| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Elimusertib hydrochloride_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.144376 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0914369 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0652265 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0644888 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0633876 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0578444 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0524907 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0523167 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0518897 |
| KRT18 | keratin 18, type I | 0.0511202 |
| EXPH5 | exophilin 5 | 0.0485269 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0453472 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0441092 |
| PDZD8 | PDZ domain containing 8 | 0.0440899 |
| FOXP1 | forkhead box P1 | 0.0427683 |
| ATXN1 | ataxin 1 | 0.042047 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0407675 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0403302 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0391045 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0390827 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0366255 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0349974 |
| FBXO32 | F-box protein 32 | 0.0346615 |
| TLE4 | transducin-like enhancer of split 4 | 0.0346282 |
| PGCKA1 | PDCD10 and GCKIII kinases associated 1 | 0.0344652 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0342087 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0336694 |
| FAM13A | family with sequence similarity 13, member A | 0.0330639 |
| MYO5B | myosin VB | 0.0324248 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0321698 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0320941 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0319113 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0314432 |
| KLF6 | Kruppel-like factor 6 | 0.030434 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.030338 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0301031 |
| TMC5 | transmembrane channel-like 5 | 0.02986 |
| FHL2 | four and a half LIM domains 2 | 0.0294232 |
| GOLGA4 | golgin A4 | 0.0293303 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0279117 |
| SHROOM3 | shroom family member 3 | 0.0262521 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.026009 |
| NEBL | nebulette | 0.0255802 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0254559 |
| JMJD1C | jumonji domain containing 1C | 0.0253882 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0252907 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0249107 |
| BCAS1 | breast carcinoma amplified sequence 1 | 0.0244656 |
| DPP4 | dipeptidyl-peptidase 4 | 0.0242008 |
| CANX | calnexin | 0.0241434 |
| NDRG1 | N-myc downstream regulated 1 | 0.0240886 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0236983 |
| GLCCI1 | glucocorticoid induced 1 | 0.023509 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0233913 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0233896 |
| PGK1 | phosphoglycerate kinase 1 | 0.0233813 |
| EHF | ets homologous factor | 0.0228999 |
| ETV6 | ets variant 6 | 0.0226003 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.0220159 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0212494 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0212487 |
| ITGB8 | integrin, beta 8 | 0.0211246 |
| MYOF | myoferlin | 0.0211133 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0210662 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0207592 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0207461 |
| LDHA | lactate dehydrogenase A | 0.0206645 |
| HYOU1 | hypoxia up-regulated 1 | 0.0205207 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.020409 |
| ATF3 | activating transcription factor 3 | 0.0200582 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0191284 |
| CALR | calreticulin | 0.018933 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.01887 |
| TJP1 | tight junction protein 1 | 0.0187512 |
| KIZ | kizuna centrosomal protein | 0.0185219 |
| EREG | epiregulin | 0.0184789 |
| ZNF292 | zinc finger protein 292 | 0.0184668 |
| UBC | ubiquitin C | 0.01838 |
| RPL7 | ribosomal protein L7 | 0.0179168 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0179031 |
| OCLN | occludin | 0.017561 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0173679 |
| JMY | junction mediating and regulatory protein, p53 cofactor | 0.0173395 |
| C3ORF52 | chromosome 3 open reading frame 52 | 0.0172955 |
| CAB39 | calcium binding protein 39 | 0.0172481 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.017076 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0167078 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0166114 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.016582 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0165003 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.016182 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0160979 |
| RND3 | Rho family GTPase 3 | 0.0159348 |
| NT5DC3 | 5'-nucleotidase domain containing 3 | 0.0158405 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.0158354 |
| ADD3 | adducin 3 (gamma) | 0.0157578 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0157543 |
| AHR | aryl hydrocarbon receptor | 0.015615 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0155317 |
