| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Elimusertib hydrochloride_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.437184 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.141872 |
| VEGFA | vascular endothelial growth factor A | 0.0990168 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0976578 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0735609 |
| CALR | calreticulin | 0.0680612 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0623674 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0615845 |
| POSTN | periostin, osteoblast specific factor | 0.0552408 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0499467 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0477538 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0451759 |
| RIGI | RNA sensor RIG-I | 0.0409155 |
| COL3A1 | collagen, type III, alpha 1 | 0.0407037 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0401482 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0401385 |
| LDHA | lactate dehydrogenase A | 0.0397192 |
| FLNA | filamin A, alpha | 0.038551 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0365447 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0364363 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0344865 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.033444 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0315698 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0298808 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0274784 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0272722 |
| SP100 | SP100 nuclear antigen | 0.0265439 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0263804 |
| PLSCR1 | phospholipid scramblase 1 | 0.025798 |
| HYOU1 | hypoxia up-regulated 1 | 0.0245734 |
| PLEC | plectin | 0.0232696 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0228922 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0217085 |
| ARRDC3 | arrestin domain containing 3 | 0.0215983 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0207266 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0204368 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.0201225 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0200882 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0191183 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0189292 |
| CANX | calnexin | 0.0188116 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0187012 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.018501 |
| ADAR | adenosine deaminase, RNA-specific | 0.0183405 |
| MSN | moesin | 0.0179634 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0177124 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0176497 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0173463 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0172913 |
| ATL1 | atlastin GTPase 1 | 0.016749 |
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | 0.0165641 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0164555 |
| OPTN | optineurin | 0.0162815 |
| CFB | complement factor B | 0.0162533 |
| ATF4 | activating transcription factor 4 | 0.0162171 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0161718 |
| TNS1 | tensin 1 | 0.0161325 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0160651 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0160627 |
| CABIN1 | calcineurin binding protein 1 | 0.0158524 |
| KIF1B | kinesin family member 1B | 0.0155375 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.015494 |
| MANF | mesencephalic astrocyte-derived neurotrophic factor | 0.0153869 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0153296 |
| FYTTD1 | forty-two-three domain containing 1 | 0.0152541 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0149872 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0149596 |
| UBC | ubiquitin C | 0.0148862 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0147723 |
| MYO9B | myosin IXB | 0.0147116 |
| ACTN4 | actinin, alpha 4 | 0.01439 |
| ATL3 | atlastin GTPase 3 | 0.014388 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.014115 |
| CLIC4 | chloride intracellular channel 4 | 0.0140804 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | 0.0140792 |
| FAM219A | family with sequence similarity 219, member A | 0.0140289 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0140029 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0140003 |
| APP | amyloid beta (A4) precursor protein | 0.0139473 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0139392 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0138611 |
| INTS6 | integrator complex subunit 6 | 0.013821 |
| BRD2 | bromodomain containing 2 | 0.0137752 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0135957 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0135469 |
| PML | promyelocytic leukemia | 0.0131696 |
| JUN | jun proto-oncogene | 0.0130429 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0129426 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0129173 |
| CLU | clusterin | 0.0128557 |
| PPP1R18 | protein phosphatase 1, regulatory subunit 18 | 0.0126605 |
| SEPTIN9 | septin 9 | 0.0126158 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.012439 |
| RPL3 | ribosomal protein L3 | 0.0123881 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0123752 |
| SAMD9L | sterile alpha motif domain containing 9-like | 0.0121718 |
| DOCK7 | dedicator of cytokinesis 7 | 0.0120989 |
| IFI44L | interferon-induced protein 44-like | 0.0119933 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0119571 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0118724 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.218927 |
| COL1A1 | collagen, type I, alpha 1 | -0.174387 |
| CADM1 | cell adhesion molecule 1 | -0.158897 |
| NDRG1 | N-myc downstream regulated 1 | -0.15698 |
| IER3 | immediate early response 3 | -0.121613 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.121342 |
| TPM4 | tropomyosin 4 | -0.106023 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0981641 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0967466 |
| FTL | ferritin, light polypeptide | -0.0923138 |
| STC1 | stanniocalcin 1 | -0.0884698 |
| CDH13 | cadherin 13 | -0.0785805 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0748726 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0696295 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0656375 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0655685 |
| CD44 | CD44 molecule (Indian blood group) | -0.0612912 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0584508 |
| ATP13A3 | ATPase type 13A3 | -0.0567528 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0559304 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0543795 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0539896 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0538928 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0533438 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0530159 |
| GOLGA4 | golgin A4 | -0.0511787 |
| PDE10A | phosphodiesterase 10A | -0.0505639 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0497874 |
| HMGA2 | high mobility group AT-hook 2 | -0.0475787 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0471078 |
| RPL35A | ribosomal protein L35a | -0.044877 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0444577 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0441433 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0435748 |
| CLMP | CXADR-like membrane protein | -0.0432932 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0432765 |
| INHBA | inhibin, beta A | -0.0429352 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.042626 |
| LOX | lysyl oxidase | -0.0425935 |
| RPS6 | ribosomal protein S6 | -0.042459 |
| ASPH | aspartate beta-hydroxylase | -0.0405111 |
| TMSB10 | thymosin beta 10 | -0.039077 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0388458 |
| VCAN | versican | -0.0388225 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0387967 |
| CAVIN1 | caveolae associated protein 1 | -0.0385369 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0383923 |
| STC2 | stanniocalcin 2 | -0.0376496 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0375173 |
| GLIS3 | GLIS family zinc finger 3 | -0.0373757 |
| BNC2 | basonuclin 2 | -0.0370244 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0361956 |
| ANTXR2 | anthrax toxin receptor 2 | -0.03537 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0351411 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0349731 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0348337 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0348159 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0345944 |
| GNAS | GNAS complex locus | -0.0342203 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0331408 |
| SYNJ2 | synaptojanin 2 | -0.0331306 |
| RPS8 | ribosomal protein S8 | -0.0330606 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0329867 |
| PTK2 | protein tyrosine kinase 2 | -0.0328268 |
| CALD1 | caldesmon 1 | -0.0328082 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0325344 |
| FRMD4A | FERM domain containing 4A | -0.0320159 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0308935 |
| RPL37A | ribosomal protein L37a | -0.0308731 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.030329 |
| MTDH | metadherin | -0.03025 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0302025 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0297563 |
| RTN4 | reticulon 4 | -0.029308 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0286788 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0285829 |
| OSMR | oncostatin M receptor | -0.0284479 |
| ACTG1 | actin gamma 1 | -0.0283489 |
| RUNX1 | runt-related transcription factor 1 | -0.0280334 |
| RPL11 | ribosomal protein L11 | -0.027876 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0277301 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0277274 |
| HLA-B | major histocompatibility complex, class I, B | -0.0275875 |
| CD109 | CD109 molecule | -0.0273889 |
| RPL37 | ribosomal protein L37 | -0.027175 |
| RPL30 | ribosomal protein L30 | -0.026797 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0266931 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0264601 |
| VIM | vimentin | -0.0264573 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.026399 |
| FBN1 | fibrillin 1 | -0.0261774 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0260838 |
| RPL31 | ribosomal protein L31 | -0.0259056 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0253846 |
| CMIP | c-Maf inducing protein | -0.0252617 |
| EVI5 | ecotropic viral integration site 5 | -0.0250758 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0248598 |
| COL1A2 | collagen, type I, alpha 2 | -0.0246409 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0245245 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0245152 |
