| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Elimusertib hydrochloride perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Elimusertib hydrochloride_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| C3 | complement component 3 | 0.184463 |
| TF | transferrin | 0.0968736 |
| FN1 | fibronectin 1 | 0.08591 |
| DSPP | dentin sialophosphoprotein | 0.0833332 |
| APOB | apolipoprotein B | 0.0772236 |
| VEGFA | vascular endothelial growth factor A | 0.0630617 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0590582 |
| CFB | complement factor B | 0.0553866 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0541091 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0446528 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0358572 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0343367 |
| SVIL | supervillin | 0.0338516 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0335122 |
| SMAD3 | SMAD family member 3 | 0.0314709 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0302302 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0284833 |
| CPE | carboxypeptidase E | 0.0279468 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0278784 |
| JAK1 | Janus kinase 1 | 0.0277504 |
| TNS1 | tensin 1 | 0.0272366 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0271831 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0263507 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0253443 |
| FGA | fibrinogen alpha chain | 0.025098 |
| PEG3 | paternally expressed 3 | 0.0248102 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0245366 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0244407 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0242223 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0242113 |
| RPL3 | ribosomal protein L3 | 0.0227333 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0224426 |
| CANX | calnexin | 0.0219047 |
| EFNA1 | ephrin-A1 | 0.0210986 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0210497 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0206849 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0205019 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0204688 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0199704 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0198511 |
| FAM107B | family with sequence similarity 107, member B | 0.0196717 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0196484 |
| CCNY | cyclin Y | 0.0192595 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0187965 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0186744 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0186682 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0186173 |
| AFDN | afadin, adherens junction formation factor | 0.0185367 |
| MATR3 | matrin 3 | 0.018235 |
| ECE1 | endothelin converting enzyme 1 | 0.0181834 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0175252 |
| SDC2 | syndecan 2 | 0.0173785 |
| CRY1 | cryptochrome circadian clock 1 | 0.0173614 |
| CLEC16A | C-type lectin domain family 16, member A | 0.0173509 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0172066 |
| GSE1 | Gse1 coiled-coil protein | 0.017189 |
| CEP250 | centrosomal protein 250kDa | 0.0171491 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0170795 |
| MED13L | mediator complex subunit 13-like | 0.0170772 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0170614 |
| CMIP | c-Maf inducing protein | 0.016962 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0169325 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0166721 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.0162364 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0161805 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0161408 |
| SEPTIN9 | septin 9 | 0.016019 |
| CABIN1 | calcineurin binding protein 1 | 0.0159721 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.0158947 |
| TMF1 | TATA element modulatory factor 1 | 0.0156189 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0155845 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0155018 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0153058 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | 0.0151487 |
| OPTN | optineurin | 0.0151308 |
| RPL7 | ribosomal protein L7 | 0.015125 |
| FOXN3 | forkhead box N3 | 0.0149068 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0147311 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 | 0.0142942 |
| KYNU | kynureninase | 0.014287 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0138917 |
| JMY | junction mediating and regulatory protein, p53 cofactor | 0.0138836 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0138413 |
| TMEM181 | transmembrane protein 181 | 0.0136734 |
| HELZ | helicase with zinc finger | 0.0136241 |
| FGB | fibrinogen beta chain | 0.0134796 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | 0.0134742 |
| FERMT2 | fermitin family member 2 | 0.0134022 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0132316 |
| BRD4 | bromodomain containing 4 | 0.0131414 |
| RAB11FIP3 | RAB11 family interacting protein 3 (class II) | 0.0130479 |
| RBM33 | RNA binding motif protein 33 | 0.0130113 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.012967 |
| FGG | fibrinogen gamma chain | 0.0129525 |
| MRTFA | myocardin related transcription factor A | 0.0129314 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | 0.0129024 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0128522 |
