Elimusertib hydrochloride_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Elimusertib hydrochloride perturbation in Hs 766T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Elimusertib hydrochloride_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.0791455
PDE4D phosphodiesterase 4D, cAMP-specific 0.0623239
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.059793
KLF5 Kruppel-like factor 5 (intestinal) 0.058086
PLEC plectin 0.0564387
KRT17 keratin 17, type I 0.0559222
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0525324
EXT1 exostosin glycosyltransferase 1 0.0481003
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0474243
TGM2 transglutaminase 2 0.0445927
AOPEP aminopeptidase O (putative) 0.0443811
SAMD9 sterile alpha motif domain containing 9 0.0442064
AHNAK2 AHNAK nucleoprotein 2 0.0437208
CANX calnexin 0.0428472
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0421242
KIAA1217 KIAA1217 0.041533
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0405656
MXRA5 matrix-remodelling associated 5 0.040003
ANXA1 annexin A1 0.0394601
MTSS1 metastasis suppressor 1 0.0383581
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0382697
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0374794
MYOF myoferlin 0.0373456
CAV1 caveolin 1, caveolae protein, 22kDa 0.0368457
MYH9 myosin, heavy chain 9, non-muscle 0.0360997
FTH1 ferritin, heavy polypeptide 1 0.033628
BHLHE40 basic helix-loop-helix family, member e40 0.0335276
TMSB4X thymosin beta 4, X-linked 0.0333788
ITGB8 integrin, beta 8 0.0325085
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0323749
MBNL2 muscleblind-like splicing regulator 2 0.0320231
AHNAK AHNAK nucleoprotein 0.0317019
ARRDC3 arrestin domain containing 3 0.0311699
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0292589
RNF213 ring finger protein 213 0.0292505
DSPP dentin sialophosphoprotein 0.0288807
CEP250 centrosomal protein 250kDa 0.028491
CSNK1A1 casein kinase 1, alpha 1 0.0281928
FNDC3B fibronectin type III domain containing 3B 0.0275749
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0258653
EHBP1L1 EH domain binding protein 1-like 1 0.0257072
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0256399
DOK5 docking protein 5 0.0254746
ADM adrenomedullin 0.0253958
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0251724
CALR calreticulin 0.0248839
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.024848
PARP14 poly (ADP-ribose) polymerase family, member 14 0.024791
DIAPH1 diaphanous-related formin 1 0.024142
IFI16 interferon, gamma-inducible protein 16 0.0238129
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0234018
BLCAP bladder cancer associated protein 0.0233213
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0232347
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0230357
KRT14 keratin 14, type I 0.0229902
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0229655
ZSWIM6 zinc finger, SWIM-type containing 6 0.0228568
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0224603
UBC ubiquitin C 0.0219627
RIGI RNA sensor RIG-I 0.0218453
DSCAM Down syndrome cell adhesion molecule 0.0217596
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0217076
HSPA8 heat shock 70kDa protein 8 0.021648
SSBP3 single stranded DNA binding protein 3 0.0215283
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 0.0215214
TXNIP thioredoxin interacting protein 0.0214582
MACF1 microtubule-actin crosslinking factor 1 0.0214219
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0211201
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0211055
COL17A1 collagen, type XVII, alpha 1 0.0208862
RAD51B RAD51 paralog B 0.0206678
RRBP1 ribosome binding protein 1 0.0205127
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.0204925
NCOR2 nuclear receptor corepressor 2 0.0197131
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.019624
EHF ets homologous factor 0.0194902
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0193013
IFI44L interferon-induced protein 44-like 0.019197
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.0189248
PRELID2 PRELI domain containing 2 0.0188947
PLCE1 phospholipase C, epsilon 1 0.0188719
FLNA filamin A, alpha 0.0183092
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0182159
HLA-E major histocompatibility complex, class I, E 0.017967
ATF4 activating transcription factor 4 0.0178031
RSF1 remodeling and spacing factor 1 0.0177946
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0177585
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 0.0177411
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0176769
GPRC5B G protein-coupled receptor, class C, group 5, member B 0.0176637
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0174454
ZNF395 zinc finger protein 395 0.0174408
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.0173345
EPS8 epidermal growth factor receptor pathway substrate 8 0.0173018
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0172015
