| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Elimusertib hydrochloride_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.180255 |
| FLNA | filamin A, alpha | 0.132127 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.129709 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.10531 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | 0.104626 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.101477 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0914759 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0849531 |
| APP | amyloid beta (A4) precursor protein | 0.0750761 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0708689 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0675465 |
| OXR1 | oxidation resistance 1 | 0.0662275 |
| ACTN4 | actinin, alpha 4 | 0.0657126 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0580285 |
| RPS4X | ribosomal protein S4, X-linked | 0.0558289 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0532097 |
| ZNF608 | zinc finger protein 608 | 0.0529815 |
| MYOF | myoferlin | 0.0518798 |
| PCBP2 | poly(rC) binding protein 2 | 0.0518529 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0503752 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.050091 |
| SMAD3 | SMAD family member 3 | 0.0499809 |
| EZR | ezrin | 0.0481099 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0477953 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0476178 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0475941 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0461385 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0457192 |
| MT2A | metallothionein 2A | 0.0446715 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0444202 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0441641 |
| ANXA1 | annexin A1 | 0.0433416 |
| PKM | pyruvate kinase, muscle | 0.04107 |
| PRELID2 | PRELI domain containing 2 | 0.0393243 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0389052 |
| PTMA | prothymosin, alpha | 0.0388342 |
| WWC1 | WW and C2 domain containing 1 | 0.0373607 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0372744 |
| RBPMS | RNA binding protein with multiple splicing | 0.0370602 |
| CANX | calnexin | 0.0369872 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0364206 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0356707 |
| DNM2 | dynamin 2 | 0.035546 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0354031 |
| ANXA11 | annexin A11 | 0.0351316 |
| LDHA | lactate dehydrogenase A | 0.034943 |
| RPL3 | ribosomal protein L3 | 0.0347848 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0347686 |
| CALR | calreticulin | 0.0347577 |
| APOL1 | apolipoprotein L, 1 | 0.0344281 |
| SET | SET nuclear proto-oncogene | 0.0342976 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0341274 |
| SEPTIN9 | septin 9 | 0.0338756 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0334196 |
| IRS2 | insulin receptor substrate 2 | 0.0332755 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0327347 |
| PLEC | plectin | 0.0326884 |
| TMF1 | TATA element modulatory factor 1 | 0.0320024 |
| TPI1 | triosephosphate isomerase 1 | 0.0318884 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0317887 |
| PAX8 | paired box 8 | 0.0313774 |
| DSG2 | desmoglein 2 | 0.0313266 |
| SVIL | supervillin | 0.0307352 |
| GOLGA4 | golgin A4 | 0.0301658 |
| KRT18 | keratin 18, type I | 0.0301373 |
| DIAPH1 | diaphanous-related formin 1 | 0.0300399 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.029887 |
| BICC1 | BicC family RNA binding protein 1 | 0.0297745 |
| OPTN | optineurin | 0.0286772 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.028189 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0278071 |
| GOLGB1 | golgin B1 | 0.0278 |
| TRIM2 | tripartite motif containing 2 | 0.0277964 |
| VEGFA | vascular endothelial growth factor A | 0.0276562 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0275626 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0272376 |
| GLIS3 | GLIS family zinc finger 3 | 0.0271841 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0271189 |
| DSPP | dentin sialophosphoprotein | 0.0265781 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0264401 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0263772 |
| POU5F1 | POU class 5 homeobox 1 | 0.026096 |
| TBC1D9B | TBC1 domain family, member 9B (with GRAM domain) | 0.0259726 |
| GYS1 | glycogen synthase 1 (muscle) | 0.025939 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0259129 |
| CHD3 | chromodomain helicase DNA binding protein 3 | 0.0258525 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0257605 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0255869 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.025427 |
| XPO1 | exportin 1 | 0.0254228 |
| SCRN1 | secernin 1 | 0.0252413 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0251484 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0249397 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.024777 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0247271 |
| UBC | ubiquitin C | 0.024708 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0245092 |
| ACTG1 | actin gamma 1 | 0.0244094 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0241691 |
| HELZ | helicase with zinc finger | 0.0237764 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.150339 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.116356 |
