| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Elimusertib hydrochloride_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.153 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0845302 |
| INTS6 | integrator complex subunit 6 | 0.0802864 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0610643 |
| LRRC23 | leucine rich repeat containing 23 | 0.060059 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0501329 |
| JUN | jun proto-oncogene | 0.0482197 |
| RNF213 | ring finger protein 213 | 0.0467921 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0429216 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0427393 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0411804 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.03876 |
| WWOX | WW domain containing oxidoreductase | 0.0380705 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0374609 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0356579 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0340504 |
| TENM3 | teneurin transmembrane protein 3 | 0.0329519 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0329479 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0327232 |
| VCL | vinculin | 0.032606 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0319233 |
| TPI1 | triosephosphate isomerase 1 | 0.0314063 |
| FHIT | fragile histidine triad | 0.0313364 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0303124 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0301621 |
| ATF3 | activating transcription factor 3 | 0.0293034 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0292637 |
| MACROD2 | MACRO domain containing 2 | 0.0289092 |
| DSPP | dentin sialophosphoprotein | 0.0287052 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0285224 |
| KRT19 | keratin 19, type I | 0.0277859 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.0274485 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0273245 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0267847 |
| FLNA | filamin A, alpha | 0.0266847 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0261953 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0261512 |
| ACTN4 | actinin, alpha 4 | 0.025821 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.025691 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0252082 |
| TUFT1 | tuftelin 1 | 0.0246134 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0245519 |
| AEBP2 | AE binding protein 2 | 0.0242091 |
| CALR | calreticulin | 0.0241319 |
| RPL4 | ribosomal protein L4 | 0.023964 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0236838 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0232559 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 | 0.0231925 |
| RPS4X | ribosomal protein S4, X-linked | 0.0229275 |
| KDM3B | lysine (K)-specific demethylase 3B | 0.0228403 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0226816 |
| KRT18 | keratin 18, type I | 0.0221916 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0220439 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0219691 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0218005 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.021604 |
| TNS3 | tensin 3 | 0.0215786 |
| HOMER1 | homer scaffolding protein 1 | 0.0215727 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0214715 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0211804 |
| RIGI | RNA sensor RIG-I | 0.0209949 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0206925 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0206291 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | 0.0206104 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.020472 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0204217 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0203539 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0200216 |
| UTRN | utrophin | 0.0198428 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0195353 |
| RPL7 | ribosomal protein L7 | 0.0194434 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0193951 |
| B2M | beta-2-microglobulin | 0.0190526 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0190327 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0188683 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0188092 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0184855 |
| RGS6 | regulator of G-protein signaling 6 | 0.0184366 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.018413 |
| PPL | periplakin | 0.0183571 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0181784 |
| BZW2 | basic leucine zipper and W2 domains 2 | 0.0181314 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0181269 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0179503 |
| IER2 | immediate early response 2 | 0.017871 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | 0.0178488 |
| KITLG | KIT ligand | 0.0176368 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | 0.0173447 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0173176 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0171816 |
| FAM53C | family with sequence similarity 53, member C | 0.0171808 |
| LDHA | lactate dehydrogenase A | 0.0171074 |
| EFNB2 | ephrin-B2 | 0.0170685 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0169241 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0168301 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0166948 |
| SKI | SKI proto-oncogene | 0.0165948 |
| BAIAP2 | BAI1-associated protein 2 | 0.0164732 |
| CEP250 | centrosomal protein 250kDa | 0.0163577 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0161679 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.202077 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.132231 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.127701 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.118738 |
| GOLGA4 | golgin A4 | -0.114543 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0943675 |
| DSCAM | Down syndrome cell adhesion molecule | -0.087895 |
| FAT1 | FAT atypical cadherin 1 | -0.0759858 |
| TMSB10 | thymosin beta 10 | -0.0752857 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0746341 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0676003 |
| ARF4 | ADP-ribosylation factor 4 | -0.0624549 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0593499 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0590045 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0585732 |
| ZNF638 | zinc finger protein 638 | -0.0582266 |
| SETD5 | SET domain containing 5 | -0.0563483 |
| ZNF292 | zinc finger protein 292 | -0.0560761 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0560521 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0553914 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0552197 |
| TPM4 | tropomyosin 4 | -0.0549323 |
| MED13L | mediator complex subunit 13-like | -0.0522494 |
| AHNAK | AHNAK nucleoprotein | -0.0522172 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0522135 |
| SRP54 | signal recognition particle 54kDa | -0.0519168 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0495641 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0478482 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0474842 |
| NF1 | neurofibromin 1 | -0.0466805 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0458903 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.0456893 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0454293 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0447625 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.04468 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0440975 |
| TXNRD1 | thioredoxin reductase 1 | -0.0437139 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.043401 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.043274 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0428693 |
| NUP58 | nucleoporin 58 | -0.042768 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0424253 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0422993 |
| RAD51B | RAD51 paralog B | -0.0421648 |
| ANKRD17 | ankyrin repeat domain 17 | -0.04202 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0419018 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0414772 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0413785 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0413479 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0412221 |
| VMP1 | vacuole membrane protein 1 | -0.0411719 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0410504 |
| JMJD1C | jumonji domain containing 1C | -0.0408341 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0406756 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0406693 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0402524 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.040073 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0399872 |
| HMGA1 | high mobility group AT-hook 1 | -0.0398902 |
| RBM39 | RNA binding motif protein 39 | -0.0398674 |
| TMF1 | TATA element modulatory factor 1 | -0.0393119 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0390073 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0387826 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0386979 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0386332 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0385516 |
| USP34 | ubiquitin specific peptidase 34 | -0.0382581 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0381793 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0376682 |
| PRELID2 | PRELI domain containing 2 | -0.0376052 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0371245 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0369653 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.036944 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0368238 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0367927 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0367525 |
| RPS6 | ribosomal protein S6 | -0.0367193 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0366663 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0366557 |
| TMEM41B | transmembrane protein 41B | -0.0361504 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0357314 |
| CDK19 | cyclin-dependent kinase 19 | -0.035515 |
| WDR45B | WD repeat domain 45B | -0.0354144 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0351272 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0350241 |
| SEC24A | SEC24 family member A | -0.0349796 |
| MORF4L2 | mortality factor 4 like 2 | -0.0349529 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.034846 |
| MKI67 | marker of proliferation Ki-67 | -0.0345587 |
| OGA | O-GlcNAcase | -0.0344282 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0343977 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.033994 |
| FTL | ferritin, light polypeptide | -0.0339346 |
| HM13 | histocompatibility (minor) 13 | -0.0338677 |
| ZNF207 | zinc finger protein 207 | -0.0338382 |
| COPA | coatomer protein complex, subunit alpha | -0.0338318 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0337321 |
| CDCP1 | CUB domain containing protein 1 | -0.0335349 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0335266 |
| SNX9 | sorting nexin 9 | -0.0330677 |
