| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Elimusertib hydrochloride_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.300645 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.214186 |
| COL5A1 | collagen, type V, alpha 1 | 0.177764 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.135427 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.103119 |
| SEPTIN9 | septin 9 | 0.0984862 |
| PLEC | plectin | 0.0849319 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0816181 |
| CANX | calnexin | 0.0698438 |
| SMAD3 | SMAD family member 3 | 0.0695755 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.067875 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0615633 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.061472 |
| PCBP3 | poly(rC) binding protein 3 | 0.0603921 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0567772 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0567251 |
| VEGFA | vascular endothelial growth factor A | 0.0555033 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0546303 |
| FLNA | filamin A, alpha | 0.0543713 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0542134 |
| TNS1 | tensin 1 | 0.0450302 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0439194 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0431246 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0427759 |
| MYOF | myoferlin | 0.0420876 |
| LOX | lysyl oxidase | 0.042035 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0408459 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0402567 |
| AHNAK | AHNAK nucleoprotein | 0.0401324 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0395401 |
| CALR | calreticulin | 0.0395112 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0388157 |
| HDLBP | high density lipoprotein binding protein | 0.038544 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0376677 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0371186 |
| L1CAM | L1 cell adhesion molecule | 0.0363899 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0360761 |
| DSPP | dentin sialophosphoprotein | 0.0351958 |
| RPS4X | ribosomal protein S4, X-linked | 0.0351168 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0341576 |
| TRAM2 | translocation associated membrane protein 2 | 0.0337016 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0334287 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0324193 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0321935 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0320462 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0314653 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0306852 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0306073 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0301086 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0299296 |
| NAV1 | neuron navigator 1 | 0.0293409 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0291279 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0286777 |
| G0S2 | G0/G1 switch 2 | 0.0284603 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0283489 |
| ANGPTL4 | angiopoietin-like 4 | 0.0280017 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0273014 |
| RND3 | Rho family GTPase 3 | 0.0272636 |
| ADM | adrenomedullin | 0.0271819 |
| MT1E | metallothionein 1E | 0.0271661 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0271224 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0269828 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0269054 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0263746 |
| LOXL2 | lysyl oxidase-like 2 | 0.0261898 |
| IRS2 | insulin receptor substrate 2 | 0.0253109 |
| MLPH | melanophilin | 0.0249104 |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | 0.0245812 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0240725 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0239958 |
| LMNA | lamin A/C | 0.0239122 |
| RHBDF2 | rhomboid 5 homolog 2 (Drosophila) | 0.0238064 |
| GRIK4 | glutamate receptor, ionotropic, kainate 4 | 0.0237723 |
| NAV2 | neuron navigator 2 | 0.023761 |
| HLA-E | major histocompatibility complex, class I, E | 0.0236802 |
| ZNF395 | zinc finger protein 395 | 0.0234641 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0232756 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.023158 |
| FAM219A | family with sequence similarity 219, member A | 0.0226721 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0226507 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0225781 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0217826 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0216615 |
| GPC5 | glypican 5 | 0.0213255 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0212115 |
| INTS6 | integrator complex subunit 6 | 0.0211771 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0209349 |
| ARFGEF3 | ARFGEF family member 3 | 0.0208544 |
| GRAMD1B | GRAM domain containing 1B | 0.0207893 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0204789 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0203034 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0202716 |
| S100A10 | S100 calcium binding protein A10 | 0.0202649 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | 0.0199831 |
| PFKP | phosphofructokinase, platelet | 0.0199088 |
| CEP250 | centrosomal protein 250kDa | 0.0198966 |
| LAMB3 | laminin, beta 3 | 0.0197071 |
| ARRDC3 | arrestin domain containing 3 | 0.0196243 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.0196236 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0192302 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.162639 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.132687 |
| IGF2 | insulin-like growth factor 2 | -0.10891 |
| EXT1 | exostosin glycosyltransferase 1 | -0.103069 |
| NDRG1 | N-myc downstream regulated 1 | -0.102124 |
| EGR1 | early growth response 1 | -0.10118 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.100781 |
| GLIS3 | GLIS family zinc finger 3 | -0.0994373 |
| CDH13 | cadherin 13 | -0.0955587 |
| HMGA2 | high mobility group AT-hook 2 | -0.0954916 |
| CD44 | CD44 molecule (Indian blood group) | -0.0913767 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0885004 |
| FN1 | fibronectin 1 | -0.0846503 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0777616 |
| ACTG1 | actin gamma 1 | -0.0763076 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0740206 |
| ASPH | aspartate beta-hydroxylase | -0.0734189 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0725919 |
| TMSB10 | thymosin beta 10 | -0.0722722 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0680213 |
| STC1 | stanniocalcin 1 | -0.0678593 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0628308 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0610973 |
| CDCP1 | CUB domain containing protein 1 | -0.0601638 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.059684 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0534095 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0502863 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0488984 |
| FMN1 | formin 1 | -0.0488425 |
| CADM1 | cell adhesion molecule 1 | -0.0487836 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0471665 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0468604 |
| RTN4 | reticulon 4 | -0.0464729 |
| IER3 | immediate early response 3 | -0.046143 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0456563 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0447432 |
| SBF2 | SET binding factor 2 | -0.0400835 |
| RPL37A | ribosomal protein L37a | -0.0397751 |
| TENM2 | teneurin transmembrane protein 2 | -0.0393849 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0390472 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0388006 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0372808 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0372471 |
| DIAPH2 | diaphanous-related formin 2 | -0.0368666 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0368224 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0361291 |
| CENPF | centromere protein F, 350/400kDa | -0.0357742 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0357722 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0351536 |
| CCDC91 | coiled-coil domain containing 91 | -0.0350836 |
| CLMP | CXADR-like membrane protein | -0.0347885 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0345682 |
| VMP1 | vacuole membrane protein 1 | -0.0339984 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0337038 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0334016 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.0309999 |
| RPS19 | ribosomal protein S19 | -0.0306523 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0304674 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0302791 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0302062 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0301149 |
| TXNRD1 | thioredoxin reductase 1 | -0.0298973 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0297392 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0294207 |
| POTEF | POTE ankyrin domain family, member F | -0.0291892 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0290275 |
| FRMD4A | FERM domain containing 4A | -0.0288974 |
| TUBB6 | tubulin, beta 6 class V | -0.0288627 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0288282 |
| RPLP2 | ribosomal protein, large, P2 | -0.0285392 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0285255 |
| IL1B | interleukin 1, beta | -0.0283415 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0282694 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0282302 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0281731 |
| ENO1 | enolase 1, (alpha) | -0.0281346 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0279585 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.027802 |
| SPAG9 | sperm associated antigen 9 | -0.0277613 |
| PTK2 | protein tyrosine kinase 2 | -0.027716 |
| RUNX2 | runt-related transcription factor 2 | -0.0276509 |
| MSN | moesin | -0.0275161 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0274804 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0271959 |
| RPL35A | ribosomal protein L35a | -0.0269439 |
| WDR45B | WD repeat domain 45B | -0.0266818 |
| CD109 | CD109 molecule | -0.0266649 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0266188 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0265565 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0264273 |
| COL1A1 | collagen, type I, alpha 1 | -0.0262579 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0262252 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0261765 |
| DTNA | dystrobrevin, alpha | -0.0259622 |
| USP3 | ubiquitin specific peptidase 3 | -0.0258141 |
| DNMBP | dynamin binding protein | -0.025656 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0255146 |
| RBM39 | RNA binding motif protein 39 | -0.0253522 |
| ATP13A3 | ATPase type 13A3 | -0.0252274 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0250479 |
