550319
VIM vimentin -0.0535691
GDF15 growth differentiation factor 15 -0.0525587
FTL ferritin, light polypeptide -0.0524349
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0492123
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0485729
PGK1 phosphoglycerate kinase 1 -0.0481518
SLC38A1 solute carrier family 38, member 1 -0.046876
ADAM19 ADAM metallopeptidase domain 19 -0.0467169
PTPRD protein tyrosine phosphatase, receptor type, D -0.0463995
WSB1 WD repeat and SOCS box containing 1 -0.0459541
ITGB8 integrin, beta 8 -0.045804
VGF VGF nerve growth factor inducible -0.0451665
PPP1R12B protein phosphatase 1, regulatory subunit 12B -0.0450749
SCFD2 sec1 family domain containing 2 -0.0449593
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0448777
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0436673
IER3 immediate early response 3 -0.0425627
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0420955
NBAS neuroblastoma amplified sequence -0.0416711
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0415967
FRMD5 FERM domain containing 5 -0.0407795
TNNC1 troponin C type 1 (slow) -0.0404093
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 -0.0400052
PTK2 protein tyrosine kinase 2 -0.0399418
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0398879
PDE10A phosphodiesterase 10A -0.0396442
SIPA1L2 signal-induced proliferation-associated 1 like 2 -0.0394043
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.039362
ACTG1 actin gamma 1 -0.0393455
TBC1D22A TBC1 domain family, member 22A -0.0392873
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0386515
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0385618
WDR45B WD repeat domain 45B -0.0382593
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.037926
LOC112694756 uncharaterized LOC112694756 -0.0367741
RPL31 ribosomal protein L31 -0.0365004
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0361714
RPL26 ribosomal protein L26 -0.0360966
IL1RAP interleukin 1 receptor accessory protein -0.0358962
SORBS2 sorbin and SH3 domain containing 2 -0.0351414
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0350141
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0348929
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0348831
SDC2 syndecan 2 -0.0346155
PDIA3 protein disulfide isomerase family A, member 3 -0.0346106
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0345977
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0345506
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -0.0344521
ENO1 enolase 1, (alpha) -0.0343514
DCT dopachrome tautomerase -0.0342894
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0335088
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0334075
RPLP2 ribosomal protein, large, P2 -0.0331837
ZNF704 zinc finger protein 704 -0.0331095
CLMN calmin (calponin-like, transmembrane) -0.0330572
TAC4 tachykinin 4 (hemokinin) -0.0329585
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0327899
RFX7 regulatory factor X, 7 -0.0327157
FOXJ3 forkhead box J3 -0.0325331
SSH1 slingshot protein phosphatase 1 -0.0325304
PARVB parvin, beta -0.032513
MEF2A myocyte enhancer factor 2A -0.0322448
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0320439
IGF1R insulin-like growth factor 1 receptor -0.0320087
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0318981
CD36 CD36 molecule (thrombospondin receptor) -0.0315005
ARMC9 armadillo repeat containing 9 -0.0313703
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0313178
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0303615
EGR1 early growth response 1 -0.0302925
EHBP1 EH domain binding protein 1 -0.0301581
DOCK4 dedicator of cytokinesis 4 -0.0300815
SASH1 SAM and SH3 domain containing 1 -0.0298035