| PCBP2 | poly(rC) binding protein 2 | 0.012836 |
| SKI | SKI proto-oncogene | 0.0128123 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.012778 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.430051 |
| SLC38A2 | solute carrier family 38, member 2 | -0.132023 |
| EHBP1 | EH domain binding protein 1 | -0.121998 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.105015 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0915441 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0825049 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0823598 |
| APOA2 | apolipoprotein A-II | -0.0797791 |
| FRMD5 | FERM domain containing 5 | -0.0748871 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0747731 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0747629 |
| FTL | ferritin, light polypeptide | -0.0726569 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0722599 |
| ASPH | aspartate beta-hydroxylase | -0.0609203 |
| RPS24 | ribosomal protein S24 | -0.0593734 |
| MT2A | metallothionein 2A | -0.0580439 |
| GPC6 | glypican 6 | -0.0569892 |
| GPC3 | glypican 3 | -0.0569718 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0535053 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0534421 |
| TMEM123 | transmembrane protein 123 | -0.0525694 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0523046 |
| FMNL2 | formin-like 2 | -0.051745 |
| RPL37A | ribosomal protein L37a | -0.0485131 |
| RPL35A | ribosomal protein L35a | -0.0481765 |
| ENO1 | enolase 1, (alpha) | -0.0476069 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0464084 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0457276 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0430645 |
| TMSB10 | thymosin beta 10 | -0.0419792 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0410113 |
| RPS19 | ribosomal protein S19 | -0.040837 |
| RPS27A | ribosomal protein S27a | -0.0395082 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0388976 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0388573 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0388124 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.038468 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0366412 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0363168 |
| RPL34 | ribosomal protein L34 | -0.0357007 |
| HMGA1 | high mobility group AT-hook 1 | -0.0355378 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0349527 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0346139 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.033875 |
| RPS8 | ribosomal protein S8 | -0.0338478 |
| RPLP0 | ribosomal protein, large, P0 | -0.0321212 |
| RPS21 | ribosomal protein S21 | -0.0318579 |
| RPLP1 | ribosomal protein, large, P1 | -0.031676 |
| RPLP2 | ribosomal protein, large, P2 | -0.0312158 |
| IER3 | immediate early response 3 | -0.0305103 |
| RPS29 | ribosomal protein S29 | -0.0304009 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0298185 |
| RPL12 | ribosomal protein L12 | -0.0297267 |
| ATP10A | ATPase, class V, type 10A | -0.0290661 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0289247 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0287145 |
| APOE | apolipoprotein E | -0.0282952 |
| EGR1 | early growth response 1 | -0.0279398 |
| RPL31 | ribosomal protein L31 | -0.0278448 |
| RPS6 | ribosomal protein S6 | -0.0273849 |
| RPL37 | ribosomal protein L37 | -0.0267425 |
| NPR2 | natriuretic peptide receptor 2 | -0.0259406 |
| APOC1 | apolipoprotein C-I | -0.0253583 |
| RACK1 | receptor for activated C kinase 1 | -0.0252595 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0251642 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0247522 |
| GNAS | GNAS complex locus | -0.0247366 |
| OSMR | oncostatin M receptor | -0.0246149 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0239307 |
| GK | glycerol kinase | -0.02368 |
| ITGA1 | integrin, alpha 1 | -0.0236618 |
| RPS16 | ribosomal protein S16 | -0.0236213 |
| ACTG1 | actin gamma 1 | -0.0235651 |
| DST | dystonin | -0.0231782 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0229977 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0228167 |
| H1-0 | H1.0 linker histone | -0.0222023 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0221642 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0218581 |
| FAM135A | family with sequence similarity 135, member A | -0.0216583 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0216536 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0216417 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.0212094 |
| STK17A | serine/threonine kinase 17a | -0.0210728 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0209788 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0208333 |
| CNKSR3 | CNKSR family member 3 | -0.0207992 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | -0.0207522 |
| ATXN1 | ataxin 1 | -0.0206834 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0206643 |
| TPM4 | tropomyosin 4 | -0.0203837 |
| RPS11 | ribosomal protein S11 | -0.0200682 |
| AHSG | alpha-2-HS-glycoprotein | -0.0199684 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0198366 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0198155 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.0198052 |
| FNDC3A | fibronectin type III domain containing 3A | -0.01979 |
| NHSL1 | NHS-like 1 | -0.0192971 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0191142 |
| PARD3 | par-3 family cell polarity regulator | -0.0190318 |