| TM4SF4 | transmembrane 4 L six family member 4 | 0.0155148 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.156292 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.143505 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.130168 |
| SLC45A4 | solute carrier family 45, member 4 | -0.12728 |
| FTL | ferritin, light polypeptide | -0.126725 |
| ANXA2 | annexin A2 | -0.109521 |
| LAMA4 | laminin, alpha 4 | -0.0962668 |
| EGR1 | early growth response 1 | -0.0702251 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0642147 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0584573 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0541651 |
| TMSB10 | thymosin beta 10 | -0.0540347 |
| RPLP2 | ribosomal protein, large, P2 | -0.0538444 |
| INTS6 | integrator complex subunit 6 | -0.0527736 |
| DIAPH2 | diaphanous-related formin 2 | -0.0520886 |
| POTEF | POTE ankyrin domain family, member F | -0.0520414 |
| RPL37A | ribosomal protein L37a | -0.0498381 |
| MCL1 | myeloid cell leukemia 1 | -0.0483413 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0482023 |
| KRT8 | keratin 8, type II | -0.0475157 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0474436 |
| TMEM65 | transmembrane protein 65 | -0.0473129 |
| PTMA | prothymosin, alpha | -0.0464414 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.046048 |
| DGKH | diacylglycerol kinase, eta | -0.0445761 |
| RPS12 | ribosomal protein S12 | -0.0443575 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | -0.0436684 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0428561 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0414064 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0412459 |
| RPL31 | ribosomal protein L31 | -0.0411182 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0404264 |
| SKIL | SKI-like proto-oncogene | -0.0394478 |
| B2M | beta-2-microglobulin | -0.0393711 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0392049 |
| RPL35A | ribosomal protein L35a | -0.0390935 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0388372 |
| ITGA6 | integrin, alpha 6 | -0.0386669 |
| CAPN8 | calpain 8 | -0.0383189 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0372954 |
| RPL9 | ribosomal protein L9 | -0.0366386 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0351539 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0345454 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0344327 |
| WASF2 | WAS protein family, member 2 | -0.0344182 |
| JUP | junction plakoglobin | -0.0339682 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0337252 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0334842 |
| MKI67 | marker of proliferation Ki-67 | -0.0333899 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.033215 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0331006 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0330817 |
| CTBP2 | C-terminal binding protein 2 | -0.0329992 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0329671 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0324226 |
| ECT2 | epithelial cell transforming 2 | -0.0323777 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0322791 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0320149 |
| NTN4 | netrin 4 | -0.0309294 |
| RPS24 | ribosomal protein S24 | -0.0307019 |
| POMP | proteasome maturation protein | -0.0304812 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0303948 |
| PRR5L | proline rich 5 like | -0.0301106 |
| RPS3 | ribosomal protein S3 | -0.0297186 |
| RPS19 | ribosomal protein S19 | -0.0294172 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0291496 |
| FLNB | filamin B, beta | -0.0290309 |
| NIBAN2 | niban apoptosis regulator 2 | -0.0288989 |
| RPS25 | ribosomal protein S25 | -0.0285661 |
| ASPH | aspartate beta-hydroxylase | -0.028435 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0284306 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0277511 |
| SQSTM1 | sequestosome 1 | -0.0272158 |
| LAMB3 | laminin, beta 3 | -0.0269689 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0269256 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0267012 |
| HMGA1 | high mobility group AT-hook 1 | -0.0262234 |
| RTN4 | reticulon 4 | -0.0259619 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0259001 |
| RPL11 | ribosomal protein L11 | -0.0258655 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.0256371 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0256044 |
| KLF10 | Kruppel-like factor 10 | -0.0255345 |
| CENPF | centromere protein F, 350/400kDa | -0.0254044 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0252969 |
| EXOC4 | exocyst complex component 4 | -0.0252154 |
| RPL13A | ribosomal protein L13a | -0.0250632 |
| RCOR1 | REST corepressor 1 | -0.0250416 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.024807 |
| KLF12 | Kruppel-like factor 12 | -0.024771 |
| NF1 | neurofibromin 1 | -0.0246457 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0246186 |
| TRIB1 | tribbles pseudokinase 1 | -0.0244028 |
| ACTN4 | actinin, alpha 4 | -0.024328 |
| NPSR1 | neuropeptide S receptor 1 | -0.0242308 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0241873 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0241754 |
| SERTAD2 | SERTA domain containing 2 | -0.0239105 |
| GSN | gelsolin | -0.02368 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0236647 |