MX1 MX dynamin-like GTPase 1 0.0169844
KLF4 Kruppel-like factor 4 (gut) 0.0169058
FNIP1 folliculin interacting protein 1 0.0167542
PDIA4 protein disulfide isomerase family A, member 4 0.0166098
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0162924

decreased expression

Symbol Name Standardized Value
FLNB filamin B, beta -0.175491
NDRG1 N-myc downstream regulated 1 -0.110037
B2M beta-2-microglobulin -0.0823886
HLA-B major histocompatibility complex, class I, B -0.076716
POTEF POTE ankyrin domain family, member F -0.0733669
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0729533
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0722466
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0670902
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0631823
IFITM1 interferon induced transmembrane protein 1 -0.0623987
ITGA6 integrin, alpha 6 -0.0616019
RPLP2 ribosomal protein, large, P2 -0.0584948
FTL ferritin, light polypeptide -0.0579702
TRIO trio Rho guanine nucleotide exchange factor -0.0559637
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0555046
RPL37A ribosomal protein L37a -0.0551727
TMSB10 thymosin beta 10 -0.0535262
TPT1 tumor protein, translationally-controlled 1 -0.0533094
RBM39 RNA binding motif protein 39 -0.0508479
RPS12 ribosomal protein S12 -0.0499861
RPS19 ribosomal protein S19 -0.0490764
IGF2 insulin-like growth factor 2 -0.0483477
MT2A metallothionein 2A -0.0444127
S100A11 S100 calcium binding protein A11 -0.0442877
IFI6 interferon, alpha-inducible protein 6 -0.043637
STC1 stanniocalcin 1 -0.0414845
RPS25 ribosomal protein S25 -0.0407282
EGR1 early growth response 1 -0.0393989
BCL2L1 BCL2-like 1 -0.0383662
RPS21 ribosomal protein S21 -0.0378219
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.037294
RPL31 ribosomal protein L31 -0.0370556
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0369834
RPS3 ribosomal protein S3 -0.0369145
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0358861
GNAS GNAS complex locus -0.0349403
CTSA cathepsin A -0.0349378
RPL12 ribosomal protein L12 -0.0348727
FOSL1 FOS-like antigen 1 -0.034453
CAPRIN2 caprin family member 2 -0.0334028
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0333599
MBNL1 muscleblind-like splicing regulator 1 -0.0324341
ANXA2 annexin A2 -0.0324147
CD44 CD44 molecule (Indian blood group) -0.0320056
RPL37 ribosomal protein L37 -0.0319238
MTPN myotrophin -0.0307856
WSB1 WD repeat and SOCS box containing 1 -0.0305873
RPS27 ribosomal protein S27 -0.0304185
ENO1 enolase 1, (alpha) -0.030039
RPL36 ribosomal protein L36 -0.0298267
PTMA prothymosin, alpha -0.029768
RPL36A ribosomal protein L36a -0.0289657
CES2 carboxylesterase 2 -0.0289304
ANKRD10 ankyrin repeat domain 10 -0.0285521
ALCAM activated leukocyte cell adhesion molecule -0.0283668
RPL11 ribosomal protein L11 -0.0282496
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0282033
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0281565
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0281468
RPS29 ribosomal protein S29 -0.0273739
RPL35A ribosomal protein L35a -0.0271239
RPL9 ribosomal protein L9 -0.0265964
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0265961
POMP proteasome maturation protein -0.0265907
RPL26 ribosomal protein L26 -0.0265625
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0263774
SERTAD2 SERTA domain containing 2 -0.025873
EFHD2 EF-hand domain family, member D2 -0.0258333
EMP1 epithelial membrane protein 1 -0.0258061
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0257983
CTSD cathepsin D -0.0256015
LAMA5 laminin, alpha 5 -0.0255765
WASF2 WAS protein family, member 2 -0.0255072
GOLGA4 golgin A4 -0.0251069
RPS6 ribosomal protein S6 -0.0249896
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0246559
IFITM3 interferon induced transmembrane protein 3 -0.0241322
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0237273
CD59 CD59 molecule, complement regulatory protein -0.0237232
FOXO1 forkhead box O1 -0.0237002
DOCK5 dedicator of cytokinesis 5 -0.0235378
CYB5R3 cytochrome b5 reductase 3 -0.0235375
DPYD dihydropyrimidine dehydrogenase -0.0233795
VDAC1 voltage-dependent anion channel 1 -0.0232991
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0230626
GBP4 guanylate binding protein 4 -0.0230391
ZEB1 zinc finger E-box binding homeobox 1 -0.0229219
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0228953
RPS8 ribosomal protein S8 -0.0228262
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0228127
RPS24 ribosomal protein S24 -0.0227246
CNRIP1 cannabinoid receptor interacting protein 1 -0.0225813
HSPG2 heparan sulfate proteoglycan 2 -0.0225106
RPS14 ribosomal protein S14 -0.0224571
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0222258
ANKRD33B ankyrin repeat domain 33B -0.022184
RASAL2 RAS protein activator like 2 -0.0221372
IFI27 interferon, alpha-inducible protein 27 -0.0220481
RPL13A ribosomal protein L13a -0.0219999
ADAM10 ADAM metallopeptidase domain 10 -0.0219296