| ASPH | aspartate beta-hydroxylase | -0.115825 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.100391 |
| HMGA2 | high mobility group AT-hook 2 | -0.0956648 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0913799 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0872077 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0846254 |
| CD44 | CD44 molecule (Indian blood group) | -0.0826613 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0780545 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0713139 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0712543 |
| AHNAK | AHNAK nucleoprotein | -0.0679564 |
| RPL31 | ribosomal protein L31 | -0.0661184 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.056291 |
| RPL37A | ribosomal protein L37a | -0.0554695 |
| FTL | ferritin, light polypeptide | -0.0538722 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0533736 |
| NF1 | neurofibromin 1 | -0.0517064 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0506876 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0497147 |
| RPS24 | ribosomal protein S24 | -0.048008 |
| LAMC2 | laminin, gamma 2 | -0.0478287 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0457429 |
| EGFR | epidermal growth factor receptor | -0.0448602 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0437909 |
| CCND1 | cyclin D1 | -0.0434825 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0415707 |
| LAMA4 | laminin, alpha 4 | -0.0411544 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0405857 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0403964 |
| MAP4 | microtubule-associated protein 4 | -0.0403156 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0383787 |
| RPS3 | ribosomal protein S3 | -0.0378523 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0373409 |
| FLNB | filamin B, beta | -0.0367245 |
| RPS12 | ribosomal protein S12 | -0.0362134 |
| GPR39 | G protein-coupled receptor 39 | -0.0361149 |
| PCED1B | PC-esterase domain containing 1B | -0.0348794 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0347012 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0342903 |
| ANXA2 | annexin A2 | -0.0340513 |
| RPS25 | ribosomal protein S25 | -0.0337177 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.032974 |
| SBF2 | SET binding factor 2 | -0.0328835 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0320827 |
| ATG7 | autophagy related 7 | -0.0318045 |
| VDAC1 | voltage-dependent anion channel 1 | -0.031369 |
| DIAPH3 | diaphanous-related formin 3 | -0.0313125 |
| RPS27A | ribosomal protein S27a | -0.0311485 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0310086 |
| ITGA6 | integrin, alpha 6 | -0.0307642 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0293337 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0289279 |
| DOCK3 | dedicator of cytokinesis 3 | -0.0286747 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.028432 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0278569 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.0275189 |
| RPS19 | ribosomal protein S19 | -0.027462 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0269806 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0267929 |
| SLC38A2 | solute carrier family 38, member 2 | -0.026681 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0262032 |
| RPL30 | ribosomal protein L30 | -0.0261826 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0261047 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | -0.0259658 |
| PTK2 | protein tyrosine kinase 2 | -0.0259079 |
| EREG | epiregulin | -0.0258883 |
| FMNL2 | formin-like 2 | -0.0253143 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0253098 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0248113 |
| IER3 | immediate early response 3 | -0.0246824 |
| EHBP1 | EH domain binding protein 1 | -0.0246624 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0245637 |
| RPS16 | ribosomal protein S16 | -0.0244639 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0243897 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0238402 |
| ATP13A3 | ATPase type 13A3 | -0.0238362 |
| RASA2 | RAS p21 protein activator 2 | -0.0237738 |
| THOC2 | THO complex 2 | -0.0237657 |
| FBXO11 | F-box protein 11 | -0.0236259 |
| BTBD7 | BTB (POZ) domain containing 7 | -0.0235864 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0234826 |
| RPS29 | ribosomal protein S29 | -0.0234211 |
| RPL28 | ribosomal protein L28 | -0.023326 |
| PARD3 | par-3 family cell polarity regulator | -0.0231912 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0231846 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.0225677 |
| MTAP | methylthioadenosine phosphorylase | -0.0225667 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0225175 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0224031 |
| RPL35A | ribosomal protein L35a | -0.0223691 |
| RYK | receptor-like tyrosine kinase | -0.0222868 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0222694 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0221789 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0220571 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0218762 |
| NABP1 | nucleic acid binding protein 1 | -0.0218514 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0216879 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0216098 |
