Elimusertib hydrochloride_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Elimusertib hydrochloride perturbation in H4 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Elimusertib hydrochloride_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.179359
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.110569
TIMP3 TIMP metallopeptidase inhibitor 3 0.105318
TGFBI transforming growth factor, beta-induced, 68kDa 0.0894907
VIM vimentin 0.087335
KYNU kynureninase 0.0794924
FLNA filamin A, alpha 0.0742614
B2M beta-2-microglobulin 0.0642782
COL5A1 collagen, type V, alpha 1 0.063614
FN1 fibronectin 1 0.0573004
HLA-B major histocompatibility complex, class I, B 0.0513122
MYLK myosin light chain kinase 0.0497152
PLEC plectin 0.0459037
MYH9 myosin, heavy chain 9, non-muscle 0.0448083
HDAC9 histone deacetylase 9 0.0448064
AHNAK AHNAK nucleoprotein 0.0427352
DST dystonin 0.042181
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0417181
IGFBP5 insulin-like growth factor binding protein 5 0.0411645
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.038454
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0371466
ZBTB20 zinc finger and BTB domain containing 20 0.0343008
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0341353
NLGN1 neuroligin 1 0.0337486
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0328575
PRSS23 protease, serine, 23 0.0303009
C1S complement component 1, s subcomponent 0.0301863
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0299765
FSTL1 follistatin-like 1 0.0298851
COL3A1 collagen, type III, alpha 1 0.0295182
PDIA4 protein disulfide isomerase family A, member 4 0.0293887
NAV1 neuron navigator 1 0.0270041
SAMD4A sterile alpha motif domain containing 4A 0.0265477
IGFBP3 insulin-like growth factor binding protein 3 0.0262233
TNS3 tensin 3 0.0258106
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.025737
NFE2L1 nuclear factor, erythroid 2-like 1 0.0254633
C3 complement component 3 0.0251065
MKI67 marker of proliferation Ki-67 0.0246526
CTSB cathepsin B 0.024612
LDHA lactate dehydrogenase A 0.024403
HLA-A major histocompatibility complex, class I, A 0.0242185
PTPRD protein tyrosine phosphatase, receptor type, D 0.0234003
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.023359
ATXN1 ataxin 1 0.0233576
CALR calreticulin 0.0231251
AHR aryl hydrocarbon receptor 0.0226876
FBN1 fibrillin 1 0.0225198
ENO1 enolase 1, (alpha) 0.0224273
LOXL2 lysyl oxidase-like 2 0.0223692
APP amyloid beta (A4) precursor protein 0.0219403
CUX1 cut-like homeobox 1 0.0218731
PDE4D phosphodiesterase 4D, cAMP-specific 0.0217275
APLP2 amyloid beta (A4) precursor-like protein 2 0.0215036
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0214958
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.0212475
FLNB filamin B, beta 0.020926
FAM107B family with sequence similarity 107, member B 0.0208335
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0200665
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0198435
LIMCH1 LIM and calponin homology domains 1 0.0198169
FAT1 FAT atypical cadherin 1 0.0195957
ANTXR1 anthrax toxin receptor 1 0.0195817
RPS4X ribosomal protein S4, X-linked 0.0193167
RAD51B RAD51 paralog B 0.0192811
L1CAM L1 cell adhesion molecule 0.0189788
TMSB4X thymosin beta 4, X-linked 0.0189269
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0188463
COL12A1 collagen, type XII, alpha 1 0.0186168
SYTL2 synaptotagmin-like 2 0.0185918
EHBP1L1 EH domain binding protein 1-like 1 0.0183012
MYO1E myosin IE 0.0182844
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0176998
DGKI diacylglycerol kinase, iota 0.0168578
RNF220 ring finger protein 220 0.0168186
COL6A1 collagen, type VI, alpha 1 0.0165543
FKBP9 FK506 binding protein 9, 63 kDa 0.0165136
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0164254
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0163201
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0162339
SDF4 stromal cell derived factor 4 0.0159744
INTS6 integrator complex subunit 6 0.0159716
LMNA lamin A/C 0.0159235
CKAP4 cytoskeleton-associated protein 4 0.0158692
LAMB1 laminin, beta 1 0.01585
MRC2 mannose receptor, C type 2 0.0153941
EMP3 epithelial membrane protein 3 0.015163
RPL23 ribosomal protein L23 0.0151336
PSD3 pleckstrin and Sec7 domain containing 3 0.0151218
PSAT1 phosphoserine aminotransferase 1 0.014981
PDLIM5 PDZ and LIM domain 5 0.0149293
SFTPA2 surfactant protein A2 0.0149228
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0149087
RNF213 ring finger protein 213 0.0148749
CEP112 centrosomal protein 112kDa 0.0146793
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0145821
SVIL supervillin 0.014367
AOPEP aminopeptidase O (putative) 0.0143408
C1R complement component 1, r subcomponent 0.014323
NCOR2 nuclear receptor corepressor 2 0.0142953

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.230893
CXCL8 chemokine (C-X-C motif) ligand 8 -0.176738
FTL ferritin, light polypeptide -0.133061
NDRG1 N-myc downstream regulated 1 -0.129788
RTN4 reticulon 4 -0.0969208
NAMPT nicotinamide phosphoribosyltransferase -0.0862914
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0845846
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0840827
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0812877
GARS1 glycyl-tRNA synthetase 1 -0.0807994
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0693935
HILPDA hypoxia inducible lipid droplet-associated -0.0655928
TRA2A transformer 2 alpha homolog (Drosophila) -0.0638219
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0604008
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.060218
CADM1 cell adhesion molecule 1 -0.0597499
ATP13A3 ATPase type 13A3 -0.0594851
HELZ helicase with zinc finger -0.0563241
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0563156
MAP1B microtubule-associated protein 1B -0.0539476
ANKRD17 ankyrin repeat domain 17 -0.0533217
RAB7A RAB7A, member RAS oncogene family -0.0505376
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0505136
SBF2 SET binding factor 2 -0.0501387
DGKD diacylglycerol kinase, delta 130kDa -0.0495767
FNDC3B fibronectin type III domain containing 3B -0.0474938
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0464847
COPB1 coatomer protein complex, subunit beta 1 -0.0453813
ANKRD11 ankyrin repeat domain 11 -0.045292
RLF rearranged L-myc fusion -0.0452511
CLTC clathrin, heavy chain (Hc) -0.0452223
NALF1 NALCN channel auxiliary factor 1 -0.0451486
GOLGA4 golgin A4 -0.0442383
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0436125
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0429922
SRP54 signal recognition particle 54kDa -0.0429161
KMT2E lysine (K)-specific methyltransferase 2E -0.0428392
USP3 ubiquitin specific peptidase 3 -0.0425727
TMSB10 thymosin beta 10 -0.0423965
COG5 component of oligomeric golgi complex 5 -0.0423243
TNNC1 troponin C type 1 (slow) -0.0421835
EGR1 early growth response 1 -0.0421293
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0418588
SETD5 SET domain containing 5 -0.0407568
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0404707
FAM13A family with sequence similarity 13, member A -0.0399804
FOXJ3 forkhead box J3 -0.0399165
GLS2 glutaminase 2 (liver, mitochondrial) -0.039203
RBM39 RNA binding motif protein 39 -0.0390159
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0388866
NOP58 NOP58 ribonucleoprotein -0.0387703
ZCCHC7 zinc finger, CCHC domain containing 7 -0.038759
AFF4 AF4/FMR2 family, member 4 -0.0386614
KMT2C lysine (K)-specific methyltransferase 2C -0.0384123
LCORL ligand dependent nuclear receptor corepressor-like -0.0380934
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0380778
GLIS3 GLIS family zinc finger 3 -0.0379913
GNAS GNAS complex locus -0.0368244
LMAN1 lectin, mannose-binding, 1 -0.0366881
PRRC2C proline-rich coiled-coil 2C -0.036519
PDIA3 protein disulfide isomerase family A, member 3 -0.0365073
BIRC6 baculoviral IAP repeat containing 6 -0.0360907
AVL9 AVL9 homolog (S. cerevisiase) -0.0354069
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0350734
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0349742
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0348005
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0346068
RAB6A RAB6A, member RAS oncogene family -0.0345677
COPA coatomer protein complex, subunit alpha -0.0345452
TTC3 tetratricopeptide repeat domain 3 -0.0340318
USP47 ubiquitin specific peptidase 47 -0.0337617
LPP LIM domain containing preferred translocation partner in lipoma -0.0337325
STC1 stanniocalcin 1 -0.0329948
HMGA1 high mobility group AT-hook 1 -0.0328222
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.032664
OGA O-GlcNAcase -0.0325593
JMJD1C jumonji domain containing 1C -0.0323557
ACBD3 acyl-CoA binding domain containing 3 -0.0323109
RASA2 RAS p21 protein activator 2 -0.032242
LRRC49 leucine rich repeat containing 49 -0.0322011
WDR45B WD repeat domain 45B -0.0317446
EGFR epidermal growth factor receptor -0.0315866
SUCO SUN domain containing ossification factor -0.0313217
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0312383
ADAM17 ADAM metallopeptidase domain 17 -0.0311012
ANTXR2 anthrax toxin receptor 2 -0.0310062
TFG TRK-fused gene -0.0309286
VMP1 vacuole membrane protein 1 -0.0307416
TMEM39A transmembrane protein 39A -0.0304725
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0304466
SNX13 sorting nexin 13 -0.0301444
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0301378
TM9SF3 transmembrane 9 superfamily member 3 -0.0299587
ELL2 elongation factor, RNA polymerase II, 2 -0.0298873
WAC WW domain containing adaptor with coiled-coil -0.0297722
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0296967
RAB1A RAB1A, member RAS oncogene family -0.0296049
ZNF292 zinc finger protein 292 -0.0294441
CLINT1 clathrin interactor 1 -0.0289729
PHF21A PHD finger protein 21A -0.0289233